UniProtKB - P42081 (CD86_HUMAN)
T-lymphocyte activation antigen CD86
CD86
Functioni
GO - Molecular functioni
- coreceptor activity Source: UniProtKB
- signaling receptor activity Source: ProtInc
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- activation of phospholipase C activity Source: UniProtKB
- activation of protein kinase C activity Source: UniProtKB
- adaptive immune response Source: UniProtKB-KW
- B cell activation Source: UniProtKB
- CD40 signaling pathway Source: UniProtKB
- cell surface receptor signaling pathway Source: GO_Central
- cellular response to lipopolysaccharide Source: GO_Central
- cytokine-mediated signaling pathway Source: Reactome
- immune response Source: GO_Central
- immunoglobulin production Source: UniProtKB
- negative regulation of T cell proliferation Source: GO_Central
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of interleukin-2 production Source: UniProtKB
- positive regulation of interleukin-4 production Source: UniProtKB
- positive regulation of lymphotoxin A biosynthetic process Source: UniProtKB
- positive regulation of NIK/NF-kappaB signaling Source: UniProtKB
- positive regulation of protein kinase B signaling Source: Reactome
- positive regulation of T cell proliferation Source: GO_Central
- positive regulation of T-helper 2 cell differentiation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- signal transduction Source: GO_Central
- T cell costimulation Source: GO_Central
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Adaptive immunity, Host-virus interaction, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P42081 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-389356, CD28 co-stimulation R-HSA-389357, CD28 dependent PI3K/Akt signaling R-HSA-389359, CD28 dependent Vav1 pathway R-HSA-389513, CTLA4 inhibitory signaling R-HSA-6783783, Interleukin-10 signaling R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
SIGNORi | P42081 |
Names & Taxonomyi
Protein namesi | Recommended name: T-lymphocyte activation antigen CD86Alternative name(s): Activation B7-2 antigen B70 BU63 CTLA-4 counter-receptor B7.2 FUN-1 CD_antigen: CD86 |
Gene namesi | Name:CD86 Synonyms:CD28LG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000114013.15 |
HGNCi | HGNC:1705, CD86 |
MIMi | 601020, gene |
neXtProti | NX_P42081 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 247 | ExtracellularSequence analysisAdd BLAST | 224 | |
Transmembranei | 248 – 268 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 269 – 329 | CytoplasmicSequence analysisAdd BLAST | 61 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 942 |
OpenTargetsi | ENSG00000114013 |
PharmGKBi | PA26243 |
Miscellaneous databases
Pharosi | P42081, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2364156 |
DrugBanki | DB01281, Abatacept DB00098, Antithymocyte immunoglobulin (rabbit) DB06681, Belatacept DB11752, Bryostatin 1 |
DrugCentrali | P42081 |
GuidetoPHARMACOLOGYi | 2745 |
Polymorphism and mutation databases
BioMutai | CD86 |
DMDMi | 317373339 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000014550 | 24 – 329 | T-lymphocyte activation antigen CD86Add BLAST | 306 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 33 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 40 ↔ 110 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 47 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 135 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 146 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 154 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 157 ↔ 218 | PROSITE-ProRule annotation | ||
Glycosylationi | 177 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 213 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Ubl conjugationProteomic databases
MassIVEi | P42081 |
PaxDbi | P42081 |
PeptideAtlasi | P42081 |
PRIDEi | P42081 |
ProteomicsDBi | 18249 19349 55481 [P42081-1] 55482 [P42081-2] 55483 [P42081-3] 55484 [P42081-4] |
PTM databases
GlyGeni | P42081, 8 sites |
iPTMneti | P42081 |
PhosphoSitePlusi | P42081 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000114013, Expressed in monocyte and 191 other tissues |
ExpressionAtlasi | P42081, baseline and differential |
Genevisiblei | P42081, HS |
Organism-specific databases
HPAi | ENSG00000114013, Tissue enhanced (blood, brain) |
Interactioni
Subunit structurei
Homodimer.
Interacts with MARCH8.
Interacts (via cytoplasmic domain) with PHB and PHB2; the interactions increases after priming with CD40 (By similarity).
By similarityCurated3 Publications(Microbial infection) Interacts with adenovirus subgroup b fiber protein.
