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Protein

Vacuolar ATPase assembly integral membrane protein VMA21

Gene

VMA21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions with VOA1 in assembly of the integral membrane sector (also called V0 sector) of the V-ATPase in the endoplasmic reticulum. Escorts the assembled V0 sector in COPII vesicles. Also required for normal packaging of the SNARE BOS1 and possibly the ER to Golgi transport receptor ERV29.UniRule annotation6 Publications

Miscellaneous

Present with 1480 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • vacuolar proton-transporting V-type ATPase complex assembly Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30815-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar ATPase assembly integral membrane protein VMA21UniRule annotation
Gene namesi
Name:VMA21UniRule annotation
Ordered Locus Names:YGR105W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR105W
SGDiS000003337 VMA21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicUniRule annotationAdd BLAST13
Transmembranei14 – 34HelicalUniRule annotationAdd BLAST21
Topological domaini35 – 38LumenalUniRule annotation4
Transmembranei39 – 59HelicalUniRule annotationAdd BLAST21
Topological domaini60 – 77CytoplasmicUniRule annotationAdd BLAST18

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74 – 75KK → QQ: Mislocalizes to the vacuole membrane and stay associated with the V0 sector after transport out of the ER. 2 Publications2
Mutagenesisi74K → Q: Secretion from ER. 1
Mutagenesisi75K → Q: Secretion from ER. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000658751 – 77Vacuolar ATPase assembly integral membrane protein VMA21Add BLAST77

Proteomic databases

MaxQBiP41806
PaxDbiP41806
TopDownProteomicsiP41806

Interactioni

Protein-protein interaction databases

BioGridi33348, 913 interactors
DIPiDIP-5526N
IntActiP41806, 10 interactors
MINTiP41806
STRINGi4932.YGR105W

Structurei

3D structure databases

ProteinModelPortaliP41806
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi74 – 77Prevents secretion from ER4

Sequence similaritiesi

Belongs to the VMA21 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000234560
InParanoidiP41806
OMAiAAMIIFP
OrthoDBiEOG092C5PNH

Family and domain databases

HAMAPiMF_03058 VMA21, 1 hit
InterProiView protein in InterPro
IPR019013 Vma21
PANTHERiPTHR31792 PTHR31792, 1 hit
PfamiView protein in Pfam
PF09446 VMA21, 1 hit

Sequencei

Sequence statusi: Complete.

P41806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDVPRAVI NKLMLFTAAM VVLPVLTFFI IQQFTPNTLI SGGLAAAMAN
60 70
VVLIVYIVVA FREDTEDHKV DGNKKED
Length:77
Mass (Da):8,435
Last modified:November 1, 1995 - v1
Checksum:iD09719B2A2839A4B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70V → G in AAS56142 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09329 Genomic DNA Translation: AAA74455.1
Z72890 Genomic DNA Translation: CAA97109.1
AY557816 Genomic DNA Translation: AAS56142.1
BK006941 Genomic DNA Translation: DAA08198.1
PIRiS47941
RefSeqiNP_011619.3, NM_001181234.3

Genome annotation databases

EnsemblFungiiYGR105W; YGR105W; YGR105W
GeneIDi852997
KEGGisce:YGR105W

Similar proteinsi

Entry informationi

Entry nameiVMA21_YEAST
AccessioniPrimary (citable) accession number: P41806
Secondary accession number(s): D6VUN7, Q6Q5Q3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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