UniProtKB - P41594 (GRM5_HUMAN)

BLAST

>sp|P41594|GRM5_HUMAN Metabotropic glutamate receptor 5 OS=Homo sapiens OX=9606 GN=GRM5 PE=1 SV=2
MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAV
REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS
EEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLS
DKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGI
CIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFL
LLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQ
HRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP
GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD
YINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKEN
EYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVV
FIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYS
ALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIM
HDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYT
TCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS
TVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMG
NGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRG
LGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPS
PISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMML
STAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAA
RESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTL
IIRDYTQSSSSL

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History
Entry version 175 (07 Nov 2018)
Sequence version 2 (01 Oct 1996)
Previous versions | rss
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Protein

Metabotropic glutamate receptor 5

Gene

GRM5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	64	Glutamate1 Publication	1
Binding siteⁱ	152	Glutamate1 Publication	1
Binding siteⁱ	223	Glutamate1 Publication	1
Binding siteⁱ	305	Glutamate1 Publication	1
Binding siteⁱ	396	Glutamate1 Publication	1

GO - Molecular functionⁱ

glutamate receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7908515
G protein-coupled receptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 7908515
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein tyrosine kinase activator activity
Source: ARUK-UCL
Traceable author statementⁱ
- 24012003
protein tyrosine kinase binding Source: ARUK-UCL

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-mediated signaling using intracellular calcium source
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 24012003
cellular response to amyloid-beta
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 24012003
chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 7908515
cognition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23227193
G protein-coupled glutamate receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 7908515
G protein-coupled receptor signaling pathway Source: Reactome
learning Source: Ensembl
learning or memory Source: ARUK-UCL
locomotory behavior Source: Ensembl
modulation of age-related behavioral decline Source: ARUK-UCL
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 7908515
positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
postsynaptic modulation of chemical synaptic transmission Source: Ensembl
regulation of intracellular calcium activated chloride channel activity
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 24012003
regulation of long-term neuronal synaptic plasticity Source: Ensembl
regulation of protein phosphorylation
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 24012003
regulation of synaptic transmission, glutamatergic
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of translation
Source: ARUK-UCL
Traceable author statementⁱ
- 24012003
regulation of translational elongation
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 24012003
synapse organization Source: ARUK-UCL
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-416476 G alpha (q) signalling events R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-6794361 Neurexins and neuroligins
SignaLinkⁱ	P41594
SIGNORⁱ	P41594

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metabotropic glutamate receptor 5 Short name: mGluR5
Gene namesⁱ	Name:GRM5 Synonyms:GPRC1E, MGLUR5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168959.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4597 GRM5
MIMⁱ	604102 gene
neXtProtⁱ	NX_P41594

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 580	Extracellular1 PublicationAdd BLAST	559
Transmembraneⁱ	581 – 603	Helical; Name=1Add BLAST	23
Topological domainⁱ	604 – 613	Cytoplasmic1 Publication	10
Transmembraneⁱ	614 – 636	Helical; Name=2Add BLAST	23
Topological domainⁱ	637 – 644	Extracellular1 Publication	8
Transmembraneⁱ	645 – 667	Helical; Name=3Add BLAST	23
Topological domainⁱ	668 – 693	Cytoplasmic1 PublicationAdd BLAST	26
Transmembraneⁱ	694 – 714	Helical; Name=4Add BLAST	21
Topological domainⁱ	715 – 737	Extracellular1 PublicationAdd BLAST	23
Transmembraneⁱ	738 – 759	Helical; Name=5Add BLAST	22
Topological domainⁱ	760 – 772	Cytoplasmic1 PublicationAdd BLAST	13
Transmembraneⁱ	773 – 795	Helical; Name=6Add BLAST	23
Topological domainⁱ	796 – 798	Extracellular1 Publication	3
Transmembraneⁱ	799 – 820	Helical; Name=7Add BLAST	22
Topological domainⁱ	821 – 1212	Cytoplasmic1 PublicationAdd BLAST	392

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	613	S → A or K: Increased constitutive signaling activity. 1 Publication	1
Mutagenesisⁱ	614	S → D: Decreased constitutive signaling activity. 1 Publication	1
Mutagenesisⁱ	665	K → A: Increased constitutive signaling activity. 1 Publication	1
Mutagenesisⁱ	770	E → A: Increased constitutive signaling activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2915
Open Targets More...OpenTargetsⁱ	ENSG00000168959
PharmGKBⁱ	PA28994

Chemistry databases

ChEMBLⁱ	CHEMBL3227
Drug and drug target database More...DrugBankⁱ	DB00659 Acamprosate DB06060 ADX-48621 DB05070 ADX10059 DB06201 Rufinamide
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	293

Polymorphism and mutation databases

BioMutaⁱ	GRM5
DMDMⁱ	1709020

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000012932	21 – 1212	Metabotropic glutamate receptor 5Add BLAST		1192

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	57 ↔ 99
Glycosylationⁱ	88	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	210	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	241 ↔ 530	By similarity
Disulfide bondⁱ	276 ↔ 278
Disulfide bondⁱ	365 ↔ 381
Glycosylationⁱ	378	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	382	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	419 ↔ 426
Glycosylationⁱ	445	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	511 ↔ 531	By similarity
Disulfide bondⁱ	515 ↔ 534	By similarity
Disulfide bondⁱ	537 ↔ 549	By similarity
Disulfide bondⁱ	552 ↔ 565	By similarity
Disulfide bondⁱ	644 ↔ 733
Glycosylationⁱ	734	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	861	PhosphoserineBy similarity	1
Modified residueⁱ	869	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	925	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	1018	PhosphoserineBy similarity	1
Modified residueⁱ	1020	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	P41594
PeptideAtlas More...PeptideAtlasⁱ	P41594
PRIDEⁱ	P41594
ProteomicsDBⁱ	55471 55472 [P41594-2]

PTM databases

iPTMnetⁱ	P41594
PhosphoSitePlusⁱ	P41594

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168959 Expressed in 113 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_GRM5
ExpressionAtlasⁱ	P41594 baseline and differential
Genevisibleⁱ	P41594 HS

Interactionⁱ

Subunit structureⁱ

The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN (By similarity). Isoform 2 interacts with NECAB2 (PubMed:19694902). Interacts with CAMK2A (PubMed:28130356).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NECAB2	Q7Z6G3	2	EBI-14039683,EBI-950070

With

Entry

#Exp.

IntAct

Notes

NECAB2

Q7Z6G3

EBI-14039683,EBI-950070

GO - Molecular functionⁱ

protein tyrosine kinase binding Source: ARUK-UCL

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109172, 8 interactors
IntActⁱ	P41594, 5 interactors
STRINGⁱ	9606.ENSP00000306138

Chemistry databases

BindingDBⁱ

P41594

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	29 – 31	Combined sources	3
Beta strandⁱ	34 – 41	Combined sources	8
Beta strandⁱ	49 – 51	Combined sources	3
Turnⁱ	52 – 55	Combined sources	4
Turnⁱ	62 – 65	Combined sources	4
Helixⁱ	66 – 81	Combined sources	16
Beta strandⁱ	91 – 97	Combined sources	7
Helixⁱ	102 – 112	Combined sources	11
Beta strandⁱ	143 – 147	Combined sources	5
Helixⁱ	152 – 162	Combined sources	11
Helixⁱ	163 – 165	Combined sources	3
Beta strandⁱ	169 – 173	Combined sources	5
Helixⁱ	177 – 180	Combined sources	4
Turnⁱ	182 – 184	Combined sources	3
Beta strandⁱ	188 – 192	Combined sources	5
Helixⁱ	195 – 208	Combined sources	14
Beta strandⁱ	213 – 219	Combined sources	7
Helixⁱ	222 – 235	Combined sources	14
Turnⁱ	236 – 239	Combined sources	4
Beta strandⁱ	241 – 248	Combined sources	8
Helixⁱ	254 – 267	Combined sources	14
Turnⁱ	268 – 270	Combined sources	3
Beta strandⁱ	273 – 277	Combined sources	5
Helixⁱ	280 – 293	Combined sources	14
Beta strandⁱ	300 – 303	Combined sources	4
Turnⁱ	307 – 309	Combined sources	3
Helixⁱ	311 – 314	Combined sources	4
Helixⁱ	318 – 321	Combined sources	4
Beta strandⁱ	325 – 329	Combined sources	5
Helixⁱ	335 – 342	Combined sources	8
Turnⁱ	346 – 348	Combined sources	3
Helixⁱ	355 – 363	Combined sources	9
Turnⁱ	387 – 390	Combined sources	4
Helixⁱ	397 – 418	Combined sources	22
Helixⁱ	427 – 429	Combined sources	3
Helixⁱ	434 – 441	Combined sources	8
Beta strandⁱ	445 – 447	Combined sources	3
Beta strandⁱ	449 – 451	Combined sources	3
Beta strandⁱ	453 – 455	Combined sources	3
Beta strandⁱ	466 – 475	Combined sources	10
Beta strandⁱ	479 – 488	Combined sources	10
Beta strandⁱ	491 – 494	Combined sources	4
Helixⁱ	569 – 575	Combined sources	7
Helixⁱ	579 – 603	Combined sources	25
Turnⁱ	604 – 606	Combined sources	3
Helixⁱ	608 – 611	Combined sources	4
Helixⁱ	615 – 630	Combined sources	16
Helixⁱ	632 – 635	Combined sources	4
Helixⁱ	641 – 678	Combined sources	38
Helixⁱ	690 – 714	Combined sources	25
Helixⁱ	738 – 760	Combined sources	23
Turnⁱ	761 – 763	Combined sources	3
Helixⁱ	766 – 793	Combined sources	28
Helixⁱ	798 – 817	Combined sources	20
Helixⁱ	819 – 827	Combined sources	9
Turnⁱ	829 – 831	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P41594
SMRⁱ	P41594
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P41594

