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UniProtKB - P41920 (YRB1_YEAST)
Protein
Ran-specific GTPase-activating protein 1
Gene
YRB1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- small GTPase binding Source: SGD
GO - Biological processi
- G1/S transition of mitotic cell cycle Source: SGD
- protein import into nucleus Source: SGD
- RNA export from nucleus Source: SGD
- ubiquitin-dependent protein catabolic process Source: SGD
Keywordsi
Molecular function | GTPase activation |
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-3232142, SUMOylation of ubiquitinylation proteins R-SCE-4085377, SUMOylation of SUMOylation proteins R-SCE-4551638, SUMOylation of chromatin organization proteins R-SCE-4570464, SUMOylation of RNA binding proteins |
Names & Taxonomyi
Protein namesi | Recommended name: Ran-specific GTPase-activating protein 1Alternative name(s): Chromosome stability protein 20 Perinuclear array-localized protein Ran-binding protein 1 Short name: RANBP1 |
Gene namesi | Name:YRB1 Synonyms:CST20, HTN1, SFO1 Ordered Locus Names:YDR002W ORF Names:YD8119.08 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002409, YRB1 |
VEuPathDBi | FungiDB:YDR002W |
Subcellular locationi
Nucleus
- nuclear pore Source: GO_Central
- nucleus Source: SGD
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213670 | 1 – 201 | Ran-specific GTPase-activating protein 1Add BLAST | 201 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P41920 |
PaxDbi | P41920 |
PRIDEi | P41920 |
PTM databases
iPTMneti | P41920 |
Interactioni
Subunit structurei
Interacts with GSP1 and PRP20.
GO - Molecular functioni
- small GTPase binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 32055, 265 interactors |
DIPi | DIP-838N |
IntActi | P41920, 6 interactors |
MINTi | P41920 |
STRINGi | 4932.YDR002W |
Miscellaneous databases
RNActi | P41920, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P41920 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P41920 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 200 | RanBD1PROSITE-ProRule annotationAdd BLAST | 137 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 66 | DisorderedSequence analysisAdd BLAST | 66 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 18 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 33 – 66 | Basic and acidic residuesSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the RANBP1 family.Curated
Phylogenomic databases
eggNOGi | KOG0864, Eukaryota |
GeneTreei | ENSGT00900000141073 |
HOGENOMi | CLU_067861_2_1_1 |
InParanoidi | P41920 |
OMAi | FEPVIHL |
Family and domain databases
CDDi | cd13179, RanBD_RanBP1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
IDEALi | IID50175 |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR000156, Ran_bind_dom IPR045255, RanBP1-like IPR045256, RanBP1_RanBD |
PANTHERi | PTHR23138, PTHR23138, 1 hit |
Pfami | View protein in Pfam PF00638, Ran_BP1, 1 hit |
SMARTi | View protein in SMART SM00160, RanBD, 1 hit |
PROSITEi | View protein in PROSITE PS50196, RANBD1, 1 hit |
i Sequence
Sequence statusi: Complete.
P41920-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSEDKKPVV DKKEEAAPKP PSSAVFSMFG GKKAEKPETK KDEEDTKEET
60 70 80 90 100
KKEGDDAPES PDIHFEPVVH LEKVDVKTME EDEEVLYKVR AKLFRFDADA
110 120 130 140 150
KEWKERGTGD CKFLKNKKTN KVRILMRRDK TLKICANHII APEYTLKPNV
160 170 180 190 200
GSDRSWVYAC TADIAEGEAE AFTFAIRFGS KENADKFKEE FEKAQEINKK
A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z33503 Genomic DNA Translation: CAA83911.1 X65925 Genomic DNA No translation available. L38489 Genomic DNA Translation: AAA57276.1 Z48008 Genomic DNA Translation: CAA88062.1 BK006938 Genomic DNA Translation: DAA11849.1 |
PIRi | S50219 |
RefSeqi | NP_010285.1, NM_001180310.1 |
Genome annotation databases
EnsemblFungii | YDR002W_mRNA; YDR002W; YDR002W |
GeneIDi | 851565 |
KEGGi | sce:YDR002W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z33503 Genomic DNA Translation: CAA83911.1 X65925 Genomic DNA No translation available. L38489 Genomic DNA Translation: AAA57276.1 Z48008 Genomic DNA Translation: CAA88062.1 BK006938 Genomic DNA Translation: DAA11849.1 |
PIRi | S50219 |
RefSeqi | NP_010285.1, NM_001180310.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3M1I | X-ray | 2.00 | B | 11-201 | [»] | |
4GMX | X-ray | 2.10 | B | 62-201 | [»] | |
4GPT | X-ray | 2.22 | B | 62-201 | [»] | |
