Metabotropic glutamate receptor 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• adenylate cyclase inhibiting G protein-coupled glutamate receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• glutamate receptor activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5."
    Minakami R., Katsuki F., Yamamoto T., Nakamura K., Sugiyama H.
    Biochem. Biophys. Res. Commun. 199:1136-1143(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
• G protein-coupled receptor activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5."
    Minakami R., Katsuki F., Yamamoto T., Nakamura K., Sugiyama H.
    Biochem. Biophys. Res. Commun. 199:1136-1143(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
• G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Structural insights into the activation of metabotropic glutamate receptors."
    Koehl A., Hu H., Feng D., Sun B., Zhang Y., Robertson M.J., Chu M., Kobilka T.S., Laeremans T., Steyaert J., Tarrasch J., Dutta S., Fonseca R., Weis W.I., Mathiesen J.M., Skiniotis G., Kobilka B.K.
    Nature 566:79-84(2019) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein tyrosine kinase activator activity Source: ARUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• protein tyrosine kinase binding Source: ARUK-UCL

GO - Biological processⁱ

• calcium-mediated signaling using intracellular calcium source Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• cellular response to amyloid-beta Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• chemical synaptic transmission Source: ProtIncTraceable author statementⁱ
  • Ref.1

    "Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5."
    Minakami R., Katsuki F., Yamamoto T., Nakamura K., Sugiyama H.
    Biochem. Biophys. Res. Commun. 199:1136-1143(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
• cognition Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals."
    Swaminathan S., Huentelman M.J., Corneveaux J.J., Myers A.J., Faber K.M., Foroud T., Mayeux R., Shen L., Kim S., Turk M., Hardy J., Reiman E.M., Saykin A.J., Weiner M., Aisen P., Weiner M., Aisen P., Petersen R.

    , Jack C.R. Jr., Jagust W., Trojanowki J.Q., Toga A.W., Beckett L., Green R.C., Saykin A.J., Morris J., Liu E., Green R.C., Montine T., Petersen R., Aisen P., Gamst A., Thomas R.G., Donohue M., Walter S., Gessert D., Sather T., Beckett L., Harvey D., Gamst A., Donohue M., Kornak J., Jack C.R. Jr., Dale A., Bernstein M., Felmlee J., Fox N., Thompson P., Schuff N., Alexander G., DeCarli C., Jagust W., Bandy D., Koeppe R.A., Foster N., Reiman E.M., Chen K., Mathis C., Morris J., Cairns N.J., Taylor-Reinwald L., Trojanowki J.Q., Shaw L., Lee V.M., Korecka M., Toga A.W., Crawford K., Neu S., Saykin A.J., Foroud T.M., Potkin S., Shen L., Kachaturian Z., Frank R., Snyder P.J., Molchan S., Kaye J., Quinn J., Lind B., Dolen S., Schneider L.S., Pawluczyk S., Spann B.M., Brewer J., Vanderswag H., Heidebrink J.L., Lord J.L., Petersen R., Johnson K., Doody R.S., Villanueva-Meyer J., Chowdhury M., Stern Y., Honig L.S., Bell K.L., Morris J.C., Ances B., Carroll M., Leon S., Mintun M.A., Schneider S., Marson D., Griffith R., Clark D., Grossman H., Mitsis E., Romirowsky A., deToledo-Morrell L., Shah R.C., Duara R., Varon D., Roberts P., Albert M., Onyike C., Kielb S., Rusinek H., de Leon M.J., Glodzik L., De Santi S., Doraiswamy P., Petrella J.R., Coleman R., Arnold S.E., Karlawish J.H., Wolk D., Smith C.D., Jicha G., Hardy P., Lopez O.L., Oakley M., Simpson D.M., Porsteinsson A.P., Goldstein B.S., Martin K., Makino K.M., Ismail M., Brand C., Mulnard R.A., Thai G., Mc-Adams-Ortiz C., Womack K., Mathews D., Quiceno M., Diaz-Arrastia R., King R., Weiner M., Martin-Cook K., DeVous M., Levey A.I., Lah J.J., Cellar J.S., Burns J.M., Anderson H.S., Swerdlow R.H., Apostolova L., Lu P.H., Bartzokis G., Silverman D.H., Graff-Radford N.R., Parfitt F., Johnson H., Farlow M.R., Hake A.M., Matthews B.R., Herring S., van Dyck C.H., Carson R.E., MacAvoy M.G., Chertkow H., Bergman H., Hosein C., Black S., Stefanovic B., Caldwell C., Hsiung G.Y., Feldman H., Mudge B., Assaly M., Kertesz A., Rogers J., Trost D., Bernick C., Munic D., Kerwin D., Mesulam M.M., Lipowski K., Wu C.K., Johnson N., Sadowsky C., Martinez W., Villena T., Turner R.S., Johnson K., Reynolds B., Sperling R.A., Johnson K.A., Marshall G., Frey M., Yesavage J., Taylor J.L., Lane B., Rosen A., Tinklenberg J., Sabbagh M., Belden C., Jacobson S., Kowall N., Killiany R., Budson A.E., Norbash A., Johnson P.L., Obisesan T.O., Wolday S., Bwayo S.K., Lerner A., Hudson L., Ogrocki P., Fletcher E., Carmichael O., Olichney J., DeCarli C., Kittur S., Borrie M., Lee T.Y., Bartha R., Johnson S., Asthana S., Carlsson C.M., Potkin S.G., Preda A., Nguyen D., Tariot P., Fleisher A., Reeder S., Bates V., Capote H., Rainka M., Scharre D.W., Kataki M., Zimmerman E.A., Celmins D., Brown A.D., Pearlson G.D., Blank K., Anderson K., Saykin A.J., Santulli R.B., Schwartz E.S., Sink K.M., Williamson J.D., Garg P., Watkins F., Ott B.R., Querfurth H., Tremont G., Salloway S., Malloy P., Correia S., Rosen H.J., Miller B.L., Mintzer J., Spicer K., Rachinsky I., Rogers J., Kertesz A., Drost D., Mayeux R., Foroud T., Lee J.H., Wijsman E.M., Green R., Kowall N., Farrer L., Schmechel D.E., Blacker D., Growdon J., Hyman B.T., Tanzi R.E., Boeve B., Graff-Radford N., Pericak-Vance M., Silverman J.M., Beeri M.S., Sano M., Johnson N., Mesulam M., Weintraub S., Bigio E., Kaye J., Kramer P., Bennett D.A., Harrell L.E., Bartzokis G., Geffen D., Markesbery W., Smith C., Trojanowski J.Q., Van Deerlin V., DeKosky S.T., Sweet R., Chui I., Varpetian A., Diaz-Arrastia R., Rosenberg R., Bird T., Raskind M., Schellenberg G.D., Goate A., Morris J., Morrison-Bogorad M., Miller M.
    PLoS One 7:e50640-e50640(2012) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled glutamate receptor signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.1