EvolutionaryTraceⁱ

P41594

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	173 – 175	Glutamate binding		3
Regionⁱ	805 – 809	Allosteric effector binding		5

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 3 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1056 Eukaryota ENOG410XR6W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118884
HOGENOMⁱ	HOG000218636
HOVERGENⁱ	HBG107965
InParanoidⁱ	P41594
KEGG Orthology (KO) More...KOⁱ	K04604
OMAⁱ	DLTGCDP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G177R
PhylomeDBⁱ	P41594
TreeFamⁱ	TF313240

Family and domain databases

Gene3Dⁱ	2.10.50.30, 1 hit
InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR000337 GPCR_3 IPR011500 GPCR_3_9-Cys_dom IPR038550 GPCR_3_9-Cys_sf IPR017978 GPCR_3_C IPR017979 GPCR_3_CS IPR000162 GPCR_3_mtglu_rcpt IPR000202 GPCR_3_mtglu_rcpt_5 IPR019588 Metabotropic_Glu_rcpt_Homer-bd IPR028082 Peripla_BP_I
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00003 7tm_3, 1 hit PF01094 ANF_receptor, 1 hit PF10606 GluR_Homer-bdg, 1 hit PF07562 NCD3G, 1 hit
PRINTSⁱ	PR00248 GPCRMGR PR01055 MTABOTROPC5R PR00593 MTABOTROPICR
SMARTⁱ	View protein in SMART SM01229 GluR_Homer-bdg, 1 hit
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
PROSITEⁱ	View protein in PROSITE PS00979 G_PROTEIN_RECEP_F3_1, 1 hit PS00980 G_PROTEIN_RECEP_F3_2, 1 hit PS00981 G_PROTEIN_RECEP_F3_3, 1 hit PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 2 (identifier: P41594-1) [UniParc]FASTA Add to basket

Also known as: 5b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD 
        60         70         80         90        100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW 
       110        120        130        140        150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG 
       160        170        180        190        200
SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR 
       210        220        230        240        250
AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS 
       260        270        280        290        300
NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL 
       310        320        330        340        350
LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH 
       360        370        380        390        400
RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV 
       410        420        430        440        450
INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS 
       460        470        480        490        500
GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW 
       510        520        530        540        550
SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK 
       560        570        580        590        600
ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV 
       610        620        630        640        650
FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG 
       660        670        680        690        700
IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL 
       710        720        730        740        750
ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL 
       760        770        780        790        800
ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII 
       810        820        830        840        850
TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG 
       860        870        880        890        900
KSSSAASRSS SLVNLWKRRG SSGETLRYKD RRLAQHKSEI ECFTPKGSMG 
       910        920        930        940        950
NGGRATMSSS NGKSVTWAQN EKSSRGQHLW QRLSIHINKK ENPNQTAVIK 
       960        970        980        990       1000
PFPKSTESRG LGAGAGAGGS AGGVGATGGA GCAGAGPGGP ESPDAGPKAL 
      1010       1020       1030       1040       1050
YDVAEAEEHF PAPARPRSPS PISTLSHRAG SASRTDDDVP SLHSEPVARS 
      1060       1070       1080       1090       1100
SSSQGSLMEQ ISSVVTRFTA NISELNSMML STAAPSPGVG APLCSSYLIP 
      1110       1120       1130       1140       1150
KEIQLPTTMT TFAEIQPLPA IEVTGGAQPA AGAQAAGDAA RESPAAGPEA 
      1160       1170       1180       1190       1200
AAAKPDLEEL VALTPPSPFR DSVDSGSTTP NSPVSESALC IPSSPKYDTL 
      1210 
IIRDYTQSSS SL

Length:1,212

Mass (Da):132,469

Last modified:October 1, 1996 - v2

Checksum:ⁱA3C73606681C6A25

Isoform 1 (identifier: P41594-2) [UniParc]FASTA Add to basket

Also known as: 5a

The sequence of this isoform differs from the canonical sequence as follows:
877-908: Missing.

