UniProtKB - P42128 (FOXK1_MOUSE)

BLAST

>sp|P42128|FOXK1_MOUSE Forkhead box protein K1 OS=Mus musculus OX=10090 GN=Foxk1 PE=1 SV=2
MAEVGEDSGARALLALRSAPCSPVLCAAAAAAAFPATTSPPPPAQPPPGPPALPAEPGPG
PVPSTVATATTTAPALVAAAAASVRQSPGPALARLEGREFEFLMRQPSVTIGRNSSQGSV
DLSMGLSSFISRRHLQLSFQEPHFYLRCLGKNGVFVDGAFQRRGAPALQLPQQCTFRFPS
TAIKIQFTSLYHKEEAPASPLRPLYPQISPLKIHIPEPDLRSLVSPIPSPTGTISVPNSC
PASPRGAGSSSYRFVQNVTSDLQLAAEFAAKAASEQQADASGGDSPKDESKPPYSYAQLI
VQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPG
KGSFWRIDPASEAKLVEQAFRKRRQRGVSCFRTPFGPLSSRSAPASPTHPGLMSPRSSGL
QTPECLSREGSPIPHDPDLGSKLASVPEYRYSQSAPGSPVSAQPVIMAVPPRPSNLVAKP
VAYMPASIVTSQQPSGHAIHVVQQAPTVTMVRVVTTSANSANGYILASQGSTGTSHDTAG
TAVLDLGNEARGLEEKPTIAFATIPAASRVIQTVASQMAPGVPGHTVTILQPATPVTIGQ
HHLPVRAVTQNGKHAVPTNSLTGNAYALSSPLQLLAAQASSSTPVVITRVCEVGPEEPAA
AVSVAANAAPTPAASTTTSASSSGEPEVKRSRVEEPGGTATTQPTAMAATGPQGPGTGE

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History
Entry version 182 (07 Nov 2018)
Sequence version 2 (28 Nov 2006)
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Protein

Forkhead box protein K1

Gene

Foxk1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene (PubMed:8007964). Important regulatory factor of the myogenic progenitor cell population (PubMed:9271401). Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells (PubMed:12446708). Represses myogenic differentiation by inhibiting MEFC acitivity (PubMed:22956541). Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli (PubMed:9271401, PubMed:22956541). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (PubMed:10792059). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (By similarity). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (By similarity).By similarity5 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	291 – 386	Fork-headPROSITE-ProRule annotationAdd BLAST		96

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10620510
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 9271401
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 9271401
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8007964
- 9271401
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
muscle organ development Source: UniProtKB-KW
negative regulation of cell cycle
Source: UniProtKB
Traceable author statementⁱ
- 10620510
negative regulation of cell growth
Source: UniProtKB
Inferred from direct assayⁱ
- 10620510
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 9271401
- 10620510
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 8007964
regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 9271401

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding, Repressor
Biological process	Differentiation, Myogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5689603 UCH proteinases

Reactomeⁱ

R-MMU-5689603 UCH proteinases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Forkhead box protein K1 Alternative name(s): Myocyte nuclear factor Short name: MNF
Gene namesⁱ	Name:Foxk1 Synonyms:Mnf
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1347488 Foxk1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mutants exhibit a growth deficiency and a severe impairment in skeletal muscle regeneration following injury (PubMed:12446708, PubMed:10792059). They show atrophic skeletal muscles and their satellite cell function is impaired (PubMed:10792059). Double knockouts of CDKN1A and FOXK1 don't show significant differences compared to wild-type (PubMed:12446708).2 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	333	K → A: Decreases DNA-binding. No effect on transcriptional repression. 1 Publication		1
Mutagenesisⁱ	340	R → A: Abolishes DNA-binding. No effect on transcriptional repression. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000091857	2 – 719	Forkhead box protein K1Add BLAST		718

