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Entry version 157 (12 Aug 2020)
Sequence version 1 (01 Nov 1995)
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Protein

Homeobox protein ceh-18

Gene

ceh-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Directs gonadal sheath cell differentiation and function (PubMed:9405097). Also directs gonad migration and plays a role in specifying the differentiated phenotypes of epidermal cells during postembryonic development (PubMed:7958868). Plays a role in oogenesis, regulating a sheath cell signal that causes oocytes to maintain diakinesis arrest during meiosis (PubMed:7958868). Negatively regulates oocyte maturation, ovulation and MAPK activation in oocytes when sperm are not available for fertilization (PubMed:12533508). May be recruited by akir-1 to the promoter regions of antimicrobial peptide genes to control gene expression in response to fungal infection (PubMed:30036395).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi421 – 480HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein ceh-18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ceh-181 PublicationImported
ORF Names:ZC64.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
ZC64.3a ; CE25674 ; WBGene00000441 ; ceh-18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable, but some animals exhibit sterile and lethal phenotypes including hermaphrodite sterility, embryonic lethality and larval arrest (PubMed:7958868). Defective ovulation and terminal differentiation of oocytes, which result from a delay or an inability to complete meiosis during oogenesis (PubMed:7958868, PubMed:9405097). Defects in gonadal migration (PubMed:7958868). Defective sheath cell differentiation in terms of cell shape and position and defective functions which include weaker sheath cell contractions (PubMed:9405097). Abnormal hypodermal cell differentiation (PubMed:7958868). Defective MAPK activation in oocytes in the presence and absence of sperm (PubMed:12533508). RNAi-mediated knockdown reduces survival following fungal infection by D.coniospora (PubMed:30036395).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001007821 – 542Homeobox protein ceh-18Add BLAST542

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P41934

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41934

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the gonadal sheath cells that signal the oocyte, but not in the oocyte.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First expressed in embryos at the three-fold stage (PubMed:7958868). After hatching expressed in the syncytial hypodermal cells located throughout the body, pharyngeal muscle, seam cells P hypodermal blast cells, body muscle and anterior touch cells (PubMed:7958868). Expressed in the distal tip cell of the somatic ginad from the L2 stage of larval development through to the adult stage (PubMed:7958868).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000441, Expressed in material anatomical entity and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P41934, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with akir-1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
45607, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P41934, 15 interactors

STRING: functional protein association networks

More...
STRINGi
6239.ZC64.3a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P41934

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini290 – 364POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi48 – 72Glu-rich (acidic)Add BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the POU transcription factor family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3802, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171806

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039438_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41934

Identification of Orthologs from Complete Genome Data

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OMAi
MNQRNAL

Database of Orthologous Groups

More...
OrthoDBi
834648at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P41934

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
IPR013847, POU
IPR000327, POU_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit
PF00157, Pou, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00028, POUDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 1 hit
SM00352, POU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00035, POU_1, 1 hit
PS00465, POU_2, 1 hit
PS51179, POU_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P41934-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTLENTFQF LAEVFEANGG CLVTERVSPS LSGASKRKSR PVKRIITEDE
60 70 80 90 100
VIPEEEVVEE EEEEKVEQPS EEVTCPAMQV DATDAILASL RQIANNDLSE
110 120 130 140 150
HCIREDEGNT SAEVFSNGNG EDMEQAGLAG TDLLRRVADM LQGNHNGSLN
160 170 180 190 200
SHFLQQQFAA FKETVDPTPV STNGNGLLTP ITTQLSPLFT STDAFNSPEK
210 220 230 240 250
LLQAIMTPSL GFLGANGLGA SNSGLLSSPL IAPSPTLLQS LMNTPTQPTA
260 270 280 290 300
SLTPKKAENR PPVVSQTLKA SKRRLFDDTS RIEAASMSGD DRIDMNELEA
310 320 330 340 350
FAQTFKKQRI KFGFTQGDVG VALGKRYGTD FSQTTISRFE ALNLSFKNMC
360 370 380 390 400
KLRPLLKEWL ADVEMAIEGG ATVTDLIDKK TIHNGNHHTI HHVDIHETSI
410 420 430 440 450
SNSISSVTAS SLLSREQHVK RRRKRTNLDM NQRNALDTFF ALNPRPDHDK
460 470 480 490 500
MTDIANSLEL DRDVVRVWFC NRRQKMRRVD EPIEGEMVTP SVSPVFPHFS
510 520 530 540
SMSALEQIQE AARLASCQAS NDDSDGTSGS PDAPSNDGCS DL
Length:542
Mass (Da):59,480
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34A97C7CC4B850E6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U16367 mRNA Translation: AAA52203.1
BX284606 Genomic DNA Translation: CCD71431.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A54963

NCBI Reference Sequences

More...
RefSeqi
NP_741758.1, NM_171659.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZC64.3a.1; ZC64.3a.1; WBGene00000441

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180671

UCSC genome browser

More...
UCSCi
ZC64.3b, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16367 mRNA Translation: AAA52203.1
BX284606 Genomic DNA Translation: CCD71431.1
PIRiA54963
RefSeqiNP_741758.1, NM_171659.4

3D structure databases

SMRiP41934
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi45607, 7 interactors
IntActiP41934, 15 interactors
STRINGi6239.ZC64.3a

Proteomic databases

EPDiP41934
PaxDbiP41934

Genome annotation databases

EnsemblMetazoaiZC64.3a.1; ZC64.3a.1; WBGene00000441
GeneIDi180671
UCSCiZC64.3b, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180671
WormBaseiZC64.3a ; CE25674 ; WBGene00000441 ; ceh-18

Phylogenomic databases

eggNOGiKOG3802, Eukaryota
GeneTreeiENSGT00940000171806
HOGENOMiCLU_039438_0_0_1
InParanoidiP41934
OMAiMNQRNAL
OrthoDBi834648at2759
PhylomeDBiP41934

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P41934

Gene expression databases

BgeeiWBGene00000441, Expressed in material anatomical entity and 4 other tissues
ExpressionAtlasiP41934, baseline and differential

Family and domain databases

CDDicd00086, homeodomain, 1 hit
Gene3Di1.10.260.40, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
IPR013847, POU
IPR000327, POU_dom
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF00157, Pou, 1 hit
PRINTSiPR00028, POUDOMAIN
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00352, POU, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00035, POU_1, 1 hit
PS00465, POU_2, 1 hit
PS51179, POU_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHM18_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41934
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 12, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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