    "Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5."
    Minakami R., Katsuki F., Yamamoto T., Nakamura K., Sugiyama H.
    Biochem. Biophys. Res. Commun. 199:1136-1143(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
• learning Source: Ensembl
• learning or memory Source: ARUK-UCL
• locomotory behavior Source: Ensembl
• modulation of age-related behavioral decline Source: ARUK-UCL
• phospholipase C-activating G protein-coupled glutamate receptor signaling pathway Source: ProtIncTraceable author statementⁱ
  • Ref.1

    "Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5."
    Minakami R., Katsuki F., Yamamoto T., Nakamura K., Sugiyama H.
    Biochem. Biophys. Res. Commun. 199:1136-1143(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
• positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
• postsynaptic modulation of chemical synaptic transmission Source: Ensembl
• regulation of intracellular calcium activated chloride channel activity Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of long-term neuronal synaptic plasticity Source: Ensembl
• regulation of protein phosphorylation Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic transmission, glutamatergic Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of translation Source: ARUK-UCLTraceable author statementⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of translational elongation Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein."
    Um J.W., Kaufman A.C., Kostylev M., Heiss J.K., Stagi M., Takahashi H., Kerrisk M.E., Vortmeyer A., Wisniewski T., Koleske A.J., Gunther E.C., Nygaard H.B., Strittmatter S.M.
    Neuron 79:887-902(2013) [PubMed] [Europe PMC] [Abstract]
• synapse organization Source: ARUK-UCL
• trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Structural insights into the activation of metabotropic glutamate receptors."
    Koehl A., Hu H., Feng D., Sun B., Zhang Y., Robertson M.J., Chu M., Kobilka T.S., Laeremans T., Steyaert J., Tarrasch J., Dutta S., Fonseca R., Weis W.I., Mathiesen J.M., Skiniotis G., Kobilka B.K.
    Nature 566:79-84(2019) [PubMed] [Europe PMC] [Abstract]
• protein tyrosine kinase binding Source: ARUK-UCL

