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UniProtKB - P42081 (CD86_HUMAN)

Entry version 205 (29 Sep 2021)
Sequence version 2 (11 Jan 2011)
Previous versions | rss
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Protein

T-lymphocyte activation antigen CD86

Gene

CD86

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824).

Also involved in the regulation of B cells function, plays a role in regulating the level of IgG1 produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).

By similarity1 Publication

Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

1 Publication

(Microbial infection) Acts as a receptor for adenovirus subgroup B.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processAdaptive immunity, Host-virus interaction, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P42081

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-389356, CD28 co-stimulation
R-HSA-389357, CD28 dependent PI3K/Akt signaling
R-HSA-389359, CD28 dependent Vav1 pathway
R-HSA-389513, CTLA4 inhibitory signaling
R-HSA-6783783, Interleukin-10 signaling
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P42081

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-lymphocyte activation antigen CD86
Alternative name(s):
Activation B7-2 antigen
B70
BU63
CTLA-4 counter-receptor B7.2
FUN-1
CD_antigen: CD86
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD86
Synonyms:CD28LG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1705, CD86

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601020, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P42081

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000114013

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 247ExtracellularSequence analysisAdd BLAST224
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Topological domaini269 – 329CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		942

Open Targets

More...OpenTargetsi		ENSG00000114013

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26243

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P42081, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2364156

Drug and drug target database

More...DrugBanki		DB01281, Abatacept
DB00098, Antithymocyte immunoglobulin (rabbit)
DB06681, Belatacept
DB11752, Bryostatin 1

DrugCentral

More...DrugCentrali		P42081

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2745

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD86

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373339

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001455024 – 329T-lymphocyte activation antigen CD86Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 110PROSITE-ProRule annotation1 Publication
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 218PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P42081

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P42081

PeptideAtlas

More...PeptideAtlasi		P42081

PRoteomics IDEntifications database

More...PRIDEi		P42081

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		18249
19349
55481 [P42081-1]
55482 [P42081-2]
55483 [P42081-3]
55484 [P42081-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P42081, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P42081

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P42081

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by activated B-lymphocytes and monocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114013, Expressed in monocyte and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P42081, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P42081, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114013, Tissue enhanced (blood, brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with MARCH8.

Interacts (via cytoplasmic domain) with PHB and PHB2; the interactions increases after priming with CD40 (By similarity).

By similarityCurated3 Publications

(Microbial infection) Interacts with adenovirus subgroup b fiber protein.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107380, 6 interactors

Database of interacting proteins

More...DIPi		DIP-35606N

Protein interaction database and analysis system

More...IntActi		P42081, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000332049

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P42081, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P42081

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P42081

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 131Ig-like V-typeAdd BLAST99
Domaini150 – 225Ig-like C2-typeAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni277 – 329DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi284 – 313Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi314 – 329Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S1FF, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161500

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1271925_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P42081

Identification of Orthologs from Complete Genome Data

More...OMAi		YLGRTSF

Database of Orthologous Groups

More...OrthoDBi		1051626at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P42081

TreeFam database of animal gene trees

More...TreeFami		TF331083

Family and domain databases

Conserved Domains Database

More...CDDi		cd16087, IgV_CD86, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037677, CD86_IgV
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13895, Ig_2, 1 hit
PF07686, V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 1 hit
SM00406, IGv, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P42081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL 
        60         70         80         90        100
SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL 
       110        120        130        140        150
QIKDKGLYQC IIHHKKPTGM IRIHQMNSEL SVLANFSQPE IVPISNITEN 
       160        170        180        190        200
VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGVMQKSQ DNVTELYDVS 
       210        220        230        240        250
ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT 
       260        270        280        290        300
AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK 
       310        320 
IHIPERSDEA QRVFKSSKTS SCDKSDTCF
Length:329
Mass (Da):37,682
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC249DAEEB889D911
GO
Isoform 2 (identifier: P42081-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:323
Mass (Da):37,007
Checksum:iA492C705D89B65B7
GO
Isoform 3 (identifier: P42081-2) [UniParc]FASTAAdd to basket
Also known as: CD86 deltaEC

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     22-234: Missing.

