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Protein

Aryl hydrocarbon receptor

Gene

Ahr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor, Repressor
Biological processBiological rhythms, Cell cycle, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor
Short name:
Ah receptor
Short name:
AhR
Gene namesi
Name:Ahr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2074 Ahr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5400

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000134641 – 9By similarity9
ChainiPRO_000001346510 – 853Aryl hydrocarbon receptorAdd BLAST844

Proteomic databases

PaxDbiP41738
PRIDEiP41738

PTM databases

iPTMnetiP41738
PhosphoSitePlusiP41738

Expressioni

Tissue specificityi

Expressed in all tissues tested including brain, heart, kidney, liver, lung, spleen, skeletal muscle and thymus.2 Publications

Inductioni

Induced or repressed by TGF-beta in a cell-specific fashion. Repressed by dioxin, retinoic acid, and TPA.1 Publication

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with IVNS1ABP (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with MYBBP1A and NEDD8. Interacts with ARNTL/BMAL1. Interacts with HSP90AB1 (By similarity). Interacts with ARNT; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ArntP417392EBI-1162880,EBI-1162920

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247719, 4 interactors
IntActiP41738, 2 interactors
STRINGi10116.ENSRNOP00000006618

Chemistry databases

BindingDBiP41738

Structurei

3D structure databases

ProteinModelPortaliP41738
SMRiP41738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 79bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini116 – 179PAS 1PROSITE-ProRule annotationAdd BLAST64
Domaini273 – 340PAS 2PROSITE-ProRule annotationAdd BLAST68
Domaini346 – 384PACAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 65DNA-bindingBy similarityAdd BLAST29
Regioni116 – 124Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activityBy similarity9
Regioni264 – 266Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activityBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi596 – 637Gln-richAdd BLAST42

Domaini

The PAS 1 domain is essential for dimerization and also required for AHR:ARNT heterodimerization.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3560 Eukaryota
ENOG410XRZH LUCA
HOGENOMiHOG000252935
HOVERGENiHBG007313
InParanoidiP41738
PhylomeDBiP41738

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR033348 AHR
IPR039091 AHR/AHRR
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
PANTHERiPTHR10649 PTHR10649, 1 hit
PTHR10649:SF9 PTHR10649:SF9, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P41738-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSGANITYA SRKRRKPVQK TVKPVPAEGI KSNPSKRHRD RLNTELDRLA
60 70 80 90 100
SLLPFPQDVI NKLDKLSVLR LSVSYLRAKS FFDVALKSTP ADRSRGQDQC
110 120 130 140 150
RAQVRDWQDL QEGEFLLQAL NGFVLVVTAD ALVFYASSTI QDYLGFQQSD
160 170 180 190 200
VIHQSVYELI HTEDRAEFQR QLHWALNPSQ CTDSAQGVDE THGLPQPAVY
210 220 230 240 250
YTPDQLPPEN TAFMERCFRC RLRCLLDNSS GFLAMNFQGR LKYLHGQNKK
260 270 280 290 300
GKDGALLPPQ LALFAIATPL QPPSILEIRT KNFIFRTKHK LDFTPIGCDA
310 320 330 340 350
KGQLILGYTE VELCNKGSGY QFIHAADMLH CAESHIRMIK TGESGMTVFR
360 370 380 390 400
LLAKHSRWRW VQSNARLIYR NGRPDYIIAT QRPLTDEEGR EHLQKRSMTL
410 420 430 440 450
PFMFATGEAV LYEISSPFSP IMDPLPIRTK SNTSRKDWAP QSTPSKDSFH
460 470 480 490 500
PNSLMSALIQ QDESIYLCPP SSPAPLDSHF LMDSMSECGS WQGSFAVASN
510 520 530 540 550
EALLKHEEIR HTQDVNLTLS GGPSELFPDN KNNDLYSIMR NLGIDFEDIR
560 570 580 590 600
SMQNEEFFRT DSSGEVDFKD IDITDEILTY VQDSLNNSTL LNSACQQQPV
610 620 630 640 650
SQHLSCMLQE RLQLEQQQQL QQQHPTQTLE PQRQLCQVEV PQHELGQKTK
660 670 680 690 700
HMQVNGMFAS WNPAPPVSFS CPQQERKHYS LFSGLQGTAQ EFPYKSEVDS
710 720 730 740 750
MPYTQNFAPC NQSLLPEHSK GTQLDFPGRD FERSLHPNAS NLEDFVSCLQ
760 770 780 790 800
VPENQRHGIN SQSAMVSPQA YYAGAMSMYQ CQAGPQHTPV DQMQYSPEIP
810 820 830 840 850
GSQAFLSKFQ SPSILNEAYS ADLSSIGHLQ TAAHLPRLAE AQPLPDITPS

