UniProtKB - P41743 (KPCI_HUMAN)
Protein kinase C iota type
PRKCI
Functioni
Catalytic activityi
Activity regulationi
Kineticsi
- KM=13.5 µM for ATP (for recombinant purified PRKCI)1 Publication
- Vmax=7.4 pmol/min/mg enzyme1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 283 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 378 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 140 – 190 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 51 | |
Nucleotide bindingi | 260 – 268 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- calcium-dependent protein kinase C activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
- phospholipid binding Source: UniProtKB
- protein kinase activity Source: UniProtKB
- protein kinase C activity Source: BHF-UCL
- protein serine/threonine kinase activity Source: UniProtKB
GO - Biological processi
- actin filament organization Source: Ensembl
- bicellular tight junction assembly Source: Reactome
- cell-cell junction organization Source: UniProtKB
- cell migration Source: Ensembl
- cellular response to insulin stimulus Source: BHF-UCL
- cytoskeleton organization Source: UniProtKB
- establishment of apical/basal cell polarity Source: Ensembl
- establishment or maintenance of epithelial cell apical/basal polarity Source: UniProtKB
- eye photoreceptor cell development Source: Ensembl
- Golgi vesicle budding Source: Ensembl
- intracellular signal transduction Source: GO_Central
- membrane organization Source: UniProtKB
- negative regulation of apoptotic process Source: Reactome
- negative regulation of glial cell apoptotic process Source: UniProtKB
- negative regulation of neuron apoptotic process Source: UniProtKB
- peptidyl-serine phosphorylation Source: WormBase
- positive regulation of endothelial cell apoptotic process Source: UniProtKB
- positive regulation of glial cell proliferation Source: UniProtKB
- positive regulation of glucose import Source: BHF-UCL
- positive regulation of neuron projection development Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of Notch signaling pathway Source: Reactome
- positive regulation of protein localization to plasma membrane Source: BHF-UCL
- protein phosphorylation Source: UniProtKB
- protein targeting to membrane Source: UniProtKB
- regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl
- response to interleukin-1 Source: Ensembl
- secretion Source: UniProtKB
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.11.13, 2681 |
PathwayCommonsi | P41743 |
Reactomei | R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-209543, p75NTR recruits signalling complexes R-HSA-420029, Tight junction interactions |
SABIO-RKi | P41743 |
SignaLinki | P41743 |
SIGNORi | P41743 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase C iota type (EC:2.7.11.13)Alternative name(s): Atypical protein kinase C-lambda/iota Short name: PRKC-lambda/iota Short name: aPKC-lambda/iota nPKC-iota |
Gene namesi | Name:PRKCI Synonyms:DXS1179E |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163558.12 |
HGNCi | HGNC:9404, PRKCI |
MIMi | 600539, gene |
neXtProti | NX_P41743 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Endosome
- Endosome 1 Publication
Other locations
Note: Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A.2 Publications
Cytoskeleton
- microtubule cytoskeleton Source: HPA
Cytosol
- cytosol Source: UniProtKB
Endosome
- endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- intercellular bridge Source: HPA
Golgi apparatus
- Golgi membrane Source: GOC
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- bicellular tight junction Source: Ensembl
- cell leading edge Source: Ensembl
- glutamatergic synapse Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
