Aryl hydrocarbon receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• aryl hydrocarbon receptor binding Source: RGD
• chaperone binding Source: RGD
• cis-regulatory region sequence-specific DNA binding Source: RGD
• DNA binding Source: RGD
• DNA-binding transcription factor activity Source: RGD
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
• E-box binding Source: UniProtKB
• Hsp90 protein binding Source: RGD
• identical protein binding Source: RGD
• nuclear receptor activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.2

    "Dioxin-dependent, DNA sequence-specific binding of a multiprotein complex containing the Ah receptor."
    Elferink C.J., Whitlock J.P. Jr.
    Receptor 4:157-173(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 236-251 AND 702-708, FUNCTION, TISSUE SPECIFICITY.
• protein heterodimerization activity Source: UniProtKB
• protein homodimerization activity Source: UniProtKB
• RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
• sequence-specific DNA binding Source: RGD
• sequence-specific double-stranded DNA binding Source: UniProtKB
• TBP-class protein binding Source: RGD
• TFIID-class transcription factor complex binding Source: RGD
• toxic substance binding Source: RGDInferred from direct assayⁱ
  • "Recombinant expression of aryl hydrocarbon receptor for quantitative ligand-binding analysis."
    Fan M.Q., Bell A.R., Bell D.R., Clode S., Fernandes A., Foster P.M., Fry J.R., Jiang T., Loizou G., MacNicoll A., Miller B.G., Rose M., Shaikh-Omar O., Tran L., White S.
    Anal Biochem 384:279-287(2009) [PubMed] [Europe PMC] [Abstract]
• transcription cis-regulatory region binding Source: RGD
• transcription coactivator binding Source: RGD

GO - Biological processⁱ

• apoptotic process Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.5

    "Role of the aryl hydrocarbon receptor in cell cycle regulation."
    Puga A., Xia Y., Elferink C.
    Chem. Biol. Interact. 141:117-130(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: REVIEW ON ROLE IN CELL CYCLE.
• B cell homeostasis Source: RGD
• blood circulation Source: RGD
• blood vessel development Source: RGD
• blood vessel diameter maintenance Source: RGD
• blood vessel morphogenesis Source: RGD
• blood vessel remodeling Source: RGD
• branching involved in blood vessel morphogenesis Source: RGD
• camera-type eye development Source: RGD
• cAMP-mediated signaling Source: RGD
• cardiac left ventricle morphogenesis Source: RGD
• cell cycle Source: UniProtKB-KW
• cell morphogenesis Source: RGD
• cellular response to 2,3,7,8-tetrachlorodibenzodioxine Source: UniProtKBInferred from direct assayⁱ
  • Ref.3

    "Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain."
    Pohjanvirta R., Wong J.M.Y., Li W., Harper P.A., Tuomisto J., Okey A.B.
    Mol. Pharmacol. 54:86-93(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HAN/WISTAR ALA-497; HAN/WISTAR-DV; HAN/WISTAR-SIV AND HAN/WISTAR-LIV.
• cellular response to 3-methylcholanthrene Source: RGD
• cellular response to cAMP Source: RGD
• cellular response to forskolin Source: RGD
• cellular response to glucocorticoid stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Glucocorticoid-enhanced expression of dioxin target genes through regulation of the rat aryl hydrocarbon receptor."
    Sonneveld E., Jonas A., Meijer O.C., Brouwer A., van der Burg B.
    Toxicol Sci 99:455-469(2007) [PubMed] [Europe PMC] [Abstract]
• circadian regulation of gene expression Source: UniProtKB
• circumferential growth involved in left ventricle morphogenesis Source: RGD
• common bile duct development Source: RGD
• embryonic hemopoiesis Source: RGD
• gland development Source: RGD
• glomerulus morphogenesis Source: RGD
• immune system process Source: RGD
• kidney morphogenesis Source: RGD
• liver development Source: RGD
• lymphocyte homeostasis Source: RGD
• negative regulation of alkaline phosphatase activity Source: RGDInferred from direct assayⁱ
  • "3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo."
    Naruse M., Ishihara Y., Miyagawa-Tomita S., Koyama A., Hagiwara H.
    Endocrinology 143:3575-3581(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of calcium ion transmembrane transport Source: RGDInferred from direct assayⁱ
  • "3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo."
    Naruse M., Ishihara Y., Miyagawa-Tomita S., Koyama A., Hagiwara H.
    Endocrinology 143:3575-3581(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA biosynthetic process Source: RGDInferred from direct assayⁱ
  • "3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo."
    Naruse M., Ishihara Y., Miyagawa-Tomita S., Koyama A., Hagiwara H.
    Endocrinology 143:3575-3581(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of necrotic cell death Source: RGD
• negative regulation of osteoblast differentiation Source: RGDInferred from direct assayⁱ
  • "3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo."
    Naruse M., Ishihara Y., Miyagawa-Tomita S., Koyama A., Hagiwara H.
    Endocrinology 143:3575-3581(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of osteoblast proliferation Source: RGDInferred from direct assayⁱ
  • "3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo."
    Naruse M., Ishihara Y., Miyagawa-Tomita S., Koyama A., Hagiwara H.
    Endocrinology 143:3575-3581(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of systemic arterial blood pressure Source: RGD
• negative regulation of T cell mediated immune response to tumor cell Source: UniProtKB
• negative regulation of transcription, DNA-templated Source: UniProtKB
• negative regulation of transcription by RNA polymerase II Source: RGD
• negative regulation of vasoconstriction Source: RGD
• ovarian follicle development Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Aryl hydrocarbon receptor antagonists attenuate the deleterious effects of benzo[a]pyrene on isolated rat follicle development."
    Neal M.S., Mulligan Tuttle A.M., Casper R.F., Lagunov A., Foster W.G.
    Reprod Biomed Online 21:100-108(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell size Source: RGD
• positive regulation of growth rate Source: RGD
• positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: RGD
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: UniProtKB
• post-embryonic hemopoiesis Source: RGD
• prostate gland development Source: RGD
• regulation of adaptive immune response Source: UniProtKB
• regulation of B cell proliferation Source: RGD
• regulation of cell cycle Source: UniProtKBTraceable author statementⁱ
  • Ref.5

