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UniProtKB - P42081 (CD86_HUMAN)

Protein

T-lymphocyte activation antigen CD86

Gene

CD86

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
(Microbial infection) Acts as a receptor for adenovirus subgroup B.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • coreceptor activity Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
  • signaling receptor activity Source: ProtInc
  • virus receptor activity Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processAdaptive immunity, Host-virus interaction, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-389356 CD28 co-stimulation
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-389359 CD28 dependent Vav1 pathway
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P42081

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-lymphocyte activation antigen CD86
Alternative name(s):
Activation B7-2 antigen
B70
BU63
CTLA-4 counter-receptor B7.2
FUN-1
CD_antigen: CD86
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD86
Synonyms:CD28LG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000114013.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:1705 CD86

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601020 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P42081

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 247ExtracellularSequence analysisAdd BLAST224
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Topological domaini269 – 329CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		942

Open Targets

More...OpenTargetsi		ENSG00000114013

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26243

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2364156

Drug and drug target database

More...DrugBanki		DB01281 Abatacept
DB00098 Anti-thymocyte Globulin (Rabbit)
DB06681 Belatacept

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2745

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD86

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373339

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001455024 – 329T-lymphocyte activation antigen CD86Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 110PROSITE-ProRule annotation1 Publication
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 218PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P42081

PeptideAtlas

More...PeptideAtlasi		P42081

PRoteomics IDEntifications database

More...PRIDEi		P42081

ProteomicsDB human proteome resource

More...ProteomicsDBi		55481
55482 [P42081-2]
55483 [P42081-3]
55484 [P42081-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P42081

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P42081

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by activated B-lymphocytes and monocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114013 Expressed in 172 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

More...CleanExi		HS_CD86

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P42081 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P42081 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB004319

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with MARCH8.Curated3 Publications
(Microbial infection) Interacts with adenovirus subgroup b fiber protein.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107380, 6 interactors

Database of interacting proteins

More...DIPi		DIP-35606N

Protein interaction database and analysis system

More...IntActi		P42081, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000332049

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P42081

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P42081

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P42081

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 131Ig-like V-typeAdd BLAST99
Domaini150 – 225Ig-like C2-typeAdd BLAST76

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IYP1 Eukaryota
ENOG410ZD66 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161500

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000276893

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG004093

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P42081

KEGG Orthology (KO)

More...KOi		K05413

Identification of Orthologs from Complete Genome Data

More...OMAi		YQCFIHH

Database of Orthologous Groups

More...OrthoDBi		EOG091G0QVY

Database for complete collections of gene phylogenies

More...PhylomeDBi		P42081

TreeFam database of animal gene trees

More...TreeFami		TF331083

Family and domain databases

Conserved Domains Database

More...CDDi		cd16087 IgV_CD86, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037677 CD86_IgV
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P42081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL 
        60         70         80         90        100
SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL 
       110        120        130        140        150
QIKDKGLYQC IIHHKKPTGM IRIHQMNSEL SVLANFSQPE IVPISNITEN 
       160        170        180        190        200
VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGVMQKSQ DNVTELYDVS 
       210        220        230        240        250
ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT 
       260        270        280        290        300
AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK 
       310        320 
IHIPERSDEA QRVFKSSKTS SCDKSDTCF
Length:329
Mass (Da):37,682
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC249DAEEB889D911
GO
Isoform 2 (identifier: P42081-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:323
Mass (Da):37,007
Checksum:iA492C705D89B65B7
GO
Isoform 3 (identifier: P42081-2) [UniParc]FASTAAdd to basket
Also known as: CD86 deltaEC

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     22-234: Missing.

Show »
Length:110
Mass (Da):12,818
Checksum:i0AE70C853C85F666
GO
Isoform 4 (identifier: P42081-4) [UniParc]FASTAAdd to basket
Also known as: CD86 deltaTM

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     235-282: Missing.

Show »
Length:275
Mass (Da):31,293
Checksum:i137A523F73708BD5
GO
Isoform 5 (identifier: P42081-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-133: Missing.

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):24,773
Checksum:i7AF72282EEF8B7CE
GO
Isoform 6 (identifier: P42081-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: No experimental confirmation available.
Show »
Length:247
Mass (Da):28,420
Checksum:i60CBC08652F42C26
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JXS1C9JXS1_HUMAN
T-lymphocyte activation antigen CD8...
CD86
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4F8H7C4F8_HUMAN
T-lymphocyte activation antigen CD8...
CD86
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27K → E in AAA86473 (PubMed:7541777).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021916170S → N. Corresponds to variant dbSNP:rs9282642Ensembl.1
Natural variantiVAR_055003185V → I8 PublicationsCorresponds to variant dbSNP:rs2681417Ensembl.1
Natural variantiVAR_014650310A → T2 PublicationsCorresponds to variant dbSNP:rs1129055Ensembl.1
Natural variantiVAR_021917323D → N. Corresponds to variant dbSNP:rs9282648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0472201 – 82Missing in isoform 6. CuratedAdd BLAST82
Alternative sequenceiVSP_0231241 – 6Missing in isoform 2, isoform 3 and isoform 4. 3 Publications6
Alternative sequenceiVSP_00912522 – 234Missing in isoform 3. 1 PublicationAdd BLAST213
Alternative sequenceiVSP_04722122 – 133Missing in isoform 5. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_040324235 – 282Missing in isoform 4. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U04343 mRNA Translation: AAB03814.1
L25259 mRNA Translation: AAA58389.1
CR541844 mRNA Translation: CAG46642.1
EF064748 Genomic DNA Translation: ABK41931.1
AK294663 mRNA Translation: BAH11839.1
AK301237 mRNA Translation: BAH13438.1
AK316203 mRNA Translation: BAH14574.1
AC068630 Genomic DNA No translation available.
BC040261 mRNA Translation: AAH40261.1
U17722
, U17717, U17718, U17719, U17721 Genomic DNA Translation: AAA86473.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3009.1 [P42081-1]
CCDS43138.1 [P42081-3]
CCDS56272.1 [P42081-5]
CCDS56273.1 [P42081-6]
CCDS74991.1 [P42081-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A48754
JC7605

