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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Peromyscus maniculatus (North American deer mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi175Zinc 1; catalyticBy similarity1
Binding sitei224NADBy similarity1
Binding sitei229NADBy similarity1
Binding sitei370NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NADBy similarity6
Nucleotide bindingi293 – 295NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase A subunit
Gene namesi
Name:ADH1
Synonyms:ADH-1
OrganismiPeromyscus maniculatus (North American deer mouse)
Taxonomic identifieri10042 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeNeotominaePeromyscus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001606672 – 375Alcohol dehydrogenase 1Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei234N6-succinyllysineBy similarity1
Modified residuei340N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP41680

Structurei

3D structure databases

ProteinModelPortaliP41680
SMRiP41680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41680-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAGKVIKC KAAVLWEPHK PFSIEDIEVA PPKAHEVRIK MVATGVCRSD
60 70 80 90 100
DHVVSRSLAS PLPAVLGHEG AGIVESVGEG VTSVKPGDKV IPLFTPQCGK
110 120 130 140 150
CRICKHPEYN LCMKNDLMQP RGTLLDGTSR FTCRGKAIHN FISTSTFSQY
160 170 180 190 200
TVVDEMAVAK IDGASPLEKV CLIGCGFSTG YGSAVKVAKV TPGSTCAVFG
210 220 230 240 250
LGGVGLSVII GCKAAGAARI IAVDINKDKF AKAKELGATE CINPLDYSKP
260 270 280 290 300
IQEVLQEMTD GGVDFSFEVI GRLDTMTSSL LSCHASCGVS VIVGVPPNAQ
310 320 330 340 350
SLSVNPMSLL MGRSWKGAIF GGFKSKDSVP KLVTDFMAKK FPLEPLITHV
360 370
LPFEKINEAF DLLRAGKSIR TVLTF
Length:375
Mass (Da):39,834
Last modified:January 23, 2007 - v2
Checksum:iBA6878B0A071F901
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15703 mRNA Translation: AAA40591.1
PIRiA49107

Similar proteinsi

Entry informationi

Entry nameiADH1_PERMA
AccessioniPrimary (citable) accession number: P41680
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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