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Protein

Thiamine pyrophosphokinase

Gene

tnr3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Involved in the regulation of thiamine metabolism, phosphate metabolism, mating and cell growth.1 Publication

Catalytic activityi

ATP + thiamine = AMP + thiamine diphosphate.

GO - Molecular functioni

  • 8-oxo-dGDP phosphatase activity Source: PomBase
  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: UniProtKB-KW
  • thiamine binding Source: InterPro
  • thiamine diphosphokinase activity Source: PomBase

GO - Biological processi

  • thiamine biosynthetic process Source: PomBase
  • thiamine diphosphate biosynthetic process Source: GO_Central
  • thiamine metabolic process Source: PomBase
  • thiamine salvage Source: PomBase

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BRENDAi2.7.6.2 5613

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine pyrophosphokinase (EC:2.7.6.2)
Short name:
TPK
Short name:
Thiamine kinase
Gene namesi
Name:tnr3
ORF Names:SPAC6F12.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC6F12.05c
PomBaseiSPAC6F12.05c tnr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726101 – 569Thiamine pyrophosphokinaseAdd BLAST569

Proteomic databases

MaxQBiP41888
PaxDbiP41888
PRIDEiP41888

PTM databases

iPTMnetiP41888

Interactioni

Protein-protein interaction databases

BioGridi279468, 17 interactors
STRINGi4896.SPAC6F12.05c.1

Structurei

3D structure databases

ProteinModelPortaliP41888
SMRiP41888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 276Nudix hydrolasePROSITE-ProRule annotationAdd BLAST141

Phylogenomic databases

InParanoidiP41888
OrthoDBiEOG092C0M95
PhylomeDBiP41888

Family and domain databases

CDDicd07995 TPK, 1 hit
Gene3Di3.40.50.10240, 1 hit
InterProiView protein in InterPro
IPR031804 DUF4743
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
IPR006282 Thi_PPkinase
IPR007373 Thiamin_PyroPKinase_B1-bd
IPR036371 TPK_B1-bd_sf
IPR007371 TPK_catalytic
IPR036759 TPK_catalytic_sf
PfamiView protein in Pfam
PF15916 DUF4743, 1 hit
PF00293 NUDIX, 1 hit
PF04265 TPK_B1_binding, 1 hit
PF04263 TPK_catalytic, 1 hit
SMARTiView protein in SMART
SM00983 TPK_B1_binding, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
SSF63862 SSF63862, 1 hit
SSF63999 SSF63999, 1 hit
TIGRFAMsiTIGR01378 thi_PPkinase, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequencei

Sequence statusi: Complete.

P41888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSSITSAK QLNAEELLDE CDSFNGEFVP GTIPFRANGA AIGYVTPLVL
60 70 80 90 100
EILIKADNFK FNWVYVPGEY IEINASTFEK RTDILAKVLE HWRHNNTFGI
110 120 130 140 150
ADQWRNELYT VYGKSKKPVL AVERGGFWLF GFLSTGVHCT MYIPATKEHP
160 170 180 190 200
LRIWVPRRSP TKQTWPNYLD NSVAGGIAHG DSVIGTMIKE FSEEANLDVS
210 220 230 240 250
SMNLIPCGTV SYIKMEKRHW IQPELQYVFD LPVDDLVIPR INDGEVAGFS
260 270 280 290 300
LLPLNQVLHE LELKSFKPNC ALVLLDFLIR HGIITPQHPQ YLQTLERIHR
310 320 330 340 350
PLPVPVGKYE RGDSFEDTSK KAETCVPAKP QKATHQLAPC KAWLRDYDTD
360 370 380 390 400
QKFAVLLLNQ PIDIPDDRFR TLWKRASIRV CADGGANQLR NYDSSLKPDY
410 420 430 440 450
VVGDFDSLTD ETKAYYKEMG VNIVFDPCQN TTDFMKCHKI IKEHGIDTIF
460 470 480 490 500
VLCGMGGRVD HAIGNLNHLF WAASISEKNE VFLLTELNVS TLLQPGINHV
510 520 530 540 550
DCHDNIGLHC GLLPVGQSVY VKKTSGLEWN IEDRICQFGG LVSSCNVVTK
560
ATVTIEVNNF IVWTMETRL
Length:569
Mass (Da):64,236
Last modified:November 1, 1995 - v1
Checksum:i5118042478DF00FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84417 Genomic DNA Translation: CAA59135.1
CU329670 Genomic DNA Translation: CAB11089.1
PIRiS52350
RefSeqiNP_593291.1, NM_001018721.2

Genome annotation databases

EnsemblFungiiSPAC6F12.05c.1; SPAC6F12.05c.1:pep; SPAC6F12.05c
GeneIDi2543032
KEGGispo:SPAC6F12.05c

Similar proteinsi

Entry informationi

Entry nameiTNR3_SCHPO
AccessioniPrimary (citable) accession number: P41888
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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