ECI1

Functionⁱ

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.

Catalytic activityⁱ

a (3Z)-enoyl-CoA
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
a 4-saturated (2E)-enoyl-CoA
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Delta 3, delta 2-enoyl-CoA isomerase is the protein that copurifies with human glutathione S-transferases from S-hexylglutathione affinity matrices."
  Takahashi Y., Hirata Y., Burstein Y., Listowsky I.
  Biochem. J. 304:849-852(1994) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE OF 42-84; 89-116; 190-220; 242-255 AND 288-298, CATALYTIC ACTIVITY.
EC:
5.3.3.8
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Delta 3, delta 2-enoyl-CoA isomerase is the protein that copurifies with human glutathione S-transferases from S-hexylglutathione affinity matrices."
  Takahashi Y., Hirata Y., Burstein Y., Listowsky I.
  Biochem. J. 304:849-852(1994) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE OF 42-84; 89-116; 190-220; 242-255 AND 288-298, CATALYTIC ACTIVITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
a (3Z)-enoyl-CoA
zoom
=
a 4-saturated (2E)-enoyl-CoA
zoom
a (3E)-enoyl-CoA
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
a 4-saturated (2E)-enoyl-CoA
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Delta 3, delta 2-enoyl-CoA isomerase is the protein that copurifies with human glutathione S-transferases from S-hexylglutathione affinity matrices."
  Takahashi Y., Hirata Y., Burstein Y., Listowsky I.
  Biochem. J. 304:849-852(1994) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE OF 42-84; 89-116; 190-220; 242-255 AND 288-298, CATALYTIC ACTIVITY.
EC:
5.3.3.8
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Delta 3, delta 2-enoyl-CoA isomerase is the protein that copurifies with human glutathione S-transferases from S-hexylglutathione affinity matrices."
  Takahashi Y., Hirata Y., Burstein Y., Listowsky I.
  Biochem. J. 304:849-852(1994) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE OF 42-84; 89-116; 190-220; 242-255 AND 288-298, CATALYTIC ACTIVITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
a (3E)-enoyl-CoA
zoom
=
a 4-saturated (2E)-enoyl-CoA
zoom

Pathwayⁱ: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	153	Substrate; via amide nitrogenCombined sources1 Publication	1
Binding siteⁱ	177	SubstrateCombined sources1 Publication	1
Siteⁱ	178	Important for catalytic activity1 Publication	1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid beta-oxidation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BRENDAⁱ	5.3.3.8 2681
Reactomeⁱ	R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
UniPathwayⁱ	UPA00659

Chemistry databases

SwissLipidsⁱ	SLP:000001184

SwissLipidsⁱ

SLP:000001184

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Enoyl-CoA delta isomerase 1, mitochondrial (EC:5.3.3.8) Alternative name(s): 3,2-trans-enoyl-CoA isomerase Delta(3),Delta(2)-enoyl-CoA isomerase Short name: D3,D2-enoyl-CoA isomerase Dodecenoyl-CoA isomerase
Gene namesⁱ	Name:ECI1 Synonyms:DCI
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2703 ECI1
MIMⁱ	600305 gene
neXtProtⁱ	NX_P42126

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	178	E → A: Loss of activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1632
Open Targets More...OpenTargetsⁱ	ENSG00000167969
PharmGKBⁱ	PA27173

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB03127 Benzamidine DB02910 Octanoyl-Coenzyme A

DrugBankⁱ

DB03127 Benzamidine
DB02910 Octanoyl-Coenzyme A

Polymorphism and mutation databases

BioMutaⁱ	ECI1
DMDMⁱ	1169204

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 41	MitochondrionBy similarityAdd BLAST		41
ChainⁱPRO_0000007420	42 – 302	Enoyl-CoA delta isomerase 1, mitochondrialAdd BLAST		261

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	61	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	61	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	84	N6-succinyllysineBy similarity	1
Modified residueⁱ	89	N6-acetyllysineCombined sources	1
Modified residueⁱ	283	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	283	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	288	N6-succinyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P42126
jPOSTⁱ	P42126
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P42126
PaxDbⁱ	P42126
PeptideAtlas More...PeptideAtlasⁱ	P42126
PRIDEⁱ	P42126
ProteomicsDBⁱ	55485 55486 [P42126-2]
TopDownProteomicsⁱ	P42126-1 [P42126-1] P42126-2 [P42126-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P42126