1 PublicationBinary interactionsi
Hide detailsP42081
With | #Exp. | IntAct |
---|---|---|
CTLA4 [P16410] | 3 | EBI-1030956,EBI-1030991 |
Isoform 2 [P42081-3]
Protein-protein interaction databases
BioGRIDi | 107380, 6 interactors |
DIPi | DIP-35606N |
IntActi | P42081, 8 interactors |
STRINGi | 9606.ENSP00000332049 |
Miscellaneous databases
RNActi | P42081, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P42081 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42081 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 131 | Ig-like V-typeAdd BLAST | 99 | |
Domaini | 150 – 225 | Ig-like C2-typeAdd BLAST | 76 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S1FF, Eukaryota |
GeneTreei | ENSGT00940000161500 |
HOGENOMi | CLU_1271925_0_0_1 |
InParanoidi | P42081 |
OMAi | KYIGRTS |
OrthoDBi | 1051626at2759 |
PhylomeDBi | P42081 |
TreeFami | TF331083 |
Family and domain databases
CDDi | cd16087, IgV_CD86, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR037677, CD86_IgV IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL
60 70 80 90 100
SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL
110 120 130 140 150
QIKDKGLYQC IIHHKKPTGM IRIHQMNSEL SVLANFSQPE IVPISNITEN
160 170 180 190 200
VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGVMQKSQ DNVTELYDVS
210 220 230 240 250
ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT
260 270 280 290 300
AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK
310 320
IHIPERSDEA QRVFKSSKTS SCDKSDTCF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C4F8 | H7C4F8_HUMAN | T-lymphocyte activation antigen CD8... | CD86 | 277 | Annotation score: | ||
C9JXS1 | C9JXS1_HUMAN | T-lymphocyte activation antigen CD8... | CD86 | 167 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | K → E in AAA86473 (PubMed:7541777).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021916 | 170 | S → N. Corresponds to variant dbSNP:rs9282642Ensembl. | 1 | |
Natural variantiVAR_055003 | 185 | V → I8 PublicationsCorresponds to variant dbSNP:rs2681417Ensembl. | 1 | |
Natural variantiVAR_014650 | 310 | A → T2 PublicationsCorresponds to variant dbSNP:rs1129055Ensembl. | 1 | |
Natural variantiVAR_021917 | 323 | D → N. Corresponds to variant dbSNP:rs9282648EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047220 | 1 – 82 | Missing in isoform 6. CuratedAdd BLAST | 82 | |
Alternative sequenceiVSP_023124 | 1 – 6 | Missing in isoform 2, isoform 3 and isoform 4. 3 Publications | 6 | |
Alternative sequenceiVSP_009125 | 22 – 234 | Missing in isoform 3. 1 PublicationAdd BLAST | 213 | |
Alternative sequenceiVSP_047221 | 22 – 133 | Missing in isoform 5. 1 PublicationAdd BLAST | 112 | |
Alternative sequenceiVSP_040324 | 235 – 282 | Missing in isoform 4. 1 PublicationAdd BLAST | 48 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04343 mRNA Translation: AAB03814.1 L25259 mRNA Translation: AAA58389.1 CR541844 mRNA Translation: CAG46642.1 EF064748 Genomic DNA Translation: ABK41931.1 AK294663 mRNA Translation: BAH11839.1 AK301237 mRNA Translation: BAH13438.1 AK316203 mRNA Translation: BAH14574.1 AC068630 Genomic DNA No translation available. BC040261 mRNA Translation: AAH40261.1 U17722 , U17717, U17718, U17719, U17721 Genomic DNA Translation: AAA86473.1 |
CCDSi | CCDS3009.1 [P42081-1] |
PIRi | A48754 JC7605 |
RefSeqi | NP_001193853.1, NM_001206924.1 NP_001193854.1, NM_001206925.1 NP_008820.3, NM_006889.4 NP_787058.4, NM_175862.4 [P42081-1] NP_795711.1, NM_176892.1 |
Genome annotation databases
Ensembli | ENST00000264468; ENSP00000264468; ENSG00000114013 [P42081-4] ENST00000330540; ENSP00000332049; ENSG00000114013 [P42081-1] ENST00000393627; ENSP00000377248; ENSG00000114013 [P42081-3] ENST00000469710; ENSP00000418988; ENSG00000114013 [P42081-6] ENST00000493101; ENSP00000420230; ENSG00000114013 [P42081-5] |
GeneIDi | 942 |
KEGGi | hsa:942 |
