UniProtKB - P42165 (IFNA1_CHICK)
Functioni
Has antiviral activities.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- type I interferon receptor binding Source: GO_Central
GO - Biological processi
- adaptive immune response Source: GO_Central
- B cell differentiation Source: GO_Central
- B cell proliferation Source: GO_Central
- cytokine-mediated signaling pathway Source: GO_Central
- defense response to virus Source: UniProtKB-KW
- humoral immune response Source: GO_Central
- natural killer cell activation involved in immune response Source: GO_Central
- positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
- response to exogenous dsRNA Source: GO_Central
- T cell activation involved in immune response Source: GO_Central
Keywordsi
Molecular function | Cytokine |
Biological process | Antiviral defense |
Enzyme and pathway databases
Reactomei | R-GGA-909733, Interferon alpha/beta signaling R-GGA-912694, Regulation of IFNA signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon type A1/A2 |
Gene namesi | Name:IFNA1 AND Name:IFNA2 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000016428 | 32 – 193 | Interferon type A1/A2Add BLAST | 162 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 129 | By similarity | ||
Disulfide bondi | 61 ↔ 155 | Sequence analysis | ||
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 68 ↔ 168 | By similarity | ||
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 108 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 186 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P42165 |
Expressioni
Developmental stagei
Appears first at 3 hours post-infection, increases to give the strongest signal at about 9 hours and gradually wanes to almost nothing at 24 hours.
Gene expression databases
Bgeei | ENSGALG00000013245, Expressed in heart and 10 other tissues |
Interactioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- type I interferon receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000043040 |
Family & Domainsi
Sequence similaritiesi
Belongs to the alpha/beta interferon family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SQGR, Eukaryota |
GeneTreei | ENSGT01000000214430 |
HOGENOMi | CLU_109427_1_0_1 |
InParanoidi | P42165 |
OMAi | IMEIMRS |
OrthoDBi | 1358010at2759 |
PhylomeDBi | P42165 |
TreeFami | TF336177 |
Family and domain databases
CDDi | cd00095, IFab, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta IPR015588, Interferon_beta |
PANTHERi | PTHR11691, PTHR11691, 1 hit PTHR11691:SF68, PTHR11691:SF68, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
PRINTSi | PR00266, INTERFERONAB |
SMARTi | View protein in SMART SM00076, IFabd, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00252, INTERFERON_A_B_D, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P42165-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVPASPQHP RGYGILLLTL LLKALATTAS ACNHLRPQDA TFSHDSLQLL
60 70 80 90 100
RDMAPTLPQL CPQHNASCSF NDTILDTSNT RQADKTTHDI LQHLFKILSS
110 120 130 140 150
PSTPAHWNDS QRQSLLNRIH RYTQHLEQCL DSSDTRSRTR WPRNLHLTIK
160 170 180 190
KHFSCLHTFL QDNDYSACAW EHVRLQARAW FLHIHNLTGN TRT
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 65 | N → S. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07868 mRNA Translation: AAA50213.1 X92477 Genomic DNA Translation: CAA63215.1 X92476 Genomic DNA Translation: CAA63214.1 |
PIRi | I50693 |
RefSeqi | NP_990758.1, NM_205427.1 XP_004937152.1, XM_004937095.2 XP_004937153.1, XM_004937096.2 XP_015132923.1, XM_015277437.1 XP_015132925.1, XM_015277439.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07868 mRNA Translation: AAA50213.1 X92477 Genomic DNA Translation: CAA63215.1 X92476 Genomic DNA Translation: CAA63214.1 |
PIRi | I50693 |
RefSeqi | NP_990758.1, NM_205427.1 XP_004937152.1, XM_004937095.2 XP_004937153.1, XM_004937096.2 XP_015132923.1, XM_015277437.1 XP_015132925.1, XM_015277439.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000043040 |
Proteomic databases
PaxDbi | P42165 |
Genome annotation databases
Organism-specific databases
CTDi | 396398 |
Phylogenomic databases
eggNOGi | ENOG502SQGR, Eukaryota |
GeneTreei | ENSGT01000000214430 |
HOGENOMi | CLU_109427_1_0_1 |
InParanoidi | P42165 |
OMAi | IMEIMRS |
OrthoDBi | 1358010at2759 |
PhylomeDBi | P42165 |
TreeFami | TF336177 |
Enzyme and pathway databases
Reactomei | R-GGA-909733, Interferon alpha/beta signaling R-GGA-912694, Regulation of IFNA signaling |
Miscellaneous databases
PROi | PR:P42165 |
Gene expression databases
Bgeei | ENSGALG00000013245, Expressed in heart and 10 other tissues |
Family and domain databases
CDDi | cd00095, IFab, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta IPR015588, Interferon_beta |
PANTHERi | PTHR11691, PTHR11691, 1 hit PTHR11691:SF68, PTHR11691:SF68, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
PRINTSi | PR00266, INTERFERONAB |
SMARTi | View protein in SMART SM00076, IFabd, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00252, INTERFERON_A_B_D, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFNA1_CHICK | |
Accessioni | P42165Primary (citable) accession number: P42165 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families