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Protein

Syntaxin UFE1

Gene

UFE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Syntaxin required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

GO - Molecular functioni

GO - Biological processi

  • endoplasmic reticulum membrane fusion Source: SGD
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: SGD
  • vesicle fusion with endoplasmic reticulum Source: SGD

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33612-MONOMER

Protein family/group databases

MoonDBiP41834 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin UFE1
Gene namesi
Name:UFE1
Ordered Locus Names:YOR075W
ORF Names:YOR29-26
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

SGDiS000005601 UFE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 324CytoplasmicSequence analysisAdd BLAST324
Transmembranei325 – 342Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST18
Topological domaini343 – 346LumenalSequence analysis4

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102831 – 346Syntaxin UFE1Add BLAST346

Proteomic databases

MaxQBiP41834
PaxDbiP41834
PRIDEiP41834

Interactioni

Subunit structurei

Component of a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34474, 157 interactors
DIPiDIP-2942N
IntActiP41834, 11 interactors
MINTiP41834
STRINGi4932.YOR075W

Structurei

3D structure databases

ProteinModelPortaliP41834
SMRiP41834
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 317t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000248643
InParanoidiP41834
KOiK08492
OMAiLTPLFRQ
OrthoDBiEOG092C3I7B

Family and domain databases

InterProiView protein in InterPro
IPR019529 Syntaxin-18_N
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF10496 Syntaxin-18_N, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

P41834-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSDLTPIFR KYVAVIDDAR NEQNGIDDHV ERKQEDFGNS NETCEMFRDS
60 70 80 90 100
FIKECARLLK FLVELNKVIK QIEKNYLDDF NMSDAEKDEF DMECRLQIQQ
110 120 130 140 150
YFKKFEFLEN YEMERHNLSL KRFQSKSHRW SKILSNKNDN TKHVIHPQDI
160 170 180 190 200
ENGVYEFRLG VLRCLNLWIK YVSSKFTTIQ QERLILENKM NFNSTPMPTL
210 220 230 240 250
SNNADDFSAD AIDISVSQSA PVETVQDEVK HYEETISKLT QEQLQVLETE
260 270 280 290 300
HSELLNQKNE QLKKVETINK TILDIVNIQN ELSNHLTVQS QNINLMLNNQ
310 320 330 340
DDIELNIKKG NKELRKAKRA AGRTAKMTTY GAIIMGVFIL FLDYVG
Length:346
Mass (Da):40,539
Last modified:October 1, 1996 - v2
Checksum:iDDC164793510A897
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15081 Genomic DNA Translation: AAC13730.1
U53416 Genomic DNA Translation: AAB50196.1
Z74983 Genomic DNA Translation: CAA99268.1
Z70678 Genomic DNA Translation: CAA94560.1
BK006948 Genomic DNA Translation: DAA10854.1
PIRiS66958
RefSeqiNP_014718.1, NM_001183494.1

Genome annotation databases

EnsemblFungiiYOR075W; YOR075W; YOR075W
GeneIDi854242
KEGGisce:YOR075W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15081 Genomic DNA Translation: AAC13730.1
U53416 Genomic DNA Translation: AAB50196.1
Z74983 Genomic DNA Translation: CAA99268.1
Z70678 Genomic DNA Translation: CAA94560.1
BK006948 Genomic DNA Translation: DAA10854.1
PIRiS66958
RefSeqiNP_014718.1, NM_001183494.1

3D structure databases

ProteinModelPortaliP41834
SMRiP41834
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34474, 157 interactors
DIPiDIP-2942N
IntActiP41834, 11 interactors
MINTiP41834
STRINGi4932.YOR075W

Protein family/group databases

MoonDBiP41834 Predicted

Proteomic databases

MaxQBiP41834
PaxDbiP41834
PRIDEiP41834

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR075W; YOR075W; YOR075W
GeneIDi854242
KEGGisce:YOR075W

Organism-specific databases

SGDiS000005601 UFE1

Phylogenomic databases

HOGENOMiHOG000248643
InParanoidiP41834
KOiK08492
OMAiLTPLFRQ
OrthoDBiEOG092C3I7B

Enzyme and pathway databases

BioCyciYEAST:G3O-33612-MONOMER

Miscellaneous databases

PROiPR:P41834

Family and domain databases

InterProiView protein in InterPro
IPR019529 Syntaxin-18_N
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF10496 Syntaxin-18_N, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUFE1_YEAST
AccessioniPrimary (citable) accession number: P41834
Secondary accession number(s): D6W2D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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Main funding by: National Institutes of Health

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