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Protein

Alcohol dehydrogenase 6

Gene

ADH6

Organism
Peromyscus maniculatus (North American deer mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi175Zinc 1; catalyticBy similarity1
Binding sitei224NADBy similarity1
Binding sitei229NADBy similarity1
Binding sitei370NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NADBy similarity6
Nucleotide bindingi293 – 295NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 6 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase 2
Short name:
ADH-2
Gene namesi
Name:ADH6
OrganismiPeromyscus maniculatus (North American deer mouse)
Taxonomic identifieri10042 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeNeotominaePeromyscus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606891 – 375Alcohol dehydrogenase 6Add BLAST375

Structurei

3D structure databases

ProteinModelPortaliP41681
SMRiP41681
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P41681-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAGKVIRC KAAVLWKPGA PLTMEEIDVA PPKGKEVRVK MVAAGICGTD
60 70 80 90 100
IKSLDNKKLA PFCPIIMGHE GTGIVESVGE GVSTVKTGDK VIILCLPQCG
110 120 130 140 150
ECNTCLNSKN NICKEVRLSG THLTSEGNSR ITCKGKTTYQ YITTGTFSEY
160 170 180 190 200
IVIKEISVAK VDEDALLEKA CIIGCGFATG FGAAINSAKV SPGSTCAVFG
210 220 230 240 250
LGGVGLSVIM GCKAAGAARI IAVDTNKDKF AKAKTVGATE CIDPQDFEKP
260 270 280 290 300
IQQVLFDMMN DGADFTFEVT GNPETVETAL ASCHKDHGVC VIVGSLASWI
310 320 330 340 350
QLNINSHLFF SGRTLKGSVL GGWKTKEEIP KLVSDYTAKK FNLDPLITHT
360 370
LTLDKVNEAI QLMKNGQCIR CVLLP
Length:375
Mass (Da):39,828
Last modified:November 1, 1995 - v1
Checksum:iF0194982C94DE279
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15704 mRNA Translation: AAA40592.1
PIRiB49107

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15704 mRNA Translation: AAA40592.1
PIRiB49107

3D structure databases

ProteinModelPortaliP41681
SMRiP41681
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH6_PERMA
AccessioniPrimary (citable) accession number: P41681
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 22, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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