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	87	PhosphoserineBy similarity	1
Modified residueⁱ	147	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	177	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	199	PhosphoserineCombined sources	1
Modified residueⁱ	209	PhosphoserineCombined sources	1
Modified residueⁱ	225	PhosphoserineCombined sources	1
Modified residueⁱ	229	PhosphoserineCombined sources	1
Modified residueⁱ	231	PhosphothreonineCombined sources	1
Modified residueⁱ	233	PhosphothreonineCombined sources	1
Modified residueⁱ	239	PhosphoserineCombined sources	1
Modified residueⁱ	243	PhosphoserineCombined sources	1
Modified residueⁱ	281	PhosphoserineCombined sources	1
Modified residueⁱ	285	PhosphoserineCombined sources	1
Modified residueⁱ	402	PhosphoserineBy similarity	1
Modified residueⁱ	406	PhosphoserineBy similarity	1
Modified residueⁱ	408	PhosphothreonineBy similarity	1
Modified residueⁱ	414	PhosphoserineBy similarity	1
Modified residueⁱ	422	PhosphothreonineCombined sources	1
Modified residueⁱ	427	PhosphoserineCombined sources	1
Modified residueⁱ	431	PhosphoserineCombined sources	1
Modified residueⁱ	445	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	P42128
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P42128
PaxDbⁱ	P42128
PeptideAtlas More...PeptideAtlasⁱ	P42128
PRIDEⁱ	P42128

PTM databases

iPTMnetⁱ	P42128
PhosphoSitePlusⁱ	P42128

Expressionⁱ

Tissue specificityⁱ

Expressed in tissues and cells in which the myoglobin gene is transcriptionally active including cardiac and skeletal myocytes, brain and kidney. In the adult brain, expressed in the piriform cortex and the indusium griseum. In the hippocampus, expression is localized to the dentate gyrus and CA3 area. In the cerebellum, expression is confined to the Purkinje cell layer.3 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000056493 Expressed in 264 organ(s), highest expression level in blood
CleanExⁱ	MM_FOXK1
ExpressionAtlasⁱ	P42128 baseline and differential
Genevisibleⁱ	P42128 MM

Interactionⁱ

Subunit structureⁱ

Interacts with SIN3A and SIN3B (via PAH2) to form a complex which represses transcription (PubMed:10620510). Interacts with FOXO4 and MEF2C; both interactions inhibit FOXO4 and MEF2C transactivation activity (PubMed:22956541). Interacts with DVL2 and DVL3; the interaction induces DVL2 nuclear translocation (By similarity).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Sin3b	Q62141-2	11	EBI-878270,EBI-591466

With

Entry

#Exp.

IntAct

Notes

Sin3b

Q62141-2

EBI-878270,EBI-591466

Protein-protein interaction databases

BioGridⁱ	201459, 1 interactor
IntActⁱ	P42128, 2 interactors
Molecular INTeraction database More...MINTⁱ	P42128
STRINGⁱ	10090.ENSMUSP00000072616

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	292 – 294	Combined sources	3
Helixⁱ	298 – 304	Combined sources	7
Beta strandⁱ	307 – 312	Combined sources	6
Helixⁱ	314 – 324	Combined sources	11
Beta strandⁱ	326 – 330	Combined sources	5
Helixⁱ	335 – 345	Combined sources	11
Beta strandⁱ	347 – 356	Combined sources	10
Beta strandⁱ	360 – 362	Combined sources	3
Beta strandⁱ	365 – 367	Combined sources	3
Helixⁱ	372 – 380	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P42128
SMRⁱ	P42128
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P42128

EvolutionaryTraceⁱ

P42128

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	109 – 161	FHAPROSITE-ProRule annotationAdd BLAST		53

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 40	Interaction with SIN3A and SIN3B2 PublicationsAdd BLAST		39
Regionⁱ	81 – 406	Required for interaction with FOXO4 and MEF2C1 PublicationAdd BLAST		326

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	10 – 82	Ala-richAdd BLAST		73
Compositional biasⁱ	35 – 63	Pro-richAdd BLAST		29