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        10         20         30         40         50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD 
        60         70         80         90        100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW 
       110        120        130        140        150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG 
       160        170        180        190        200
SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR 
       210        220        230        240        250
AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS 
       260        270        280        290        300
NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL 
       310        320        330        340        350
LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH 
       360        370        380        390        400
RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV 
       410        420        430        440        450
INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS 
       460        470        480        490        500
GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW 
       510        520        530        540        550
SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK 
       560        570        580        590        600
ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV 
       610        620        630        640        650
FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG 
       660        670        680        690        700
IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL 
       710        720        730        740        750
ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL 
       760        770        780        790        800
ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII 
       810        820        830        840        850
TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG 
       860        870        880        890        900
KSSSAASRSS SLVNLWKRRG SSGETLSSNG KSVTWAQNEK SSRGQHLWQR 
       910        920        930        940        950
LSIHINKKEN PNQTAVIKPF PKSTESRGLG AGAGAGGSAG GVGATGGAGC 
       960        970        980        990       1000
AGAGPGGPES PDAGPKALYD VAEAEEHFPA PARPRSPSPI STLSHRAGSA 
      1010       1020       1030       1040       1050
SRTDDDVPSL HSEPVARSSS SQGSLMEQIS SVVTRFTANI SELNSMMLST 
      1060       1070       1080       1090       1100
AAPSPGVGAP LCSSYLIPKE IQLPTTMTTF AEIQPLPAIE VTGGAQPAAG 
      1110       1120       1130       1140       1150
AQAAGDAARE SPAAGPEAAA AKPDLEELVA LTPPSPFRDS VDSGSTTPNS 
      1160       1170       1180
PVSESALCIP SSPKYDTLII RDYTQSSSSL

Show »

Length:1,180

Mass (Da):128,874

Checksum:ⁱ3DBACB2E8B341647

Isoform 3 (identifier: P41594-3) [UniParc]FASTA Add to basket

Also known as: 5d

The sequence of this isoform differs from the canonical sequence as follows:
896-1165: Missing.

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MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD 
        60         70         80         90        100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW 
       110        120        130        140        150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG 
       160        170        180        190        200
SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR 
       210        220        230        240        250
AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS 
       260        270        280        290        300
NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL 
       310        320        330        340        350
LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH 
       360        370        380        390        400
RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV 
       410        420        430        440        450
INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS 
       460        470        480        490        500
GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW 
       510        520        530        540        550
SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK 
       560        570        580        590        600
ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV 
       610        620        630        640        650
FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG 
       660        670        680        690        700
IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL 
       710        720        730        740        750
ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL 
       760        770        780        790        800
ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII 
       810        820        830        840        850
TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG 
       860        870        880        890        900
KSSSAASRSS SLVNLWKRRG SSGETLRYKD RRLAQHKSEI ECFTPPSPFR 
       910        920        930        940 
DSVDSGSTTP NSPVSESALC IPSSPKYDTL IIRDYTQSSS SL

Show »

Length:942

Mass (Da):105,432

Checksum:ⁱEF45A35CADD56535

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A8MT20	A8MT20_HUMAN	Metabotropic glutamate receptor 5 Metabotropic glutamate receptor 5	GRM5	298	Annotation score:
H7C223	H7C223_HUMAN	Metabotropic glutamate receptor 5 Metabotropic glutamate receptor 5	GRM5	87	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002030	877 – 908	Missing in isoform 1. 1 PublicationAdd BLAST		32
Alternative sequenceⁱVSP_047710	896 – 1165	Missing in isoform 3. 1 PublicationAdd BLAST		270

