UniProtKB - P42060 (RL22_BACSU)
50S ribosomal protein L22
rplV
Functioni
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
UniRule annotationThe globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
UniRule annotationGO - Molecular functioni
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- ribosome assembly Source: GO_Central
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU01210-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L22UniRule annotation |
Gene namesi | Name:rplVUniRule annotation Ordered Locus Names:BSU01210 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosolic large ribosomal subunit Source: GO_Central
Other locations
- large ribosomal subunit Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125119 | 1 – 113 | 50S ribosomal protein L22Add BLAST | 113 |
Proteomic databases
jPOSTi | P42060 |
PaxDbi | P42060 |
PRIDEi | P42060 |
Interactioni
Subunit structurei
Part of the 50S ribosomal subunit.
1 PublicationProtein-protein interaction databases
IntActi | P42060, 1 interactor |
STRINGi | 224308.BSU01210 |
Structurei
Secondary structure
3D structure databases
SMRi | P42060 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0091, Bacteria |
InParanoidi | P42060 |
OMAi | KRIQPRA |
PhylomeDBi | P42060 |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_B, Ribosomal_L22_B, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR036394, Ribosomal_L22/L17_sf IPR005727, Ribosomal_L22_bac/chlpt-type |
PANTHERi | PTHR13501, PTHR13501, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01044, rplV_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MQAKAVARTV RIAPRKARLV MDLIRGKQVG EAVSILNLTP RAASPIIEKV
60 70 80 90 100
LKSAIANAEH NYEMDANNLV ISQAFVDEGP TLKRFRPRAM GRASQINKRT
110
SHITIVVSEK KEG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 35 | I → N in CAA88014 (Ref. 1) Curated | 1 | |
Sequence conflicti | 41 – 42 | RA → IS in CAA88014 (Ref. 1) Curated | 2 | |
Sequence conflicti | 85 | F → L in CAA88014 (Ref. 1) Curated | 1 | |
Sequence conflicti | 105 | I → V in CAA88014 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z47978 Genomic DNA Translation: CAA88014.1 U43929 Genomic DNA Translation: AAC45961.1 D50303 Genomic DNA No translation available. D50302 Genomic DNA Translation: BAA08836.1 AL009126 Genomic DNA Translation: CAB11897.1 |
PIRi | H69696 |
RefSeqi | NP_388002.1, NC_000964.3 WP_003156475.1, NZ_JNCM01000029.1 |
Genome annotation databases
EnsemblBacteriai | CAB11897; CAB11897; BSU_01210 |
GeneIDi | 66327858 938123 |
KEGGi | bsu:BSU01210 |
PATRICi | fig|224308.179.peg.124 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z47978 Genomic DNA Translation: CAA88014.1 U43929 Genomic DNA Translation: AAC45961.1 D50303 Genomic DNA No translation available. D50302 Genomic DNA Translation: BAA08836.1 AL009126 Genomic DNA Translation: CAB11897.1 |
PIRi | H69696 |
RefSeqi | NP_388002.1, NC_000964.3 WP_003156475.1, NZ_JNCM01000029.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J3V | electron microscopy | 13.30 | S | 1-113 | [»] | |
3J3W | electron microscopy | 10.70 | S | 1-113 | [»] | |
3J9W | electron microscopy | 3.90 | BV | 1-113 | [»] | |
5NJT | electron microscopy | 3.80 | l | 2-110 | [»] | |
6HA1 | electron microscopy | 3.10 | S | 1-113 | [»] | |
6HA8 | electron microscopy | 3.50 | S | 1-113 | [»] | |
6HTQ | electron microscopy | 4.50 | S | 2-110 | [»] | |
6PPF | electron microscopy | 3.40 | S | 1-113 | [»] | |
6PPK | electron microscopy | 4.40 | S | 1-113 | [»] | |
6PVK | electron microscopy | 3.40 | S | 1-113 | [»] | |
6TNN | electron microscopy | 3.07 | l | 1-113 | [»] | |
6TPQ | electron microscopy | 3.07 | l | 1-113 | [»] | |
7AQC | electron microscopy | 2.99 | S | 1-113 | [»] | |
7AQD | electron microscopy | 3.10 | S | 1-113 | [»] | |
7AS8 | electron microscopy | 2.90 | W | 1-113 | [»] | |
7AS9 | electron microscopy | 3.50 | W | 1-113 | [»] | |
7OPE | electron microscopy | 3.20 | W | 1-113 | [»] | |
SMRi | P42060 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P42060, 1 interactor |
STRINGi | 224308.BSU01210 |
Proteomic databases
jPOSTi | P42060 |
PaxDbi | P42060 |
PRIDEi | P42060 |
Genome annotation databases
EnsemblBacteriai | CAB11897; CAB11897; BSU_01210 |
GeneIDi | 66327858 938123 |
KEGGi | bsu:BSU01210 |
PATRICi | fig|224308.179.peg.124 |
Phylogenomic databases
eggNOGi | COG0091, Bacteria |
InParanoidi | P42060 |
OMAi | KRIQPRA |
PhylomeDBi | P42060 |
Enzyme and pathway databases
BioCyci | BSUB:BSU01210-MONOMER |
Miscellaneous databases
PROi | PR:P42060 |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_B, Ribosomal_L22_B, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR036394, Ribosomal_L22/L17_sf IPR005727, Ribosomal_L22_bac/chlpt-type |
PANTHERi | PTHR13501, PTHR13501, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01044, rplV_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL22_BACSU | |
Accessioni | P42060Primary (citable) accession number: P42060 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families