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Entry version 188 (13 Nov 2019)
Sequence version 1 (01 Nov 1995)
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Protein

5-hydroxytryptamine receptor 2B

Gene

HTR2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity).By similarity11 Publications

Miscellaneous

Binds lysergic acid diethylamine (LSD) in the orthosteric pocket, but is not the principal LSD receptor in the brain. Bound LSD dissociates extremely slowly, with a residence time of about 46 minutes at 37 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei209Hydrophobic barrier that decreases the speed of ligand binding and dissociation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390666 Serotonin receptors
R-HSA-416476 G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P41595

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.3.7 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-hydroxytryptamine receptor 2B
Short name:
5-HT-2B
Short name:
5-HT2B
Alternative name(s):
Serotonin receptor 2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5294 HTR2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601122 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41595

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 56Extracellular3 PublicationsAdd BLAST56
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei57 – 79Helical; Name=13 PublicationsAdd BLAST23
Topological domaini80 – 90Cytoplasmic3 PublicationsAdd BLAST11
Transmembranei91 – 113Helical; Name=23 PublicationsAdd BLAST23
Topological domaini114 – 129Extracellular3 PublicationsAdd BLAST16
Transmembranei130 – 151Helical; Name=33 PublicationsAdd BLAST22
Topological domaini152 – 171Cytoplasmic3 PublicationsAdd BLAST20
Transmembranei172 – 192Helical; Name=43 PublicationsAdd BLAST21
Topological domaini193 – 216Extracellular3 PublicationsAdd BLAST24
Transmembranei217 – 239Helical; Name=53 PublicationsAdd BLAST23
Topological domaini240 – 324Cytoplasmic3 PublicationsAdd BLAST85
Transmembranei325 – 345Helical; Name=63 PublicationsAdd BLAST21
Topological domaini346 – 360Extracellular3 PublicationsAdd BLAST15
Transmembranei361 – 382Helical; Name=73 PublicationsAdd BLAST22
Topological domaini383 – 481Cytoplasmic3 PublicationsAdd BLAST99

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi132L → A: No effect on agonist binding. 1 Publication1
Mutagenesisi135D → A: Abolishes agonist binding. 1 Publication1
Mutagenesisi136V → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi139S → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi140T → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi208V → A: No effect on agonist binding. 1 Publication1
Mutagenesisi209L → A: No effect on agonist binding. Strongly increases dissociation of bound lysergic acid diethylamine, without affecting binding affinity. Reduces signaling via arrestins, but has no effect on signaling via the phosphatidylinositol-calcium second messenger system. 2 Publications1
Mutagenesisi211K → A: Impairs protein folding and stability. Strongly reduced cell surface expression. 1 Publication1
Mutagenesisi217F → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi218M → A: No effect on agonist binding. 1 Publication1
Mutagenesisi225A → S: No effect on agonist binding. 1 Publication1
Mutagenesisi337W → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi340F → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi344N → A: Slightly decreases agonist binding. 1 Publication1
Mutagenesisi347L → A: No effect on agonist binding. 1 Publication1
Mutagenesisi348V → A: No effect on agonist binding. 1 Publication1
Mutagenesisi362L → A: No effect on agonist binding. 1 Publication1
Mutagenesisi363E → A: No effect on agonist binding. 1 Publication1
Mutagenesisi366V → A: No effect on agonist binding. 1 Publication1
Mutagenesisi370Y → A: Slightly decreases agonist binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3357

Open Targets

More...
OpenTargetsi
ENSG00000135914

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29554

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P41595

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1833

Drug and drug target database

More...
DrugBanki
DB00543 Amoxapine
DB00714 Apomorphine
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB06016 Cariprazine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB01242 Clomipramine
DB11273 Dihydroergocornine
DB13345 Dihydroergocristine
DB00320 Dihydroergotamine
DB01142 Doxepin
DB00216 Eletriptan
DB05492 Epicept NP-1
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB06678 Esmirtazapine
DB00574 Fenfluramine
DB12141 Gilteritinib
DB01221 Ketamine
DB00589 Lisuride
DB04829 Lysergic acid diethylamide
DB00353 Methylergometrine
DB00247 Methysergide
DB06148 Mianserin
DB01454 Midomafetamine
DB00805 Minaprine
DB06229 Ocaperidone
DB05461 OPC-28326
DB01186 Pergolide
DB09286 Pipamperone
DB06153 Pizotifen
DB05607 PRX-08066
DB09304 Setiptiline
DB01079 Tegaserod
DB13025 Tiapride
DB00508 Triflupromazine
DB01392 Yohimbine

DrugCentral

More...
DrugCentrali
P41595

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HTR2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1168220

