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Protein

Cell division control protein 7

Gene

cdc7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein kinase essential for cell division. Plays a key role in initiation of septum formation and cytokinesis.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38ATPPROSITE-ProRule annotation1
Active sitei131Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

  • activation of protein kinase activity Source: GO_Central
  • positive regulation of division septum assembly Source: PomBase
  • regulation of apoptotic process Source: GO_Central
  • regulation of protein localization to mitotic spindle pole body Source: PomBase
  • septation initiation signaling Source: PomBase
  • signal transduction by protein phosphorylation Source: GO_Central
  • stress-activated protein kinase signaling cascade Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24 5613
2.7.12.2 5613

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 7 (EC:2.7.11.1)
Gene namesi
Name:cdc7
ORF Names:SPBC21.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC21.06c
PomBaseiSPBC21.06c cdc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857651 – 1062Cell division control protein 7Add BLAST1062

Proteomic databases

MaxQBiP41892
PaxDbiP41892
PRIDEiP41892

PTM databases

iPTMnetiP41892

Interactioni

Subunit structurei

Interacts with spg1. Seems to interact with cdc11.1 Publication

Protein-protein interaction databases

BioGridi277185, 38 interactors
STRINGi4896.SPBC21.06c.1

Structurei

3D structure databases

ProteinModelPortaliP41892
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 259Protein kinasePROSITE-ProRule annotationAdd BLAST251

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi483 – 490Asp/Glu-rich (acidic)8

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000188178
InParanoidiP41892
OMAiKLLRHPW
OrthoDBiEOG092C0D2J
PhylomeDBiP41892

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P41892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNIQASSIT LGDCLGKGAF GAVYRGLNIK NGETVAVKKV KLSKMLKSDL
60 70 80 90 100
SVIKMEIDLL KNLDHPNIVK YRGSYQTNDS LCIILEYCEN GSLRSICKNF
110 120 130 140 150
GKIPENLVAL YTFQVLQGLL YLHNQGVIHR DIKGANILTT KDGTIKLADF
160 170 180 190 200
GVATKINALE DHSVVGSPYW MAPEVIELVG ATTASDIWSV GCTVIELLDG
210 220 230 240 250
NPPYYDLDPT SALFRMVKDE HPPLPSNISS AAKSFLMQCF QKDPNLRIKT
260 270 280 290 300
RKLLKHPWVI MNQTSSKFSD AIDEVQKYNE RVKESTLTAI IEPTSNRINP
310 320 330 340 350
TLHSGRQSSY HMPESPKTPI AESPDHDNWD NEFQGTLKIS DDVLKKSEHF
360 370 380 390 400
MDFCSNFKGK NNSSSITSSP SKSRHAFNSD QISESNNFNA SPLSTPLKAQ
410 420 430 440 450
FDPSKPALNR SIDHQKTPQH KRYLSTEFKE NIPDGIEKFV ETPRDSEFTD
460 470 480 490 500
IFPTSSIKVQ GLRKETGLGT LVLNKCYGSW NNEENEDGEE SDIFDSIETN
510 520 530 540 550
LENLDIENNI ALDKRTHLAS LLSSLLGSLR DKNIGSKDTT VSQIASILSE
560 570 580 590 600
DLSLKREIIQ AHGILPLLET LREIKTPDVQ LLLLKLINTV AFDDHTTLQK
610 620 630 640 650
VCFAGGLPLM LSFSNREHSF EFRYESAIFI QQMYRTSALT LQMFLSSNGL
660 670 680 690 700
NSLLLFIKED YGTNRDFVFV GVEGIWKLLR QQDYIPKNDI CTMVVNDSLE
710 720 730 740 750
PLTKAMLKAL ATDDDSSRMS LTRICEILLA LSQADNYVKE SLLCESALRR
760 770 780 790 800
ILRILLYLPH SDMAITLQFF KQLSMVPSSL SLLRKVHIIP LLTHILGDSK
810 820 830 840 850
IEKGRKEIRS EALAALFNVC KLDKKSQEEA VISGAIPLLQ EVIIKDRLFK
860 870 880 890 900
EFALPILLAL PQAGPVSRIY LWQNKCLDFF LSLLSDLNWQ SAVFDTIASW
910 920 930 940 950
LQFELREVQR VLAEKRNVQL VLKVFCISQS ASSNRMLDTL GRVCQISPRL
960 970 980 990 1000
AASYGQPIIF QKFKEKLTHK GTKPIVVLNI FQIMKSMCEA SSQSVAYIAH
1010 1020 1030 1040 1050
CGLPDVVANL NQTSDSVLVK ELAKDLLKYL KVPQGPINEH KSPISKPHMP
1060
PPRWQPKQPL TQ
Length:1,062
Mass (Da):119,291
Last modified:November 1, 1995 - v1
Checksum:i04459AD60C0E2EDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78799 Genomic DNA Translation: CAA55382.1
CU329671 Genomic DNA Translation: CAB36886.1
PIRiS46367
RefSeqiNP_596340.1, NM_001022261.2

Genome annotation databases

EnsemblFungiiSPBC21.06c.1; SPBC21.06c.1:pep; SPBC21.06c
GeneIDi2540660
KEGGispo:SPBC21.06c

Similar proteinsi

Entry informationi

Entry nameiCDC7_SCHPO
AccessioniPrimary (citable) accession number: P41892
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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