UCSCi | uc003eet.4, human [P42081-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CD86 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04343 mRNA Translation: AAB03814.1 L25259 mRNA Translation: AAA58389.1 CR541844 mRNA Translation: CAG46642.1 EF064748 Genomic DNA Translation: ABK41931.1 AK294663 mRNA Translation: BAH11839.1 AK301237 mRNA Translation: BAH13438.1 AK316203 mRNA Translation: BAH14574.1 AC068630 Genomic DNA No translation available. BC040261 mRNA Translation: AAH40261.1 U17722 , U17717, U17718, U17719, U17721 Genomic DNA Translation: AAA86473.1 |
CCDSi | CCDS3009.1 [P42081-1] |
PIRi | A48754 JC7605 |
RefSeqi | NP_001193853.1, NM_001206924.1 NP_001193854.1, NM_001206925.1 NP_008820.3, NM_006889.4 NP_787058.4, NM_175862.4 [P42081-1] NP_795711.1, NM_176892.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I85 | X-ray | 3.20 | A/B | 26-134 | [»] | |
1NCN | X-ray | 2.70 | A/B | 26-134 | [»] | |
5YXK | X-ray | 1.90 | A/B/C/D | 26-134 | [»] | |
SMRi | P42081 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107380, 6 interactors |
DIPi | DIP-35606N |
IntActi | P42081, 8 interactors |
STRINGi | 9606.ENSP00000332049 |
Chemistry databases
ChEMBLi | CHEMBL2364156 |
DrugBanki | DB01281, Abatacept DB00098, Antithymocyte immunoglobulin (rabbit) DB06681, Belatacept DB11752, Bryostatin 1 |
DrugCentrali | P42081 |
GuidetoPHARMACOLOGYi | 2745 |
PTM databases
GlyGeni | P42081, 8 sites |
iPTMneti | P42081 |
PhosphoSitePlusi | P42081 |
Polymorphism and mutation databases
BioMutai | CD86 |
DMDMi | 317373339 |
Proteomic databases
MassIVEi | P42081 |
PaxDbi | P42081 |
PeptideAtlasi | P42081 |
PRIDEi | P42081 |
ProteomicsDBi | 18249 19349 55481 [P42081-1] 55482 [P42081-2] 55483 [P42081-3] 55484 [P42081-4] |
Protocols and materials databases
ABCDi | P42081, 17 sequenced antibodies |
Antibodypediai | 3810, 1954 antibodies |
DNASUi | 942 |
Genome annotation databases
Ensembli | ENST00000264468; ENSP00000264468; ENSG00000114013 [P42081-4] ENST00000330540; ENSP00000332049; ENSG00000114013 [P42081-1] ENST00000393627; ENSP00000377248; ENSG00000114013 [P42081-3] ENST00000469710; ENSP00000418988; ENSG00000114013 [P42081-6] ENST00000493101; ENSP00000420230; ENSG00000114013 [P42081-5] |
GeneIDi | 942 |
KEGGi | hsa:942 |
UCSCi | uc003eet.4, human [P42081-1] |
Organism-specific databases
CTDi | 942 |
DisGeNETi | 942 |
EuPathDBi | HostDB:ENSG00000114013.15 |
GeneCardsi | CD86 |
HGNCi | HGNC:1705, CD86 |
HPAi | ENSG00000114013, Tissue enhanced (blood, brain) |
MIMi | 601020, gene |
neXtProti | NX_P42081 |
OpenTargetsi | ENSG00000114013 |
PharmGKBi | PA26243 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1FF, Eukaryota |
GeneTreei | ENSGT00940000161500 |
HOGENOMi | CLU_1271925_0_0_1 |
InParanoidi | P42081 |
OMAi | KYIGRTS |
OrthoDBi | 1051626at2759 |
PhylomeDBi | P42081 |
TreeFami | TF331083 |
Enzyme and pathway databases
PathwayCommonsi | P42081 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-389356, CD28 co-stimulation R-HSA-389357, CD28 dependent PI3K/Akt signaling R-HSA-389359, CD28 dependent Vav1 pathway R-HSA-389513, CTLA4 inhibitory signaling R-HSA-6783783, Interleukin-10 signaling R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
SIGNORi | P42081 |
Miscellaneous databases
BioGRID-ORCSi | 942, 61 hits in 844 CRISPR screens |
ChiTaRSi | CD86, human |
EvolutionaryTracei | P42081 |
GeneWikii | CD86 |
GenomeRNAii | 942 |
Pharosi | P42081, Tclin |
PROi | PR:P42081 |
RNActi | P42081, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114013, Expressed in monocyte and 191 other tissues |
ExpressionAtlasi | P42081, baseline and differential |
Genevisiblei | P42081, HS |
Family and domain databases
CDDi | cd16087, IgV_CD86, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR037677, CD86_IgV IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD86_HUMAN | |
Accessioni | P42081Primary (citable) accession number: P42081 Secondary accession number(s): A0N0P0 Q7M4L5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries