UniProtKB - P41738 (AHR_RAT)

BLAST

>sp|P41738|AHR_RAT Aryl hydrocarbon receptor OS=Rattus norvegicus OX=10116 GN=Ahr PE=1 SV=2
MSSGANITYASRKRRKPVQKTVKPVPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVI
NKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRSRGQDQCRAQVRDWQDLQEGEFLLQAL
NGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQ
CTDSAQGVDETHGLPQPAVYYTPDQLPPENTAFMERCFRCRLRCLLDNSSGFLAMNFQGR
LKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDA
KGQLILGYTEVELCNKGSGYQFIHAADMLHCAESHIRMIKTGESGMTVFRLLAKHSRWRW
VQSNARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSMTLPFMFATGEAVLYEISSPFSP
IMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPNSLMSALIQQDESIYLCPPSSPAPLDSHF
LMDSMSECGSWQGSFAVASNEALLKHEEIRHTQDVNLTLSGGPSELFPDNKNNDLYSIMR
NLGIDFEDIRSMQNEEFFRTDSSGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPV
SQHLSCMLQERLQLEQQQQLQQQHPTQTLEPQRQLCQVEVPQHELGQKTKHMQVNGMFAS
WNPAPPVSFSCPQQERKHYSLFSGLQGTAQEFPYKSEVDSMPYTQNFAPCNQSLLPEHSK
GTQLDFPGRDFERSLHPNASNLEDFVSCLQVPENQRHGINSQSAMVSPQAYYAGAMSMYQ
CQAGPQHTPVDQMQYSPEIPGSQAFLSKFQSPSILNEAYSADLSSIGHLQTAAHLPRLAE
AQPLPDITPSGFL

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History
Entry version 156 (07 Nov 2018)
Sequence version 2 (25 Mar 2003)
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Protein

Aryl hydrocarbon receptor

Gene

Ahr

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

aryl hydrocarbon receptor activity
Source: RGD
Inferred from direct assayⁱ
- 18938125
DNA binding
Source: RGD
Traceable author statementⁱ
- 12193573
DNA-binding transcription factor activity
Source: RGD
Traceable author statementⁱ
- 12193573
E-box binding Source: UniProtKB
nuclear receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7812217
protein heterodimerization activity Source: UniProtKB
protein homodimerization activity Source: UniProtKB
sequence-specific double-stranded DNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 12213388
cell cycle Source: UniProtKB-KW
cellular response to 2,3,7,8-tetrachlorodibenzodioxine
Source: UniProtKB
Inferred from direct assayⁱ
- 9658193
cellular response to glucocorticoid stimulus
Source: RGD
Inferred from expression patternⁱ
- 17690134
circadian regulation of gene expression Source: UniProtKB
negative regulation of transcription, DNA-templated Source: UniProtKB
ovarian follicle development
Source: RGD
Inferred from mutant phenotypeⁱ
- 20466593
positive regulation of transcription, DNA-templated Source: UniProtKB
regulation of cell cycle
Source: UniProtKB
Traceable author statementⁱ
- 12213388
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 7812217
response to estradiol
Source: RGD
Inferred from expression patternⁱ
- 20176079
response to organic cyclic compound
Source: RGD
Inferred from mutant phenotypeⁱ
- 20403408
response to xenobiotic stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 9658193
transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 7812217
xenobiotic metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor, Repressor
Biological process	Biological rhythms, Cell cycle, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aryl hydrocarbon receptor Short name: Ah receptor Short name: AhR
Gene namesⁱ	Name:Ahr
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	2074 Ahr

RGDⁱ

2074 Ahr

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL5400

ChEMBLⁱ

CHEMBL5400

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
PropeptideⁱPRO_0000013464	1 – 9	By similarity		9
ChainⁱPRO_0000013465	10 – 853	Aryl hydrocarbon receptorAdd BLAST		844

