IFNG

Functionⁱ

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
interferon-gamma receptor binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
astrocyte activation Source: Ensembl
cell cycle arrest Source: Ensembl
defense response to virus Source: UniProtKB-KW
extrinsic apoptotic signaling pathway Source: Ensembl
humoral immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
interferon-gamma-mediated signaling pathway Source: Ensembl
macrophage activation involved in immune response Source: Ensembl
macrophage differentiation Source: Ensembl
microglial cell activation Source: Ensembl
negative regulation of interleukin-17 production Source: Ensembl
negative regulation of smooth muscle cell proliferation Source: Ensembl
negative regulation of tau-protein kinase activity Source: Ensembl
negative regulation of transcription, DNA-templated Source: Ensembl
positive regulation of amyloid-beta formation Source: Ensembl
positive regulation of autophagy Source: UniProtKB
positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response Source: Ensembl
positive regulation of chemokine production Source: Ensembl
positive regulation of core promoter binding Source: Ensembl
positive regulation of epithelial cell migration Source: Ensembl
positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
positive regulation of inflammatory response Source: Ensembl
positive regulation of interleukin-12 production Source: Ensembl
positive regulation of interleukin-23 production Source: Ensembl
positive regulation of interleukin-6 production Source: Ensembl
positive regulation of killing of cells of other organism Source: Ensembl
positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
positive regulation of neurogenesis Source: Ensembl
positive regulation of neuron death Source: Ensembl
positive regulation of nitric oxide biosynthetic process Source: Ensembl
positive regulation of osteoclast differentiation Source: Ensembl
positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
positive regulation of protein-containing complex assembly Source: Ensembl
positive regulation of protein deacetylation Source: Ensembl
positive regulation of protein import into nucleus Source: Ensembl
positive regulation of protein serine/threonine kinase activity Source: Ensembl
positive regulation of smooth muscle cell apoptotic process Source: Ensembl
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
positive regulation of vitamin D biosynthetic process Source: Ensembl
regulation of growth Source: UniProtKB-KW
regulation of insulin secretion Source: Ensembl
regulation of protein ADP-ribosylation Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Antiviral defense, Growth regulation

Enzyme and pathway databases

Reactomeⁱ	R-CFA-877300, Interferon gamma signaling R-CFA-877312, Regulation of IFNG signaling

Reactomeⁱ

R-CFA-877300, Interferon gamma signaling
R-CFA-877312, Regulation of IFNG signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon gamma Short name: IFN-gamma
Gene namesⁱ	Name:IFNG
Organismⁱ	Canis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifierⁱ	9615 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus
Proteomesⁱ	UP000002254 Componentⁱ: Chromosome 10

Organism-specific databases

VGNCⁱ	VGNC:41879, IFNG

VGNCⁱ

VGNC:41879, IFNG

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	By similarityAdd BLAST		23
ChainⁱPRO_0000016437	24 – 166	Interferon gammaAdd BLAST		143

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	24	Pyrrolidone carboxylic acidBy similarity	1
Glycosylationⁱ	39	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbⁱ	P42161

PaxDbⁱ

P42161

Expressionⁱ

Tissue specificityⁱ

Released primarily from activated T lymphocytes.

Gene expression databases

Bgeeⁱ	ENSCAFG00000000408, Expressed in stomach and 24 other tissues

Bgeeⁱ

ENSCAFG00000000408, Expressed in stomach and 24 other tissues

Interactionⁱ

Subunit structureⁱ

Homodimer.

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9612.ENSCAFP00000000588

STRINGⁱ

9612.ENSCAFP00000000588

Structureⁱ

3D structure databases

SMRⁱ	P42161
ModBaseⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the type II (or gamma) interferon family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG502SBGW, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007831
HOGENOMⁱ	CLU_135106_0_0_1
InParanoidⁱ	P42161
OMAⁱ	WKEESDK
Database of Orthologous Groups More...OrthoDBⁱ	1382686at2759
TreeFamⁱ	TF336308

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR002069, Interferon_gamma
PANTHERⁱ	PTHR11419, PTHR11419, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00714, IFN-gamma, 1 hit
PIRSFⁱ	PIRSF001936, IFN-gamma, 1 hit
SUPFAMⁱ	SSF47266, SSF47266, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P42161-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNYTSYILAF QLCVILCSSG CNCQAMFFKE IENLKEYFNA SNPDVSDGGS 
        60         70         80         90        100
LFVDILKKWR EESDKTIIQS QIVSFYLKLF DNFKDNQIIQ RSMDTIKEDM 
       110        120        130        140        150
LGKFLNSSTS KREDFLKLIQ IPVNDLQVQR KAINELIKVM NDLSPRSNLR 
       160 
KRKRSQNLFR GRRASK

Length:166

Mass (Da):19,395

Last modified:December 1, 2000 - v2

Checksum:ⁱ72179B0B637402DB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	19	S → L in AAB22724 (PubMed:1640120).Curated		1
Sequence conflictⁱ	22	N → Y in AAB22724 (PubMed:1640120).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF126247 mRNA Translation: AAD31423.1 EF095772 mRNA Translation: ABL01503.1 S41201 mRNA Translation: AAB22724.2
NCBI Reference Sequences More...RefSeqⁱ	NP_001003174.1, NM_001003174.1

Genome annotation databases

Ensemblⁱ	ENSCAFT00000000643; ENSCAFP00000000588; ENSCAFG00000000408 ENSCAFT00030018940; ENSCAFP00030016532; ENSCAFG00030010221 ENSCAFT00040042312; ENSCAFP00040036908; ENSCAFG00040022768
GeneIDⁱ	403801
KEGGⁱ	cfa:403801

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P42161	Interferon gamma		VULVU		166	UniRef100_P42161
Interferon gamma		CANLF		166
Interferon gamma		NYCPR		166
Interferon gamma		VULVU		166
Interferon gamma (Fragment)		CANLF		99
+2

Protein	Similar proteins		Species	Score	Length	Source
P42161	Interferon gamma		VULVU		166	UniRef90_P42161
Interferon gamma		AILME		166
Interferon gamma		MUSPF		166
Interferon gamma		CANLF		166
Interferon gamma		NYCPR		166
+28

Protein	Similar proteins		Species	Score	Length	Source
P42161	Interferon gamma		VULVU		166	UniRef50_P42161
Interferon gamma		AILME		166
Interferon gamma		MUSPF		166
Interferon gamma		MARMO		166
Interferon gamma	)	RABIT		167
+63

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF126247 mRNA Translation: AAD31423.1 EF095772 mRNA Translation: ABL01503.1 S41201 mRNA Translation: AAB22724.2
RefSeqⁱ	NP_001003174.1, NM_001003174.1

3D structure databases

SMRⁱ	P42161
ModBaseⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9612.ENSCAFP00000000588

STRINGⁱ

9612.ENSCAFP00000000588

Proteomic databases

PaxDbⁱ	P42161

PaxDbⁱ

P42161

Genome annotation databases

Ensemblⁱ	ENSCAFT00000000643; ENSCAFP00000000588; ENSCAFG00000000408 ENSCAFT00030018940; ENSCAFP00030016532; ENSCAFG00030010221 ENSCAFT00040042312; ENSCAFP00040036908; ENSCAFG00040022768
GeneIDⁱ	403801
KEGGⁱ	cfa:403801

Organism-specific databases

CTDⁱ	3458
VGNCⁱ	VGNC:41879, IFNG

Phylogenomic databases

eggNOGⁱ	ENOG502SBGW, Eukaryota
GeneTreeⁱ	ENSGT00390000007831
HOGENOMⁱ	CLU_135106_0_0_1
InParanoidⁱ	P42161
OMAⁱ	WKEESDK
OrthoDBⁱ	1382686at2759
TreeFamⁱ	TF336308

Enzyme and pathway databases

Reactomeⁱ	R-CFA-877300, Interferon gamma signaling R-CFA-877312, Regulation of IFNG signaling

Reactomeⁱ

R-CFA-877300, Interferon gamma signaling
R-CFA-877312, Regulation of IFNG signaling

Gene expression databases

Bgeeⁱ	ENSCAFG00000000408, Expressed in stomach and 24 other tissues

Bgeeⁱ

ENSCAFG00000000408, Expressed in stomach and 24 other tissues

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR002069, Interferon_gamma
PANTHERⁱ	PTHR11419, PTHR11419, 1 hit
Pfamⁱ	View protein in Pfam PF00714, IFN-gamma, 1 hit
PIRSFⁱ	PIRSF001936, IFN-gamma, 1 hit
SUPFAMⁱ	SSF47266, SSF47266, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IFNG_CANLF
Accessionⁱ	P42161Primary (citable) accession number: P42161 Secondary accession number(s): A1E294, Q9TVA0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	December 1, 2000
	Last modified:	February 10, 2021
	This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P42161 (IFNG_CANLF)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Interferon gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