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150834
HOGENOMⁱ	HOG000072588
HOVERGENⁱ	HBG051649
InParanoidⁱ	P42128
KEGG Orthology (KO) More...KOⁱ	K09404
OMAⁱ	VTIGQHH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G099F
PhylomeDBⁱ	P42128
TreeFamⁱ	TF325718

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00059 FH, 1 hit cd00060 FHA, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000253 FHA_dom IPR001766 Fork_head_dom IPR008984 SMAD_FHA_dom_sf IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00498 FHA, 1 hit PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit SM00240 FHA, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50006 FHA_DOMAIN, 1 hit PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P42128-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEVGEDSGA RALLALRSAP CSPVLCAAAA AAAFPATTSP PPPAQPPPGP 
        60         70         80         90        100
PALPAEPGPG PVPSTVATAT TTAPALVAAA AASVRQSPGP ALARLEGREF 
       110        120        130        140        150
EFLMRQPSVT IGRNSSQGSV DLSMGLSSFI SRRHLQLSFQ EPHFYLRCLG 
       160        170        180        190        200
KNGVFVDGAF QRRGAPALQL PQQCTFRFPS TAIKIQFTSL YHKEEAPASP 
       210        220        230        240        250
LRPLYPQISP LKIHIPEPDL RSLVSPIPSP TGTISVPNSC PASPRGAGSS 
       260        270        280        290        300
SYRFVQNVTS DLQLAAEFAA KAASEQQADA SGGDSPKDES KPPYSYAQLI 
       310        320        330        340        350
VQAISSAQDR QLTLSGIYAH ITKHYPYYRT ADKGWQNSIR HNLSLNRYFI 
       360        370        380        390        400
KVPRSQEEPG KGSFWRIDPA SEAKLVEQAF RKRRQRGVSC FRTPFGPLSS 
       410        420        430        440        450
RSAPASPTHP GLMSPRSSGL QTPECLSREG SPIPHDPDLG SKLASVPEYR 
       460        470        480        490        500
YSQSAPGSPV SAQPVIMAVP PRPSNLVAKP VAYMPASIVT SQQPSGHAIH 
       510        520        530        540        550
VVQQAPTVTM VRVVTTSANS ANGYILASQG STGTSHDTAG TAVLDLGNEA 
       560        570        580        590        600
RGLEEKPTIA FATIPAASRV IQTVASQMAP GVPGHTVTIL QPATPVTIGQ 
       610        620        630        640        650
HHLPVRAVTQ NGKHAVPTNS LTGNAYALSS PLQLLAAQAS SSTPVVITRV 
       660        670        680        690        700
CEVGPEEPAA AVSVAANAAP TPAASTTTSA SSSGEPEVKR SRVEEPGGTA 
       710 
TTQPTAMAAT GPQGPGTGE

Length:719

Mass (Da):74,920

Last modified:November 28, 2006 - v2

Checksum:ⁱ0A0D3049B7846328

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2JG71	A0A0G2JG71_MOUSE		Forkhead box protein K1 Forkhead box protein K1	Foxk1	181	Annotation score:

Sequence cautionⁱ

The sequence AAA37529 differs from that shown. Reason: Frameshift at positions 61, 88, 582, 603, 615 and 711.Curated

The sequence AAB69641 differs from that shown. Reason: Frameshift at positions 61 and 88.Curated

The sequence BAE25880 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	43	Missing in AAA37529 (PubMed:8007964).Curated	1
Sequence conflictⁱ	43	Missing in AAB69641 (PubMed:9271401).Curated	1
Sequence conflictⁱ	402 – 403	SA → RS in AAA37529 (PubMed:8007964).Curated	2
Sequence conflictⁱ	407 – 411	PTHPG → HTSHA in AAB69641 (PubMed:9271401).Curated	5
Sequence conflictⁱ	551	R → A in AAA37529 (PubMed:8007964).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L26507 mRNA Translation: AAA37529.1 Frameshift. AK144418 mRNA Translation: BAE25880.1 Different initiation. AK147375 mRNA Translation: BAE27871.1 U95016 mRNA Translation: AAB69641.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19826.1
PIRⁱ	A56051
NCBI Reference Sequences More...RefSeqⁱ	NP_951031.2, NM_199068.2
UniGeneⁱ	Mm.24214

