UniProtKB - P41892 (CDC7_SCHPO)
Protein
Cell division control protein 7
Gene
cdc7
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Protein kinase essential for cell division. Plays a key role in initiation of septum formation and cytokinesis.1 Publication
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 38 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 131 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 15 – 23 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: PomBase
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- positive regulation of mitotic division septum assembly Source: PomBase
- regulation of protein localization to mitotic spindle pole body Source: PomBase
- septation initiation signaling Source: PomBase
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Cell division |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.24, 5613 2.7.12.2, 5613 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cdc7 ORF Names:SPBC21.06c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC21.06c, cdc7 |
VEuPathDBi | FungiDB:SPBC21.06c |
Subcellular locationi
Cytoskeleton
- mitotic spindle pole body Source: PomBase
- new mitotic spindle pole body Source: PomBase
Nucleus
- nucleus Source: PomBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085765 | 1 – 1062 | Cell division control protein 7Add BLAST | 1062 |
Proteomic databases
MaxQBi | P41892 |
PaxDbi | P41892 |
PRIDEi | P41892 |
PTM databases
iPTMneti | P41892 |
Interactioni
Subunit structurei
Interacts with spg1. Seems to interact with cdc11.
1 PublicationProtein-protein interaction databases
BioGRIDi | 277185, 47 interactors |
STRINGi | 4896.SPBC21.06c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 259 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 251 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 483 – 490 | Asp/Glu-rich (acidic) | 8 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0198, Eukaryota |
HOGENOMi | CLU_001872_2_1_1 |
InParanoidi | P41892 |
OMAi | KLLRHPW |
PhylomeDBi | P41892 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
P41892-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHNIQASSIT LGDCLGKGAF GAVYRGLNIK NGETVAVKKV KLSKMLKSDL
60 70 80 90 100
SVIKMEIDLL KNLDHPNIVK YRGSYQTNDS LCIILEYCEN GSLRSICKNF
110 120 130 140 150
GKIPENLVAL YTFQVLQGLL YLHNQGVIHR DIKGANILTT KDGTIKLADF
160 170 180 190 200
GVATKINALE DHSVVGSPYW MAPEVIELVG ATTASDIWSV GCTVIELLDG
210 220 230 240 250
NPPYYDLDPT SALFRMVKDE HPPLPSNISS AAKSFLMQCF QKDPNLRIKT
260 270 280 290 300
RKLLKHPWVI MNQTSSKFSD AIDEVQKYNE RVKESTLTAI IEPTSNRINP
310 320 330 340 350
TLHSGRQSSY HMPESPKTPI AESPDHDNWD NEFQGTLKIS DDVLKKSEHF
360 370 380 390 400
MDFCSNFKGK NNSSSITSSP SKSRHAFNSD QISESNNFNA SPLSTPLKAQ
410 420 430 440 450
FDPSKPALNR SIDHQKTPQH KRYLSTEFKE NIPDGIEKFV ETPRDSEFTD
460 470 480 490 500
IFPTSSIKVQ GLRKETGLGT LVLNKCYGSW NNEENEDGEE SDIFDSIETN
510 520 530 540 550
LENLDIENNI ALDKRTHLAS LLSSLLGSLR DKNIGSKDTT VSQIASILSE
560 570 580 590 600
DLSLKREIIQ AHGILPLLET LREIKTPDVQ LLLLKLINTV AFDDHTTLQK
610 620 630 640 650
VCFAGGLPLM LSFSNREHSF EFRYESAIFI QQMYRTSALT LQMFLSSNGL
660 670 680 690 700
NSLLLFIKED YGTNRDFVFV GVEGIWKLLR QQDYIPKNDI CTMVVNDSLE
710 720 730 740 750
PLTKAMLKAL ATDDDSSRMS LTRICEILLA LSQADNYVKE SLLCESALRR
760 770 780 790 800
ILRILLYLPH SDMAITLQFF KQLSMVPSSL SLLRKVHIIP LLTHILGDSK
810 820 830 840 850
IEKGRKEIRS EALAALFNVC KLDKKSQEEA VISGAIPLLQ EVIIKDRLFK
860 870 880 890 900
EFALPILLAL PQAGPVSRIY LWQNKCLDFF LSLLSDLNWQ SAVFDTIASW
910 920 930 940 950
LQFELREVQR VLAEKRNVQL VLKVFCISQS ASSNRMLDTL GRVCQISPRL
960 970 980 990 1000
AASYGQPIIF QKFKEKLTHK GTKPIVVLNI FQIMKSMCEA SSQSVAYIAH
1010 1020 1030 1040 1050
CGLPDVVANL NQTSDSVLVK ELAKDLLKYL KVPQGPINEH KSPISKPHMP
1060
PPRWQPKQPL TQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78799 Genomic DNA Translation: CAA55382.1 CU329671 Genomic DNA Translation: CAB36886.1 |
PIRi | S46367 |
RefSeqi | NP_596340.1, NM_001022261.2 |
Genome annotation databases
EnsemblFungii | SPBC21.06c.1; SPBC21.06c.1:pep; SPBC21.06c |
GeneIDi | 2540660 |
KEGGi | spo:SPBC21.06c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78799 Genomic DNA Translation: CAA55382.1 CU329671 Genomic DNA Translation: CAB36886.1 |
PIRi | S46367 |
RefSeqi | NP_596340.1, NM_001022261.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 277185, 47 interactors |
STRINGi | 4896.SPBC21.06c.1 |
PTM databases
iPTMneti | P41892 |
Proteomic databases
MaxQBi | P41892 |
PaxDbi | P41892 |
PRIDEi | P41892 |
Genome annotation databases
EnsemblFungii | SPBC21.06c.1; SPBC21.06c.1:pep; SPBC21.06c |
GeneIDi | 2540660 |
KEGGi | spo:SPBC21.06c |
Organism-specific databases
PomBasei | SPBC21.06c, cdc7 |
VEuPathDBi | FungiDB:SPBC21.06c |
Phylogenomic databases
eggNOGi | KOG0198, Eukaryota |
HOGENOMi | CLU_001872_2_1_1 |
InParanoidi | P41892 |
OMAi | KLLRHPW |
PhylomeDBi | P41892 |
Enzyme and pathway databases
BRENDAi | 2.7.11.24, 5613 2.7.12.2, 5613 |
Miscellaneous databases
PROi | PR:P41892 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDC7_SCHPO | |
Accessioni | P41892Primary (citable) accession number: P41892 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families