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000689531 – 4815-hydroxytryptamine receptor 2BAdd BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi128 ↔ 207PROSITE-ProRule annotationCombined sources3 Publications
Disulfide bondi350 ↔ 353PROSITE-ProRule annotationCombined sources3 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi397S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P41595

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41595

PeptideAtlas

More...
PeptideAtlasi
P41595

PRoteomics IDEntifications database

More...
PRIDEi
P41595

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55473

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P41595

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P41595

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135914 Expressed in 126 organ(s), highest expression level in decidua

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P41595 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012867
HPA063658

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with MPDZ.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109589, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P41595, 27 interactors

Molecular INTeraction database

More...
MINTi
P41595

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000258400

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P41595

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1481
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P41595

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni135 – 140Agonist bindingCombined sources3 Publications6
Regioni337 – 341Agonist bindingCombined sources3 Publications5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi152 – 154DRY motif; important for ligand-induced conformation changes2 Publications3
Motifi212 – 215[DE]RFG motif; may stabilize a conformation that preferentially activates signaling via beta-arrestin family members2 Publications4
Motifi376 – 380NPxxY motif; important for ligand-induced conformation changes and signaling2 Publications5
Motifi479 – 481PDZ-binding1 Publication3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.3 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00960000186619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000240378

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41595

KEGG Orthology (KO)

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KOi
K04157

Identification of Orthologs from Complete Genome Data

More...
OMAi
YITCNYQ

Database of Orthologous Groups

More...
OrthoDBi
962038at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P41595

TreeFam database of animal gene trees

More...
TreeFami
TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000482 5HT2B_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...
PANTHERi
PTHR24247:SF31 PTHR24247:SF31, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00651 5HT2BRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P41595-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSYRVSEL QSTIPEHILQ STFVHVISSN WSGLQTESIP EEMKQIVEEQ
60 70 80 90 100
GNKLHWAALL ILMVIIPTIG GNTLVILAVS LEKKLQYATN YFLMSLAVAD
110 120 130 140 150
LLVGLFVMPI ALLTIMFEAM WPLPLVLCPA WLFLDVLFST ASIMHLCAIS
160 170 180 190 200
VDRYIAIKKP IQANQYNSRA TAFIKITVVW LISIGIAIPV PIKGIETDVD
210 220 230 240 250
NPNNITCVLT KERFGDFMLF GSLAAFFTPL AIMIVTYFLT IHALQKKAYL
260 270 280 290 300
VKNKPPQRLT WLTVSTVFQR DETPCSSPEK VAMLDGSRKD KALPNSGDET
310 320 330 340 350
LMRRTSTIGK KSVQTISNEQ RASKVLGIVF FLFLLMWCPF FITNITLVLC
360 370 380 390 400
DSCNQTTLQM LLEIFVWIGY VSSGVNPLVY TLFNKTFRDA FGRYITCNYR
410 420 430 440 450
ATKSVKTLRK RSSKIYFRNP MAENSKFFKK HGIRNGINPA MYQSPMRLRS
460 470 480
STIQSSSIIL LDTLLLTENE GDKTEEQVSY V
Length:481
Mass (Da):54,298
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDA4447ECDBA3B46
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti452T → P in CAA85319 (PubMed:7926008).Curated1
Sequence conflicti477Q → R in AAH63123 (PubMed:15489334).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

A variation at a single nucleotide base, which results in an erroneous stop codon and affects Gln-20, triggers non-sense mediated RNA decay, such that no HTR2B-receptor protein is expressed. It is associated with impulsive behavior and co-segregates with disorders characterized by impulsivity. However, the presence of this variant is not in itself sufficient to cause impulsive behavior: male sex, testosterone level, alcohol and stress exposure are other factors playing important roles.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06457445Q → E1 PublicationCorresponds to variant dbSNP:rs78484969Ensembl.1
Natural variantiVAR_064575173F → L1 PublicationCorresponds to variant dbSNP:rs77570025Ensembl.1
Natural variantiVAR_064576388R → W1 PublicationCorresponds to variant dbSNP:rs77982984Ensembl.1
Natural variantiVAR_055907421M → V. Corresponds to variant dbSNP:rs6736017Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X77307 mRNA Translation: CAA54513.1
Z36748 mRNA Translation: CAA85319.1
AF156160, AF156158, AF156159 Genomic DNA Translation: AAD39259.1
AY136751 mRNA Translation: AAN01277.1
AC009407 Genomic DNA Translation: AAX93128.1
AK313741 mRNA Translation: BAG36482.1
CH471063 Genomic DNA Translation: EAW70949.1
BC063123 mRNA Translation: AAH63123.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2483.1

