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Entry version 175 (12 Aug 2020)
Sequence version 1 (01 Nov 1995)
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Protein

Asparagine-rich zinc finger protein AZF1

Gene

AZF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential transcription factor; suppressor for a mitochondrial RNA polymerase mutant.

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri593 – 615C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 702C2H2-type 4PROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-33642-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Asparagine-rich zinc finger protein AZF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AZF1
Ordered Locus Names:YOR113W
ORF Names:O3244, YOR3244W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YOR113W

Saccharomyces Genome Database

More...
SGDi
S000005639, AZF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000468021 – 914Asparagine-rich zinc finger protein AZF1Add BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei61PhosphoserineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P41696

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41696

PRoteomics IDEntifications database

More...
PRIDEi
P41696

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P41696

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34509, 179 interactors

Protein interaction database and analysis system

More...
IntActi
P41696, 10 interactors

Molecular INTeraction database

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MINTi
P41696

STRING: functional protein association networks

More...
STRINGi
4932.YOR113W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P41696, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P41696

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi136 – 143Poly-Gln8
Compositional biasi146 – 154Poly-Gln9
Compositional biasi362 – 381Poly-AsnAdd BLAST20
Compositional biasi856 – 860Poly-Ser5
Compositional biasi861 – 868Poly-Asn8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri593 – 615C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 702C2H2-type 4PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000068109

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010433_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41696

Identification of Orthologs from Complete Genome Data

More...
OMAi
KQHECPY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P41696-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPPTAQFMG PTQAGQNESQ NQSSGEAGEQ NQEHGQGPTP ILNQSQPASS
60 70 80 90 100
QPQHQQQRNE SISYYTNFNQ PRYSTDASIN SFLNISDNVP VTSTGGPSSG
110 120 130 140 150
GAYSNLPRLS TSSTHQPPDL SQIGRGFSIV NNLFPQQQQL QNQHRQQQQQ
160 170 180 190 200
QQQQSHQQPP FKTPSFSTGL TGSSSQYQFL PRNDNTSQPP SKRNSVYLGP
210 220 230 240 250
NDGPDFEFFS MQQSQQPQFQ PSSRRESNSM RPPLLIPAAT TKSQSNGTNN
260 270 280 290 300
SGNMNTNADY ESFFNTGTNN SNSNQNPYFL SSRNNSLKFN PEDFDFQFKR
310 320 330 340 350
RNSFVRGTLD HSSQNAFIPE SRLNSLSVNN KANGDPVADN VTNNMKGKSN
360 370 380 390 400
EVDNDDGNDS SNNNNNNNNN NNNENNNDNN NDNNDNSINS ATSTNIPNQE
410 420 430 440 450
DHSLASTDTT SNSRKDLKEI EQRLRKHLND EDNYSSAISR PLDKNDVIEG
460 470 480 490 500
SEGLNKHIDE SGMQPNIIKK RKKDDSTVYV KNEMPRTDPP MSKDNSTSAE
510 520 530 540 550
GAAMANFSGK EPPIPDISSV SDDATNLIGA TKVDQLMLII QARKKGFTEK
560 570 580 590 600
VNTTQDGDLL FNQTMDILPP KSELVGGVEK PKGTQNTRAV KKHECPYCHR
610 620 630 640 650
LFSQATHLEV HVRSHIGYKP FVCDYCGKRF TQGGNLRTHE RLHTGEKPYS
660 670 680 690 700
CDICDKKFSR KGNLAAHLVT HQKLKPFVCK LENCNKTFTQ LGNMKAHQNR
710 720 730 740 750
FHKETLNALT AKLAEMNPSE NIPLEERQLL EYFASIYKNS NRGIKGRGKG
760 770 780 790 800
VGTKKSTISS PENHPASTIL NPNTNANNAI ANDSENNGNP EGNIDSSSNS
810 820 830 840 850
NPGSHSMISP TQKDMGTLQS QFIQNNFNNS VNSSNPSNQP IINYNYTTLP
860 870 880 890 900
HSRLGSSSSS NTNNNNSNFS VGAAPGVLMA PTTNNDFSFN LDQSNDNERS
910
QQEQVRFKNI NYKS
Length:914
Mass (Da):101,170
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA1898DAB68AD050
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z26253 Genomic DNA Translation: CAA81212.1
X90518 Genomic DNA Translation: CAA62111.1
X94335 Genomic DNA Translation: CAA64033.1
Z75021 Genomic DNA Translation: CAA99311.1
BK006948 Genomic DNA Translation: DAA10888.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S46593

NCBI Reference Sequences

More...
RefSeqi
NP_014756.3, NM_001183532.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR113W_mRNA; YOR113W; YOR113W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854280

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR113W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26253 Genomic DNA Translation: CAA81212.1
X90518 Genomic DNA Translation: CAA62111.1
X94335 Genomic DNA Translation: CAA64033.1
Z75021 Genomic DNA Translation: CAA99311.1
BK006948 Genomic DNA Translation: DAA10888.1
PIRiS46593
RefSeqiNP_014756.3, NM_001183532.3

3D structure databases

SMRiP41696
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi34509, 179 interactors
IntActiP41696, 10 interactors
MINTiP41696
STRINGi4932.YOR113W

PTM databases

iPTMnetiP41696

Proteomic databases

MaxQBiP41696
PaxDbiP41696
PRIDEiP41696

Genome annotation databases

EnsemblFungiiYOR113W_mRNA; YOR113W; YOR113W
GeneIDi854280
KEGGisce:YOR113W

Organism-specific databases

EuPathDBiFungiDB:YOR113W
SGDiS000005639, AZF1

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00530000068109
HOGENOMiCLU_010433_0_0_1
InParanoidiP41696
OMAiKQHECPY

Enzyme and pathway databases

BioCyciYEAST:G3O-33642-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P41696
RNActiP41696, protein

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 4 hits
SUPFAMiSSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAZF1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41696
Secondary accession number(s): D6W2H2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 12, 2020
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
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