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD 
        60         70         80         90        100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW 
       110        120        130        140        150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG 
       160        170        180        190        200
SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR 
       210        220        230        240        250
AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS 
       260        270        280        290        300
NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL 
       310        320        330        340        350
LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH 
       360        370        380        390        400
RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV 
       410        420        430        440        450
INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS 
       460        470        480        490        500
GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW 
       510        520        530        540        550
SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK 
       560        570        580        590        600
ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV 
       610        620        630        640        650
FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG 
       660        670        680        690        700
IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL 
       710        720        730        740        750
ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL 
       760        770        780        790        800
ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII 
       810        820        830        840        850
TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG 
       860        870        880        890        900
KSSSAASRSS SLVNLWKRRG SSGETLRYKD RRLAQHKSEI ECFTPKGSMG 
       910        920        930        940        950
NGGRATMSSS NGKSVTWAQN EKSSRGQHLW QRLSIHINKK ENPNQTAVIK 
       960        970        980        990       1000
PFPKSTESRG LGAGAGAGGS AGGVGATGGA GCAGAGPGGP ESPDAGPKAL 
      1010       1020       1030       1040       1050
YDVAEAEEHF PAPARPRSPS PISTLSHRAG SASRTDDDVP SLHSEPVARS 
      1060       1070       1080       1090       1100
SSSQGSLMEQ ISSVVTRFTA NISELNSMML STAAPSPGVG APLCSSYLIP 
      1110       1120       1130       1140       1150
KEIQLPTTMT TFAEIQPLPA IEVTGGAQPA AGAQAAGDAA RESPAAGPEA 
      1160       1170       1180       1190       1200
AAAKPDLEEL VALTPPSPFR DSVDSGSTTP NSPVSESALC IPSSPKYDTL 
      1210 
IIRDYTQSSS SL                                          

        10         20         30         40         50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD 
        60         70         80         90        100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW 
       110        120        130        140        150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG 
       160        170        180        190        200
SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR 
       210        220        230        240        250
AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS 
       260        270        280        290        300
NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL 
       310        320        330        340        350
LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH 
       360        370        380        390        400
RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV 
       410        420        430        440        450
INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS 
       460        470        480        490        500
GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW 
       510        520        530        540        550
SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK 
       560        570        580        590        600
ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV 
       610        620        630        640        650
FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG 
       660        670        680        690        700
IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL 
       710        720        730        740        750
ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL 
       760        770        780        790        800
ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII 
       810        820        830        840        850
TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG 
       860        870        880        890        900
KSSSAASRSS SLVNLWKRRG SSGETLSSNG KSVTWAQNEK SSRGQHLWQR 
       910        920        930        940        950
LSIHINKKEN PNQTAVIKPF PKSTESRGLG AGAGAGGSAG GVGATGGAGC 
       960        970        980        990       1000
AGAGPGGPES PDAGPKALYD VAEAEEHFPA PARPRSPSPI STLSHRAGSA 
      1010       1020       1030       1040       1050
SRTDDDVPSL HSEPVARSSS SQGSLMEQIS SVVTRFTANI SELNSMMLST 
      1060       1070       1080       1090       1100
AAPSPGVGAP LCSSYLIPKE IQLPTTMTTF AEIQPLPAIE VTGGAQPAAG 
      1110       1120       1130       1140       1150
AQAAGDAARE SPAAGPEAAA AKPDLEELVA LTPPSPFRDS VDSGSTTPNS 
      1160       1170       1180
PVSESALCIP SSPKYDTLII RDYTQSSSSL                       

        10         20         30         40         50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD 
        60         70         80         90        100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW 
       110        120        130        140        150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG 
       160        170        180        190        200
SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR 
       210        220        230        240        250
AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS 
       260        270        280        290        300
NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL 
       310        320        330        340        350
LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH 
       360        370        380        390        400
RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV 
       410        420        430        440        450
INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS 
       460        470        480        490        500
GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW 
       510        520        530        540        550
SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK 
       560        570        580        590        600
ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV 
       610        620        630        640        650
FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG 
       660        670        680        690        700
IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL 
       710        720        730        740        750
ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL 
       760        770        780        790        800
ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII 
       810        820        830        840        850
TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG 
       860        870        880        890        900
KSSSAASRSS SLVNLWKRRG SSGETLRYKD RRLAQHKSEI ECFTPPSPFR 
       910        920        930        940 
DSVDSGSTTP NSPVSESALC IPSSPKYDTL IIRDYTQSSS SL         

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. Human chromosome 11
   Human chromosome 11: entries, gene names and cross-references to MIM
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
4. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
5. SIMILARITY comments
   Index of protein domains and families