Genome annotation databases

Ensemblⁱ	ENSMUST00000072837; ENSMUSP00000072616; ENSMUSG00000056493
GeneIDⁱ	17425
KEGGⁱ	mmu:17425
UCSC genome browser More...UCSCⁱ	uc009aio.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P42128	forkhead box protein K1		TURTR		716	UniRef90_P42128
Forkhead box K1		RAT		616
Forkhead box protein K1		FUKDA		616
cDNA FLJ55600, highly similar to Homo sapiens forkhead box K1 (FOXK1), mRNA		HUMAN		583
UPI000A31B332		MUSCR		720
+8

Protein	Similar proteins		Species	Score	Length	Source
P42128	Forkhead box protein K1		HUMAN		733	UniRef50_P42128
forkhead box protein K1		TURTR		716
Forkhead box protein K1		FUKDA		616
Forkhead box K1		RAT		616
Uncharacterized protein		COLAP		652
+298

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L26507 mRNA Translation: AAA37529.1 Frameshift. AK144418 mRNA Translation: BAE25880.1 Different initiation. AK147375 mRNA Translation: BAE27871.1 U95016 mRNA Translation: AAB69641.1 Frameshift.
CCDSⁱ	CCDS19826.1
PIRⁱ	A56051
RefSeqⁱ	NP_951031.2, NM_199068.2
UniGeneⁱ	Mm.24214

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2A3S	NMR	-	A	289-389	[»]
	2D2W	NMR	-	A	289-389	[»]
ProteinModelPortalⁱ	P42128
SMRⁱ	P42128
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201459, 1 interactor
IntActⁱ	P42128, 2 interactors
MINTⁱ	P42128
STRINGⁱ	10090.ENSMUSP00000072616

PTM databases

iPTMnetⁱ	P42128
PhosphoSitePlusⁱ	P42128

Proteomic databases

EPDⁱ	P42128
MaxQBⁱ	P42128
PaxDbⁱ	P42128
PeptideAtlasⁱ	P42128
PRIDEⁱ	P42128

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	17425
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000072837; ENSMUSP00000072616; ENSMUSG00000056493
GeneIDⁱ	17425
KEGGⁱ	mmu:17425
UCSCⁱ	uc009aio.1 mouse

Organism-specific databases

CTDⁱ	221937
MGIⁱ	MGI:1347488 Foxk1

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
GeneTreeⁱ	ENSGT00930000150834
HOGENOMⁱ	HOG000072588
HOVERGENⁱ	HBG051649
InParanoidⁱ	P42128
KOⁱ	K09404
OMAⁱ	VTIGQHH
OrthoDBⁱ	EOG091G099F
PhylomeDBⁱ	P42128
TreeFamⁱ	TF325718

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5689603 UCH proteinases

Reactomeⁱ

R-MMU-5689603 UCH proteinases

Miscellaneous databases

ChiTaRSⁱ	Foxk1 mouse
EvolutionaryTraceⁱ	P42128
Protein Ontology More...PROⁱ	PR:P42128
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000056493 Expressed in 264 organ(s), highest expression level in blood
CleanExⁱ	MM_FOXK1
ExpressionAtlasⁱ	P42128 baseline and differential
Genevisibleⁱ	P42128 MM

Family and domain databases

CDDⁱ	cd00059 FH, 1 hit cd00060 FHA, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000253 FHA_dom IPR001766 Fork_head_dom IPR008984 SMAD_FHA_dom_sf IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00498 FHA, 1 hit PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit SM00240 FHA, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50006 FHA_DOMAIN, 1 hit PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOXK1_MOUSE
Accessionⁱ	P42128Primary (citable) accession number: P42128 Secondary accession number(s): O35939, Q3UHI6, Q3UN67
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 28, 2006
	Last modified:	November 7, 2018
	This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P42128 (FOXK1_MOUSE)

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Forkhead box protein K1

Foxk1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