Proteomic databases

PaxDbⁱ	P41738
PRIDEⁱ	P41738

PTM databases

iPTMnetⁱ	P41738
PhosphoSitePlusⁱ	P41738

Expressionⁱ

Tissue specificityⁱ

Expressed in all tissues tested including brain, heart, kidney, liver, lung, spleen, skeletal muscle and thymus.2 Publications

Inductionⁱ

Induced or repressed by TGF-beta in a cell-specific fashion. Repressed by dioxin, retinoic acid, and TPA.1 Publication

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). Interacts with IVNS1ABP (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with MYBBP1A and NEDD8. Interacts with ARNTL/BMAL1. Interacts with HSP90AB1 (By similarity). Interacts with ARNT; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Arnt	P41739	2	EBI-1162880,EBI-1162920

With

Entry

#Exp.

IntAct

Notes

Arnt

P41739

EBI-1162880,EBI-1162920

GO - Molecular functionⁱ

protein heterodimerization activity Source: UniProtKB
protein homodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	247719, 4 interactors
IntActⁱ	P41738, 2 interactors
STRINGⁱ	10116.ENSRNOP00000006618

Chemistry databases

BindingDBⁱ

P41738

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P41738
SMRⁱ	P41738
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	26 – 79	bHLHPROSITE-ProRule annotationAdd BLAST	54
Domainⁱ	116 – 179	PAS 1PROSITE-ProRule annotationAdd BLAST	64
Domainⁱ	273 – 340	PAS 2PROSITE-ProRule annotationAdd BLAST	68
Domainⁱ	346 – 384	PACAdd BLAST	39

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	37 – 65	DNA-bindingBy similarityAdd BLAST	29
Regionⁱ	116 – 124	Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activityBy similarity	9
Regionⁱ	264 – 266	Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activityBy similarity	3

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	596 – 637	Gln-richAdd BLAST		42

Domainⁱ

The PAS 1 domain is essential for dimerization and also required for AHR:ARNT heterodimerization.By similarity

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3560 Eukaryota ENOG410XRZH LUCA
HOGENOMⁱ	HOG000252935
HOVERGENⁱ	HBG007313
InParanoidⁱ	P41738
PhylomeDBⁱ	P41738

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR033348 AHR IPR039091 AHR/AHRR IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3
PANTHERⁱ	PTHR10649 PTHR10649, 1 hit PTHR10649:SF9 PTHR10649:SF9, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P41738-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSGANITYA SRKRRKPVQK TVKPVPAEGI KSNPSKRHRD RLNTELDRLA 
        60         70         80         90        100
SLLPFPQDVI NKLDKLSVLR LSVSYLRAKS FFDVALKSTP ADRSRGQDQC 
       110        120        130        140        150
RAQVRDWQDL QEGEFLLQAL NGFVLVVTAD ALVFYASSTI QDYLGFQQSD 
       160        170        180        190        200
VIHQSVYELI HTEDRAEFQR QLHWALNPSQ CTDSAQGVDE THGLPQPAVY 
       210        220        230        240        250
YTPDQLPPEN TAFMERCFRC RLRCLLDNSS GFLAMNFQGR LKYLHGQNKK 
       260        270        280        290        300
GKDGALLPPQ LALFAIATPL QPPSILEIRT KNFIFRTKHK LDFTPIGCDA 
       310        320        330        340        350
KGQLILGYTE VELCNKGSGY QFIHAADMLH CAESHIRMIK TGESGMTVFR 
       360        370        380        390        400
LLAKHSRWRW VQSNARLIYR NGRPDYIIAT QRPLTDEEGR EHLQKRSMTL 
       410        420        430        440        450
PFMFATGEAV LYEISSPFSP IMDPLPIRTK SNTSRKDWAP QSTPSKDSFH 
       460        470        480        490        500
PNSLMSALIQ QDESIYLCPP SSPAPLDSHF LMDSMSECGS WQGSFAVASN 
       510        520        530        540        550
EALLKHEEIR HTQDVNLTLS GGPSELFPDN KNNDLYSIMR NLGIDFEDIR 
       560        570        580        590        600
SMQNEEFFRT DSSGEVDFKD IDITDEILTY VQDSLNNSTL LNSACQQQPV 
       610        620        630        640        650
SQHLSCMLQE RLQLEQQQQL QQQHPTQTLE PQRQLCQVEV PQHELGQKTK 
       660        670        680        690        700
HMQVNGMFAS WNPAPPVSFS CPQQERKHYS LFSGLQGTAQ EFPYKSEVDS 
       710        720        730        740        750
MPYTQNFAPC NQSLLPEHSK GTQLDFPGRD FERSLHPNAS NLEDFVSCLQ 
       760        770        780        790        800
VPENQRHGIN SQSAMVSPQA YYAGAMSMYQ CQAGPQHTPV DQMQYSPEIP 
       810        820        830        840        850
GSQAFLSKFQ SPSILNEAYS ADLSSIGHLQ TAAHLPRLAE AQPLPDITPS 

GFL

Length:853

Mass (Da):96,227

Last modified:March 25, 2003 - v2

Checksum:ⁱ4EED0EE795FF1327

Isoform 2 (identifier: P41738-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
142-376: Missing.

« Hide

        10         20         30         40         50
MSSGANITYA SRKRRKPVQK TVKPVPAEGI KSNPSKRHRD RLNTELDRLA 
        60         70         80         90        100
SLLPFPQDVI NKLDKLSVLR LSVSYLRAKS FFDVALKSTP ADRSRGQDQC 
       110        120        130        140        150
RAQVRDWQDL QEGEFLLQAL NGFVLVVTAD ALVFYASSTI QIIATQRPLT 
       160        170        180        190        200
DEEGREHLQK RSMTLPFMFA TGEAVLYEIS SPFSPIMDPL PIRTKSNTSR 
       210        220        230        240        250
KDWAPQSTPS KDSFHPNSLM SALIQQDESI YLCPPSSPAP LDSHFLMDSM 
       260        270        280        290        300
SECGSWQGSF AVASNEALLK HEEIRHTQDV NLTLSGGPSE LFPDNKNNDL 
       310        320        330        340        350
YSIMRNLGID FEDIRSMQNE EFFRTDSSGE VDFKDIDITD EILTYVQDSL 
       360        370        380        390        400
NNSTLLNSAC QQQPVSQHLS CMLQERLQLE QQQQLQQQHP TQTLEPQRQL 
       410        420        430        440        450
CQVEVPQHEL GQKTKHMQVN GMFASWNPAP PVSFSCPQQE RKHYSLFSGL 
       460        470        480        490        500
QGTAQEFPYK SEVDSMPYTQ NFAPCNQSLL PEHSKGTQLD FPGRDFERSL 
       510        520        530        540        550
HPNASNLEDF VSCLQVPENQ RHGINSQSAM VSPQAYYAGA MSMYQCQAGP 
       560        570        580        590        600
QHTPVDQMQY SPEIPGSQAF LSKFQSPSIL NEAYSADLSS IGHLQTAAHL 
       610 
PRLAEAQPLP DITPSGFL

Show »

Length:618

Mass (Da):69,332

Checksum:ⁱ2BA470B081D008B9

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3V6M2	G3V6M2_RAT		Aryl hydrocarbon receptor Aryl hydrocarbon receptor (RCG61977, isoform CRA_b)	Ahr rCG_61977	853	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	74	S → T in AAA56897 (PubMed:8065918).Curated	1
Sequence conflictⁱ	659	A → V in AAA56897 (PubMed:8065918).Curated	1
Sequence conflictⁱ	679 – 682	YSLF → ICLL in AAA56897 (PubMed:8065918).Curated	4
Sequence conflictⁱ	739	A → V in AAA56897 (PubMed:8065918).Curated	1
Sequence conflictⁱ	744	D → E in AAA56897 (PubMed:8065918).Curated	1
Sequence conflictⁱ	770	A → G in AAA56897 (PubMed:8065918).Curated	1
Sequence conflictⁱ	787	H → D in AAA56897 (PubMed:8065918).Curated	1
Sequence conflictⁱ	794	Q → H in AAA19451 (PubMed:7812217).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	497	V → A in strain: Han/Wistar, Han/Wistar-dv, Han/Wistar-siv and Han/Wistar-liv. 1 Publication	1
Natural variantⁱ	766 – 808	Missing in strain: Han/Wistar-dv. Add BLAST	43
Natural variantⁱ	809 – 853	FQSPS…PSGFL → IRAFYRE in strain: Han/Wistar-siv and Han/Wistar-liv. Add BLAST	45

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002091	142 – 376	Missing in isoform 2. 1 PublicationAdd BLAST		235

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09000 mRNA Translation: AAA56897.1 U04860 mRNA Translation: AAA19451.1 AF082124 mRNA Translation: AAC35168.1 AF082125 mRNA Translation: AAC35169.1 AF082126 mRNA Translation: AAC35170.1
PIRⁱ	S58375
UniGeneⁱ	Rn.91370

Genome annotation databases

UCSC genome browser More...UCSCⁱ	RGD:2074 rat [P41738-1]

UCSCⁱ

RGD:2074 rat [P41738-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P41738	Aryl hydrocarbon receptor (Fragment)		RAT		853	UniRef100_P41738
Aryl hydrocarbon receptor (Fragment)		RAT		844

Protein	Similar proteins		Species	Score	Length	Source
P41738	Aryl hydrocarbon receptor (Fragment)		RAT		853	UniRef90_P41738
UPI000048440C		MOUSE		688
Aryl hydrocarbon receptor (Fragment)		RAT		844
Aryl hydrocarbon receptor		RAT		853
Aryl hydrocarbon receptor (Fragment)		RAT		810
+1

Protein	Similar proteins		Species	Score	Length	Source
P41738	Aryl hydrocarbon receptor	)	MOUSE		848	UniRef50_P30561
Aryl hydrocarbon receptor		MUSMM		883
Aryl hydrocarbon receptor		MUSSI		854
Aryl hydrocarbon receptor		MUSSP		854
Aryl hydrocarbon receptor		MUSCR		854
+466

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09000 mRNA Translation: AAA56897.1 U04860 mRNA Translation: AAA19451.1 AF082124 mRNA Translation: AAC35168.1 AF082125 mRNA Translation: AAC35169.1 AF082126 mRNA Translation: AAC35170.1
PIRⁱ	S58375
UniGeneⁱ	Rn.91370

3D structure databases

ProteinModelPortalⁱ	P41738
SMRⁱ	P41738
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	247719, 4 interactors
IntActⁱ	P41738, 2 interactors
STRINGⁱ	10116.ENSRNOP00000006618

Chemistry databases

BindingDBⁱ	P41738
ChEMBLⁱ	CHEMBL5400

PTM databases

iPTMnetⁱ	P41738
PhosphoSitePlusⁱ	P41738

Proteomic databases

PaxDbⁱ	P41738
PRIDEⁱ	P41738

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

UCSCⁱ	RGD:2074 rat [P41738-1]

UCSCⁱ

RGD:2074 rat [P41738-1]

Organism-specific databases

RGDⁱ	2074 Ahr

RGDⁱ

2074 Ahr

Phylogenomic databases

eggNOGⁱ	KOG3560 Eukaryota ENOG410XRZH LUCA
HOGENOMⁱ	HOG000252935
HOVERGENⁱ	HBG007313
InParanoidⁱ	P41738
PhylomeDBⁱ	P41738

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P41738

PROⁱ

PR:P41738

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR033348 AHR IPR039091 AHR/AHRR IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3
PANTHERⁱ	PTHR10649 PTHR10649, 1 hit PTHR10649:SF9 PTHR10649:SF9, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AHR_RAT
Accessionⁱ	P41738Primary (citable) accession number: P41738 Secondary accession number(s): O88930, O89105
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	March 25, 2003
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P41738 (AHR_RAT)

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Aryl hydrocarbon receptor

Ahr

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