UniProtKB - P41594 (GRM5_HUMAN)
Protein
Metabotropic glutamate receptor 5
Gene
GRM5
Organism
Homo sapiens (Human)
Status
Functioni
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 64 | Glutamate1 Publication | 1 | |
Binding sitei | 152 | Glutamate1 Publication | 1 | |
Binding sitei | 223 | Glutamate1 Publication | 1 | |
Binding sitei | 305 | Glutamate1 Publication | 1 | |
Binding sitei | 396 | Glutamate1 Publication | 1 |
GO - Molecular functioni
- glutamate receptor activity Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB
- G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential Source: GO_Central
- identical protein binding Source: IntAct
- neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Source: GO_Central
- protein tyrosine kinase activator activity Source: ARUK-UCL
- protein tyrosine kinase binding Source: ARUK-UCL
GO - Biological processi
- calcium-mediated signaling using intracellular calcium source Source: ARUK-UCL
- cellular response to amyloid-beta Source: ARUK-UCL
- chemical synaptic transmission Source: ProtInc
- cognition Source: UniProtKB
- G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
- learning Source: Ensembl
- learning or memory Source: ARUK-UCL
- locomotory behavior Source: Ensembl
- modulation of age-related behavioral decline Source: ARUK-UCL
- phospholipase C-activating G protein-coupled glutamate receptor signaling pathway Source: ProtInc
- positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
- regulation of intracellular calcium activated chloride channel activity Source: ARUK-UCL
- regulation of long-term neuronal synaptic plasticity Source: Ensembl
- regulation of protein phosphorylation Source: ARUK-UCL
- regulation of synaptic transmission, glutamatergic Source: GO_Central
- regulation of translation Source: ARUK-UCL
- regulation of translational elongation Source: ARUK-UCL
- synapse organization Source: ARUK-UCL
- trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P41594 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-6794361, Neurexins and neuroligins |
SignaLinki | P41594 |
SIGNORi | P41594 |
Names & Taxonomyi
Protein namesi | Recommended name: Metabotropic glutamate receptor 5Short name: mGluR5 |
Gene namesi | Name:GRM5 Synonyms:GPRC1E, MGLUR5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168959.14 |
HGNCi | HGNC:4597, GRM5 |
MIMi | 604102, gene |
neXtProti | NX_P41594 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
- postsynaptic density membrane Source: GO_Central
Other locations
- cytoplasm Source: Ensembl
- neuron projection Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 580 | Extracellular1 PublicationAdd BLAST | 559 | |
Transmembranei | 581 – 603 | Helical; Name=1Add BLAST | 23 | |
Topological domaini | 604 – 613 | Cytoplasmic1 Publication | 10 | |
Transmembranei | 614 – 636 | Helical; Name=2Add BLAST | 23 | |
Topological domaini | 637 – 644 | Extracellular1 Publication | 8 | |
Transmembranei | 645 – 667 | Helical; Name=3Add BLAST | 23 | |
Topological domaini | 668 – 693 | Cytoplasmic1 PublicationAdd BLAST | 26 | |
Transmembranei | 694 – 714 | Helical; Name=4Add BLAST | 21 | |
Topological domaini | 715 – 737 | Extracellular1 PublicationAdd BLAST | 23 | |
Transmembranei | 738 – 759 | Helical; Name=5Add BLAST | 22 | |
Topological domaini | 760 – 772 | Cytoplasmic1 PublicationAdd BLAST | 13 | |
Transmembranei | 773 – 795 | Helical; Name=6Add BLAST | 23 | |
Topological domaini | 796 – 798 | Extracellular1 Publication | 3 | |
Transmembranei | 799 – 820 | Helical; Name=7Add BLAST | 22 | |
Topological domaini | 821 – 1212 | Cytoplasmic1 PublicationAdd BLAST | 392 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 613 | S → A or K: Increased constitutive signaling activity. 1 Publication | 1 | |