- Schmidt-Lanterman incisure Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Endosome, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 29 | K → A: No effect on interaction with SQSTM1. 1 Publication | 1 | |
Mutagenesisi | 72 | D → A: Loss of interaction with ECT2, PARD6A and with SQSTM1. 3 Publications | 1 | |
Mutagenesisi | 85 | E → A: Slight decrease of interaction with PARD6A. Loss of interaction with PARD6A; when associated with A-91. 1 Publication | 1 | |
Mutagenesisi | 91 | R → A: Slight decrease of interaction with PARD6A. Loss of interaction with PARD6A; when associated with A-85. 1 Publication | 1 | |
Mutagenesisi | 265 | Y → F: No effect on the SRC-mediated phosphorylation state. No effect on SRC-induced enzyme activity. Little effect on TRAF6-mediated activation of NF-kappa-B. Decreased binding to KPNB1/importin-beta. 2 Publications | 1 | |
Mutagenesisi | 274 | K → R: No effect on activity. 1 Publication | 1 | |
Mutagenesisi | 274 | K → W: Abolishes activity. 1 Publication | 1 | |
Mutagenesisi | 280 | Y → F: No effect on the SRC-mediated phosphorylation state. No effect on SRC-induced enzyme activity. No effect on TRAF6-mediated activation of NF-kappa-B. 1 Publication | 1 | |
Mutagenesisi | 334 | Y → F: No effect on the SRC-mediated phosphorylation state. Significant reduction of SRC-induced enzyme activity. Greatly reduced TRAF6-mediated activation of NF-kappa-B. Reduces NGF-dependent cell survival. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogene, Tumor suppressorOrganism-specific databases
DisGeNETi | 5584 |
OpenTargetsi | ENSG00000163558 |
PharmGKBi | PA33768 |
Miscellaneous databases
Pharosi | P41743, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2598 |
DrugBanki | DB03777, Bisindolylmaleimide I DB12010, Fostamatinib DB00675, Tamoxifen |
DrugCentrali | P41743 |
GuidetoPHARMACOLOGYi | 1490 |
Polymorphism and mutation databases
BioMutai | PRKCI |
DMDMi | 239938658 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000055710 | 2 – 596 | Protein kinase C iota typeAdd BLAST | 595 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylprolineCombined sources | 1 | |
Modified residuei | 3 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 7 | PhosphoserineCombined sources | 1 | |
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 9 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 265 | Phosphotyrosine; by SRC2 Publications | 1 | |
Modified residuei | 280 | Phosphotyrosine; by SRC1 Publication | 1 | |
Modified residuei | 334 | Phosphotyrosine; by SRC1 Publication | 1 | |
Modified residuei | 412 | Phosphothreonine; by PDPK11 Publication | 1 | |
Modified residuei | 564 | PhosphothreonineCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P41743 |
jPOSTi | P41743 |
MassIVEi | P41743 |
MaxQBi | P41743 |
PaxDbi | P41743 |
PeptideAtlasi | P41743 |
PRIDEi | P41743 |
ProteomicsDBi | 55477 |
PTM databases
iPTMneti | P41743 |
PhosphoSitePlusi | P41743 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000163558, Expressed in testis and 246 other tissues |
Genevisiblei | P41743, HS |
Organism-specific databases
HPAi | ENSG00000163558, Low tissue specificity |
Interactioni
Subunit structurei
Forms a complex with SQSTM1 and MP2K5 (By similarity).
Interacts directly with SQSTM1 (Probable).
Interacts with IKBKB.
Interacts with PARD6A, PARD6B and PARD6G.
Part of a quaternary complex containing aPKC, PARD3, a PARD6 protein (PARD6A, PARD6B or PARD6G) and a GTPase protein (CDC42 or RAC1).
Part of a complex with LLGL1 and PARD6B.
Interacts with ADAP1/CENTA1. Interaction with SMG1, through the ZN-finger domain, activates the kinase activity.
Interacts with CDK7.
Forms a complex with RAB2A and GAPDH involved in recruitment onto the membrane of vesicular tubular clusters (VTCs).
Interacts with ECT2 ('Thr-359' phosphorylated form).
Interacts with VAMP2 (PubMed:17313651).
Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529).