OGPⁱ

P42126

PTM databases

iPTMnetⁱ	P42126
PhosphoSitePlusⁱ	P42126
SwissPalmⁱ	P42126

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000167969 Expressed in 217 organ(s), highest expression level in apex of heart
ExpressionAtlasⁱ	P42126 baseline and differential
Genevisibleⁱ	P42126 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041746 HPA043227

HPAⁱ

HPA041746
HPA043227

Interactionⁱ

Subunit structureⁱ

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridⁱ	108000, 12 interactors
IntActⁱ	P42126, 7 interactors
Molecular INTeraction database More...MINTⁱ	P42126
STRINGⁱ	9606.ENSP00000301729

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	46 – 52	Combined sources	7
Turnⁱ	53 – 56	Combined sources	4
Beta strandⁱ	57 – 62	Combined sources	6
Turnⁱ	65 – 67	Combined sources	3
Helixⁱ	72 – 87	Combined sources	16
Beta strandⁱ	93 – 100	Combined sources	8
Beta strandⁱ	102 – 104	Combined sources	3
Helixⁱ	110 – 113	Combined sources	4
Helixⁱ	118 – 136	Combined sources	19
Beta strandⁱ	139 – 146	Combined sources	8
Beta strandⁱ	148 – 150	Combined sources	3
Helixⁱ	152 – 158	Combined sources	7
Beta strandⁱ	161 – 167	Combined sources	7
Helixⁱ	178 – 181	Combined sources	4
Helixⁱ	187 – 197	Combined sources	11
Helixⁱ	199 – 208	Combined sources	10
Helixⁱ	214 – 219	Combined sources	6
Beta strandⁱ	222 – 227	Combined sources	6
Helixⁱ	229 – 231	Combined sources	3
Helixⁱ	232 – 244	Combined sources	13
Helixⁱ	248 – 267	Combined sources	20
Helixⁱ	270 – 281	Combined sources	12
Helixⁱ	284 – 290	Combined sources	7
Helixⁱ	293 – 299	Combined sources	7

Show more details

3D structure databases

SMRⁱ	P42126
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P42126

EvolutionaryTraceⁱ

P42126

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	106 – 110	Substrate bindingCombined sources1 Publication		5

Sequence similaritiesⁱ

Belongs to the enoyl-CoA hydratase/isomerase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	ENOG410ISNQ Eukaryota COG1024 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005678
InParanoidⁱ	P42126
KEGG Orthology (KO) More...KOⁱ	K13238
OMAⁱ	TMHHAGI
Database of Orthologous Groups More...OrthoDBⁱ	974911at2759
PhylomeDBⁱ	P42126
TreeFamⁱ	TF314436

Family and domain databases

InterProⁱ	View protein in InterPro IPR029045 ClpP/crotonase-like_dom_sf IPR018376 Enoyl-CoA_hyd/isom_CS IPR001753 Enoyl-CoA_hydra/iso
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00378 ECH_1, 1 hit
SUPFAMⁱ	SSF52096 SSF52096, 1 hit
PROSITEⁱ	View protein in PROSITE PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P42126-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALVASVRVP ARVLLRAGAR LPGAALGRTE RAAGGGDGAR RFGSQRVLVE 
        60         70         80         90        100
PDAGAGVAVM KFKNPPVNSL SLEFLTELVI SLEKLENDKS FRGVILTSDR 
       110        120        130        140        150
PGVFSAGLDL TEMCGRSPAH YAGYWKAVQE LWLRLYQSNL VLVSAINGAC 
       160        170        180        190        200
PAGGCLVALT CDYRILADNP RYCIGLNETQ LGIIAPFWLK DTLENTIGHR 
       210        220        230        240        250
AAERALQLGL LFPPAEALQV GIVDQVVPEE QVQSTALSAI AQWMAIPDHA 
       260        270        280        290        300
RQLTKAMMRK ATASRLVTQR DADVQNFVSF ISKDSIQKSL QMYLERLKEE 

KG

Length:302

Mass (Da):32,816

Last modified:November 1, 1995 - v1

Checksum:ⁱ6E63827DE9BE886B

GO

Isoform 2 (identifier: P42126-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
172-188: Missing.

« Hide

        10         20         30         40         50
MALVASVRVP ARVLLRAGAR LPGAALGRTE RAAGGGDGAR RFGSQRVLVE 
        60         70         80         90        100
PDAGAGVAVM KFKNPPVNSL SLEFLTELVI SLEKLENDKS FRGVILTSDR 
       110        120        130        140        150
PGVFSAGLDL TEMCGRSPAH YAGYWKAVQE LWLRLYQSNL VLVSAINGAC 
       160        170        180        190        200
PAGGCLVALT CDYRILADNP RLKDTLENTI GHRAAERALQ LGLLFPPAEA 
       210        220        230        240        250
LQVGIVDQVV PEEQVQSTAL SAIAQWMAIP DHARQLTKAM MRKATASRLV 
       260        270        280 
TQRDADVQNF VSFISKDSIQ KSLQMYLERL KEEKG

Note: No experimental confirmation available.