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D28538 mRNA Translation: BAA05891.1 D28539 mRNA Translation: BAA05892.1 AY608336 mRNA Translation: AAT37960.1 AP000626 Genomic DNA No translation available. AP001482 Genomic DNA No translation available. AP001828 Genomic DNA No translation available. AP003120 Genomic DNA No translation available. AP006214 Genomic DNA No translation available. AP006215 Genomic DNA No translation available. S64316 mRNA Translation: AAD13954.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44694.1 [P41594-1] CCDS8283.1 [P41594-2]
PIRⁱ	JC2131 JC2132
NCBI Reference Sequences More...RefSeqⁱ	NP_000833.1, NM_000842.4 [P41594-2] NP_001137303.1, NM_001143831.2 [P41594-1] XP_006718891.1, XM_006718828.3 [P41594-1] XP_011541094.1, XM_011542792.1 [P41594-1] XP_016873116.1, XM_017017627.1 [P41594-2]
UniGeneⁱ	Hs.147361 Hs.616625

Genome annotation databases

Ensemblⁱ	ENST00000305432; ENSP00000305905; ENSG00000168959 [P41594-2] ENST00000305447; ENSP00000306138; ENSG00000168959 [P41594-1] ENST00000455756; ENSP00000405690; ENSG00000168959 [P41594-2]
GeneIDⁱ	2915
KEGGⁱ	hsa:2915
UCSC genome browser More...UCSCⁱ	uc001pcq.4 human [P41594-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P41594	Glutamate receptor, metabotropic 5 (Fragment)		MACFA		293	UniRef100_P41594
Metabotropic glutamate receptor 5 isoform b (Fragment)		MACMU		60
Uncharacterized protein (Fragment)		NEOLE		312
P41594-2	cDNA FLJ75523, highly similar to Homo sapiens glutamate receptor, metabotropic 5 (GRM5), mRNA (Fragment)		HUMAN		905	UniRef100_P41594-2

Protein	Similar proteins		Species	Score	Length	Source
P41594	Metabotropic glutamate receptor 5	)	RAT		1203	UniRef90_P31424
Metabotropic glutamate receptor 5		MOUSE		1203
Glutamate metabotropic receptor 5		CANLF		1238
Uncharacterized protein (Fragment)		NEOLE		76
metabotropic glutamate receptor 5		ODORO		220
+91
P41594-2	Isoform 1 of Metabotropic glutamate receptor 5		RAT		1171	UniRef90_P31424-2
Uncharacterized protein		MACMU		1180
Uncharacterized protein		COLAP		1180
Uncharacterized protein		PAPAN		1180
Uncharacterized protein		CERAT		1180
+33
P41594-3	metabotropic glutamate receptor 5 isoform X3		PHYCD		1146	UniRef90_P41594-3
metabotropic glutamate receptor 5 isoform X1		LEPWE		1144
GRM5 variant 9		HUMAN		1141
Metabotropic glutamate receptor 5		RAT		962
metabotropic glutamate receptor 5 isoform X4		LIPVE		942
+19

Protein	Similar proteins		Species	Score	Length	Source
P41594	Metabotropic glutamate receptor 5	)	RAT		1203	UniRef50_P31424
Metabotropic glutamate receptor 5		MOUSE		1203
Glutamate metabotropic receptor 5		CANLF		1238
Uncharacterized protein (Fragment)		NEOLE		76
metabotropic glutamate receptor 5		ODORO		220
+568
P41594-3	Metabotropic glutamate receptor 1	)	RAT		1199	UniRef50_P23385
Metabotropic glutamate receptor 1		MOUSE		1199
Metabotropic glutamate receptor 1	)	HUMAN		1194
Uncharacterized protein		MYOLU		1205
Metabotropic glutamate receptor type I (Fragment)		SHEEP		56
+580

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D28538 mRNA Translation: BAA05891.1 D28539 mRNA Translation: BAA05892.1 AY608336 mRNA Translation: AAT37960.1 AP000626 Genomic DNA No translation available. AP001482 Genomic DNA No translation available. AP001828 Genomic DNA No translation available. AP003120 Genomic DNA No translation available. AP006214 Genomic DNA No translation available. AP006215 Genomic DNA No translation available. S64316 mRNA Translation: AAD13954.1
CCDSⁱ	CCDS44694.1 [P41594-1] CCDS8283.1 [P41594-2]
PIRⁱ	JC2131 JC2132
RefSeqⁱ	NP_000833.1, NM_000842.4 [P41594-2] NP_001137303.1, NM_001143831.2 [P41594-1] XP_006718891.1, XM_006718828.3 [P41594-1] XP_011541094.1, XM_011542792.1 [P41594-1] XP_016873116.1, XM_017017627.1 [P41594-2]
UniGeneⁱ	Hs.147361 Hs.616625