By similarityCurated17 PublicationsBinary interactionsi
Hide detailsP41743
Protein-protein interaction databases
BioGRIDi | 111570, 113 interactors |
CORUMi | P41743 |
DIPi | DIP-31311N |
ELMi | P41743 |
IntActi | P41743, 146 interactors |
MINTi | P41743 |
STRINGi | 9606.ENSP00000295797 |
Chemistry databases
BindingDBi | P41743 |
Miscellaneous databases
RNActi | P41743, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P41743 |
SMRi | P41743 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P41743 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 108 | PB1PROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 254 – 522 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 269 | |
Domaini | 523 – 594 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 253 | Regulatory domainAdd BLAST | 252 | |
Regioni | 2 – 28 | Required for interaction with RAB2Add BLAST | 27 | |
Regioni | 72 – 91 | Interaction with PARD6AAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 125 – 134 | PseudosubstrateBy similarity | 10 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 140 – 190 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG0695, Eukaryota |
GeneTreei | ENSGT00940000153497 |
HOGENOMi | CLU_000288_63_29_1 |
InParanoidi | P41743 |
OMAi | LCVHKKC |
OrthoDBi | 614710at2759 |
PhylomeDBi | P41743 |
TreeFami | TF102004 |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd06404, PB1_aPKC, 1 hit cd05618, STKc_aPKC_iota, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR034661, aPKC_iota IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR034877, PB1_aPKC IPR000270, PB1_dom IPR002219, PE/DAG-bd IPR012233, PKC IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00564, PB1, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000554, PKC_zeta, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00666, PB1, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS51745, PB1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MPTQRDSSTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL
60 70 80 90 100
CNEVRDMCSF DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE
110 120 130 140 150
LLIHVFPCVP ERPGMPCPGE DKSIYRRGAR RWRKLYCANG HTFQAKRFNR
160 170 180 190 200
RAHCAICTDR IWGLGRQGYK CINCKLLVHK KCHKLVTIEC GRHSLPQEPV
210 220 230 240 250
MPMDQSSMHS DHAQTVIPYN PSSHESLDQV GEEKEAMNTR ESGKASSSLG
260 270 280 290 300
LQDFDLLRVI GRGSYAKVLL VRLKKTDRIY AMKVVKKELV NDDEDIDWVQ
310 320 330 340 350
TEKHVFEQAS NHPFLVGLHS CFQTESRLFF VIEYVNGGDL MFHMQRQRKL
360 370 380 390 400
PEEHARFYSA EISLALNYLH ERGIIYRDLK LDNVLLDSEG HIKLTDYGMC
410 420 430 440 450
KEGLRPGDTT STFCGTPNYI APEILRGEDY GFSVDWWALG VLMFEMMAGR
460 470 480 490 500
SPFDIVGSSD NPDQNTEDYL FQVILEKQIR IPRSLSVKAA SVLKSFLNKD
510 520 530 540 550
PKERLGCHPQ TGFADIQGHP FFRNVDWDMM EQKQVVPPFK PNISGEFGLD
560 570 580 590
NFDSQFTNEP VQLTPDDDDI VRKIDQSEFE GFEYINPLLM SAEECV
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 485 | L → M in AAH22016 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 508 | H → L in AAH22016 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 560 | P → R in AAH22016 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042322 | 118 | P → L in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042323 | 130 | R → C1 PublicationCorresponds to variant dbSNP:rs56154494Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L18964 mRNA Translation: AAA60171.1 Different initiation. L33881 mRNA Translation: AAB17011.1 Different initiation. CH471052 Genomic DNA Translation: EAW78513.1 CH471052 Genomic DNA Translation: EAW78515.1 BC022016 mRNA Translation: AAH22016.3 Different initiation. |
CCDSi | CCDS3212.2 |
PIRi | A49509 |
RefSeqi | NP_002731.4, NM_002740.5 |
Genome annotation databases
Ensembli | ENST00000295797; ENSP00000295797; ENSG00000163558 |
GeneIDi | 5584 |
KEGGi | hsa:5584 |
