UniProtKB - P41877 (ISW1_CAEEL)
Protein
Chromatin-remodeling complex ATPase chain isw-1
Gene
isw-1
Organism
Caenorhabditis elegans
Status
Functioni
Energy-transducing component of a NURF-like (nucleosome-remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates.Curated1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 157 – 164 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: GO_Central
- DNA-dependent ATPase activity Source: GO_Central
- helicase activity Source: UniProtKB-KW
- nucleosome binding Source: InterPro
- nucleosome-dependent ATPase activity Source: InterPro
GO - Biological processi
- ATP-dependent chromatin remodeling Source: InterPro
- multicellular organism development Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: WormBase
- positive regulation of vulval development Source: WormBase
Keywordsi
Molecular function | Activator, Chromatin regulator, Developmental protein, Helicase, Hydrolase |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Chromatin-remodeling complex ATPase chain isw-1 (EC:3.6.4.-)Alternative name(s): Nucleosome-remodeling factor subunit isw-1 |
Gene namesi | Name:isw-1Imported ORF Names:F37A4.8Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F37A4.8 ; CE29792 ; WBGene00002169 ; isw-1 |
Pathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074317 | 1 – 1009 | Chromatin-remodeling complex ATPase chain isw-1Add BLAST | 1009 |
Proteomic databases
EPDi | P41877 |
PaxDbi | P41877 |
PeptideAtlasi | P41877 |
PTM databases
iPTMneti | P41877 |
Expressioni
Gene expression databases
Bgeei | WBGene00002169, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Subunit structurei
Part of a nucleosome-remodeling factor-like (NURF-like) complex containing nurf-1 and isw-1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 41160, 4 interactors |
STRINGi | 6239.F37A4.8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 144 – 309 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 166 | |
Domaini | 439 – 590 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 152 | |
Domaini | 797 – 848 | SANT 1PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 899 – 963 | SANT 2PROSITE-ProRule annotationAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 260 – 263 | DEAH box | 4 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0385, Eukaryota |
GeneTreei | ENSGT00940000157297 |
HOGENOMi | CLU_000315_0_0_1 |
InParanoidi | P41877 |
OMAi | QEIYYFR |
OrthoDBi | 61251at2759 |
PhylomeDBi | P41877 |
Family and domain databases
Gene3Di | 1.10.1040.30, 1 hit 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR009057, Homeobox-like_sf IPR015194, ISWI_HAND-dom IPR036306, ISWI_HAND-dom_sf IPR027417, P-loop_NTPase IPR001005, SANT/Myb IPR017884, SANT_dom IPR015195, SLIDE IPR038718, SNF2-like_sf IPR000330, SNF2_dom |
Pfami | View protein in Pfam PF09110, HAND, 1 hit PF00271, Helicase_C, 1 hit PF09111, SLIDE, 1 hit PF00176, SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit SM00717, SANT, 2 hits |
SUPFAMi | SSF101224, SSF101224, 1 hit SSF46689, SSF46689, 2 hits SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51293, SANT, 1 hit |
i Sequence
Sequence statusi: Complete.
