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Protein

Steroid hormone receptor family member cnr14

Gene

sex-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi148 – 223Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri151 – 171NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri187 – 211NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding transcription factor activity Source: WormBase
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: WormBase
  • steroid hormone receptor activity Source: InterPro
  • zinc ion binding Source: InterPro

GO - Biological processi

  • dosage compensation by hypoactivation of X chromosome Source: WormBase
  • negative regulation of transcription by RNA polymerase II Source: WormBase
  • primary sex determination Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid hormone receptor family member cnr14
Alternative name(s):
Nuclear receptor subfamily 1 group G member 1
Gene namesi
Name:sex-1Imported
Synonyms:cnr-14Imported, nhr-24Imported, nr1g1Imported
ORF Names:F44A6.2Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF44A6.2 ; CE03323 ; WBGene00004786 ; sex-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535231 – 534Steroid hormone receptor family member cnr14Add BLAST534

Proteomic databases

EPDiP41830
PaxDbiP41830
PeptideAtlasiP41830
PRIDEiP41830

Expressioni

Tissue specificityi

Most abundant in embryos.

Gene expression databases

BgeeiWBGene00004786
ExpressionAtlasiP41830 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi46145, 10 interactors
DIPiDIP-24967N
IntActiP41830, 15 interactors
STRINGi6239.F44A6.2.2

Structurei

3D structure databases

ProteinModelPortaliP41830
SMRiP41830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini252 – 493NR LBDPROSITE-ProRule annotationAdd BLAST242

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 171NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri187 – 211NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IMDH Eukaryota
ENOG410YTU0 LUCA
GeneTreeiENSGT00870000136388
InParanoidiP41830
KOiK08701
OMAiRKIDYRC
OrthoDBiEOG091G0E6M
PhylomeDBiP41830

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P41830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFETKPNYL LLTNPDTPLS VCTSPYYSPS GKTASIPSSE ASKPEGTNGQ
60 70 80 90 100
WSHLPTGATY VTDEFSSEFQ IQNGSTAAQS GNANNYADPL SHRRYFNNVN
110 120 130 140 150
GYNHHQFYDT ASQASVSSPA TSVTSSLSPP DSLSNGHTTQ RHHIGKAISF
160 170 180 190 200
CKVCGDKASG YHYGVTSCEG CKGFFRRSIQ RKIDYRCLKQ QVCEIKRESR
210 220 230 240 250
NRCQYCRFKK CLDSGMSKDS VRQMKFRNAM RDDKSPDSVF VPEISTLERQ
260 270 280 290 300
EEVDAVYEAV LRAHTTFSFY TDIKIRSIVA RPFNVRINED SKMNRLNAWQ
310 320 330 340 350
IYAHEIDVDI KEVVNFVKEI PKFNFINGND KAVLLRKNAF PLYLLRIVRG
360 370 380 390 400
MSNRGLMLRD GRLIDFKSLQ LLYGSLADEM LAFANHIITI GCTDGDIALF
410 420 430 440 450
IVLILCQPLT TEQQFSTNFK SQLQLLEMFD FYKKVLFQKM TCRIDGCDTY
460 470 480 490 500
KQLMKCIHEL NRLNELHKQQ LNILRENLSF LNLPPLVVEM FQLSTLPLPV
510 520 530
NHNNQENQYT PAPEHQSPQP QQPTPNQQQT PVHC
Length:534
Mass (Da):60,848
Last modified:October 1, 1996 - v2
Checksum:iE6E888F18750E1B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13074 mRNA Translation: AAA96982.1
Z50858 Genomic DNA Translation: CAA90722.1
PIRiT22154
RefSeqiNP_001024662.1, NM_001029491.2
UniGeneiCel.17916

Genome annotation databases

EnsemblMetazoaiF44A6.2.1; F44A6.2.1; WBGene00004786
F44A6.2.2; F44A6.2.2; WBGene00004786
GeneIDi181231
KEGGicel:CELE_F44A6.2
UCSCiF44A6.2.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiCNR14_CAEEL
AccessioniPrimary (citable) accession number: P41830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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