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UniProtKB - P41819 (DIM1_YEAST)

Entry version 173 (25 May 2022)
Sequence version 1 (01 Nov 1995)
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Protein

Dimethyladenosine transferase

Gene

DIM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei37S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei39S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei64S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei85S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei113S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei128S-adenosyl-L-methioninePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processRibosome biogenesis, rRNA processing
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dimethyladenosine transferase (EC:2.1.1.183)
Alternative name(s):
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
18S rRNA dimethylase
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DIM1
Ordered Locus Names:YPL266W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000006187, DIM1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YPL266W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001014641 – 318Dimethyladenosine transferaseAdd BLAST318

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P41819

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P41819

PRoteomics IDEntifications database

More...PRIDEi		P41819

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P41819

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		35947, 291 interactors

Database of interacting proteins

More...DIPi		DIP-3924N

Protein interaction database and analysis system

More...IntActi		P41819, 20 interactors

STRING: functional protein association networks

More...STRINGi		4932.YPL266W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P41819, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P41819

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P41819

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0820, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183142

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_041220_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P41819

Identification of Orthologs from Complete Genome Data

More...OMAi		VNAQMWA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001737, KsgA/Erm
IPR020596, rRNA_Ade_Mease_Trfase_CS
IPR020598, rRNA_Ade_methylase_Trfase_N
IPR011530, rRNA_adenine_dimethylase
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...PANTHERi		PTHR11727, PTHR11727, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00398, RrnaAD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00650, rADc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00755, ksgA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01131, RRNA_A_DIMETH, 1 hit
PS51689, SAM_RNA_A_N6_MT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P41819-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKAAKKKYS GATSSKQVSA EKHLSSVFKF NTDLGQHILK NPLVAQGIVD 
        60         70         80         90        100
KAQIRPSDVV LEVGPGTGNL TVRILEQAKN VVAVEMDPRM AAELTKRVRG 
       110        120        130        140        150
TPVEKKLEIM LGDFMKTELP YFDICISNTP YQISSPLVFK LINQPRPPRV 
       160        170        180        190        200
SILMFQREFA LRLLARPGDS LYCRLSANVQ MWANVTHIMK VGKNNFRPPP 
       210        220        230        240        250
QVESSVVRLE IKNPRPQVDY NEWDGLLRIV FVRKNRTISA GFKSTTVMDI 
       260        270        280        290        300
LEKNYKTFLA MNNEMVDDTK GSMHDVVKEK IDTVLKETDL GDKRAGKCDQ 
       310 
NDFLRLLYAF HQVGIHFS
Length:318
Mass (Da):35,951
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE77C9DF574A042A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L26480 Genomic DNA Translation: AAA57357.1
Z73622 Genomic DNA Translation: CAA98001.1
BK006949 Genomic DNA Translation: DAA11170.1

Protein sequence database of the Protein Information Resource

More...PIRi		S47985

NCBI Reference Sequences

More...RefSeqi		NP_015057.1, NM_001184080.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YPL266W_mRNA; YPL266W; YPL266W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		855862

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YPL266W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26480 Genomic DNA Translation: AAA57357.1
Z73622 Genomic DNA Translation: CAA98001.1
BK006949 Genomic DNA Translation: DAA11170.1
PIRiS47985
RefSeqiNP_015057.1, NM_001184080.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6RBDelectron microscopy3.47y1-318[»]
6ZQDelectron microscopy3.80JL1-318[»]
6ZQEelectron microscopy7.10JL1-318[»]
6ZQFelectron microscopy4.90JL1-318[»]
6ZQGelectron microscopy3.50JL1-318[»]
7AJUelectron microscopy3.80JL1-318[»]
AlphaFoldDBiP41819
SMRiP41819
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi35947, 291 interactors
DIPiDIP-3924N
IntActiP41819, 20 interactors
STRINGi4932.YPL266W

PTM databases

iPTMnetiP41819

Proteomic databases

MaxQBiP41819
PaxDbiP41819
PRIDEiP41819

Genome annotation databases

EnsemblFungiiYPL266W_mRNA; YPL266W; YPL266W
GeneIDi855862
KEGGisce:YPL266W

Organism-specific databases

SGDiS000006187, DIM1
VEuPathDBiFungiDB:YPL266W

Phylogenomic databases

eggNOGiKOG0820, Eukaryota
GeneTreeiENSGT00950000183142
HOGENOMiCLU_041220_2_0_1
InParanoidiP41819
OMAiVNAQMWA

Miscellaneous databases

Protein Ontology

More...PROi		PR:P41819
RNActiP41819, protein

Family and domain databases

Gene3Di3.40.50.150, 1 hit
InterProiView protein in InterPro
IPR001737, KsgA/Erm
IPR020596, rRNA_Ade_Mease_Trfase_CS
IPR020598, rRNA_Ade_methylase_Trfase_N
IPR011530, rRNA_adenine_dimethylase
IPR029063, SAM-dependent_MTases
PANTHERiPTHR11727, PTHR11727, 1 hit
PfamiView protein in Pfam
PF00398, RrnaAD, 1 hit
SMARTiView protein in SMART
SM00650, rADc, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
TIGRFAMsiTIGR00755, ksgA, 1 hit
PROSITEiView protein in PROSITE
PS01131, RRNA_A_DIMETH, 1 hit
PS51689, SAM_RNA_A_N6_MT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIM1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41819
Secondary accession number(s): D6W3A4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 25, 2022
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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