GFL
Length:853
Mass (Da):96,227
Last modified:March 25, 2003 - v2
Checksum:i4EED0EE795FF1327
GO
Isoform 2 (identifier: P41738-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     142-376: Missing.

Show »
Length:618
Mass (Da):69,332
Checksum:i2BA470B081D008B9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V6M2G3V6M2_RAT
Aryl hydrocarbon receptor
Ahr rCG_61977
853Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74S → T in AAA56897 (PubMed:8065918).Curated1
Sequence conflicti659A → V in AAA56897 (PubMed:8065918).Curated1
Sequence conflicti679 – 682YSLF → ICLL in AAA56897 (PubMed:8065918).Curated4
Sequence conflicti739A → V in AAA56897 (PubMed:8065918).Curated1
Sequence conflicti744D → E in AAA56897 (PubMed:8065918).Curated1
Sequence conflicti770A → G in AAA56897 (PubMed:8065918).Curated1
Sequence conflicti787H → D in AAA56897 (PubMed:8065918).Curated1
Sequence conflicti794Q → H in AAA19451 (PubMed:7812217).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti497V → A in strain: Han/Wistar, Han/Wistar-dv, Han/Wistar-siv and Han/Wistar-liv. 1 Publication1
Natural varianti766 – 808Missing in strain: Han/Wistar-dv. Add BLAST43
Natural varianti809 – 853FQSPS…PSGFL → IRAFYRE in strain: Han/Wistar-siv and Han/Wistar-liv. Add BLAST45

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002091142 – 376Missing in isoform 2. 1 PublicationAdd BLAST235

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09000 mRNA Translation: AAA56897.1
U04860 mRNA Translation: AAA19451.1
AF082124 mRNA Translation: AAC35168.1
AF082125 mRNA Translation: AAC35169.1
AF082126 mRNA Translation: AAC35170.1
PIRiS58375
UniGeneiRn.91370

Genome annotation databases

UCSCiRGD:2074 rat [P41738-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09000 mRNA Translation: AAA56897.1
U04860 mRNA Translation: AAA19451.1
AF082124 mRNA Translation: AAC35168.1
AF082125 mRNA Translation: AAC35169.1
AF082126 mRNA Translation: AAC35170.1
PIRiS58375
UniGeneiRn.91370

3D structure databases

ProteinModelPortaliP41738
SMRiP41738
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247719, 4 interactors
IntActiP41738, 2 interactors
STRINGi10116.ENSRNOP00000006618

Chemistry databases

BindingDBiP41738
ChEMBLiCHEMBL5400

PTM databases

iPTMnetiP41738
PhosphoSitePlusiP41738

Proteomic databases

PaxDbiP41738
PRIDEiP41738

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2074 rat [P41738-1]

Organism-specific databases

RGDi2074 Ahr

Phylogenomic databases

eggNOGiKOG3560 Eukaryota
ENOG410XRZH LUCA
HOGENOMiHOG000252935
HOVERGENiHBG007313
InParanoidiP41738
PhylomeDBiP41738

Miscellaneous databases

PROiPR:P41738

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR033348 AHR
IPR039091 AHR/AHRR
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
PANTHERiPTHR10649 PTHR10649, 1 hit
PTHR10649:SF9 PTHR10649:SF9, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAHR_RAT
AccessioniPrimary (citable) accession number: P41738
Secondary accession number(s): O88930, O89105
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 25, 2003
Last modified: November 7, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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