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3LMK	X-ray	2.44	A/B	18-505	[»]
	4OO9	X-ray	2.60	A	569-836	[»]
	5CGC	X-ray	3.10	A	569-836	[»]
	5CGD	X-ray	2.60	A	569-836	[»]
ProteinModelPortalⁱ	P41594
SMRⁱ	P41594
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109172, 8 interactors
IntActⁱ	P41594, 5 interactors
STRINGⁱ	9606.ENSP00000306138

Chemistry databases

BindingDBⁱ	P41594
ChEMBLⁱ	CHEMBL3227
DrugBankⁱ	DB00659 Acamprosate DB06060 ADX-48621 DB05070 ADX10059 DB06201 Rufinamide
GuidetoPHARMACOLOGYⁱ	293

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P41594
PhosphoSitePlusⁱ	P41594

Polymorphism and mutation databases

BioMutaⁱ	GRM5
DMDMⁱ	1709020

Proteomic databases

PaxDbⁱ	P41594
PeptideAtlasⁱ	P41594
PRIDEⁱ	P41594
ProteomicsDBⁱ	55471 55472 [P41594-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000305432; ENSP00000305905; ENSG00000168959 [P41594-2] ENST00000305447; ENSP00000306138; ENSG00000168959 [P41594-1] ENST00000455756; ENSP00000405690; ENSG00000168959 [P41594-2]
GeneIDⁱ	2915
KEGGⁱ	hsa:2915
UCSCⁱ	uc001pcq.4 human [P41594-1]

Organism-specific databases

CTDⁱ	2915
DisGeNETⁱ	2915
EuPathDBⁱ	HostDB:ENSG00000168959.14
GeneCardsⁱ	GRM5
HGNCⁱ	HGNC:4597 GRM5
MIMⁱ	604102 gene
neXtProtⁱ	NX_P41594
OpenTargetsⁱ	ENSG00000168959
PharmGKBⁱ	PA28994
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1056 Eukaryota ENOG410XR6W LUCA
GeneTreeⁱ	ENSGT00760000118884
HOGENOMⁱ	HOG000218636
HOVERGENⁱ	HBG107965
InParanoidⁱ	P41594
KOⁱ	K04604
OMAⁱ	DLTGCDP
OrthoDBⁱ	EOG091G177R
PhylomeDBⁱ	P41594
TreeFamⁱ	TF313240

Enzyme and pathway databases

Reactomeⁱ	R-HSA-416476 G alpha (q) signalling events R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-6794361 Neurexins and neuroligins
SignaLinkⁱ	P41594
SIGNORⁱ	P41594

Miscellaneous databases

ChiTaRSⁱ	GRM5 human
EvolutionaryTraceⁱ	P41594
GenomeRNAiⁱ	2915
Protein Ontology More...PROⁱ	PR:P41594
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168959 Expressed in 113 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_GRM5
ExpressionAtlasⁱ	P41594 baseline and differential
Genevisibleⁱ	P41594 HS

Family and domain databases

Gene3Dⁱ	2.10.50.30, 1 hit
InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR000337 GPCR_3 IPR011500 GPCR_3_9-Cys_dom IPR038550 GPCR_3_9-Cys_sf IPR017978 GPCR_3_C IPR017979 GPCR_3_CS IPR000162 GPCR_3_mtglu_rcpt IPR000202 GPCR_3_mtglu_rcpt_5 IPR019588 Metabotropic_Glu_rcpt_Homer-bd IPR028082 Peripla_BP_I
Pfamⁱ	View protein in Pfam PF00003 7tm_3, 1 hit PF01094 ANF_receptor, 1 hit PF10606 GluR_Homer-bdg, 1 hit PF07562 NCD3G, 1 hit
PRINTSⁱ	PR00248 GPCRMGR PR01055 MTABOTROPC5R PR00593 MTABOTROPICR
SMARTⁱ	View protein in SMART SM01229 GluR_Homer-bdg, 1 hit
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
PROSITEⁱ	View protein in PROSITE PS00979 G_PROTEIN_RECEP_F3_1, 1 hit PS00980 G_PROTEIN_RECEP_F3_2, 1 hit PS00981 G_PROTEIN_RECEP_F3_3, 1 hit PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GRM5_HUMAN
Accessionⁱ	P41594Primary (citable) accession number: P41594 Secondary accession number(s): Q6J164
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - P41594 (GRM5_HUMAN)

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Metabotropic glutamate receptor 5

GRM5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Chemistry databases

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Polymorphism and mutation databases

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Protocols and materials databases

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Enzyme and pathway databases

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Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