P41877-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVHESSNEI NDEPMDTDSN IPESSGNDPS MEVDDEPESS DAADSFKRFE
60 70 80 90 100
RLLQKTENFS HCLSSGDAKL ATGAPVDTKK RGRPSKKNGI DGDHRHRKTE
110 120 130 140 150
QEEDEEMVAD AIKSDDLVIF DKSPFYIENG EMRDYQVRGL NWLASLQHNK
160 170 180 190 200
INGILADEMG LGKTLQTISM IGYMKHYKNK ASPHLVIVPK STLQNWANEF
210 220 230 240 250
KKWCPSINAV VLIGDEAARN QVLRDVILPQ KFDVCCTTYE MMLKVKTQLK
260 270 280 290 300
KLNWRYIIID EAHRIKNEKS KLSETVRELN SENRLLITGT PLQNNLHELW
310 320 330 340 350
ALLNFLLPDI FTSSDDFDSW FSNDAMSGNT DLVQRLHKVL QPFLLRRIKS
360 370 380 390 400
DVEKSLLPKK EVKVYVGLSK MQREWYTKVL MKDIDIINGA GKVEKARLMN
410 420 430 440 450
ILMHLRKCVN HPYLFDGAEP GPPFTTDQHL VDNSGKMVVL DKLLMKFKEQ
460 470 480 490 500
GSRVLIFSQF SRMLDLLEDF CWWRHYEYCR LDGSTPHEDR SNAIEAYNAP
510 520 530 540 550
DSKKFIFMLT TRAGGLGINL ATADVVIIYD SDWNPQSDLQ AMDRAHRIGQ
560 570 580 590 600
KKQVRVFRLI TENTVDERII EKAEAKLRLD NIVIQQGRMS EAQKTLGKGD
610 620 630 640 650
MISMIRHGAE QVFAAKDSTI SDDDIDTILE KAEVKTAELN EKMGKIDENN
660 670 680 690 700
LRNMTFEDNA KFTVYQFEGE NYKAKQADGM GHFWIEPPKR ERKANYQVDL
710 720 730 740 750
YYKEAMRAGN PTEKQSKAPR PKLPQVFDFQ FYPRRLFELL DKEIYHYRKT
760 770 780 790 800
IGYVAERPKD VPPKEAEKRQ AEEQKLINNA RPLTDKEQEE KAELLTQSVT
810 820 830 840 850
DWTKREFQQF VRGNEKYGRE DLESIAKEME RPLEEIQSYA KVFWERIEEL
860 870 880 890 900
QDSEKVLSQI EKGEARIQRK YAVKKALDAK IAKYKAPFQQ LRISYGTNKG
910 920 930 940 950
KTYTEEEDRF LVCETHRLGH DKENVFEELR QSVRMAPQFR FDWFLKSRTA
960 970 980 990 1000
MELQRRCNTL ITLIEREMGE VVESKPVIVT AADKKKSVAK DLSKSSGTPT
AKKVKATPK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284603 Genomic DNA Translation: CCD70709.1 |
PIRi | S44645 |
RefSeqi | NP_498468.2, NM_066067.5 |
Genome annotation databases
EnsemblMetazoai | F37A4.8.1; F37A4.8.1; WBGene00002169 |
GeneIDi | 175944 |
KEGGi | cel:CELE_F37A4.8 |
UCSCi | F37A4.8, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284603 Genomic DNA Translation: CCD70709.1 |
PIRi | S44645 |
RefSeqi | NP_498468.2, NM_066067.5 |
3D structure databases
SMRi | P41877 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 41160, 4 interactors |
STRINGi | 6239.F37A4.8 |
PTM databases
iPTMneti | P41877 |
Proteomic databases
EPDi | P41877 |
PaxDbi | P41877 |
PeptideAtlasi | P41877 |
Genome annotation databases
EnsemblMetazoai | F37A4.8.1; F37A4.8.1; WBGene00002169 |
GeneIDi | 175944 |
KEGGi | cel:CELE_F37A4.8 |
UCSCi | F37A4.8, c. elegans |
Organism-specific databases
CTDi | 175944 |
WormBasei | F37A4.8 ; CE29792 ; WBGene00002169 ; isw-1 |
Phylogenomic databases
eggNOGi | KOG0385, Eukaryota |
GeneTreei | ENSGT00940000157297 |
HOGENOMi | CLU_000315_0_0_1 |
InParanoidi | P41877 |
OMAi | QEIYYFR |
OrthoDBi | 61251at2759 |
PhylomeDBi | P41877 |
Miscellaneous databases
PROi | PR:P41877 |
Gene expression databases
Bgeei | WBGene00002169, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
Gene3Di | 1.10.1040.30, 1 hit 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR009057, Homeobox-like_sf IPR015194, ISWI_HAND-dom IPR036306, ISWI_HAND-dom_sf IPR027417, P-loop_NTPase IPR001005, SANT/Myb IPR017884, SANT_dom IPR015195, SLIDE IPR038718, SNF2-like_sf IPR000330, SNF2_dom |
Pfami | View protein in Pfam PF09110, HAND, 1 hit PF00271, Helicase_C, 1 hit PF09111, SLIDE, 1 hit PF00176, SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit SM00717, SANT, 2 hits |
SUPFAMi | SSF101224, SSF101224, 1 hit SSF46689, SSF46689, 2 hits SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51293, SANT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ISW1_CAEEL | |
Accessioni | P41877Primary (citable) accession number: P41877 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | May 27, 2002 | |
Last modified: | April 7, 2021 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families