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Protein

Ferritin subunit

Gene

FERH

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protection against toxic levels of iron. Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.1 Publication

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Iron 1PROSITE-ProRule annotation1
Metal bindingi92Iron 1PROSITE-ProRule annotation1
Metal bindingi92Iron 2PROSITE-ProRule annotation1
Metal bindingi95Iron 1PROSITE-ProRule annotation1
Metal bindingi140Iron 2PROSITE-ProRule annotation1
Metal bindingi175Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin subunit (EC:1.16.3.1)
Alternative name(s):
AeFer(H)
Ferritin heavy chain-like protein
Gene namesi
Name:FERH
ORF Names:AAEL007385
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000000885328 – 209Ferritin subunitAdd BLAST182

Proteomic databases

PRIDEiP41822

Expressioni

Tissue specificityi

Larvae, pupae, and adult females. Detected in midgut.1 Publication

Inductioni

By blood meal, iron and hydrogen peroxide.1 Publication

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited (By similarity).By similarity

Protein-protein interaction databases

STRINGi7159.AAEL007385-PA

Structurei

3D structure databases

ProteinModelPortaliP41822
SMRiP41822
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 193Ferritin-like diironPROSITE-ProRule annotationAdd BLAST154

Sequence similaritiesi

Belongs to the ferritin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
HOGENOMiHOG000223383
InParanoidiP41822
KOiK00522
OrthoDBiEOG091G0K3V

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41822-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMKSVFFGVV AITVAILSIY QETAQAQEQT VGATDNYQWD SVDDQCLAAL
60 70 80 90 100
HRQINKEFDA SIIYLKYAAY FAQEKINLPG FEKFFFHSAA EEREHGIKLI
110 120 130 140 150
EYALMRGKAP VDKHFKLNYD HEVPTVTTGE SALETALQKE VEVTKSIRGV
160 170 180 190 200
IKACEDGSND FHLADYLTGE YLDEQHKGQR ELAEKIATLK KMKKSAPKLG

EFLFDKNHM
Length:209
Mass (Da):23,747
Last modified:July 1, 2008 - v2
Checksum:i202953E800B17B9C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31Missing in EAT40925 (PubMed:17510324).Curated1
Sequence conflicti31Missing in EAT40926 (PubMed:17510324).Curated1
Sequence conflicti88S → A in AAA99996 (PubMed:7655055).Curated1
Sequence conflicti88S → A in AAK15639 (Ref. 2) Curated1
Sequence conflicti88S → A in AAL85607 (Ref. 3) Curated1
Sequence conflicti145K → R in AAA99996 (PubMed:7655055).Curated1
Sequence conflicti145K → R in AAK15639 (Ref. 2) Curated1
Sequence conflicti145K → R in AAL85607 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37082 mRNA Translation: AAA99996.1
AF326342 mRNA Translation: AAK15639.1
AY064106 mRNA Translation: AAL85607.1
CH477437 Genomic DNA Translation: EAT40925.1
CH477437 Genomic DNA Translation: EAT40926.1
RefSeqiXP_001652731.1, XM_001652681.1
XP_001652732.1, XM_001652682.1
UniGeneiAae.4382

Genome annotation databases

GeneIDi5569124
KEGGiaag:5569124

Similar proteinsi

Entry informationi

Entry nameiFRI_AEDAE
AccessioniPrimary (citable) accession number: P41822
Secondary accession number(s): Q172H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 1, 2008
Last modified: February 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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