Show »
Length:110
Mass (Da):12,818
Checksum:i0AE70C853C85F666
GO
Isoform 4 (identifier: P42081-4) [UniParc]FASTAAdd to basket
Also known as: CD86 deltaTM

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     235-282: Missing.

Show »
Length:275
Mass (Da):31,293
Checksum:i137A523F73708BD5
GO
Isoform 5 (identifier: P42081-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-133: Missing.

Show »
Length:217
Mass (Da):24,773
Checksum:i7AF72282EEF8B7CE
GO
Isoform 6 (identifier: P42081-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:247
Mass (Da):28,420
Checksum:i60CBC08652F42C26
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4F8H7C4F8_HUMAN
T-lymphocyte activation antigen CD8...
CD86
277Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JXS1C9JXS1_HUMAN
T-lymphocyte activation antigen CD8...
CD86
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27K → E in AAA86473 (PubMed:7541777).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021916170S → N. Corresponds to variant dbSNP:rs9282642Ensembl.1
Natural variantiVAR_055003185V → I8 PublicationsCorresponds to variant dbSNP:rs2681417Ensembl.1
Natural variantiVAR_014650310A → T2 PublicationsCorresponds to variant dbSNP:rs1129055Ensembl.1
Natural variantiVAR_021917323D → N. Corresponds to variant dbSNP:rs9282648EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0472201 – 82Missing in isoform 6. CuratedAdd BLAST82
Alternative sequenceiVSP_0231241 – 6Missing in isoform 2, isoform 3 and isoform 4. 3 Publications6
Alternative sequenceiVSP_00912522 – 234Missing in isoform 3. 1 PublicationAdd BLAST213
Alternative sequenceiVSP_04722122 – 133Missing in isoform 5. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_040324235 – 282Missing in isoform 4. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U04343 mRNA Translation: AAB03814.1
L25259 mRNA Translation: AAA58389.1
CR541844 mRNA Translation: CAG46642.1
EF064748 Genomic DNA Translation: ABK41931.1
AK294663 mRNA Translation: BAH11839.1
AK301237 mRNA Translation: BAH13438.1
AK316203 mRNA Translation: BAH14574.1
AC068630 Genomic DNA No translation available.
BC040261 mRNA Translation: AAH40261.1
U17722 U17721 Genomic DNA Translation: AAA86473.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3009.1 [P42081-1]
CCDS43138.1 [P42081-3]
CCDS56272.1 [P42081-5]
CCDS56273.1 [P42081-6]
CCDS74991.1 [P42081-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A48754
JC7605

NCBI Reference Sequences

More...RefSeqi		NP_001193853.1, NM_001206924.1 [P42081-5]
NP_001193854.1, NM_001206925.1 [P42081-6]
NP_008820.3, NM_006889.4 [P42081-3]
NP_787058.4, NM_175862.4 [P42081-1]
NP_795711.1, NM_176892.1 [P42081-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264468; ENSP00000264468; ENSG00000114013 [P42081-4]
ENST00000330540; ENSP00000332049; ENSG00000114013 [P42081-1]
ENST00000393627; ENSP00000377248; ENSG00000114013 [P42081-3]
ENST00000469710; ENSP00000418988; ENSG00000114013 [P42081-6]
ENST00000493101; ENSP00000420230; ENSG00000114013 [P42081-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		942

