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Protein

Alcohol dehydrogenase class 4 mu/sigma chain

Gene

Adh7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi174Zinc 1; catalyticBy similarity1
Binding sitei223NADBy similarity1
Binding sitei228NADBy similarity1
Binding sitei369NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 204NADBy similarity6
Nucleotide bindingi292 – 294NADBy similarity3

GO - Molecular functioni

GO - Biological processi

  • ethanol metabolic process Source: RGD
  • retinoid metabolic process Source: RGD
  • retinol metabolic process Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class 4 mu/sigma chain (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class IV mu/sigma chain
Gene namesi
Name:Adh7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621638 Adh7

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606961 – 374Alcohol dehydrogenase class 4 mu/sigma chainAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP41682
PRIDEiP41682

PTM databases

iPTMnetiP41682
PhosphoSitePlusiP41682

Expressioni

Tissue specificityi

Preferentially expressed in stomach.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015870

Structurei

3D structure databases

ProteinModelPortaliP41682
SMRiP41682
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiP41682
KOiK13951
PhylomeDBiP41682

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR028635 Zinc_ADH_IV
PANTHERiPTHR43880:SF2 PTHR43880:SF2, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P41682-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTAGKVIKC KAAVLWGTNQ PFSIEDIEVA PPKAKEVRVK ILATGICGTD
60 70 80 90 100
DHVIKGTMVS KFPVIVGHEA VGIVESVGEE VTTVRPGDKV IPLFLPQCRE
110 120 130 140 150
CNPCRNPEGN LCIRSDLTGR GVLADGTTRF TCKGKPVQHF MNTSTFTEYT
160 170 180 190 200
VLDESSVAKI DAEAPPEKAC LIGCGFSTGY GAAVKTAKVS PGSTCAVFGL
210 220 230 240 250
GGVGLSVVMG CKAAGASRII GIDINKDKFQ KALDVGATEC INPRDFTKPI
260 270 280 290 300
SEVLSDMTGN TVQYTFEVIG RLETMVDALS SCHMNYGTSV VVGAPPSAKM
310 320 330 340 350
LSYDPMLLFT GRTWKGCVFG GWKSRDDVPK LVTEFLEKKF DLGQLITHTL
360 370
PFHNISEGFE LLYSGQSIRT VLTF
Length:374
Mass (Da):40,105
Last modified:July 15, 1999 - v2
Checksum:iDD745E7FCB01E452
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V7J9G3V7J9_RAT
Alcohol dehydrogenase class 4 mu/si...
Adh7 rCG_28864
374Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 4MDTA → SNRV AA sequence (PubMed:8127901).Curated4
Sequence conflicti109G → E in CAA67297 (PubMed:10829036).Curated1
Sequence conflicti208V → I AA sequence (PubMed:8127901).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98746 mRNA Translation: CAA67297.1
PIRiA53142
RefSeqiNP_599156.1, NM_134329.1
UniGeneiRn.42935

Genome annotation databases

GeneIDi171178
KEGGirno:171178

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98746 mRNA Translation: CAA67297.1
PIRiA53142
RefSeqiNP_599156.1, NM_134329.1
UniGeneiRn.42935

3D structure databases

ProteinModelPortaliP41682
SMRiP41682
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015870

PTM databases

iPTMnetiP41682
PhosphoSitePlusiP41682

Proteomic databases

PaxDbiP41682
PRIDEiP41682

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171178
KEGGirno:171178

Organism-specific databases

CTDi131
RGDi621638 Adh7

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiP41682
KOiK13951
PhylomeDBiP41682

Miscellaneous databases

PROiPR:P41682

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR028635 Zinc_ADH_IV
PANTHERiPTHR43880:SF2 PTHR43880:SF2, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH7_RAT
AccessioniPrimary (citable) accession number: P41682
Secondary accession number(s): O55146
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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