UniProtKB - P41968 (MC3R_HUMAN)
Protein
Melanocortin receptor 3
Gene
MC3R
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.By similarity
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- melanocortin receptor activity Source: ProtInc
- melanocyte-stimulating hormone receptor activity Source: BHF-UCL
- neuropeptide binding Source: UniProtKB
- peptide hormone binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- circadian regulation of gene expression Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
- homoiothermy Source: Ensembl
- locomotor rhythm Source: Ensembl
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
- regulation of blood pressure Source: Ensembl
- regulation of feeding behavior Source: Ensembl
- regulation of heart rate Source: Ensembl
- regulation of metabolic process Source: GO_Central
- sodium ion homeostasis Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Biological rhythms |
Enzyme and pathway databases
PathwayCommonsi | P41968 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SIGNORi | P41968 |
Names & Taxonomyi
Protein namesi | Recommended name: Melanocortin receptor 3Short name: MC3-R |
Gene namesi | Name:MC3R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000124089.4 |
HGNCi | HGNC:6931, MC3R |
MIMi | 155540, gene |
neXtProti | NX_P41968 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 37 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 38 – 63 | Helical; Name=1Sequence analysisAdd BLAST | 26 | |
Topological domaini | 64 – 75 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 76 – 100 | Helical; Name=2Sequence analysisAdd BLAST | 25 | |
Topological domaini | 101 – 118 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 119 – 140 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 141 – 160 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 161 – 181 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 186 | ExtracellularSequence analysis | 5 | |
Transmembranei | 187 – 210 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 211 – 245 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 246 – 268 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 269 – 277 | ExtracellularSequence analysis | 9 | |
Transmembranei | 278 – 301 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 302 – 323 | CytoplasmicSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4159 |
MalaCardsi | MC3R |
MIMi | 602025, phenotype |
OpenTargetsi | ENSG00000124089 |
Orphaneti | 217031, NON RARE IN EUROPE: Obesity due to MC3R deficiency |
PharmGKBi | PA30675 |
Miscellaneous databases
Pharosi | P41968, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4644 |
DrugBanki | DB11653, Bremelanotide |
DrugCentrali | P41968 |
GuidetoPHARMACOLOGYi | 284 |
Polymorphism and mutation databases
BioMutai | MC3R |
DMDMi | 395398606 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069718 | 1 – 323 | Melanocortin receptor 3Add BLAST | 323 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 16 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 315 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P41968 |
PRIDEi | P41968 |
ProteomicsDBi | 55478 |
PTM databases
GlyGeni | P41968, 3 sites |
Expressioni
Tissue specificityi
Brain, placental, and gut tissues.
Gene expression databases
Bgeei | ENSG00000124089, Expressed in hypothalamus and 9 other tissues |
Genevisiblei | P41968, HS |
Organism-specific databases
HPAi | ENSG00000124089, Tissue enriched (brain) |
Interactioni
Binary interactionsi
P41968
With | #Exp. | IntAct |
---|---|---|
MRAP [Q8TCY5] | 2 | EBI-9538510,EBI-9538727 |
Protein-protein interaction databases
BioGRIDi | 110329, 1 interactor |
DIPi | DIP-48790N |
IntActi | P41968, 2 interactors |
STRINGi | 9606.ENSP00000243911 |
Chemistry databases
BindingDBi | P41968 |
Miscellaneous databases
RNActi | P41968, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00960000186617 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | P41968 |
OMAi | DQFIQHM |
OrthoDBi | 1037679at2759 |
PhylomeDBi | P41968 |
TreeFami | TF332646 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002122, Mcort_3_rcpt IPR001908, Melancort_rcpt IPR001671, Melcrt_ACTH_rcpt |
PANTHERi | PTHR22750:SF4, PTHR22750:SF4, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00535, MELNOCORTINR PR01061, MELNOCORTN3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P41968-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNASCCLPSV QPTLPNGSEH LQAPFFSNQS SSAFCEQVFI KPEVFLSLGI
60 70 80 90 100
VSLLENILVI LAVVRNGNLH SPMYFFLCSL AVADMLVSVS NALETIMIAI
110 120 130 140 150
VHSDYLTFED QFIQHMDNIF DSMICISLVA SICNLLAIAV DRYVTIFYAL
160 170 180 190 200
RYHSIMTVRK ALTLIVAIWV CCGVCGVVFI VYSESKMVIV CLITMFFAMM
210 220 230 240 250
LLMGTLYVHM FLFARLHVKR IAALPPADGV APQQHSCMKG AVTITILLGV
260 270 280 290 300
FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA
310 320
FRSLELRNTF REILCGCNGM NLG
Sequence cautioni
The sequence AAC13541 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH69105 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH69599 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH96702 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH96737 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH98169 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH98351 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAO72726 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Polymorphismi