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:942

UCSC genome browser

More...UCSCi		uc003eet.4, human [P42081-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CD86 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04343 mRNA Translation: AAB03814.1
L25259 mRNA Translation: AAA58389.1
CR541844 mRNA Translation: CAG46642.1
EF064748 Genomic DNA Translation: ABK41931.1
AK294663 mRNA Translation: BAH11839.1
AK301237 mRNA Translation: BAH13438.1
AK316203 mRNA Translation: BAH14574.1
AC068630 Genomic DNA No translation available.
BC040261 mRNA Translation: AAH40261.1
U17722 U17721 Genomic DNA Translation: AAA86473.1
CCDSiCCDS3009.1 [P42081-1]
CCDS43138.1 [P42081-3]
CCDS56272.1 [P42081-5]
CCDS56273.1 [P42081-6]
CCDS74991.1 [P42081-4]
PIRiA48754
JC7605
RefSeqiNP_001193853.1, NM_001206924.1 [P42081-5]
NP_001193854.1, NM_001206925.1 [P42081-6]
NP_008820.3, NM_006889.4 [P42081-3]
NP_787058.4, NM_175862.4 [P42081-1]
NP_795711.1, NM_176892.1 [P42081-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I85X-ray3.20A/B26-134[»]
1NCNX-ray2.70A/B26-134[»]
5YXKX-ray1.90A/B/C/D26-134[»]
SMRiP42081
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107380, 6 interactors
DIPiDIP-35606N
IntActiP42081, 8 interactors
STRINGi9606.ENSP00000332049

Chemistry databases

ChEMBLiCHEMBL2364156
DrugBankiDB01281, Abatacept
DB00098, Antithymocyte immunoglobulin (rabbit)
DB06681, Belatacept
DB11752, Bryostatin 1
DrugCentraliP42081
GuidetoPHARMACOLOGYi2745

PTM databases

GlyGeniP42081, 8 sites
iPTMnetiP42081
PhosphoSitePlusiP42081

Genetic variation databases

BioMutaiCD86
DMDMi317373339

Proteomic databases

MassIVEiP42081
PaxDbiP42081
PeptideAtlasiP42081
PRIDEiP42081
ProteomicsDBi18249
19349
55481 [P42081-1]
55482 [P42081-2]
55483 [P42081-3]
55484 [P42081-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P42081, 17 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3810, 2061 antibodies

The DNASU plasmid repository

More...DNASUi		942

Genome annotation databases

EnsembliENST00000264468; ENSP00000264468; ENSG00000114013 [P42081-4]
ENST00000330540; ENSP00000332049; ENSG00000114013 [P42081-1]
ENST00000393627; ENSP00000377248; ENSG00000114013 [P42081-3]
ENST00000469710; ENSP00000418988; ENSG00000114013 [P42081-6]
ENST00000493101; ENSP00000420230; ENSG00000114013 [P42081-5]
GeneIDi942
KEGGihsa:942
UCSCiuc003eet.4, human [P42081-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		942
DisGeNETi942

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD86
HGNCiHGNC:1705, CD86
HPAiENSG00000114013, Tissue enhanced (blood, brain)
MIMi601020, gene
neXtProtiNX_P42081
OpenTargetsiENSG00000114013
PharmGKBiPA26243
VEuPathDBiHostDB:ENSG00000114013

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S1FF, Eukaryota
GeneTreeiENSGT00940000161500
HOGENOMiCLU_1271925_0_0_1
InParanoidiP42081
OMAiYLGRTSF
OrthoDBi1051626at2759
PhylomeDBiP42081
TreeFamiTF331083

Enzyme and pathway databases

PathwayCommonsiP42081
ReactomeiR-HSA-1257604, PIP3 activates AKT signaling
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-389356, CD28 co-stimulation
R-HSA-389357, CD28 dependent PI3K/Akt signaling
R-HSA-389359, CD28 dependent Vav1 pathway
R-HSA-389513, CTLA4 inhibitory signaling
R-HSA-6783783, Interleukin-10 signaling
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SIGNORiP42081

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		942, 63 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD86, human
EvolutionaryTraceiP42081

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD86

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		942
PharosiP42081, Tclin

Protein Ontology

More...PROi		PR:P42081
RNActiP42081, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114013, Expressed in monocyte and 192 other tissues
ExpressionAtlasiP42081, baseline and differential
GenevisibleiP42081, HS

Family and domain databases

CDDicd16087, IgV_CD86, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR037677, CD86_IgV
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
PfamiView protein in Pfam
PF13895, Ig_2, 1 hit
PF07686, V-set, 1 hit
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD86_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42081
Secondary accession number(s): A0N0P0
, B7Z2F3, B7Z702, E7ETN5, E9PC27, Q13655, Q6FHB1, Q6GTS4, Q7M4L5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2011
Last modified: September 29, 2021
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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