Mutagenesisi | 614 | S → D: Decreased constitutive signaling activity. 1 Publication | 1 | |
Mutagenesisi | 665 | K → A: Increased constitutive signaling activity. 1 Publication | 1 | |
Mutagenesisi | 770 | E → A: Increased constitutive signaling activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2915 |
OpenTargetsi | ENSG00000168959 |
PharmGKBi | PA28994 |
Miscellaneous databases
Pharosi | P41594, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3227 |
DrugBanki | DB00659, Acamprosate DB05070, ADX10059 DB12733, Dipraglurant DB06201, Rufinamide |
DrugCentrali | P41594 |
GuidetoPHARMACOLOGYi | 293 |
Polymorphism and mutation databases
BioMutai | GRM5 |
DMDMi | 1709020 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000012932 | 21 – 1212 | Metabotropic glutamate receptor 5Add BLAST | 1192 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 57 ↔ 99 | |||
Glycosylationi | 88 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 210 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 241 ↔ 530 | By similarity | ||
Disulfide bondi | 276 ↔ 278 | |||
Disulfide bondi | 365 ↔ 381 | |||
Glycosylationi | 378 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 382 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 419 ↔ 426 | |||
Glycosylationi | 445 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 511 ↔ 531 | By similarity | ||
Disulfide bondi | 515 ↔ 534 | By similarity | ||
Disulfide bondi | 537 ↔ 549 | By similarity | ||
Disulfide bondi | 552 ↔ 565 | By similarity | ||
Disulfide bondi | 644 ↔ 733 | |||
Glycosylationi | 734 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 861 | PhosphoserineBy similarity | 1 | |
Modified residuei | 869 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 925 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1018 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1020 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Methylation, PhosphoproteinProteomic databases
jPOSTi | P41594 |
MassIVEi | P41594 |
PaxDbi | P41594 |
PeptideAtlasi | P41594 |
PRIDEi | P41594 |
ProteomicsDBi | 55471 [P41594-1] 55472 [P41594-2] 66504 |
PTM databases
GlyGeni | P41594, 6 sites |
iPTMneti | P41594 |
PhosphoSitePlusi | P41594 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168959, Expressed in frontal cortex and 124 other tissues |
ExpressionAtlasi | P41594, baseline and differential |
Genevisiblei | P41594, HS |
Organism-specific databases
HPAi | ENSG00000168959, Tissue enriched (brain) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP41594
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-6595175,EBI-6595175 |
Isoform 2 [P41594-1]
With | #Exp. | IntAct |
---|---|---|
NECAB2 [Q7Z6G3] | 2 | EBI-14039683,EBI-950070 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein tyrosine kinase binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 109172, 10 interactors |
IntActi | P41594, 5 interactors |
STRINGi | 9606.ENSP00000306138 |
Chemistry databases
BindingDBi | P41594 |
Miscellaneous databases
RNActi | P41594, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P41594 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P41594 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 173 – 175 | Glutamate binding | 3 | |
Regioni | 805 – 809 | Allosteric effector binding | 5 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT01010000222410 |
HOGENOMi | CLU_005389_0_1_1 |
InParanoidi | P41594 |
OMAi | SLCPGYQ |
OrthoDBi | 107675at2759 |
PhylomeDBi | P41594 |
TreeFami | TF313240 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR000202, GPCR_3_mtglu_rcpt_5 IPR019588, Metabotropic_Glu_rcpt_Homer-bd IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF10606, GluR_Homer-bdg, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01055, MTABOTROPC5R PR00593, MTABOTROPICR |
SMARTi | View protein in SMART SM01229, GluR_Homer-bdg, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2 (identifier: P41594-1) [UniParc]FASTAAdd to basket
Also known as: 5b
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD
60 70 80 90 100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW
110 120 130 140 150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG
160 170 180 190 200
SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR
210 220 230 240 250
AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS
260 270 280 290 300
NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL
310 320 330 340 350
LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH
360 370 380 390 400
RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV
410 420 430 440 450
INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS
460 470 480 490 500
GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW
510 520 530 540 550
SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK
560 570 580 590 600
ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV
610 620 630 640 650
FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG
660 670 680 690 700
IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL
710 720 730 740 750
ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL
760 770 780 790 800
ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII
810 820 830 840 850
TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG
860 870 880 890 900
KSSSAASRSS SLVNLWKRRG SSGETLRYKD RRLAQHKSEI ECFTPKGSMG
910 920 930 940 950
NGGRATMSSS NGKSVTWAQN EKSSRGQHLW QRLSIHINKK ENPNQTAVIK
960 970 980 990 1000
PFPKSTESRG LGAGAGAGGS AGGVGATGGA GCAGAGPGGP ESPDAGPKAL
1010 1020 1030 1040 1050
YDVAEAEEHF PAPARPRSPS PISTLSHRAG SASRTDDDVP SLHSEPVARS
1060 1070 1080 1090 1100
SSSQGSLMEQ ISSVVTRFTA NISELNSMML STAAPSPGVG APLCSSYLIP
1110 1120 1130 1140 1150
KEIQLPTTMT TFAEIQPLPA IEVTGGAQPA AGAQAAGDAA RESPAAGPEA
1160 1170 1180 1190 1200
AAAKPDLEEL VALTPPSPFR DSVDSGSTTP NSPVSESALC IPSSPKYDTL
1210
IIRDYTQSSS SL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MT20 | A8MT20_HUMAN | Metabotropic glutamate receptor 5 | GRM5 | 298 | Annotation score: | ||
H7C223 | H7C223_HUMAN | Metabotropic glutamate receptor 5 | GRM5 | 87 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002030 | 877 – 908 | Missing in isoform 1. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_047710 | 896 – 1165 | Missing in isoform 3. 1 PublicationAdd BLAST | 270 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D28538 mRNA Translation: BAA05891.1 D28539 mRNA Translation: BAA05892.1 AY608336 mRNA Translation: AAT37960.1 AP000626 Genomic DNA No translation available. AP001482 Genomic DNA No translation available. AP001828 Genomic DNA No translation available. AP003120 Genomic DNA No translation available. AP006214 Genomic DNA No translation available. AP006215 Genomic DNA No translation available. S64316 mRNA Translation: AAD13954.1 |
CCDSi | CCDS44694.1 [P41594-1] CCDS8283.1 [P41594-2] |
PIRi | JC2131 JC2132 |
RefSeqi | NP_000833.1, NM_000842.4 [P41594-2] NP_001137303.1, NM_001143831.2 [P41594-1] XP_006718891.1, XM_006718828.3 XP_011541094.1, XM_011542792.1 [P41594-1] XP_016873116.1, XM_017017627.1 |
Genome annotation databases
Ensembli | ENST00000305432; ENSP00000305905; ENSG00000168959 [P41594-2] ENST00000305447; ENSP00000306138; ENSG00000168959 [P41594-1] ENST00000455756; ENSP00000405690; ENSG00000168959 [P41594-2] |
GeneIDi | 2915 |
KEGGi | hsa:2915 |
UCSCi | uc001pcq.4, human [P41594-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D28538 mRNA Translation: BAA05891.1 D28539 mRNA Translation: BAA05892.1 AY608336 mRNA Translation: AAT37960.1 AP000626 Genomic DNA No translation available. AP001482 Genomic DNA No translation available. AP001828 Genomic DNA No translation available. AP003120 Genomic DNA No translation available. AP006214 Genomic DNA No translation available. AP006215 Genomic DNA No translation available. S64316 mRNA Translation: AAD13954.1 |