Show »

Length:285

Mass (Da):30,896

Checksum:ⁱF3689BA4B6F7FC72

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q96DC0	Q96DC0_HUMAN	DCI protein DCI protein (Dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase), isoform CRA_a) (Enoyl-CoA delta isomerase 1, mitochondrial)	ECI1 DCI, hCG_41028	243	Annotation score:
H3BS70	H3BS70_HUMAN	Enoyl-CoA delta isomerase 1, mitoch... Enoyl-CoA delta isomerase 1, mitochondrial	ECI1	224	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	14	L → P in AAH00762 (PubMed:15489334).Curated	1
Sequence conflictⁱ	14	L → P in AAH19316 (PubMed:15489334).Curated	1
Sequence conflictⁱ	41	R → P in CAA81065 (PubMed:7829074).Curated	1
Sequence conflictⁱ	44	S → C AA sequence (PubMed:7818490).Curated	1
Sequence conflictⁱ	54	G → A in CAA81065 (PubMed:7829074).Curated	1
Sequence conflictⁱ	78	L → F AA sequence (PubMed:7818490).Curated	1
Sequence conflictⁱ	93	G → V in AAA35485 (PubMed:8198519).Curated	1
Sequence conflictⁱ	114	Missing AA sequence (PubMed:7818490).Curated	1
Sequence conflictⁱ	192 – 193	TL → PY AA sequence (PubMed:7818490).Curated	2
Sequence conflictⁱ	204 – 207	RALQ → SAPE in AAA35485 (PubMed:8198519).Curated	4
Sequence conflictⁱ	210	L → S AA sequence (PubMed:7818490).Curated	1
Sequence conflictⁱ	213 – 215	PPA → RRP in AAA35485 (PubMed:8198519).Curated	3
Sequence conflictⁱ	242	Q → K AA sequence (PubMed:7818490).Curated	1
Sequence conflictⁱ	245	A → T AA sequence (PubMed:7818490).Curated	1
Sequence conflictⁱ	248	D → E AA sequence (PubMed:7818490).Curated	1
Sequence conflictⁱ	291	Q → E AA sequence (PubMed:7818490).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001358	172 – 188	Missing in isoform 2. 1 PublicationAdd BLAST		17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z25820 mRNA Translation: CAA81065.1 Z25821 , Z25822, Z25823, Z25824 Genomic DNA Translation: CAA81066.1 AK291127 mRNA Translation: BAF83816.1 CH471112 Genomic DNA Translation: EAW85524.1 BC000762 mRNA Translation: AAH00762.1 BC002746 mRNA Translation: AAH02746.1 BC020228 mRNA Translation: AAH20228.1 BC019316 mRNA Translation: AAH19316.1 L24774 mRNA Translation: AAA35485.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10464.1 [P42126-1] CCDS58410.1 [P42126-2]
PIRⁱ	A55723
NCBI Reference Sequences More...RefSeqⁱ	NP_001171500.1, NM_001178029.1 [P42126-2] NP_001910.2, NM_001919.3 [P42126-1]

Genome annotation databases

Ensemblⁱ	ENST00000301729; ENSP00000301729; ENSG00000167969 [P42126-1] ENST00000562238; ENSP00000456319; ENSG00000167969 [P42126-2]
GeneIDⁱ	1632
KEGGⁱ	hsa:1632
UCSC genome browser More...UCSCⁱ	uc002cpr.4 human [P42126-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P42126	Epididymis secretory sperm binding protein		HUMAN		302	UniRef100_P42126
DCI protein		HUMAN		243
Enoyl-CoA delta isomerase 1, mitochondrial (Fragment)		HUMAN		224
UPI00004C2C64		HUMAN		260

Protein	Similar proteins		Species	Score	Length	Source
P42126	Epididymis secretory sperm binding protein		HUMAN		302	UniRef90_P42126
ECI1 isoform 2		PANTR		302
Uncharacterized protein		PANPA		243
Enoyl-CoA delta isomerase 1		MACMU		302
Uncharacterized protein		MACFA		243
+35

Protein	Similar proteins		Species	Score	Length	Source
P42126	Epididymis secretory sperm binding protein		HUMAN		302	UniRef50_P42126
Uncharacterized protein		MACFA		302
ECI1 isoform 2		PANTR		302
Uncharacterized protein		PANPA		243
ECI1 isoform 2		PONAB		302
+351

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z25820 mRNA Translation: CAA81065.1 Z25821 , Z25822, Z25823, Z25824 Genomic DNA Translation: CAA81066.1 AK291127 mRNA Translation: BAF83816.1 CH471112 Genomic DNA Translation: EAW85524.1 BC000762 mRNA Translation: AAH00762.1 BC002746 mRNA Translation: AAH02746.1 BC020228 mRNA Translation: AAH20228.1 BC019316 mRNA Translation: AAH19316.1 L24774 mRNA Translation: AAA35485.1
CCDSⁱ	CCDS10464.1 [P42126-1] CCDS58410.1 [P42126-2]
PIRⁱ	A55723
RefSeqⁱ	NP_001171500.1, NM_001178029.1 [P42126-2] NP_001910.2, NM_001919.3 [P42126-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1SG4	X-ray	1.30	A/B/C	43-302	[»]
SMRⁱ	P42126
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108000, 12 interactors
IntActⁱ	P42126, 7 interactors
MINTⁱ	P42126
STRINGⁱ	9606.ENSP00000301729

Chemistry databases

DrugBankⁱ	DB03127 Benzamidine DB02910 Octanoyl-Coenzyme A
SwissLipidsⁱ	SLP:000001184

PTM databases

iPTMnetⁱ	P42126
PhosphoSitePlusⁱ	P42126
SwissPalmⁱ	P42126

Polymorphism and mutation databases

BioMutaⁱ	ECI1
DMDMⁱ	1169204

2D gel databases

OGPⁱ	P42126

OGPⁱ

P42126

Proteomic databases

EPDⁱ	P42126
jPOSTⁱ	P42126
MaxQBⁱ	P42126
PaxDbⁱ	P42126
PeptideAtlasⁱ	P42126
PRIDEⁱ	P42126
ProteomicsDBⁱ	55485 55486 [P42126-2]
TopDownProteomicsⁱ	P42126-1 [P42126-1] P42126-2 [P42126-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000301729; ENSP00000301729; ENSG00000167969 [P42126-1] ENST00000562238; ENSP00000456319; ENSG00000167969 [P42126-2]
GeneIDⁱ	1632
KEGGⁱ	hsa:1632
UCSCⁱ	uc002cpr.4 human [P42126-1]

Organism-specific databases

CTDⁱ	1632
DisGeNETⁱ	1632
GeneCardsⁱ	ECI1
HGNCⁱ	HGNC:2703 ECI1
HPAⁱ	HPA041746 HPA043227
MIMⁱ	600305 gene
neXtProtⁱ	NX_P42126
OpenTargetsⁱ	ENSG00000167969
PharmGKBⁱ	PA27173
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410ISNQ Eukaryota COG1024 LUCA
GeneTreeⁱ	ENSGT00390000005678
InParanoidⁱ	P42126
KOⁱ	K13238
OMAⁱ	TMHHAGI
OrthoDBⁱ	974911at2759
PhylomeDBⁱ	P42126
TreeFamⁱ	TF314436

Enzyme and pathway databases

UniPathwayⁱ	UPA00659
BRENDAⁱ	5.3.3.8 2681
Reactomeⁱ	R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids

Miscellaneous databases

ChiTaRSⁱ	ECI1 human
EvolutionaryTraceⁱ	P42126
GenomeRNAiⁱ	1632
Protein Ontology More...PROⁱ	PR:P42126
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167969 Expressed in 217 organ(s), highest expression level in apex of heart
ExpressionAtlasⁱ	P42126 baseline and differential
Genevisibleⁱ	P42126 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029045 ClpP/crotonase-like_dom_sf IPR018376 Enoyl-CoA_hyd/isom_CS IPR001753 Enoyl-CoA_hydra/iso
Pfamⁱ	View protein in Pfam PF00378 ECH_1, 1 hit
SUPFAMⁱ	SSF52096 SSF52096, 1 hit
PROSITEⁱ	View protein in PROSITE PS00166 ENOYL_COA_HYDRATASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ECI1_HUMAN
Accessionⁱ	P42126Primary (citable) accession number: P42126 Secondary accession number(s): A8K512 Q9UDG6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	May 8, 2019
	This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
PATHWAY comments
Index of metabolic and biosynthesis pathways
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P42126 (ECI1_HUMAN)

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Enoyl-CoA delta isomerase 1, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid beta-oxidation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: fatty acid beta-oxidation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