Protein sequence database of the Protein Information Resource

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PIRi
S43687
S49442

NCBI Reference Sequences

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RefSeqi
NP_000858.3, NM_000867.4
NP_001307687.1, NM_001320758.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000258400; ENSP00000258400; ENSG00000135914

Database of genes from NCBI RefSeq genomes

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GeneIDi
3357

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3357

UCSC genome browser

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UCSCi
uc002vro.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

On the spur of a whim - Issue 127 of March 2011

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77307 mRNA Translation: CAA54513.1
Z36748 mRNA Translation: CAA85319.1
AF156160, AF156158, AF156159 Genomic DNA Translation: AAD39259.1
AY136751 mRNA Translation: AAN01277.1
AC009407 Genomic DNA Translation: AAX93128.1
AK313741 mRNA Translation: BAG36482.1
CH471063 Genomic DNA Translation: EAW70949.1
BC063123 mRNA Translation: AAH63123.1
CCDSiCCDS2483.1
PIRiS43687
S49442
RefSeqiNP_000858.3, NM_000867.4
NP_001307687.1, NM_001320758.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IB4X-ray2.70A36-248[»]
A314-405[»]
4NC3X-ray2.80A36-248[»]
A314-405[»]
5TUDX-ray3.00A/D36-248[»]
A/D314-405[»]
5TVNX-ray2.90A41-248[»]
A313-400[»]
6DRXX-ray3.10A36-248[»]
A314-404[»]
6DRYX-ray2.92A36-248[»]
A313-404[»]
6DRZX-ray3.10A36-248[»]
A313-404[»]
6DS0X-ray3.19A36-248[»]
A314-404[»]
SMRiP41595
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109589, 3 interactors
IntActiP41595, 27 interactors
MINTiP41595
STRINGi9606.ENSP00000258400

Chemistry databases

BindingDBiP41595
ChEMBLiCHEMBL1833
DrugBankiDB00543 Amoxapine
DB00714 Apomorphine
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB06016 Cariprazine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB01242 Clomipramine
DB11273 Dihydroergocornine
DB13345 Dihydroergocristine
DB00320 Dihydroergotamine
DB01142 Doxepin
DB00216 Eletriptan
DB05492 Epicept NP-1
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB06678 Esmirtazapine
DB00574 Fenfluramine
DB12141 Gilteritinib
DB01221 Ketamine
DB00589 Lisuride
DB04829 Lysergic acid diethylamide
DB00353 Methylergometrine
DB00247 Methysergide
DB06148 Mianserin
DB01454 Midomafetamine
DB00805 Minaprine
DB06229 Ocaperidone
DB05461 OPC-28326
DB01186 Pergolide
DB09286 Pipamperone
DB06153 Pizotifen
DB05607 PRX-08066
DB09304 Setiptiline
DB01079 Tegaserod
DB13025 Tiapride
DB00508 Triflupromazine
DB01392 Yohimbine
DrugCentraliP41595
GuidetoPHARMACOLOGYi7

Protein family/group databases

TCDBi9.A.14.3.7 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP41595
PhosphoSitePlusiP41595

Polymorphism and mutation databases

BioMutaiHTR2B
DMDMi1168220

Proteomic databases

MassIVEiP41595
PaxDbiP41595
PeptideAtlasiP41595
PRIDEiP41595
ProteomicsDBi55473

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P41595

The DNASU plasmid repository

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DNASUi
3357

Genome annotation databases

EnsembliENST00000258400; ENSP00000258400; ENSG00000135914
GeneIDi3357
KEGGihsa:3357
UCSCiuc002vro.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3357
DisGeNETi3357

GeneCards: human genes, protein and diseases

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GeneCardsi
HTR2B
HGNCiHGNC:5294 HTR2B
HPAiHPA012867
HPA063658
MIMi601122 gene
neXtProtiNX_P41595
OpenTargetsiENSG00000135914
PharmGKBiPA29554

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00960000186619
HOGENOMiHOG000240378
InParanoidiP41595
KOiK04157
OMAiYITCNYQ
OrthoDBi962038at2759
PhylomeDBiP41595
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP41595

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
5-HT2B_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3357
PharosiP41595

Protein Ontology

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PROi
PR:P41595

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135914 Expressed in 126 organ(s), highest expression level in decidua
GenevisibleiP41595 HS

Family and domain databases

InterProiView protein in InterPro
IPR000482 5HT2B_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF31 PTHR24247:SF31, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00651 5HT2BRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5HT2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41595
Secondary accession number(s): B2R9D5
, Q53TI1, Q62221, Q6P523
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 13, 2019
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  8. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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