4HAT | X-ray | 1.78 | B | 62-201 | [»] | |
4HAU | X-ray | 2.00 | B | 62-201 | [»] | |
4HAV | X-ray | 2.00 | B | 62-201 | [»] | |
4HAW | X-ray | 1.90 | B | 62-201 | [»] | |
4HAX | X-ray | 2.28 | B | 62-201 | [»] | |
4HAY | X-ray | 2.30 | B | 62-201 | [»] | |
4HAZ | X-ray | 1.90 | B | 62-201 | [»] | |
4HB0 | X-ray | 2.20 | B | 62-201 | [»] | |
4HB2 | X-ray | 1.80 | B | 62-201 | [»] | |
4HB3 | X-ray | 2.80 | B | 62-201 | [»] | |
4HB4 | X-ray | 2.05 | B | 62-201 | [»] | |
4WVF | X-ray | 1.80 | B | 62-201 | [»] | |
5DH9 | X-ray | 2.55 | B | 62-201 | [»] | |
5DHA | X-ray | 2.95 | B | 62-201 | [»] | |
5DHF | X-ray | 2.29 | B | 62-201 | [»] | |
5DI9 | X-ray | 2.28 | B | 62-201 | [»] | |
5DIF | X-ray | 2.09 | B | 62-201 | [»] | |
5JLJ | X-ray | 2.50 | B | 62-201 | [»] | |
5UWH | X-ray | 2.26 | B | 62-201 | [»] | |
5UWI | X-ray | 2.14 | B | 62-201 | [»] | |
5UWJ | X-ray | 2.22 | B | 62-201 | [»] | |
5UWO | X-ray | 2.35 | B | 62-201 | [»] | |
5UWP | X-ray | 2.05 | B | 62-201 | [»] | |
5UWQ | X-ray | 2.28 | B | 62-201 | [»] | |
5UWR | X-ray | 2.24 | B | 62-201 | [»] | |
5UWS | X-ray | 2.40 | B | 62-201 | [»] | |
5UWT | X-ray | 2.34 | B | 62-201 | [»] | |
5UWU | X-ray | 2.24 | B | 62-201 | [»] | |
5UWW | X-ray | 2.15 | B | 62-201 | [»] | |
5YRO | X-ray | 2.40 | B | 62-201 | [»] | |
5YST | X-ray | 2.04 | B | 62-200 | [»] | |
5YSU | X-ray | 2.30 | B | 62-200 | [»] | |
5YTB | X-ray | 2.30 | B | 62-200 | [»] | |
5ZPU | X-ray | 2.60 | B | 62-201 | [»] | |
6A38 | X-ray | 2.69 | B | 62-201 | [»] | |
6A3A | X-ray | 2.30 | B | 62-201 | [»] | |
6A3B | X-ray | 2.51 | B | 62-201 | [»] | |
6A3C | X-ray | 2.35 | B | 62-201 | [»] | |
6A3E | X-ray | 2.70 | B | 62-201 | [»] | |
6CIT | X-ray | 2.03 | B | 62-201 | [»] | |
6KFT | X-ray | 2.51 | B | 62-201 | [»] | |
6LQ9 | X-ray | 2.50 | B | 62-201 | [»] | |
6M60 | X-ray | 2.17 | B | 62-201 | [»] | |
6M6X | X-ray | 2.88 | B | 62-201 | [»] | |
6X2M | X-ray | 2.35 | B | 62-201 | [»] | |
6X2O | X-ray | 2.55 | B | 62-201 | [»] | |
6X2P | X-ray | 2.40 | B | 62-201 | [»] | |
6X2R | X-ray | 2.30 | B | 62-201 | [»] | |
6X2S | X-ray | 2.50 | B | 62-201 | [»] | |
6X2U | X-ray | 2.20 | B | 62-201 | [»] | |
6X2V | X-ray | 2.82 | B | 62-201 | [»] | |
6X2W | X-ray | 3.00 | B | 62-201 | [»] | |
6X2X | X-ray | 2.46 | B | 62-201 | [»] | |
6X2Y | X-ray | 2.30 | B | 62-201 | [»] | |
6XJP | X-ray | 2.80 | B | 62-201 | [»] | |
6XJR | X-ray | 1.94 | B | 62-201 | [»] | |
6XJS | X-ray | 1.94 | B | 62-201 | [»] | |
6XJT | X-ray | 2.41 | B | 62-201 | [»] | |
6XJU | X-ray | 2.19 | B | 62-201 | [»] | |
7CND | X-ray | 1.80 | B | 62-201 | [»] | |
7L5E | X-ray | 1.94 | B | 62-201 | [»] | |
SMRi | P41920 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32055, 265 interactors |
DIPi | DIP-838N |
IntActi | P41920, 6 interactors |
MINTi | P41920 |
STRINGi | 4932.YDR002W |
PTM databases
iPTMneti | P41920 |
Proteomic databases
MaxQBi | P41920 |
PaxDbi | P41920 |
PRIDEi | P41920 |
Genome annotation databases
EnsemblFungii | YDR002W_mRNA; YDR002W; YDR002W |
GeneIDi | 851565 |
KEGGi | sce:YDR002W |
Organism-specific databases
SGDi | S000002409, YRB1 |
VEuPathDBi | FungiDB:YDR002W |
Phylogenomic databases
eggNOGi | KOG0864, Eukaryota |
GeneTreei | ENSGT00900000141073 |
HOGENOMi | CLU_067861_2_1_1 |
InParanoidi | P41920 |
OMAi | FEPVIHL |
Enzyme and pathway databases
Reactomei | R-SCE-3232142, SUMOylation of ubiquitinylation proteins R-SCE-4085377, SUMOylation of SUMOylation proteins R-SCE-4551638, SUMOylation of chromatin organization proteins R-SCE-4570464, SUMOylation of RNA binding proteins |
Miscellaneous databases
EvolutionaryTracei | P41920 |
PROi | PR:P41920 |
RNActi | P41920, protein |
Family and domain databases
CDDi | cd13179, RanBD_RanBP1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
IDEALi | IID50175 |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR000156, Ran_bind_dom IPR045255, RanBP1-like IPR045256, RanBP1_RanBD |
PANTHERi | PTHR23138, PTHR23138, 1 hit |
Pfami | View protein in Pfam PF00638, Ran_BP1, 1 hit |
SMARTi | View protein in SMART SM00160, RanBD, 1 hit |
PROSITEi | View protein in PROSITE PS50196, RANBD1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YRB1_YEAST | |
Accessioni | P41920Primary (citable) accession number: P41920 Secondary accession number(s): D6VRY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families