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UniProtKB - P41877 (ISW1_CAEEL)

Entry version 171 (07 Apr 2021)
Sequence version 2 (27 May 2002)
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Protein

Chromatin-remodeling complex ATPase chain isw-1

Gene

isw-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Energy-transducing component of a NURF-like (nucleosome-remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates.Curated1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi157 – 164ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: InterPro
  • multicellular organism development Source: UniProtKB-KW
  • positive regulation of transcription by RNA polymerase II Source: WormBase
  • positive regulation of vulval development Source: WormBase
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromatin-remodeling complex ATPase chain isw-1 (EC:3.6.4.-)
Alternative name(s):
Nucleosome-remodeling factor subunit isw-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:isw-1Imported
ORF Names:F37A4.8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...WormBasei		F37A4.8 ; CE29792 ; WBGene00002169 ; isw-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in sterility (PubMed:16710447). RNAi-mediated knockdown at 25 degrees Celsius rescues the larval lethality phenotype of the mep-1 (q660) single mutants (PubMed:16710447).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743171 – 1009Chromatin-remodeling complex ATPase chain isw-1Add BLAST1009

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P41877

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P41877

PeptideAtlas

More...PeptideAtlasi		P41877

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P41877

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00002169, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a nucleosome-remodeling factor-like (NURF-like) complex containing nurf-1 and isw-1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		41160, 4 interactors

STRING: functional protein association networks

More...STRINGi		6239.F37A4.8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P41877

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini144 – 309Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini439 – 590Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152
Domaini797 – 848SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini899 – 963SANT 2PROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi260 – 263DEAH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0385, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157297

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000315_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P41877

Identification of Orthologs from Complete Genome Data

More...OMAi		QEIYYFR

Database of Orthologous Groups

More...OrthoDBi		61251at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P41877

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1040.30, 1 hit
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR009057, Homeobox-like_sf
IPR015194, ISWI_HAND-dom
IPR036306, ISWI_HAND-dom_sf
IPR027417, P-loop_NTPase
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR015195, SLIDE
IPR038718, SNF2-like_sf
IPR000330, SNF2_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09110, HAND, 1 hit
PF00271, Helicase_C, 1 hit
PF09111, SLIDE, 1 hit
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00717, SANT, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101224, SSF101224, 1 hit
SSF46689, SSF46689, 2 hits
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51293, SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P41877-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVHESSNEI NDEPMDTDSN IPESSGNDPS MEVDDEPESS DAADSFKRFE 
        60         70         80         90        100
RLLQKTENFS HCLSSGDAKL ATGAPVDTKK RGRPSKKNGI DGDHRHRKTE 
       110        120        130        140        150
QEEDEEMVAD AIKSDDLVIF DKSPFYIENG EMRDYQVRGL NWLASLQHNK 
       160        170        180        190        200
INGILADEMG LGKTLQTISM IGYMKHYKNK ASPHLVIVPK STLQNWANEF 
       210        220        230        240        250
KKWCPSINAV VLIGDEAARN QVLRDVILPQ KFDVCCTTYE MMLKVKTQLK 
       260        270        280        290        300
KLNWRYIIID EAHRIKNEKS KLSETVRELN SENRLLITGT PLQNNLHELW 
       310        320        330        340        350
ALLNFLLPDI FTSSDDFDSW FSNDAMSGNT DLVQRLHKVL QPFLLRRIKS 
       360        370        380        390        400
DVEKSLLPKK EVKVYVGLSK MQREWYTKVL MKDIDIINGA GKVEKARLMN 
       410        420        430        440        450
ILMHLRKCVN HPYLFDGAEP GPPFTTDQHL VDNSGKMVVL DKLLMKFKEQ 
       460        470        480        490        500
GSRVLIFSQF SRMLDLLEDF CWWRHYEYCR LDGSTPHEDR SNAIEAYNAP 
       510        520        530        540        550
DSKKFIFMLT TRAGGLGINL ATADVVIIYD SDWNPQSDLQ AMDRAHRIGQ 
       560        570        580        590        600
KKQVRVFRLI TENTVDERII EKAEAKLRLD NIVIQQGRMS EAQKTLGKGD 
       610        620        630        640        650
MISMIRHGAE QVFAAKDSTI SDDDIDTILE KAEVKTAELN EKMGKIDENN 
       660        670        680        690        700
LRNMTFEDNA KFTVYQFEGE NYKAKQADGM GHFWIEPPKR ERKANYQVDL 
       710        720        730        740        750
YYKEAMRAGN PTEKQSKAPR PKLPQVFDFQ FYPRRLFELL DKEIYHYRKT 
       760        770        780        790        800
IGYVAERPKD VPPKEAEKRQ AEEQKLINNA RPLTDKEQEE KAELLTQSVT 
       810        820        830        840        850
DWTKREFQQF VRGNEKYGRE DLESIAKEME RPLEEIQSYA KVFWERIEEL 
       860        870        880        890        900
QDSEKVLSQI EKGEARIQRK YAVKKALDAK IAKYKAPFQQ LRISYGTNKG 
       910        920        930        940        950
KTYTEEEDRF LVCETHRLGH DKENVFEELR QSVRMAPQFR FDWFLKSRTA 
       960        970        980        990       1000
MELQRRCNTL ITLIEREMGE VVESKPVIVT AADKKKSVAK DLSKSSGTPT 

AKKVKATPK
Length:1,009
Mass (Da):116,675
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54678CF403F40825
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD70709.1

Protein sequence database of the Protein Information Resource

More...PIRi		S44645

NCBI Reference Sequences

More...RefSeqi		NP_498468.2, NM_066067.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		F37A4.8.1; F37A4.8.1; WBGene00002169

Database of genes from NCBI RefSeq genomes

More...GeneIDi		175944

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_F37A4.8

UCSC genome browser

More...UCSCi		F37A4.8, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD70709.1
PIRiS44645
RefSeqiNP_498468.2, NM_066067.5

3D structure databases

SMRiP41877
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi41160, 4 interactors
STRINGi6239.F37A4.8

PTM databases

iPTMnetiP41877

Proteomic databases

EPDiP41877
PaxDbiP41877
PeptideAtlasiP41877

Genome annotation databases

EnsemblMetazoaiF37A4.8.1; F37A4.8.1; WBGene00002169
GeneIDi175944
KEGGicel:CELE_F37A4.8
UCSCiF37A4.8, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		175944
WormBaseiF37A4.8 ; CE29792 ; WBGene00002169 ; isw-1

Phylogenomic databases

eggNOGiKOG0385, Eukaryota
GeneTreeiENSGT00940000157297
HOGENOMiCLU_000315_0_0_1
InParanoidiP41877
OMAiQEIYYFR
OrthoDBi61251at2759
PhylomeDBiP41877

Miscellaneous databases

Protein Ontology

More...PROi		PR:P41877

Gene expression databases

BgeeiWBGene00002169, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

Gene3Di1.10.1040.30, 1 hit
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR009057, Homeobox-like_sf
IPR015194, ISWI_HAND-dom
IPR036306, ISWI_HAND-dom_sf
IPR027417, P-loop_NTPase
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR015195, SLIDE
IPR038718, SNF2-like_sf
IPR000330, SNF2_dom
PfamiView protein in Pfam
PF09110, HAND, 1 hit
PF00271, Helicase_C, 1 hit
PF09111, SLIDE, 1 hit
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00717, SANT, 2 hits
SUPFAMiSSF101224, SSF101224, 1 hit
SSF46689, SSF46689, 2 hits
SSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51293, SANT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiISW1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41877
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 27, 2002
Last modified: April 7, 2021
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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