MC3R

Functionⁱ

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.By similarity

GO - Molecular functionⁱ

melanocortin receptor activity
Source: ProtInc
Traceable author statementⁱ
- 8175743
melanocyte-stimulating hormone receptor activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19743876
neuropeptide binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15927146
peptide hormone binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G-protein coupled receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 19329486
- 19743876
circadian regulation of gene expression Source: UniProtKB
G-protein coupled receptor signaling pathway Source: Reactome
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: ProtInc
Traceable author statementⁱ
- 8175743
homoiothermy Source: Ensembl
locomotor rhythm Source: Ensembl
phospholipase C-activating G-protein coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8175743
regulation of blood pressure Source: Ensembl
regulation of feeding behavior Source: Ensembl
regulation of heart rate Source: Ensembl
sodium ion homeostasis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Biological rhythms

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-418555 G alpha (s) signalling events
SIGNORⁱ	P41968

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Melanocortin receptor 3 Short name: MC3-R
Gene namesⁱ	Name:MC3R
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000124089.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6931 MC3R
MIMⁱ	155540 gene
neXtProtⁱ	NX_P41968

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 37	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	38 – 63	Helical; Name=1Sequence analysisAdd BLAST	26
Topological domainⁱ	64 – 75	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	76 – 100	Helical; Name=2Sequence analysisAdd BLAST	25
Topological domainⁱ	101 – 118	ExtracellularSequence analysisAdd BLAST	18
Transmembraneⁱ	119 – 140	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	141 – 160	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	161 – 181	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	182 – 186	ExtracellularSequence analysis	5
Transmembraneⁱ	187 – 210	Helical; Name=5Sequence analysisAdd BLAST	24
Topological domainⁱ	211 – 245	CytoplasmicSequence analysisAdd BLAST	35
Transmembraneⁱ	246 – 268	Helical; Name=6Sequence analysisAdd BLAST	23
Topological domainⁱ	269 – 277	ExtracellularSequence analysis	9
Transmembraneⁱ	278 – 301	Helical; Name=7Sequence analysisAdd BLAST	24
Topological domainⁱ	302 – 323	CytoplasmicSequence analysisAdd BLAST	22

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4159
MalaCards human disease database More...MalaCardsⁱ	MC3R
MIMⁱ	602025 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000124089
Orphanetⁱ	217031 Obesity due to MC3R deficiency
PharmGKBⁱ	PA30675

Chemistry databases

ChEMBLⁱ	CHEMBL4644
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	284

Polymorphism and mutation databases

BioMutaⁱ	MC3R
DMDMⁱ	395398606

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069718	1 – 323	Melanocortin receptor 3Add BLAST		323

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	2	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	16	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	28	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	315	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P41968
PRIDEⁱ	P41968
ProteomicsDBⁱ	55478

Expressionⁱ

Tissue specificityⁱ

Brain, placental, and gut tissues.

Gene expression databases

Bgeeⁱ	ENSG00000124089 Expressed in 4 organ(s), highest expression level in muscle tissue
CleanExⁱ	HS_MC3R
Genevisibleⁱ	P41968 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MRAP	Q8TCY5	2	EBI-9538510,EBI-9538727

With

Entry

#Exp.

IntAct

Notes

MRAP

Q8TCY5

2

EBI-9538510,EBI-9538727

Protein-protein interaction databases

BioGridⁱ	110329, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-48790N
IntActⁱ	P41968, 2 interactors
STRINGⁱ	9606.ENSP00000243911

Chemistry databases

BindingDBⁱ	P41968

BindingDBⁱ

P41968

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P41968
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00770000120529
HOGENOMⁱ	HOG000246927
HOVERGENⁱ	HBG108148
InParanoidⁱ	P41968
KEGG Orthology (KO) More...KOⁱ	K04201
OMAⁱ	VHMFLFA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BVW
PhylomeDBⁱ	P41968
TreeFamⁱ	TF332646

