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Protein

T-lymphocyte activation antigen CD86

Gene

Cd86

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-389356 CD28 co-stimulation
R-MMU-389357 CD28 dependent PI3K/Akt signaling
R-MMU-389359 CD28 dependent Vav1 pathway
R-MMU-389513 CTLA4 inhibitory signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
T-lymphocyte activation antigen CD86
Alternative name(s):
Activation B7-2 antigen
Early T-cell costimulatory molecule 1
Short name:
ETC-1
CD_antigen: CD86
Gene namesi
Name:Cd86
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:101773 Cd86

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 244ExtracellularSequence analysisAdd BLAST221
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 309CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001455124 – 309T-lymphocyte activation antigen CD86Add BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi40 ↔ 110PROSITE-ProRule annotation
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 216PROSITE-ProRule annotation
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiP42082
PeptideAtlasiP42082
PRIDEiP42082

PTM databases

iPTMnetiP42082
PhosphoSitePlusiP42082
SwissPalmiP42082

Expressioni

Tissue specificityi

Expressed on activated B-cells.

Gene expression databases

BgeeiENSMUSG00000022901 Expressed in 98 organ(s), highest expression level in spleen
CleanExiMM_CD86
ExpressionAtlasiP42082 baseline and differential
GenevisibleiP42082 MM

Interactioni

Subunit structurei

Homodimer. Interacts with MARCH8 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087047

Structurei

3D structure databases

ProteinModelPortaliP42082
SMRiP42082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 128Ig-like V-typeAdd BLAST96
Domaini150 – 223Ig-like C2-typeAdd BLAST74

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYP1 Eukaryota
ENOG410ZD66 LUCA
GeneTreeiENSGT00720000108819
HOVERGENiHBG004093
InParanoidiP42082
KOiK05413
OMAiYQCFIHH
OrthoDBiEOG091G0QVY
PhylomeDBiP42082
TreeFamiTF331083

Family and domain databases

CDDicd16087 IgV_CD86, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR037677 CD86_IgV
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P42082-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPRCTMGLA ILIFVTVLLI SDAVSVETQA YFNGTAYLPC PFTKAQNISL
60 70 80 90 100
SELVVFWQDQ QKLVLYEHYL GTEKLDSVNA KYLGRTSFDR NNWTLRLHNV
110 120 130 140 150
QIKDMGSYDC FIQKKPPTGS IILQQTLTEL SVIANFSEPE IKLAQNVTGN
160 170 180 190 200
SGINLTCTSK QGHPKPKKMY FLITNSTNEY GDNMQISQDN VTELFSISNS
210 220 230 240 250
LSLSFPDGVW HMTVVCVLET ESMKISSKPL NFTQEFPSPQ TYWKEITASV
260 270 280 290 300
TVALLLVMLL IIVCHKKPNQ PSRPSNTASK LERDSNADRE TINLKELEPQ

IASAKPNAE
Length:309
Mass (Da):34,666
Last modified:November 1, 1995 - v1
Checksum:i8F58DCD1FB81D5EA
GO
Isoform 2 (identifier: P42082-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:303
Mass (Da):33,962
Checksum:i92526096A8C6F249
GO

Sequence cautioni

The sequence AAB30744 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0231251 – 6Missing in isoform 2. Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25606 mRNA Translation: AAA79770.1
S70108 mRNA Translation: AAB30744.2 Different initiation.
U39456
, U39459, U39461, U39462, U39463, U39464, U39465, U39466 Genomic DNA Translation: AAC52334.1
U39456
, U39461, U39462, U39463, U39464, U39465, U39466 Genomic DNA Translation: AAC52336.1
CCDSiCCDS28155.1 [P42082-1]
PIRiI49522
RefSeqiNP_062261.3, NM_019388.3 [P42082-1]
XP_011244114.1, XM_011245812.1 [P42082-2]
UniGeneiMm.1452

Genome annotation databases

EnsembliENSMUST00000089620; ENSMUSP00000087047; ENSMUSG00000022901 [P42082-1]
GeneIDi12524
KEGGimmu:12524
UCSCiuc007zcq.2 mouse [P42082-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25606 mRNA Translation: AAA79770.1
S70108 mRNA Translation: AAB30744.2 Different initiation.
U39456
, U39459, U39461, U39462, U39463, U39464, U39465, U39466 Genomic DNA Translation: AAC52334.1
U39456
, U39461, U39462, U39463, U39464, U39465, U39466 Genomic DNA Translation: AAC52336.1
CCDSiCCDS28155.1 [P42082-1]
PIRiI49522
RefSeqiNP_062261.3, NM_019388.3 [P42082-1]
XP_011244114.1, XM_011245812.1 [P42082-2]
UniGeneiMm.1452

3D structure databases

ProteinModelPortaliP42082
SMRiP42082
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087047

PTM databases

iPTMnetiP42082
PhosphoSitePlusiP42082
SwissPalmiP42082

Proteomic databases

PaxDbiP42082
PeptideAtlasiP42082
PRIDEiP42082

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089620; ENSMUSP00000087047; ENSMUSG00000022901 [P42082-1]
GeneIDi12524
KEGGimmu:12524
UCSCiuc007zcq.2 mouse [P42082-1]

Organism-specific databases

CTDi942
MGIiMGI:101773 Cd86

Phylogenomic databases

eggNOGiENOG410IYP1 Eukaryota
ENOG410ZD66 LUCA
GeneTreeiENSGT00720000108819
HOVERGENiHBG004093
InParanoidiP42082
KOiK05413
OMAiYQCFIHH
OrthoDBiEOG091G0QVY
PhylomeDBiP42082
TreeFamiTF331083

Enzyme and pathway databases

ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-389356 CD28 co-stimulation
R-MMU-389357 CD28 dependent PI3K/Akt signaling
R-MMU-389359 CD28 dependent Vav1 pathway
R-MMU-389513 CTLA4 inhibitory signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

PROiPR:P42082
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022901 Expressed in 98 organ(s), highest expression level in spleen
CleanExiMM_CD86
ExpressionAtlasiP42082 baseline and differential
GenevisibleiP42082 MM

Family and domain databases

CDDicd16087 IgV_CD86, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR037677 CD86_IgV
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD86_MOUSE
AccessioniPrimary (citable) accession number: P42082
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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