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UniProtKB - P41732 (TSN7_HUMAN)
Protein
Tetraspanin-7
Gene
TSPAN7
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in cell proliferation and cell motility.
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P41732 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-416993, Trafficking of GluR2-containing AMPA receptors |
SignaLinki | P41732 |
SIGNORi | P41732 |
Protein family/group databases
TCDBi | 8.A.40.1.2, the tetraspanin (tetraspanin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Tetraspanin-7Short name: Tspan-7 Alternative name(s): Cell surface glycoprotein A15 Membrane component chromosome X surface marker 1 T-cell acute lymphoblastic leukemia-associated antigen 1 Short name: TALLA-1 Transmembrane 4 superfamily member 2 CD_antigen: CD231 |
Gene namesi | Name:TSPAN7 Synonyms:A15, DXS1692E, MXS1, TM4SF2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11854, TSPAN7 |
MIMi | 300096, gene |
neXtProti | NX_P41732 |
VEuPathDBi | HostDB:ENSG00000156298 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 40 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 41 – 56 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 57 – 75 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 76 – 86 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 87 – 112 | HelicalSequence analysisAdd BLAST | 26 | |
Topological domaini | 113 – 213 | ExtracellularSequence analysisAdd BLAST | 101 | |
Transmembranei | 214 – 234 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 235 – 249 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Intellectual developmental disorder, X-linked 58 (XLID58)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_009259 | 172 | P → H in XLID58. 1 PublicationCorresponds to variant dbSNP:rs104894951EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Mental retardationOrganism-specific databases
DisGeNETi | 7102 |
MalaCardsi | TSPAN7 |
MIMi | 300210, phenotype |
OpenTargetsi | ENSG00000156298 |
Orphaneti | 777, X-linked non-syndromic intellectual disability |
PharmGKBi | PA36555 |
Miscellaneous databases
Pharosi | P41732, Tbio |
Genetic variation databases
BioMutai | TSPAN7 |
DMDMi | 17380550 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219248 | 1 – 249 | Tetraspanin-7Add BLAST | 249 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 155 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 158 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 177 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | P41732 |
MassIVEi | P41732 |
MaxQBi | P41732 |
PaxDbi | P41732 |
PeptideAtlasi | P41732 |
PRIDEi | P41732 |
ProteomicsDBi | 55476 |
PTM databases
GlyGeni | P41732, 5 sites |
iPTMneti | P41732 |
PhosphoSitePlusi | P41732 |
SwissPalmi | P41732 |
Expressioni
Tissue specificityi
Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.
Gene expression databases
Bgeei | ENSG00000156298, Expressed in caudate nucleus and 230 other tissues |
ExpressionAtlasi | P41732, baseline and differential |
Genevisiblei | P41732, HS |
Organism-specific databases
HPAi | ENSG00000156298, Tissue enhanced (brain) |
Interactioni
Subunit structurei
(Microbial infection) Interacts with herpes simplex virus 1 (HHV-1) UL35.
1 PublicationBinary interactionsi
P41732
With | #Exp. | IntAct |
---|---|---|
FAM209A [Q5JX71] | 3 | EBI-1042779,EBI-18304435 |
GPR152 [Q8TDT2] | 3 | EBI-1042779,EBI-13345167 |
LHFPL5 [Q8TAF8] | 3 | EBI-1042779,EBI-2820517 |
MEOX2 [Q6FHY5] | 3 | EBI-1042779,EBI-16439278 |
Protein-protein interaction databases
BioGRIDi | 112957, 25 interactors |
IntActi | P41732, 20 interactors |
MINTi | P41732 |
STRINGi | 9606.ENSP00000367743 |
Miscellaneous databases
RNActi | P41732, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000156153 |
HOGENOMi | CLU_055524_3_0_1 |
InParanoidi | P41732 |
OMAi | NWNTSPY |
OrthoDBi | 1145558at2759 |
PhylomeDBi | P41732 |
TreeFami | TF352891 |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR018499, Tetraspanin/Peripherin IPR000301, Tetraspanin_animals IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
PANTHERi | PTHR19282, PTHR19282, 1 hit |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P41732-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL
60 70 80 90 100
IAENSTNAPY VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL
110 120 130 140 150
AELVAGISGF VFRHEIKDTF LRTYTDAMQT YNGNDERSRA VDHVQRSLSC
160 170 180 190 200
CGVQNYTNWS TSPYFLEHGI PPSCCMNETD CNPQDLHNLT VAATKVNQKG
210 220 230 240
CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF ITANQYEMV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DDG0 | B4DDG0_HUMAN | Tetraspanin | TSPAN7 | 266 | Annotation score: | ||
F8WC96 | F8WC96_HUMAN | Tetraspanin-7 | TSPAN7 | 45 | Annotation score: | ||
F8WF47 | F8WF47_HUMAN | Tetraspanin-7 | TSPAN7 | 43 | Annotation score: | ||
F8WF53 | F8WF53_HUMAN | Tetraspanin-7 | TSPAN7 | 63 | Annotation score: |
Sequence cautioni
The sequence BAA01501 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA06191 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 136 | E → K in CAB65594 (PubMed:10655063).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037905 | 53 | E → K1 PublicationCorresponds to variant dbSNP:rs17851592Ensembl. | 1 | |
Natural variantiVAR_037906 | 127 | A → T1 PublicationCorresponds to variant dbSNP:rs17851593Ensembl. | 1 | |
Natural variantiVAR_009259 | 172 | P → H in XLID58. 1 PublicationCorresponds to variant dbSNP:rs104894951EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10653 mRNA Translation: BAA01501.1 Different initiation. AK312343 mRNA Translation: BAG35264.1 CH471141 Genomic DNA Translation: EAW59437.1 D29808 mRNA Translation: BAA06191.1 Different initiation. AJ250562 , AJ250563, AJ250564, AJ250565, AJ250566, AJ250567, AJ250568 Genomic DNA Translation: CAB65594.1 AB062057 mRNA Translation: BAB55825.1 AB062057 mRNA Translation: BAB55824.1 CH471141 Genomic DNA Translation: EAW59438.1 BC018036 mRNA Translation: AAH18036.1 |
CCDSi | CCDS14248.1 |
PIRi | I39368 |
RefSeqi | NP_004606.2, NM_004615.3 |
Genome annotation databases
Ensembli | ENST00000378482.7; ENSP00000367743.2; ENSG00000156298.13 |
GeneIDi | 7102 |
KEGGi | hsa:7102 |
MANE-Selecti | ENST00000378482.7; ENSP00000367743.2; NM_004615.4; NP_004606.2 |
UCSCi | uc004deg.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10653 mRNA Translation: BAA01501.1 Different initiation. AK312343 mRNA Translation: BAG35264.1 CH471141 Genomic DNA Translation: EAW59437.1 D29808 mRNA Translation: BAA06191.1 Different initiation. AJ250562 , AJ250563, AJ250564, AJ250565, AJ250566, AJ250567, AJ250568 Genomic DNA Translation: CAB65594.1 AB062057 mRNA Translation: BAB55825.1 AB062057 mRNA Translation: BAB55824.1 CH471141 Genomic DNA Translation: EAW59438.1 BC018036 mRNA Translation: AAH18036.1 |
CCDSi | CCDS14248.1 |
PIRi | I39368 |
RefSeqi | NP_004606.2, NM_004615.3 |
3D structure databases
AlphaFoldDBi | P41732 |
SMRi | P41732 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112957, 25 interactors |
IntActi | P41732, 20 interactors |
MINTi | P41732 |
STRINGi | 9606.ENSP00000367743 |
Protein family/group databases
TCDBi | 8.A.40.1.2, the tetraspanin (tetraspanin) family |
PTM databases
GlyGeni | P41732, 5 sites |
iPTMneti | P41732 |
PhosphoSitePlusi | P41732 |
SwissPalmi | P41732 |
Genetic variation databases
BioMutai | TSPAN7 |
DMDMi | 17380550 |
Proteomic databases
jPOSTi | P41732 |
MassIVEi | P41732 |
MaxQBi | P41732 |
PaxDbi | P41732 |
PeptideAtlasi | P41732 |
PRIDEi | P41732 |
ProteomicsDBi | 55476 |
Protocols and materials databases
Antibodypediai | 530, 292 antibodies from 28 providers |
DNASUi | 7102 |
Genome annotation databases
Ensembli | ENST00000378482.7; ENSP00000367743.2; ENSG00000156298.13 |
GeneIDi | 7102 |
KEGGi | hsa:7102 |
MANE-Selecti | ENST00000378482.7; ENSP00000367743.2; NM_004615.4; NP_004606.2 |
UCSCi | uc004deg.5, human |
Organism-specific databases
CTDi | 7102 |
DisGeNETi | 7102 |
GeneCardsi | TSPAN7 |
HGNCi | HGNC:11854, TSPAN7 |
HPAi | ENSG00000156298, Tissue enhanced (brain) |
MalaCardsi | TSPAN7 |
MIMi | 300096, gene 300210, phenotype |
neXtProti | NX_P41732 |
OpenTargetsi | ENSG00000156298 |
Orphaneti | 777, X-linked non-syndromic intellectual disability |
PharmGKBi | PA36555 |
VEuPathDBi | HostDB:ENSG00000156298 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000156153 |
HOGENOMi | CLU_055524_3_0_1 |
InParanoidi | P41732 |
OMAi | NWNTSPY |
OrthoDBi | 1145558at2759 |
PhylomeDBi | P41732 |
TreeFami | TF352891 |
Enzyme and pathway databases
PathwayCommonsi | P41732 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-416993, Trafficking of GluR2-containing AMPA receptors |
SignaLinki | P41732 |
SIGNORi | P41732 |
Miscellaneous databases
BioGRID-ORCSi | 7102, 10 hits in 698 CRISPR screens |
ChiTaRSi | TSPAN7, human |
GeneWikii | TSPAN7 |
GenomeRNAii | 7102 |
Pharosi | P41732, Tbio |
PROi | PR:P41732 |
RNActi | P41732, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156298, Expressed in caudate nucleus and 230 other tissues |
ExpressionAtlasi | P41732, baseline and differential |
Genevisiblei | P41732, HS |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR018499, Tetraspanin/Peripherin IPR000301, Tetraspanin_animals IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
PANTHERi | PTHR19282, PTHR19282, 1 hit |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TSN7_HUMAN | |
Accessioni | P41732Primary (citable) accession number: P41732 Secondary accession number(s): B2R5W7 Q9UEY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 16, 2001 | |
Last modified: | May 25, 2022 | |
This is version 193 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families