UniProtKB - P42161 (IFNG_CANLF)
Protein
Interferon gamma
Gene
IFNG
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- interferon-gamma receptor binding Source: InterPro
GO - Biological processi
- adaptive immune response Source: GO_Central
- astrocyte activation Source: Ensembl
- cell cycle arrest Source: Ensembl
- defense response to virus Source: UniProtKB-KW
- extrinsic apoptotic signaling pathway Source: Ensembl
- humoral immune response Source: GO_Central
- interferon-gamma-mediated signaling pathway Source: Ensembl
- macrophage activation involved in immune response Source: Ensembl
- macrophage differentiation Source: Ensembl
- microglial cell activation Source: Ensembl
- negative regulation of interleukin-17 production Source: Ensembl
- negative regulation of smooth muscle cell proliferation Source: Ensembl
- negative regulation of tau-protein kinase activity Source: Ensembl
- negative regulation of transcription, DNA-templated Source: Ensembl
- positive regulation of amyloid-beta formation Source: Ensembl
- positive regulation of autophagy Source: UniProtKB
- positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response Source: Ensembl
- positive regulation of chemokine production Source: Ensembl
- positive regulation of core promoter binding Source: Ensembl
- positive regulation of epithelial cell migration Source: Ensembl
- positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
- positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
- positive regulation of inflammatory response Source: Ensembl
- positive regulation of interleukin-12 production Source: Ensembl
- positive regulation of interleukin-23 production Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of killing of cells of other organism Source: Ensembl
- positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
- positive regulation of neurogenesis Source: Ensembl
- positive regulation of neuron death Source: Ensembl
- positive regulation of nitric oxide biosynthetic process Source: Ensembl
- positive regulation of osteoclast differentiation Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
- positive regulation of protein-containing complex assembly Source: Ensembl
- positive regulation of protein deacetylation Source: Ensembl
- positive regulation of protein import into nucleus Source: Ensembl
- positive regulation of protein serine/threonine kinase activity Source: Ensembl
- positive regulation of smooth muscle cell apoptotic process Source: Ensembl
- positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
- positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
- positive regulation of vitamin D biosynthetic process Source: Ensembl
- regulation of growth Source: UniProtKB-KW
- regulation of insulin secretion Source: Ensembl
- regulation of protein ADP-ribosylation Source: Ensembl
Keywordsi
Molecular function | Cytokine |
Biological process | Antiviral defense, Growth regulation |
Enzyme and pathway databases
Reactomei | R-CFA-877300, Interferon gamma signaling R-CFA-877312, Regulation of IFNG signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon gammaShort name: IFN-gamma |
Gene namesi | Name:IFNG |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:41879, IFNG |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | By similarityAdd BLAST | 23 | |
ChainiPRO_0000016437 | 24 – 166 | Interferon gammaAdd BLAST | 143 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | Pyrrolidone carboxylic acidBy similarity | 1 | |
Glycosylationi | 39 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, Pyrrolidone carboxylic acidProteomic databases
PaxDbi | P42161 |
Expressioni
Tissue specificityi
Released primarily from activated T lymphocytes.
Gene expression databases
Bgeei | ENSCAFG00000000408, Expressed in stomach and 24 other tissues |
Interactioni
Subunit structurei
Homodimer.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- interferon-gamma receptor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000000588 |
Family & Domainsi
Sequence similaritiesi
Belongs to the type II (or gamma) interferon family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SBGW, Eukaryota |
GeneTreei | ENSGT00390000007831 |
HOGENOMi | CLU_135106_0_0_1 |
InParanoidi | P42161 |
OMAi | WKEESDK |
OrthoDBi | 1382686at2759 |
TreeFami | TF336308 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR002069, Interferon_gamma |
PANTHERi | PTHR11419, PTHR11419, 1 hit |
Pfami | View protein in Pfam PF00714, IFN-gamma, 1 hit |
PIRSFi | PIRSF001936, IFN-gamma, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P42161-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNYTSYILAF QLCVILCSSG CNCQAMFFKE IENLKEYFNA SNPDVSDGGS
60 70 80 90 100
LFVDILKKWR EESDKTIIQS QIVSFYLKLF DNFKDNQIIQ RSMDTIKEDM
110 120 130 140 150
LGKFLNSSTS KREDFLKLIQ IPVNDLQVQR KAINELIKVM NDLSPRSNLR
160
KRKRSQNLFR GRRASK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | S → L in AAB22724 (PubMed:1640120).Curated | 1 | |
Sequence conflicti | 22 | N → Y in AAB22724 (PubMed:1640120).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF126247 mRNA Translation: AAD31423.1 EF095772 mRNA Translation: ABL01503.1 S41201 mRNA Translation: AAB22724.2 |
RefSeqi | NP_001003174.1, NM_001003174.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF126247 mRNA Translation: AAD31423.1 EF095772 mRNA Translation: ABL01503.1 S41201 mRNA Translation: AAB22724.2 |
RefSeqi | NP_001003174.1, NM_001003174.1 |
3D structure databases
SMRi | P42161 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000000588 |
Proteomic databases
PaxDbi | P42161 |
Genome annotation databases
Organism-specific databases
CTDi | 3458 |
VGNCi | VGNC:41879, IFNG |
Phylogenomic databases
eggNOGi | ENOG502SBGW, Eukaryota |
GeneTreei | ENSGT00390000007831 |
HOGENOMi | CLU_135106_0_0_1 |
InParanoidi | P42161 |
OMAi | WKEESDK |
OrthoDBi | 1382686at2759 |
TreeFami | TF336308 |
Enzyme and pathway databases
Reactomei | R-CFA-877300, Interferon gamma signaling R-CFA-877312, Regulation of IFNG signaling |
Gene expression databases
Bgeei | ENSCAFG00000000408, Expressed in stomach and 24 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR002069, Interferon_gamma |
PANTHERi | PTHR11419, PTHR11419, 1 hit |
Pfami | View protein in Pfam PF00714, IFN-gamma, 1 hit |
PIRSFi | PIRSF001936, IFN-gamma, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFNG_CANLF | |
Accessioni | P42161Primary (citable) accession number: P42161 Secondary accession number(s): A1E294, Q9TVA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families