UCSCi | uc003fgs.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L18964 mRNA Translation: AAA60171.1 Different initiation. L33881 mRNA Translation: AAB17011.1 Different initiation. CH471052 Genomic DNA Translation: EAW78513.1 CH471052 Genomic DNA Translation: EAW78515.1 BC022016 mRNA Translation: AAH22016.3 Different initiation. |
CCDSi | CCDS3212.2 |
PIRi | A49509 |
RefSeqi | NP_002731.4, NM_002740.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1VD2 | NMR | - | A | 25-108 | [»] | |
1WMH | X-ray | 1.50 | A | 25-108 | [»] | |
1ZRZ | X-ray | 3.00 | A | 233-596 | [»] | |
3A8W | X-ray | 2.10 | A/B | 249-588 | [»] | |
3A8X | X-ray | 2.00 | A/B | 249-588 | [»] | |
3ZH8 | X-ray | 2.74 | A/B/C | 248-594 | [»] | |
5LI1 | X-ray | 2.00 | A | 248-596 | [»] | |
5LI9 | X-ray | 1.79 | A | 248-596 | [»] | |
5LIH | X-ray | 3.25 | A/B | 248-596 | [»] | |
6ILZ | X-ray | 3.26 | A/C/E/G | 249-588 | [»] | |
BMRBi | P41743 | |||||
SMRi | P41743 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111570, 113 interactors |
CORUMi | P41743 |
DIPi | DIP-31311N |
ELMi | P41743 |
IntActi | P41743, 146 interactors |
MINTi | P41743 |
STRINGi | 9606.ENSP00000295797 |
Chemistry databases
BindingDBi | P41743 |
ChEMBLi | CHEMBL2598 |
DrugBanki | DB03777, Bisindolylmaleimide I DB12010, Fostamatinib DB00675, Tamoxifen |
DrugCentrali | P41743 |
GuidetoPHARMACOLOGYi | 1490 |
PTM databases
iPTMneti | P41743 |
PhosphoSitePlusi | P41743 |
Polymorphism and mutation databases
BioMutai | PRKCI |
DMDMi | 239938658 |
Proteomic databases
EPDi | P41743 |
jPOSTi | P41743 |
MassIVEi | P41743 |
MaxQBi | P41743 |
PaxDbi | P41743 |
PeptideAtlasi | P41743 |
PRIDEi | P41743 |
ProteomicsDBi | 55477 |
Protocols and materials databases
Antibodypediai | 4271, 221 antibodies |
DNASUi | 5584 |
Genome annotation databases
Ensembli | ENST00000295797; ENSP00000295797; ENSG00000163558 |
GeneIDi | 5584 |
KEGGi | hsa:5584 |
UCSCi | uc003fgs.3, human |
Organism-specific databases
CTDi | 5584 |
DisGeNETi | 5584 |
EuPathDBi | HostDB:ENSG00000163558.12 |
GeneCardsi | PRKCI |
HGNCi | HGNC:9404, PRKCI |
HPAi | ENSG00000163558, Low tissue specificity |
MIMi | 600539, gene |
neXtProti | NX_P41743 |
OpenTargetsi | ENSG00000163558 |
PharmGKBi | PA33768 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0695, Eukaryota |
GeneTreei | ENSGT00940000153497 |
HOGENOMi | CLU_000288_63_29_1 |
InParanoidi | P41743 |
OMAi | LCVHKKC |
OrthoDBi | 614710at2759 |
PhylomeDBi | P41743 |
TreeFami | TF102004 |
Enzyme and pathway databases
BRENDAi | 2.7.11.13, 2681 |
PathwayCommonsi | P41743 |
Reactomei | R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-209543, p75NTR recruits signalling complexes R-HSA-420029, Tight junction interactions |
SABIO-RKi | P41743 |
SignaLinki | P41743 |
SIGNORi | P41743 |
Miscellaneous databases
BioGRID-ORCSi | 5584, 28 hits in 876 CRISPR screens |
ChiTaRSi | PRKCI, human |
EvolutionaryTracei | P41743 |
GeneWikii | PRKCI |
GenomeRNAii | 5584 |
Pharosi | P41743, Tchem |
PROi | PR:P41743 |
RNActi | P41743, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163558, Expressed in testis and 246 other tissues |
Genevisiblei | P41743, HS |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd06404, PB1_aPKC, 1 hit cd05618, STKc_aPKC_iota, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR034661, aPKC_iota IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR034877, PB1_aPKC IPR000270, PB1_dom IPR002219, PE/DAG-bd IPR012233, PKC IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00564, PB1, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000554, PKC_zeta, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00666, PB1, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS51745, PB1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KPCI_HUMAN | |
Accessioni | P41743Primary (citable) accession number: P41743 Secondary accession number(s): D3DNQ4, Q8WW06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | June 16, 2009 | |
Last modified: | December 2, 2020 | |
This is version 224 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index