    "Role of the aryl hydrocarbon receptor in cell cycle regulation."
    Puga A., Xia Y., Elferink C.
    Chem. Biol. Interact. 141:117-130(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: REVIEW ON ROLE IN CELL CYCLE.
• regulation of gene expression Source: RGD
• regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.2

    "Dioxin-dependent, DNA sequence-specific binding of a multiprotein complex containing the Ah receptor."
    Elferink C.J., Whitlock J.P. Jr.
    Receptor 4:157-173(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 236-251 AND 702-708, FUNCTION, TISSUE SPECIFICITY.
• regulation of transcription by RNA polymerase II Source: RGD
• reproductive structure development Source: RGD
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Estradiol regulates aryl hydrocarbon receptor expression in the rat uterus."
    Kretzschmar G., Papke A., Zierau O., Moller F.J., Medjakovic S., Jungbauer A., Vollmer G.
    Mol Cell Endocrinol 321:253-257(2010) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from mutant phenotypeⁱ
  • "Quantitative characterization of changes in bone geometry, mineral density and biomechanical properties in two rat strains with different Ah-receptor structures after long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin."
    Herlin M., Kalantari F., Stern N., Sand S., Larsson S., Viluksela M., Tuomisto J.T., Tuomisto J., Tuukkanen J., Jamsa T., Lind P.M., Hakansson H.
    Toxicology 273:1-11(2010) [PubMed] [Europe PMC] [Abstract]
• response to toxic substance Source: RGD
• response to xenobiotic stimulus Source: UniProtKBInferred from direct assayⁱ
  • Ref.3

    "Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain."
    Pohjanvirta R., Wong J.M.Y., Li W., Harper P.A., Tuomisto J., Okey A.B.
    Mol. Pharmacol. 54:86-93(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HAN/WISTAR ALA-497; HAN/WISTAR-DV; HAN/WISTAR-SIV AND HAN/WISTAR-LIV.
• smooth muscle tissue development Source: RGD
• spleen development Source: RGD
• T cell homeostasis Source: RGD
• transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • Ref.2

    "Dioxin-dependent, DNA sequence-specific binding of a multiprotein complex containing the Ah receptor."
    Elferink C.J., Whitlock J.P. Jr.
    Receptor 4:157-173(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 236-251 AND 702-708, FUNCTION, TISSUE SPECIFICITY.
• venous blood vessel development Source: RGD
• xenobiotic metabolic process Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• aryl hydrocarbon receptor binding Source: RGD
• chaperone binding Source: RGD
• Hsp90 protein binding Source: RGD
• identical protein binding Source: RGD
• protein heterodimerization activity Source: UniProtKB
• protein homodimerization activity Source: UniProtKB
• RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
• TBP-class protein binding Source: RGD
• TFIID-class transcription factor complex binding Source: RGD
• transcription coactivator binding Source: RGD

