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Entry version 157 (29 Sep 2021)
Sequence version 1 (01 Nov 1995)
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Protein

26S proteasome regulatory subunit 8 homolog

Gene

let1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi186 – 193ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113, SCF-beta-TrCP mediated degradation of Emi1
R-SPO-350562, Regulation of ornithine decarboxylase (ODC)
R-SPO-5687128, MAPK6/MAPK4 signaling
R-SPO-5689603, UCH proteinases
R-SPO-5689880, Ub-specific processing proteases
R-SPO-68949, Orc1 removal from chromatin
R-SPO-69017, CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-75815, Ubiquitin-dependent degradation of Cyclin D
R-SPO-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SPO-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
26S proteasome regulatory subunit 8 homolog
Alternative name(s):
Protein let1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:let1
ORF Names:SPBC23G7.12c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC23G7.12c

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC23G7.12c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000847311 – 40326S proteasome regulatory subunit 8 homologAdd BLAST403

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P41836

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41836

PRoteomics IDEntifications database

More...
PRIDEi
P41836

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P41836

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277015, 23 interactors

Protein interaction database and analysis system

More...
IntActi
P41836, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPBC23G7.12c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P41836

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0728, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000688_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41836

Identification of Orthologs from Complete Genome Data

More...
OMAi
SAGYFYQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P41836

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005937, 26S_Psome_P45-like
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR027417, P-loop_NTPase
IPR032501, Prot_ATP_ID_OB
IPR035261, PSMC5

The PANTHER Classification System

More...
PANTHERi
PTHR23073:SF102, PTHR23073:SF102, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004, AAA, 1 hit
PF17862, AAA_lid_3, 1 hit
PF16450, Prot_ATP_ID_OB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01242, 26Sp45, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00674, AAA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P41836-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEVLKTNVL QSNENIVQYY TQKIQDAELA ILQKTQNLRR LEAQRNGLNA
60 70 80 90 100
RVRLLREEIQ LLQEPGSYVG EVIKTMGKNK VLVKVHPEGK YVVDISPDID
110 120 130 140 150
IKEIKPNIRV ALRNDSYQLI KILPNKVDPL VSLMMVEKIP DSTYEMVGGL
160 170 180 190 200
EKQIKEIKEV IELPVKHPEL FESLGIPQPK GILLYGPPGT GKTLLARAVA
210 220 230 240 250
HHTDCKFIRV SGSELVQKYI GEGSRMVREL FVMAREHAPS IIFMDEIDSI
260 270 280 290 300
GSSRSDSSGG SGDSEVQRTM LELLNQLDGF EATKNIKVIM ATNRIDILDP
310 320 330 340 350
ALLRPGRIDR KIEFPPPSAE ARAEILRIHS RSMNLTRGID LKSIAEKMNG
360 370 380 390 400
ASGAELKGVC TEAGMFALRE RRVHVTQEDF ELAVAKVLNK GDSGEMSLQK

LFK
Length:403
Mass (Da):45,069
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36DEF12C39841315
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U02280 Genomic DNA Translation: AAA61615.1
CU329671 Genomic DNA Translation: CAA22628.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45176

NCBI Reference Sequences

More...
RefSeqi
NP_595870.1, NM_001021776.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC23G7.12c.1; SPBC23G7.12c.1:pep; SPBC23G7.12c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540487

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC23G7.12c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02280 Genomic DNA Translation: AAA61615.1
CU329671 Genomic DNA Translation: CAA22628.1
PIRiS45176
RefSeqiNP_595870.1, NM_001021776.2

3D structure databases

SMRiP41836
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi277015, 23 interactors
IntActiP41836, 1 interactor
STRINGi4896.SPBC23G7.12c.1

PTM databases

SwissPalmiP41836

Proteomic databases

MaxQBiP41836
PaxDbiP41836
PRIDEiP41836

Genome annotation databases

EnsemblFungiiSPBC23G7.12c.1; SPBC23G7.12c.1:pep; SPBC23G7.12c
GeneIDi2540487
KEGGispo:SPBC23G7.12c

Organism-specific databases

PomBaseiSPBC23G7.12c
VEuPathDBiFungiDB:SPBC23G7.12c

Phylogenomic databases

eggNOGiKOG0728, Eukaryota
HOGENOMiCLU_000688_2_1_1
InParanoidiP41836
OMAiSAGYFYQ
PhylomeDBiP41836

Enzyme and pathway databases

ReactomeiR-SPO-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113, SCF-beta-TrCP mediated degradation of Emi1
R-SPO-350562, Regulation of ornithine decarboxylase (ODC)
R-SPO-5687128, MAPK6/MAPK4 signaling
R-SPO-5689603, UCH proteinases
R-SPO-5689880, Ub-specific processing proteases
R-SPO-68949, Orc1 removal from chromatin
R-SPO-69017, CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-75815, Ubiquitin-dependent degradation of Cyclin D
R-SPO-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SPO-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P41836

Family and domain databases

Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR005937, 26S_Psome_P45-like
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR027417, P-loop_NTPase
IPR032501, Prot_ATP_ID_OB
IPR035261, PSMC5
PANTHERiPTHR23073:SF102, PTHR23073:SF102, 1 hit
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF17862, AAA_lid_3, 1 hit
PF16450, Prot_ATP_ID_OB, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01242, 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674, AAA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRS8_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41836
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 29, 2021
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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