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Protein

Dimethyladenosine transferase

Gene

DIM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine(1779)/N6-dimethyladenine(1780) in 18S rRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei39S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei64S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei85S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei113S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei128S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • rRNA modification Source: SGD

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processRibosome biogenesis, rRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-34149-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethyladenosine transferase (EC:2.1.1.183)
Alternative name(s):
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
18S rRNA dimethylase
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Gene namesi
Name:DIM1
Ordered Locus Names:YPL266W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL266W
SGDiS000006187 DIM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001014641 – 318Dimethyladenosine transferaseAdd BLAST318

Proteomic databases

MaxQBiP41819
PaxDbiP41819
PRIDEiP41819

PTM databases

iPTMnetiP41819

Interactioni

Protein-protein interaction databases

BioGridi35947, 261 interactors
DIPiDIP-3924N
IntActiP41819, 20 interactors
STRINGi4932.YPL266W

Structurei

3D structure databases

ProteinModelPortaliP41819
SMRiP41819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 16Lys-richAdd BLAST14

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063389
HOGENOMiHOG000227963
InParanoidiP41819
KOiK14191
OMAiSWLGTKE
OrthoDBiEOG092C481U

Family and domain databases

InterProiView protein in InterPro
IPR001737 KsgA/Erm
IPR020596 rRNA_Ade_Mease_Trfase_CS
IPR020598 rRNA_Ade_methylase_Trfase_N
IPR011530 rRNA_adenine_dimethylase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11727 PTHR11727, 1 hit
PfamiView protein in Pfam
PF00398 RrnaAD, 1 hit
SMARTiView protein in SMART
SM00650 rADc, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00755 ksgA, 1 hit
PROSITEiView protein in PROSITE
PS01131 RRNA_A_DIMETH, 1 hit
PS51689 SAM_RNA_A_N6_MT, 1 hit

Sequencei

Sequence statusi: Complete.

P41819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKAAKKKYS GATSSKQVSA EKHLSSVFKF NTDLGQHILK NPLVAQGIVD
60 70 80 90 100
KAQIRPSDVV LEVGPGTGNL TVRILEQAKN VVAVEMDPRM AAELTKRVRG
110 120 130 140 150
TPVEKKLEIM LGDFMKTELP YFDICISNTP YQISSPLVFK LINQPRPPRV
160 170 180 190 200
SILMFQREFA LRLLARPGDS LYCRLSANVQ MWANVTHIMK VGKNNFRPPP
210 220 230 240 250
QVESSVVRLE IKNPRPQVDY NEWDGLLRIV FVRKNRTISA GFKSTTVMDI
260 270 280 290 300
LEKNYKTFLA MNNEMVDDTK GSMHDVVKEK IDTVLKETDL GDKRAGKCDQ
310
NDFLRLLYAF HQVGIHFS
Length:318
Mass (Da):35,951
Last modified:November 1, 1995 - v1
Checksum:iEE77C9DF574A042A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26480 Genomic DNA Translation: AAA57357.1
Z73622 Genomic DNA Translation: CAA98001.1
BK006949 Genomic DNA Translation: DAA11170.1
PIRiS47985
RefSeqiNP_015057.1, NM_001184080.1

Genome annotation databases

EnsemblFungiiYPL266W; YPL266W; YPL266W
GeneIDi855862
KEGGisce:YPL266W

Similar proteinsi

Entry informationi

Entry nameiDIM1_YEAST
AccessioniPrimary (citable) accession number: P41819
Secondary accession number(s): D6W3A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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