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Protein

Apoptosis regulator ced-9

Gene

ced-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in programmed cell death (PCD, apoptosis) (PubMed:7907274, PubMed:10688797). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3 (PubMed:9024666, PubMed:9027313, PubMed:9604928, PubMed:12894216, PubMed:15383288, PubMed:16208361). During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway (PubMed:26074078).7 Publications

GO - Molecular functioni

  • GTPase activator activity Source: WormBase
  • protein heterodimerization activity Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processApoptosis

Protein family/group databases

TCDBi1.A.21.2.1 the bcl-2 (bcl-2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis regulator ced-9
Alternative name(s):
Cell death protein 9
Gene namesi
Name:ced-9
ORF Names:T07C4.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT07C4.8 ; CE25104 ; WBGene00000423 ; ced-9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Membrane, Mitochondrion, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi149Y → N in n1653; no effect on the interaction with ced-4. Normal elimination of presynaptic components in RME neurons in adults. 2 Publications1
Mutagenesisi169G → E in n1950; gain of function mutant. No effect on the interaction with ced-4. Impaired elimination of presynaptic components in RME neurons in adults. Abnormal accumulation of F-actin at the non-eliminated transient synapses in DD neuron dorsal cord in L4 larvae. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430971 – 280Apoptosis regulator ced-9Add BLAST280

Proteomic databases

EPDiP41958
PaxDbiP41958
PeptideAtlasiP41958

PTM databases

iPTMnetiP41958

Expressioni

Developmental stagei

Abundant expression is seen in embryos and adults.1 Publication

Gene expression databases

BgeeiWBGene00000423 Expressed in 6 organ(s), highest expression level in multi-cellular organism

Interactioni

Subunit structurei

Interacts with asymmetric homodimer ced-4; the interaction sequesters ced-4 (PubMed:9024666, PubMed:9027313, PubMed:15383288, PubMed:16208361). Interacts with egl-1; the interaction results in ced-4 release (PubMed:9604928, PubMed:12894216, PubMed:15383288). Interacts with dre-1; the interaction inhibits ced-9 activity, either directly or indirectly (PubMed:23431138). Interacts with dct-1 (PubMed:11114722). May form a complex composed of ced-9, ced-4 and mac-1 (PubMed:10101135).9 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi533094, 4 interactors
ComplexPortaliCPX-1359 ced-4-ced-9-mac-1 complex
CPX-398 ced-9-egl-1 complex
CPX-399 ced-9-ced-4 complex
DIPiDIP-250N
ELMiP41958
IntActiP41958, 4 interactors
STRINGi6239.T07C4.8

Structurei

Secondary structure

1280
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP41958
SMRiP41958
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41958

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi80 – 99BH4PROSITE-ProRule annotationAdd BLAST20
Motifi160 – 179BH1Sequence analysisAdd BLAST20
Motifi213 – 229BH2CuratedAdd BLAST17

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
HOGENOMiHOG000111534
InParanoidiP41958
KOiK20094
OMAiYVEVVEC
OrthoDBiEOG091G0QL0
PhylomeDBiP41958

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR003093 Bcl2_BH4
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PF02180 BH4, 1 hit
SMARTiView protein in SMART
SM00265 BH4, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS50063 BH4_2, 1 hit

Sequencei

Sequence statusi: Complete.

P41958-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRCTADNSL TNPAYRRRTM ATGEMKEFLG IKGTEPTDFG INSDAQDLPS
60 70 80 90 100
PSRQASTRRM SIGESIDGKI NDWEEPRLDI EGFVVDYFTH RIRQNGMEWF
110 120 130 140 150
GAPGLPCGVQ PEHEMMRVMG TIFEKKHAEN FETFCEQLLA VPRISFSLYQ
160 170 180 190 200
DVVRTVGNAQ TDQCPMSYGR LIGLISFGGF VAAKMMESVE LQGQVRNLFV
210 220 230 240 250
YTSLFIKTRI RNNWKEHNRS WDDFMTLGKQ MKEDYERAEA EKVGRRKQNR
260 270 280
RWSMIGAGVT AGAIGIVGVV VCGRMMFSLK
Length:280
Mass (Da):31,824
Last modified:November 1, 1995 - v1
Checksum:i7603675E490DD3EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26545 Genomic DNA Translation: AAA20080.1
Z29443 Genomic DNA Translation: CAA82573.2
PIRiA53189
H88578
RefSeqiNP_499284.1, NM_066883.5
UniGeneiCel.6305

Genome annotation databases

EnsemblMetazoaiT07C4.8; T07C4.8; WBGene00000423
GeneIDi3565776
KEGGicel:CELE_T07C4.8
UCSCiT07C4.8.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26545 Genomic DNA Translation: AAA20080.1
Z29443 Genomic DNA Translation: CAA82573.2
PIRiA53189
H88578
RefSeqiNP_499284.1, NM_066883.5
UniGeneiCel.6305

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OHUX-ray2.03A/B68-242[»]
1TY4X-ray2.20A/B68-237[»]
2A5YX-ray2.60A48-251[»]
ProteinModelPortaliP41958
SMRiP41958
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi533094, 4 interactors
ComplexPortaliCPX-1359 ced-4-ced-9-mac-1 complex
CPX-398 ced-9-egl-1 complex
CPX-399 ced-9-ced-4 complex
DIPiDIP-250N
ELMiP41958
IntActiP41958, 4 interactors
STRINGi6239.T07C4.8

Protein family/group databases

TCDBi1.A.21.2.1 the bcl-2 (bcl-2) family

PTM databases

iPTMnetiP41958

Proteomic databases

EPDiP41958
PaxDbiP41958
PeptideAtlasiP41958

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT07C4.8; T07C4.8; WBGene00000423
GeneIDi3565776
KEGGicel:CELE_T07C4.8
UCSCiT07C4.8.1 c. elegans

Organism-specific databases

CTDi3565776
WormBaseiT07C4.8 ; CE25104 ; WBGene00000423 ; ced-9

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
HOGENOMiHOG000111534
InParanoidiP41958
KOiK20094
OMAiYVEVVEC
OrthoDBiEOG091G0QL0
PhylomeDBiP41958

Miscellaneous databases

EvolutionaryTraceiP41958
PROiPR:P41958

Gene expression databases

BgeeiWBGene00000423 Expressed in 6 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR003093 Bcl2_BH4
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PF02180 BH4, 1 hit
SMARTiView protein in SMART
SM00265 BH4, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS50063 BH4_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCED9_CAEEL
AccessioniPrimary (citable) accession number: P41958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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