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15352 7tmA_MC3R, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR002122 Mcort_3_rcpt IPR001908 Melancort_rcpt IPR001671 Melcrt_ACTH_rcpt
PANTHERⁱ	PTHR22750:SF4 PTHR22750:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00534 MCRFAMILY PR00535 MELNOCORTINR PR01061 MELNOCORTN3R
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P41968-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNASCCLPSV QPTLPNGSEH LQAPFFSNQS SSAFCEQVFI KPEVFLSLGI 
        60         70         80         90        100
VSLLENILVI LAVVRNGNLH SPMYFFLCSL AVADMLVSVS NALETIMIAI 
       110        120        130        140        150
VHSDYLTFED QFIQHMDNIF DSMICISLVA SICNLLAIAV DRYVTIFYAL 
       160        170        180        190        200
RYHSIMTVRK ALTLIVAIWV CCGVCGVVFI VYSESKMVIV CLITMFFAMM 
       210        220        230        240        250
LLMGTLYVHM FLFARLHVKR IAALPPADGV APQQHSCMKG AVTITILLGV 
       260        270        280        290        300
FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA 
       310        320 
FRSLELRNTF REILCGCNGM NLG

Length:323

Mass (Da):36,043

Last modified:July 11, 2012 - v3

Checksum:ⁱ98B016FC80802A97

GO

Sequence cautionⁱ

The sequence AAC13541 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH69105 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH69599 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH96702 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH96737 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH98169 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH98351 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAO72726 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Polymorphismⁱ

Genetic variations in MC3R define the body mass index quantitative trait locus 9 (BMIQ9) [MIMⁱ:602025]. Variance in body mass index is a susceptibility factor for obesity.2 Publications

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_020070	44	V → I Have ligand binding and signaling properties similar to wild-type. 2 PublicationsCorresponds to variant dbSNP:rs3827103Ensembl.	1
Natural variantⁱVAR_055000	146	I → N Associated with susceptibility to obesity; completely lacks signaling in response to agonist stimulation; coexpression of the wild-type and the mutant receptor shows that it does not exert dominant-negative activity on wild-type. 2 PublicationsCorresponds to variant dbSNP:rs74315393EnsemblClinVar.	1
Natural variantⁱVAR_055001	298	I → S Associated with susceptibility to obesity; in vitro expression studies demonstrate that the mutation causes complete loss of function; transfected cells show diffuse cytoplasmic staining indicating intracellular retention of the receptor. 1 PublicationCorresponds to variant dbSNP:rs121913556EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L06155 Genomic DNA Translation: AAC13541.1 Different initiation. AY227893 mRNA Translation: AAO72726.1 Different initiation. AL139824 Genomic DNA No translation available. BC069105 mRNA Translation: AAH69105.1 Different initiation. BC069599 mRNA Translation: AAH69599.1 Different initiation. BC096702 mRNA Translation: AAH96702.1 Different initiation. BC096737 mRNA Translation: AAH96737.1 Different initiation. BC098169 mRNA Translation: AAH98169.1 Different initiation. BC098351 mRNA Translation: AAH98351.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13449.2
PIRⁱ	B46647
NCBI Reference Sequences More...RefSeqⁱ	NP_063941.3, NM_019888.3
UniGeneⁱ	Hs.248018

Genome annotation databases

Ensemblⁱ	ENST00000243911; ENSP00000243911; ENSG00000124089
GeneIDⁱ	4159
KEGGⁱ	hsa:4159
UCSC genome browser More...UCSCⁱ	uc002xxb.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P41968	Melanocortin 3 receptor		AILME		360	UniRef90_P41968
Melanocortin 3 receptor		SHEEP		324
Melanocortin 3 receptor		BOVIN		324
Melanocortin receptor 3 (Fragment)		wild yak		324
Melanocortin 3 receptor (Fragment)		BOSMU		208
+79

Protein	Similar proteins		Species	Score	Length	Source
P41968	Melanocortin receptor 4	)	HUMAN		332	UniRef50_P32245
Melanocortin receptor 4		MACFA		332
Melanocortin receptor 4		MOUSE		332
Melanocortin receptor 4		BOVIN		332
Melanocortin receptor 4		VULVU		332
+688

Entry informationⁱ

Entry nameⁱ	MC3R_HUMAN
Accessionⁱ	P41968Primary (citable) accession number: P41968 Secondary accession number(s): Q4KN27, Q9H517
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	July 11, 2012
	Last modified:	September 12, 2018
	This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P41968 (MC3R_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Melanocortin receptor 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