Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-6

Gene

IL6

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Gene namesi
Name:IL6
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001558028 – 208Interleukin-6Add BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 74By similarity
Modified residuei77PhosphoserineBy similarity1
Disulfide bondi97 ↔ 107By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000022423

Structurei

3D structure databases

ProteinModelPortaliP41683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW11 Eukaryota
ENOG4112BXV LUCA
HOVERGENiHBG000471
InParanoidiP41683
KOiK05405

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41683-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFLSTSAFS PLAFSLGLLL VVATAFPTPG PLGGDATSNR LPLTSADKME
60 70 80 90 100
ELIKYILGKI SALKKEMCDN YNKCEDSKEA LAENNLNLPK LAEKDGCFQS
110 120 130 140 150
GFNQETCLTR ITTGLQEFQI YLKFLQDKYE GDEENAKSVY TSTNVLLQML
160 170 180 190 200
KRKGKNQDEV TIPVPTVEVG LQAKLQSQEE WLRHTTIHLT LRRLEDFLQF

SLRAVRIM
Length:208
Mass (Da):23,401
Last modified:November 1, 1995 - v1
Checksum:i93B4456B2989CA4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → N in AAA16620 (PubMed:8234373).Curated1
Sequence conflicti45S → P in AAA16620 (PubMed:8234373).Curated1
Sequence conflicti133E → K in AAA16620 (PubMed:8234373).Curated1
Sequence conflicti173 – 187AKLQS…RHTTI → LSCSHRRVAEAHNN in AAA16620 (PubMed:8234373).CuratedAdd BLAST15
Sequence conflicti200 – 201FS → LR in AAA16620 (PubMed:8234373).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16914 mRNA Translation: AAA16620.1
D13227 mRNA Translation: BAA02507.1
PIRiI46084
RefSeqiNP_001009211.1, NM_001009211.1

Genome annotation databases

GeneIDi493687
KEGGifca:493687

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16914 mRNA Translation: AAA16620.1
D13227 mRNA Translation: BAA02507.1
PIRiI46084
RefSeqiNP_001009211.1, NM_001009211.1

3D structure databases

ProteinModelPortaliP41683
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000022423

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493687
KEGGifca:493687

Organism-specific databases

CTDi3569

Phylogenomic databases

eggNOGiENOG410IW11 Eukaryota
ENOG4112BXV LUCA
HOVERGENiHBG000471
InParanoidiP41683
KOiK05405

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL6_FELCA
AccessioniPrimary (citable) accession number: P41683
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 20, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again