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Protein

Aryl hydrocarbon receptor nuclear translocator

Gene

Arnt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • response to hypoxia Source: RGD
  • response to toxic substance Source: RGD

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator
Short name:
ARNT protein
Alternative name(s):
Dioxin receptor, nuclear translocator
Hypoxia-inducible factor 1-beta
Short name:
HIF-1-beta
Short name:
HIF1-beta
Gene namesi
Name:Arnt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2153 Arnt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001271212 – 800Aryl hydrocarbon receptor nuclear translocatorAdd BLAST799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei77PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP41739
PRIDEiP41739

PTM databases

iPTMnetiP41739
PhosphoSitePlusiP41739

Interactioni

Subunit structurei

Monomer. Homodimer only upon binding to a DNA (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with TACC3 (By similarity). Interacts with HIF1A, EPAS1, NPAS1 and NPAS3; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Forms a heterodimer with AHRR, as well as with other bHLH proteins. Interacts with NOCA7 (By similarity). Interacts with TACC3 (By similarity). Interacts with AHR; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity). Interacts with SIM1 and NPAS4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AhrP417382EBI-1162920,EBI-1162880

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247282, 1 interactor
IntActiP41739, 1 interactor
STRINGi10116.ENSRNOP00000060764

Structurei

3D structure databases

ProteinModelPortaliP41739
SMRiP41739
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 142bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini161 – 235PAS 1PROSITE-ProRule annotationAdd BLAST75
Domaini349 – 419PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini424 – 467PACAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 128DNA-bindingBy similarityAdd BLAST41
Regioni112 – 264Required for heterodimer formation with EPAS1By similarityAdd BLAST153
Regioni112 – 168Required for heterodimer formation with HIF1ABy similarityAdd BLAST57
Regioni167 – 171Mediates the transcription activity and dimerization of the AHR:ARNT complexBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi99 – 102Poly-Arg4
Compositional biasi503 – 518Poly-GlnAdd BLAST16

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQ5T Eukaryota
ENOG410XVHF LUCA
HOVERGENiHBG000164
InParanoidiP41739
KOiK09097
PhylomeDBiP41739

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00785 NCTRNSLOCATR
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P41739-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATTANPEM TSDVPSLGPT IASGNPGPGI QGGGAVVQRA IKRRSGLDFD
60 70 80 90 100
DEGEVNSKFL RCDDEQMCND KERFARSDDE QSSADKERLA RENHSEIERR
110 120 130 140 150
RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST
160 170 180 190 200
DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP
210 220 230 240 250
QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ
260 270 280 290 300
SSMRMCMGSR RSFICRMRCG TSSVDPVSMN RLSFLRNRCR NGLGSVKEGE
310 320 330 340 350
PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN
360 370 380 390 400
CTDMSNICQP TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC
410 420 430 440 450
HPEDQQLLRD SFQQVVKLKG QVLSVMFRFR AKNREWLWMR TSSFTFQNPY
460 470 480 490 500
SDEMSIFICT NTNVKNSSQE PRPTLSNTIQ RSQLGPTTNL SLEMGTGVLA
510 520 530 540 550
SRQQQQQQQQ QQQQQQQQTE LDMVPGRDGL ASYSHSQVSV QPVATAGSEH
560 570 580 590 600
SKPLEKSEGL FVQDRDPRFS EIYPNISADQ SKGLSSSTVP ATQQLFSQGS
610 620 630 640 650
SFPPNPRPAE NFRNSGLTPP VTIVQPSSSA GQILAQISRH SNLTQGSAPT
660 670 680 690 700
WTSSTRPGFS AQLPTQATAK TRSSQFGVNN FQTSSSFSAM SLPGAPTASP
710 720 730 740 750
STAAYPTLPN RGSNFPPETG QTTGQFQTRT AEGVGVWPQW QGQQPHHRSS
760 770 780 790 800
SNEQHVQPTS AQPSSQPEVF QEMLSMLGDQ SNTYNNEEFP DLTMFPPFSE
Length:800
Mass (Da):88,221
Last modified:November 1, 1997 - v2
Checksum:iCD71FCDF2C23BF34
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMF9F1LMF9_RAT
Aryl hydrocarbon receptor nuclear t...
Arnt
801Annotation score:
E9PTS2E9PTS2_RAT
Aryl hydrocarbon receptor nuclear t...
Arnt
785Annotation score:
A0A0G2K804A0A0G2K804_RAT
Aryl hydrocarbon receptor nuclear t...
Arnt
795Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61184 mRNA Translation: AAB03811.1
U08986 mRNA Translation: AAA56896.1
PIRiS58376
RefSeqiNP_036912.1, NM_012780.1
UniGeneiRn.10520

Genome annotation databases

GeneIDi25242
KEGGirno:25242
UCSCiRGD:2153 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61184 mRNA Translation: AAB03811.1
U08986 mRNA Translation: AAA56896.1
PIRiS58376
RefSeqiNP_036912.1, NM_012780.1
UniGeneiRn.10520

3D structure databases

ProteinModelPortaliP41739
SMRiP41739
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247282, 1 interactor
IntActiP41739, 1 interactor
STRINGi10116.ENSRNOP00000060764

PTM databases

iPTMnetiP41739
PhosphoSitePlusiP41739

Proteomic databases

PaxDbiP41739
PRIDEiP41739

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25242
KEGGirno:25242
UCSCiRGD:2153 rat

Organism-specific databases

CTDi405
RGDi2153 Arnt

Phylogenomic databases

eggNOGiENOG410IQ5T Eukaryota
ENOG410XVHF LUCA
HOVERGENiHBG000164
InParanoidiP41739
KOiK09097
PhylomeDBiP41739

Miscellaneous databases

PROiPR:P41739

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00785 NCTRNSLOCATR
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiARNT_RAT
AccessioniPrimary (citable) accession number: P41739
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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