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Protein

Beta-centractin

Gene

ACTR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP42025

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-centractin
Alternative name(s):
Actin-related protein 1B
Short name:
ARP1B
Gene namesi
Name:ACTR1B
Synonyms:CTRN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115073.7
HGNCiHGNC:168 ACTR1B
MIMi605144 gene
neXtProtiNX_P42025

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi10120
OpenTargetsiENSG00000115073
PharmGKBiPA24487

Polymorphism and mutation databases

BioMutaiACTR1B
DMDMi1168333

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890601 – 376Beta-centractinAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei4Nitrated tyrosineBy similarity1

Keywords - PTMi

Acetylation, Nitration

Proteomic databases

EPDiP42025
MaxQBiP42025
PaxDbiP42025
PeptideAtlasiP42025
PRIDEiP42025
ProteomicsDBi55480

2D gel databases

OGPiP42025
REPRODUCTION-2DPAGEiIPI00029469

PTM databases

iPTMnetiP42025
PhosphoSitePlusiP42025

Expressioni

Gene expression databases

BgeeiENSG00000115073 Expressed in 229 organ(s), highest expression level in right frontal lobe
CleanExiHS_ACTR1B
GenevisibleiP42025 HS

Organism-specific databases

HPAiHPA047443

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115424, 62 interactors
IntActiP42025, 18 interactors
MINTiP42025
STRINGi9606.ENSP00000289228

Structurei

3D structure databases

ProteinModelPortaliP42025
SMRiP42025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP42025
KOiK16575
OMAiISAPNER
OrthoDBiEOG091G08LD
PhylomeDBiP42025
TreeFamiTF300420

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR029909 Arp1
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF195 PTHR11937:SF195, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P42025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESYDIIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHMRVMAG
60 70 80 90 100
ALEGDLFIGP KAEEHRGLLT IRYPMEHGVV RDWNDMERIW QYVYSKDQLQ
110 120 130 140 150
TFSEEHPVLL TEAPLNPSKN REKAAEVFFE TFNVPALFIS MQAVLSLYAT
160 170 180 190 200
GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRVDIAGRDV SRYLRLLLRK
210 220 230 240 250
EGVDFHTSAE FEVVRTIKER ACYLSINPQK DEALETEKVQ YTLPDGSTLD
260 270 280 290 300
VGPARFRAPE LLFQPDLVGD ESEGLHEVVA FAIHKSDMDL RRTLFANIVL
310 320 330 340 350
SGGSTLFKGF GDRLLSEVKK LAPKDIKIKI SAPQERLYST WIGGSILASL
360 370
DTFKKMWVSK KEYEEDGSRA IHRKTF
Length:376
Mass (Da):42,293
Last modified:November 1, 1995 - v1
Checksum:i24C24ECEE18B83BD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02531593V → A1 PublicationCorresponds to variant dbSNP:rs11547231Ensembl.1
Natural variantiVAR_048187143A → V. Corresponds to variant dbSNP:rs11692435Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82207 mRNA Translation: CAA57691.1
AC017099 Genomic DNA Translation: AAY24280.1
CH471127 Genomic DNA Translation: EAX01924.1
CH471127 Genomic DNA Translation: EAX01927.1
BC004374 mRNA Translation: AAH04374.1
BC006372 mRNA Translation: AAH06372.1
BC010090 mRNA Translation: AAH10090.1
CCDSiCCDS2033.1
RefSeqiNP_005726.1, NM_005735.3
UniGeneiHs.98791

Genome annotation databases

EnsembliENST00000289228; ENSP00000289228; ENSG00000115073
GeneIDi10120
KEGGihsa:10120
UCSCiuc002syb.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82207 mRNA Translation: CAA57691.1
AC017099 Genomic DNA Translation: AAY24280.1
CH471127 Genomic DNA Translation: EAX01924.1
CH471127 Genomic DNA Translation: EAX01927.1
BC004374 mRNA Translation: AAH04374.1
BC006372 mRNA Translation: AAH06372.1
BC010090 mRNA Translation: AAH10090.1
CCDSiCCDS2033.1
RefSeqiNP_005726.1, NM_005735.3
UniGeneiHs.98791

3D structure databases

ProteinModelPortaliP42025
SMRiP42025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115424, 62 interactors
IntActiP42025, 18 interactors
MINTiP42025
STRINGi9606.ENSP00000289228

PTM databases

iPTMnetiP42025
PhosphoSitePlusiP42025

Polymorphism and mutation databases

BioMutaiACTR1B
DMDMi1168333

2D gel databases

OGPiP42025
REPRODUCTION-2DPAGEiIPI00029469

Proteomic databases

EPDiP42025
MaxQBiP42025
PaxDbiP42025
PeptideAtlasiP42025
PRIDEiP42025
ProteomicsDBi55480

Protocols and materials databases

DNASUi10120
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289228; ENSP00000289228; ENSG00000115073
GeneIDi10120
KEGGihsa:10120
UCSCiuc002syb.3 human

Organism-specific databases

CTDi10120
DisGeNETi10120
EuPathDBiHostDB:ENSG00000115073.7
GeneCardsiACTR1B
HGNCiHGNC:168 ACTR1B
HPAiHPA047443
MIMi605144 gene
neXtProtiNX_P42025
OpenTargetsiENSG00000115073
PharmGKBiPA24487
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP42025
KOiK16575
OMAiISAPNER
OrthoDBiEOG091G08LD
PhylomeDBiP42025
TreeFamiTF300420

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP42025

Miscellaneous databases

ChiTaRSiACTR1B human
GeneWikiiACTR1B
GenomeRNAii10120
PROiPR:P42025
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115073 Expressed in 229 organ(s), highest expression level in right frontal lobe
CleanExiHS_ACTR1B
GenevisibleiP42025 HS

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR029909 Arp1
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF195 PTHR11937:SF195, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACTY_HUMAN
AccessioniPrimary (citable) accession number: P42025
Secondary accession number(s): D3DVH2, Q53SK5, Q9BRB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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