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSSGANITYA SRKRRKPVQK TVKPVPAEGI KSNPSKRHRD RLNTELDRLA 
        60         70         80         90        100
SLLPFPQDVI NKLDKLSVLR LSVSYLRAKS FFDVALKSTP ADRSRGQDQC 
       110        120        130        140        150
RAQVRDWQDL QEGEFLLQAL NGFVLVVTAD ALVFYASSTI QDYLGFQQSD 
       160        170        180        190        200
VIHQSVYELI HTEDRAEFQR QLHWALNPSQ CTDSAQGVDE THGLPQPAVY 
       210        220        230        240        250
YTPDQLPPEN TAFMERCFRC RLRCLLDNSS GFLAMNFQGR LKYLHGQNKK 
       260        270        280        290        300
GKDGALLPPQ LALFAIATPL QPPSILEIRT KNFIFRTKHK LDFTPIGCDA 
       310        320        330        340        350
KGQLILGYTE VELCNKGSGY QFIHAADMLH CAESHIRMIK TGESGMTVFR 
       360        370        380        390        400
LLAKHSRWRW VQSNARLIYR NGRPDYIIAT QRPLTDEEGR EHLQKRSMTL 
       410        420        430        440        450
PFMFATGEAV LYEISSPFSP IMDPLPIRTK SNTSRKDWAP QSTPSKDSFH 
       460        470        480        490        500
PNSLMSALIQ QDESIYLCPP SSPAPLDSHF LMDSMSECGS WQGSFAVASN 
       510        520        530        540        550
EALLKHEEIR HTQDVNLTLS GGPSELFPDN KNNDLYSIMR NLGIDFEDIR 
       560        570        580        590        600
SMQNEEFFRT DSSGEVDFKD IDITDEILTY VQDSLNNSTL LNSACQQQPV 
       610        620        630        640        650
SQHLSCMLQE RLQLEQQQQL QQQHPTQTLE PQRQLCQVEV PQHELGQKTK 
       660        670        680        690        700
HMQVNGMFAS WNPAPPVSFS CPQQERKHYS LFSGLQGTAQ EFPYKSEVDS 
       710        720        730        740        750
MPYTQNFAPC NQSLLPEHSK GTQLDFPGRD FERSLHPNAS NLEDFVSCLQ 
       760        770        780        790        800
VPENQRHGIN SQSAMVSPQA YYAGAMSMYQ CQAGPQHTPV DQMQYSPEIP 
       810        820        830        840        850
GSQAFLSKFQ SPSILNEAYS ADLSSIGHLQ TAAHLPRLAE AQPLPDITPS 

GFL                                                    

        10         20         30         40         50
MSSGANITYA SRKRRKPVQK TVKPVPAEGI KSNPSKRHRD RLNTELDRLA 
        60         70         80         90        100
SLLPFPQDVI NKLDKLSVLR LSVSYLRAKS FFDVALKSTP ADRSRGQDQC 
       110        120        130        140        150
RAQVRDWQDL QEGEFLLQAL NGFVLVVTAD ALVFYASSTI QIIATQRPLT 
       160        170        180        190        200
DEEGREHLQK RSMTLPFMFA TGEAVLYEIS SPFSPIMDPL PIRTKSNTSR 
       210        220        230        240        250
KDWAPQSTPS KDSFHPNSLM SALIQQDESI YLCPPSSPAP LDSHFLMDSM 
       260        270        280        290        300
SECGSWQGSF AVASNEALLK HEEIRHTQDV NLTLSGGPSE LFPDNKNNDL 
       310        320        330        340        350
YSIMRNLGID FEDIRSMQNE EFFRTDSSGE VDFKDIDITD EILTYVQDSL 
       360        370        380        390        400
NNSTLLNSAC QQQPVSQHLS CMLQERLQLE QQQQLQQQHP TQTLEPQRQL 
       410        420        430        440        450
CQVEVPQHEL GQKTKHMQVN GMFASWNPAP PVSFSCPQQE RKHYSLFSGL 
       460        470        480        490        500
QGTAQEFPYK SEVDSMPYTQ NFAPCNQSLL PEHSKGTQLD FPGRDFERSL 
       510        520        530        540        550
HPNASNLEDF VSCLQVPENQ RHGINSQSAM VSPQAYYAGA MSMYQCQAGP 
       560        570        580        590        600
QHTPVDQMQY SPEIPGSQAF LSKFQSPSIL NEAYSADLSS IGHLQTAAHL 
       610 
PRLAEAQPLP DITPSGFL                                    

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