Genetic variations in MC3R define the body mass index quantitative trait locus 9 (BMIQ9) [MIMi:602025]. Variance in body mass index is a susceptibility factor for obesity.2 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020070 | 44 | V → I Have ligand binding and signaling properties similar to wild-type. 2 PublicationsCorresponds to variant dbSNP:rs3827103Ensembl. | 1 | |
Natural variantiVAR_055000 | 146 | I → N Associated with susceptibility to obesity; completely lacks signaling in response to agonist stimulation; coexpression of the wild-type and the mutant receptor shows that it does not exert dominant-negative activity on wild-type. 2 PublicationsCorresponds to variant dbSNP:rs74315393EnsemblClinVar. | 1 | |
Natural variantiVAR_055001 | 298 | I → S Associated with susceptibility to obesity; in vitro expression studies demonstrate that the mutation causes complete loss of function; transfected cells show diffuse cytoplasmic staining indicating intracellular retention of the receptor. 1 PublicationCorresponds to variant dbSNP:rs121913556EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L06155 Genomic DNA Translation: AAC13541.1 Different initiation. AY227893 mRNA Translation: AAO72726.1 Different initiation. AL139824 Genomic DNA No translation available. BC069105 mRNA Translation: AAH69105.1 Different initiation. BC069599 mRNA Translation: AAH69599.1 Different initiation. BC096702 mRNA Translation: AAH96702.1 Different initiation. BC096737 mRNA Translation: AAH96737.1 Different initiation. BC098169 mRNA Translation: AAH98169.1 Different initiation. BC098351 mRNA Translation: AAH98351.1 Different initiation. |
CCDSi | CCDS13449.2 |
PIRi | B46647 |
RefSeqi | NP_063941.3, NM_019888.3 |
Genome annotation databases
Ensembli | ENST00000243911; ENSP00000243911; ENSG00000124089 |
GeneIDi | 4159 |
KEGGi | hsa:4159 |
UCSCi | uc002xxb.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L06155 Genomic DNA Translation: AAC13541.1 Different initiation. AY227893 mRNA Translation: AAO72726.1 Different initiation. AL139824 Genomic DNA No translation available. BC069105 mRNA Translation: AAH69105.1 Different initiation. BC069599 mRNA Translation: AAH69599.1 Different initiation. BC096702 mRNA Translation: AAH96702.1 Different initiation. BC096737 mRNA Translation: AAH96737.1 Different initiation. BC098169 mRNA Translation: AAH98169.1 Different initiation. BC098351 mRNA Translation: AAH98351.1 Different initiation. |
CCDSi | CCDS13449.2 |
PIRi | B46647 |
RefSeqi | NP_063941.3, NM_019888.3 |
3D structure databases
SMRi | P41968 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110329, 1 interactor |
DIPi | DIP-48790N |
IntActi | P41968, 2 interactors |
STRINGi | 9606.ENSP00000243911 |
Chemistry databases
BindingDBi | P41968 |
ChEMBLi | CHEMBL4644 |
DrugBanki | DB11653, Bremelanotide |
DrugCentrali | P41968 |
GuidetoPHARMACOLOGYi | 284 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P41968, 3 sites |
Polymorphism and mutation databases
BioMutai | MC3R |
DMDMi | 395398606 |
Proteomic databases
PaxDbi | P41968 |
PRIDEi | P41968 |
ProteomicsDBi | 55478 |
Protocols and materials databases
Antibodypediai | 2935, 320 antibodies |
DNASUi | 4159 |
Genome annotation databases
Ensembli | ENST00000243911; ENSP00000243911; ENSG00000124089 |
GeneIDi | 4159 |
KEGGi | hsa:4159 |
UCSCi | uc002xxb.2, human |
Organism-specific databases
CTDi | 4159 |
DisGeNETi | 4159 |
EuPathDBi | HostDB:ENSG00000124089.4 |
GeneCardsi | MC3R |
HGNCi | HGNC:6931, MC3R |
HPAi | ENSG00000124089, Tissue enriched (brain) |
MalaCardsi | MC3R |
MIMi | 155540, gene 602025, phenotype |
neXtProti | NX_P41968 |
OpenTargetsi | ENSG00000124089 |
Orphaneti | 217031, NON RARE IN EUROPE: Obesity due to MC3R deficiency |
PharmGKBi | PA30675 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00960000186617 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | P41968 |
OMAi | DQFIQHM |
OrthoDBi | 1037679at2759 |
PhylomeDBi | P41968 |
TreeFami | TF332646 |
Enzyme and pathway databases
PathwayCommonsi | P41968 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SIGNORi | P41968 |
Miscellaneous databases
BioGRID-ORCSi | 4159, 4 hits in 837 CRISPR screens |
GeneWikii | Melanocortin_3_receptor |
GenomeRNAii | 4159 |
Pharosi | P41968, Tchem |
PROi | PR:P41968 |
RNActi | P41968, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124089, Expressed in hypothalamus and 9 other tissues |
Genevisiblei | P41968, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002122, Mcort_3_rcpt IPR001908, Melancort_rcpt IPR001671, Melcrt_ACTH_rcpt |
PANTHERi | PTHR22750:SF4, PTHR22750:SF4, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00535, MELNOCORTINR PR01061, MELNOCORTN3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MC3R_HUMAN | |
Accessioni | P41968Primary (citable) accession number: P41968 Secondary accession number(s): Q4KN27, Q9H517 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | July 11, 2012 | |
Last modified: | December 2, 2020 | |
This is version 180 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries