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Protein

ETS domain-containing protein Elk-3

Gene

Elk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 85ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS domain-containing protein Elk-3
Alternative name(s):
ETS-related protein ERP
ETS-related protein NET
Gene namesi
Name:Elk3
Synonyms:Erp, Net
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:101762 Elk3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040981 – 409ETS domain-containing protein Elk-3Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei115PhosphoserineBy similarity1
Cross-linki165Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei398PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP41971
MaxQBiP41971
PaxDbiP41971
PRIDEiP41971

PTM databases

iPTMnetiP41971
PhosphoSitePlusiP41971

Expressioni

Tissue specificityi

Heart, liver, lung, kidney and muscle.

Gene expression databases

BgeeiENSMUSG00000008398 Expressed in 333 organ(s), highest expression level in brain blood vessel
CleanExiMM_ELK3
ExpressionAtlasiP41971 baseline and differential
GenevisibleiP41971 MM

Interactioni

Subunit structurei

Interacts with CTBP1.

Protein-protein interaction databases

ELMiP41971
STRINGi10090.ENSMUSP00000008542

Structurei

3D structure databases

ProteinModelPortaliP41971
SMRiP41971
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi275 – 279CTBP-binding motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi208 – 212Poly-Ala5

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000237332
HOVERGENiHBG004344
InParanoidiP41971
KOiK09430
OMAiGIHFWSS
OrthoDBiEOG091G0D25
TreeFamiTF317732

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P41971-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESAITLWQF LLHLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN
60 70 80 90 100
KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPDI LKMDPHAVEI
110 120 130 140 150
SRESLLLQDG DCKVSPEGRE VHRHGLSSLK SASRNEYLHS GLYSSFTINS
160 170 180 190 200
LQNAPEAFKA IKTEKLEEPC DDSPPVEEVR TVIRFVTNKT DKHITRPVVS
210 220 230 240 250
LPSTSETAAA AASAFLASSV SAKISSLMLP NAASISSASP SSSRSPSLSP
260 270 280 290 300
DSPLPSEHRS LFLEAACHDS DSLEPLNLSS GSKTKSPSLP PKGKKPKGLE
310 320 330 340 350
ISAPQLLLSG TDIGSIALNS PALPSGSLTP AFFTAQTPSG LFLASSPLLP
360 370 380 390 400
SIHFWSSLSP VAPLSPARLQ GPNTLFQFPT LLNGHMPVPL PSLDRAPSPV

LLSPSSQKS
Length:409
Mass (Da):44,414
Last modified:July 27, 2011 - v3
Checksum:i7F6B5D1626C62ABA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UVW8G3UVW8_MOUSE
ELK3, member of ETS oncogene family...
Elk3 mCG_4801
142Annotation score:
G3UVX2G3UVX2_MOUSE
ELK3, member of ETS oncogene family...
Elk3 mCG_4801
249Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152Q → E in CAA83676 (PubMed:7958835).Curated1
Sequence conflicti199V → M in CAA83676 (PubMed:7958835).Curated1
Sequence conflicti199V → M in AAA19872 (PubMed:7909357).Curated1
Sequence conflicti235I → V in CAA83676 (PubMed:7958835).Curated1
Sequence conflicti235I → V in AAA19872 (PubMed:7909357).Curated1
Sequence conflicti235I → V in AAB46893 (PubMed:8892757).Curated1
Sequence conflicti238A → V in CAA83676 (PubMed:7958835).Curated1
Sequence conflicti269D → E in CAA83676 (PubMed:7958835).Curated1
Sequence conflicti269D → E in AAA19872 (PubMed:7909357).Curated1
Sequence conflicti269D → E in AAB46893 (PubMed:8892757).Curated1
Sequence conflicti331A → T in AAB46893 (PubMed:8892757).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32815 mRNA Translation: CAA83676.1
L19953 mRNA Translation: AAA19872.1
S82864 mRNA Translation: AAB46893.1
AK052546 mRNA Translation: BAC35034.1
CCDSiCCDS24124.1
PIRiI48680
RefSeqiNP_001309194.1, NM_001322265.1
NP_001309197.1, NM_001322268.1
NP_038536.2, NM_013508.2
UniGeneiMm.4454

Genome annotation databases

EnsembliENSMUST00000008542; ENSMUSP00000008542; ENSMUSG00000008398
GeneIDi13713
KEGGimmu:13713
UCSCiuc011xlt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32815 mRNA Translation: CAA83676.1
L19953 mRNA Translation: AAA19872.1
S82864 mRNA Translation: AAB46893.1
AK052546 mRNA Translation: BAC35034.1
CCDSiCCDS24124.1
PIRiI48680
RefSeqiNP_001309194.1, NM_001322265.1
NP_001309197.1, NM_001322268.1
NP_038536.2, NM_013508.2
UniGeneiMm.4454

3D structure databases

ProteinModelPortaliP41971
SMRiP41971
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP41971
STRINGi10090.ENSMUSP00000008542

PTM databases

iPTMnetiP41971
PhosphoSitePlusiP41971

Proteomic databases

EPDiP41971
MaxQBiP41971
PaxDbiP41971
PRIDEiP41971

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008542; ENSMUSP00000008542; ENSMUSG00000008398
GeneIDi13713
KEGGimmu:13713
UCSCiuc011xlt.1 mouse

Organism-specific databases

CTDi2004
MGIiMGI:101762 Elk3

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000237332
HOVERGENiHBG004344
InParanoidiP41971
KOiK09430
OMAiGIHFWSS
OrthoDBiEOG091G0D25
TreeFamiTF317732

Miscellaneous databases

ChiTaRSiPdia3 mouse
PROiPR:P41971
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008398 Expressed in 333 organ(s), highest expression level in brain blood vessel
CleanExiMM_ELK3
ExpressionAtlasiP41971 baseline and differential
GenevisibleiP41971 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELK3_MOUSE
AccessioniPrimary (citable) accession number: P41971
Secondary accession number(s): P97747, Q62346, Q8BWH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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