CCDSi | CCDS44694.1 [P41594-1] CCDS8283.1 [P41594-2] |
PIRi | JC2131 JC2132 |
RefSeqi | NP_000833.1, NM_000842.4 [P41594-2] NP_001137303.1, NM_001143831.2 [P41594-1] XP_006718891.1, XM_006718828.3 XP_011541094.1, XM_011542792.1 [P41594-1] XP_016873116.1, XM_017017627.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3LMK | X-ray | 2.44 | A/B | 18-505 | [»] | |
4OO9 | X-ray | 2.60 | A | 569-836 | [»] | |
5CGC | X-ray | 3.10 | A | 569-836 | [»] | |
5CGD | X-ray | 2.60 | A | 569-836 | [»] | |
6N4X | X-ray | 4.00 | A/B | 20-865 | [»] | |
6N4Y | X-ray | 3.26 | A/B/C/D | 21-571 | [»] | |
6N50 | X-ray | 3.75 | A/B/C | 21-571 | [»] | |
6N51 | electron microscopy | 4.00 | A/B | 23-826 | [»] | |
6N52 | electron microscopy | 4.00 | A/B | 20-839 | [»] | |
SMRi | P41594 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109172, 10 interactors |
IntActi | P41594, 5 interactors |
STRINGi | 9606.ENSP00000306138 |
Chemistry databases
BindingDBi | P41594 |
ChEMBLi | CHEMBL3227 |
DrugBanki | DB00659, Acamprosate DB05070, ADX10059 DB12733, Dipraglurant DB06201, Rufinamide |
DrugCentrali | P41594 |
GuidetoPHARMACOLOGYi | 293 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P41594, 6 sites |
iPTMneti | P41594 |
PhosphoSitePlusi | P41594 |
Polymorphism and mutation databases
BioMutai | GRM5 |
DMDMi | 1709020 |
Proteomic databases
jPOSTi | P41594 |
MassIVEi | P41594 |
PaxDbi | P41594 |
PeptideAtlasi | P41594 |
PRIDEi | P41594 |
ProteomicsDBi | 55471 [P41594-1] 55472 [P41594-2] 66504 |
Protocols and materials databases
ABCDi | P41594, 5 sequenced antibodies |
Antibodypediai | 2950, 535 antibodies |
Genome annotation databases
Ensembli | ENST00000305432; ENSP00000305905; ENSG00000168959 [P41594-2] ENST00000305447; ENSP00000306138; ENSG00000168959 [P41594-1] ENST00000455756; ENSP00000405690; ENSG00000168959 [P41594-2] |
GeneIDi | 2915 |
KEGGi | hsa:2915 |
UCSCi | uc001pcq.4, human [P41594-1] |
Organism-specific databases
CTDi | 2915 |
DisGeNETi | 2915 |
EuPathDBi | HostDB:ENSG00000168959.14 |
GeneCardsi | GRM5 |
HGNCi | HGNC:4597, GRM5 |
HPAi | ENSG00000168959, Tissue enriched (brain) |
MIMi | 604102, gene |
neXtProti | NX_P41594 |
OpenTargetsi | ENSG00000168959 |
PharmGKBi | PA28994 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT01010000222410 |
HOGENOMi | CLU_005389_0_1_1 |
InParanoidi | P41594 |
OMAi | SLCPGYQ |
OrthoDBi | 107675at2759 |
PhylomeDBi | P41594 |
TreeFami | TF313240 |
Enzyme and pathway databases
PathwayCommonsi | P41594 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-6794361, Neurexins and neuroligins |
SignaLinki | P41594 |
SIGNORi | P41594 |
Miscellaneous databases
BioGRID-ORCSi | 2915, 5 hits in 845 CRISPR screens |
ChiTaRSi | GRM5, human |
EvolutionaryTracei | P41594 |
GenomeRNAii | 2915 |
Pharosi | P41594, Tchem |
PROi | PR:P41594 |
RNActi | P41594, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168959, Expressed in frontal cortex and 124 other tissues |
ExpressionAtlasi | P41594, baseline and differential |
Genevisiblei | P41594, HS |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR000202, GPCR_3_mtglu_rcpt_5 IPR019588, Metabotropic_Glu_rcpt_Homer-bd IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF10606, GluR_Homer-bdg, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01055, MTABOTROPC5R PR00593, MTABOTROPICR |
SMARTi | View protein in SMART SM01229, GluR_Homer-bdg, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GRM5_HUMAN | |
Accessioni | P41594Primary (citable) accession number: P41594 Secondary accession number(s): Q6J164 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries