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UniProtKB - P42158 (CKL1_ARATH)
Protein
Casein kinase 1-like protein 1
Gene
CKL1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 38 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 128 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 15 – 23 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
GO - Biological processi
- endocytosis Source: GO_Central
- peptidyl-serine phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 399 |
Names & Taxonomyi
Protein namesi | Recommended name: Casein kinase 1-like protein 1Curated (EC:2.7.11.1Curated)Alternative name(s): Casein kinase 11 Publication Casein kinase I isoform delta-likeCurated Short name: CKI-deltaCurated Protein CASEIN KINASE I-LIKE 11 Publication |
Gene namesi | Name:CKL11 Publication Synonyms:CK11 Publication, CKI6Curated Ordered Locus Names:At4g26100 ORF Names:F20B18.210 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G26100 |
TAIRi | locus:2120765, AT4G26100 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- plasmodesma 1 Publication
Note: Present in punctate particles with granular structure.1 Publication
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- plasmodesma Source: TAIR
Keywords - Cellular componenti
Cell junction, CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000192855 | 1 – 450 | Casein kinase 1-like protein 1Add BLAST | 450 |
Post-translational modificationi
Autophosphorylated.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P42158 |
PRIDEi | P42158 |
ProteomicsDBi | 246813 |
PTM databases
iPTMneti | P42158 |
Expressioni
Tissue specificityi
Expressed in flowers.1 Publication
Gene expression databases
ExpressionAtlasi | P42158, baseline and differential |
Genevisiblei | P42158, AT |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
BioGRIDi | 14003, 6 interactors |
IntActi | P42158, 3 interactors |
STRINGi | 3702.AT4G26100.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 278 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 270 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 311 – 450 | DisorderedSequence analysisAdd BLAST | 140 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 328 – 344 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 345 – 401 | Polar residuesSequence analysisAdd BLAST | 57 | |
Compositional biasi | 423 – 450 | Basic and acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1164, Eukaryota |
HOGENOMi | CLU_019279_0_0_1 |
InParanoidi | P42158 |
OMAi | IYFCRGS |
OrthoDBi | 1097975at2759 |
PhylomeDBi | P42158 |
Family and domain databases
InterProi | View protein in InterPro IPR030509, CK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR11909:SF409, PTHR11909:SF409, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
P42158-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPRVGNKFR LGRKIGSGSF GEIYLGTNIH TNEELAIKLE NVKTKHPQLL
60 70 80 90 100
YESKLYRILQ GGTGVPNVKW FGVEGDYNVL VMDLLGPSLE DLFNFCSRKL
110 120 130 140 150
SLKSVLMLAD QMINRVEFFH SKSFLHRDLK PDNFLMGLGR RANQVYIIDF
160 170 180 190 200
GLAKKYRDST THQHIPYREN KNLTGTARYA SMNTHLGIEQ SRRDDLESLG
210 220 230 240 250
YILMYFLKGS LPWQGLKAGT KKQKYERISE KKVSTSIEAL CRGYPSEFAS
260 270 280 290 300
YFHYCRSLRF DDKPDYAYLK RIFRDLFIRE GFQFDYVFDW TILKYQQSQL
310 320 330 340 350
TAPPSRALNP AVGTSAALPP GISNIDRYTG EEEGRPHMES SRRRVSGALD
360 370 380 390 400
NSGNISNQPT SSSARDSMIP SSSLFAQSAG SSRRVTAVSG SRDNFPGSEE
410 420 430 440 450
LLQRSRTGDV SRGVIPRNSP GEAGKSTRRH YESVVKGIDN LQVSDEHHPH
Sequence cautioni
The sequence AAA50233 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | P → Q in AAA50233 (PubMed:7923358).Curated | 1 | |
Sequence conflicti | 131 – 132 | PD → QT in AAA50233 (PubMed:7923358).Curated | 2 | |
Sequence conflicti | 159 | S → M in AAA50233 (PubMed:7923358).Curated | 1 | |
Sequence conflicti | 197 | E → K in AAA50233 (PubMed:7923358).Curated | 1 | |
Sequence conflicti | 223 | Q → K in AAA50233 (PubMed:7923358).Curated | 1 | |
Sequence conflicti | 241 | C → CPIEALC in AAA50233 (PubMed:7923358).Curated | 1 | |
Sequence conflicti | 338 | M → T in AAA50233 (PubMed:7923358).Curated | 1 | |
Sequence conflicti | 387 | A → V in AAA50233 (PubMed:7923358).Curated | 1 | |
Sequence conflicti | 399 – 400 | EE → GG in AAA50233 (PubMed:7923358).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12857 mRNA Translation: AAA50233.1 Frameshift. AY943842 mRNA Translation: AAY24532.1 AL049483 Genomic DNA Translation: CAB39675.1 AL161564 Genomic DNA Translation: CAB79465.1 CP002687 Genomic DNA Translation: AEE85157.1 AY050784 mRNA Translation: AAK92719.1 AY091299 mRNA Translation: AAM14238.1 |
PIRi | T04265 |
RefSeqi | NP_194340.1, NM_118743.3 |
Genome annotation databases
EnsemblPlantsi | AT4G26100.1; AT4G26100.1; AT4G26100 |
GeneIDi | 828716 |
Gramenei | AT4G26100.1; AT4G26100.1; AT4G26100 |
KEGGi | ath:AT4G26100 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12857 mRNA Translation: AAA50233.1 Frameshift. AY943842 mRNA Translation: AAY24532.1 AL049483 Genomic DNA Translation: CAB39675.1 AL161564 Genomic DNA Translation: CAB79465.1 CP002687 Genomic DNA Translation: AEE85157.1 AY050784 mRNA Translation: AAK92719.1 AY091299 mRNA Translation: AAM14238.1 |
PIRi | T04265 |
RefSeqi | NP_194340.1, NM_118743.3 |
3D structure databases
SMRi | P42158 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 14003, 6 interactors |
IntActi | P42158, 3 interactors |
STRINGi | 3702.AT4G26100.1 |
PTM databases
iPTMneti | P42158 |
Proteomic databases
PaxDbi | P42158 |
PRIDEi | P42158 |
ProteomicsDBi | 246813 |
Genome annotation databases
EnsemblPlantsi | AT4G26100.1; AT4G26100.1; AT4G26100 |
GeneIDi | 828716 |
Gramenei | AT4G26100.1; AT4G26100.1; AT4G26100 |
KEGGi | ath:AT4G26100 |
Organism-specific databases
Araporti | AT4G26100 |
TAIRi | locus:2120765, AT4G26100 |
Phylogenomic databases
eggNOGi | KOG1164, Eukaryota |
HOGENOMi | CLU_019279_0_0_1 |
InParanoidi | P42158 |
OMAi | IYFCRGS |
OrthoDBi | 1097975at2759 |
PhylomeDBi | P42158 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 399 |
Miscellaneous databases
PROi | PR:P42158 |
Gene expression databases
ExpressionAtlasi | P42158, baseline and differential |
Genevisiblei | P42158, AT |
Family and domain databases
InterProi | View protein in InterPro IPR030509, CK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR11909:SF409, PTHR11909:SF409, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CKL1_ARATH | |
Accessioni | P42158Primary (citable) accession number: P42158 Secondary accession number(s): Q3KT07, Q9SZI1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 10, 2003 | |
Last modified: | February 23, 2022 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families