NCBI Reference Sequences

More...RefSeqi		NP_001193853.1, NM_001206924.1
NP_001193854.1, NM_001206925.1
NP_008820.3, NM_006889.4
NP_787058.4, NM_175862.4
NP_795711.1, NM_176892.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.171182

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264468; ENSP00000264468; ENSG00000114013 [P42081-4]
ENST00000330540; ENSP00000332049; ENSG00000114013 [P42081-1]
ENST00000393627; ENSP00000377248; ENSG00000114013 [P42081-3]
ENST00000469710; ENSP00000418988; ENSG00000114013 [P42081-6]
ENST00000493101; ENSP00000420230; ENSG00000114013 [P42081-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		942

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:942

UCSC genome browser

More...UCSCi		uc003eet.4 human [P42081-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CD86 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04343 mRNA Translation: AAB03814.1
L25259 mRNA Translation: AAA58389.1
CR541844 mRNA Translation: CAG46642.1
EF064748 Genomic DNA Translation: ABK41931.1
AK294663 mRNA Translation: BAH11839.1
AK301237 mRNA Translation: BAH13438.1
AK316203 mRNA Translation: BAH14574.1
AC068630 Genomic DNA No translation available.
BC040261 mRNA Translation: AAH40261.1
U17722
, U17717, U17718, U17719, U17721 Genomic DNA Translation: AAA86473.1
CCDSiCCDS3009.1 [P42081-1]
CCDS43138.1 [P42081-3]
CCDS56272.1 [P42081-5]
CCDS56273.1 [P42081-6]
CCDS74991.1 [P42081-4]
PIRiA48754
JC7605
RefSeqiNP_001193853.1, NM_001206924.1
NP_001193854.1, NM_001206925.1
NP_008820.3, NM_006889.4
NP_787058.4, NM_175862.4
NP_795711.1, NM_176892.1
UniGeneiHs.171182

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I85X-ray3.20A/B26-134[»]
1NCNX-ray2.70A/B26-134[»]
ProteinModelPortaliP42081
SMRiP42081
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107380, 6 interactors
DIPiDIP-35606N
IntActiP42081, 8 interactors
STRINGi9606.ENSP00000332049

Chemistry databases

ChEMBLiCHEMBL2364156
DrugBankiDB01281 Abatacept
DB00098 Anti-thymocyte Globulin (Rabbit)
DB06681 Belatacept
GuidetoPHARMACOLOGYi2745

PTM databases

iPTMnetiP42081
PhosphoSitePlusiP42081

Polymorphism and mutation databases

BioMutaiCD86
DMDMi317373339

Proteomic databases

PaxDbiP42081
PeptideAtlasiP42081
PRIDEiP42081
ProteomicsDBi55481
55482 [P42081-2]
55483 [P42081-3]
55484 [P42081-4]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		942
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264468; ENSP00000264468; ENSG00000114013 [P42081-4]
ENST00000330540; ENSP00000332049; ENSG00000114013 [P42081-1]
ENST00000393627; ENSP00000377248; ENSG00000114013 [P42081-3]
ENST00000469710; ENSP00000418988; ENSG00000114013 [P42081-6]
ENST00000493101; ENSP00000420230; ENSG00000114013 [P42081-5]
GeneIDi942
KEGGihsa:942
UCSCiuc003eet.4 human [P42081-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		942
DisGeNETi942
EuPathDBiHostDB:ENSG00000114013.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD86
HGNCiHGNC:1705 CD86
HPAiCAB004319
MIMi601020 gene
neXtProtiNX_P42081
OpenTargetsiENSG00000114013
PharmGKBiPA26243

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IYP1 Eukaryota
ENOG410ZD66 LUCA
GeneTreeiENSGT00940000161500
HOGENOMiHOG000276893
HOVERGENiHBG004093
InParanoidiP42081
KOiK05413
OMAiYQCFIHH
OrthoDBiEOG091G0QVY
PhylomeDBiP42081
TreeFamiTF331083

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-389356 CD28 co-stimulation
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-389359 CD28 dependent Vav1 pathway
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SIGNORiP42081

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD86 human
EvolutionaryTraceiP42081

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD86

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		942

Protein Ontology

More...PROi		PR:P42081

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114013 Expressed in 172 organ(s), highest expression level in leukocyte
CleanExiHS_CD86
ExpressionAtlasiP42081 baseline and differential
GenevisibleiP42081 HS

Family and domain databases

CDDicd16087 IgV_CD86, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR037677 CD86_IgV
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD86_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42081
Secondary accession number(s): A0N0P0
, B7Z2F3, B7Z702, E7ETN5, E9PC27, Q13655, Q6FHB1, Q6GTS4, Q7M4L5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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