UniProtKB - P41593 (PTH1R_MOUSE)
Protein
Parathyroid hormone/parathyroid hormone-related peptide receptor
Gene
Pth1r
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for parathyroid hormone and for parathyroid hormone-related peptide (PubMed:8197183). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.By similarity1 Publication
GO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- parathyroid hormone receptor activity Source: MGI
- peptide hormone binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein self-association Source: MGI
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: MGI
- aging Source: Ensembl
- bone mineralization Source: MGI
- bone resorption Source: MGI
- cell maturation Source: MGI
- cell surface receptor signaling pathway Source: InterPro
- cellular calcium ion homeostasis Source: MGI
- chondrocyte differentiation Source: MGI
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: MGI
- in utero embryonic development Source: MGI
- negative regulation of cell population proliferation Source: MGI
- ossification Source: MGI
- osteoblast development Source: MGI
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of inositol phosphate biosynthetic process Source: MGI
- skeletal system development Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-373080 Class B/2 (Secretin family receptors) R-MMU-418555 G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Parathyroid hormone/parathyroid hormone-related peptide receptorAlternative name(s): PTH/PTHrP type I receptor Short name: PTH/PTHr receptor Parathyroid hormone 1 receptor Short name: PTH1 receptor |
Gene namesi | Name:Pth1r Synonyms:Pthr, Pthr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97801 Pth1r |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Nucleus
- nucleus Source: MGI
Plasma Membrane
- apical plasma membrane Source: MGI
- basolateral plasma membrane Source: MGI
- brush border membrane Source: MGI
- integral component of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- cell Source: GOC
- cytoplasm Source: MGI
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 188 | ExtracellularSequence analysisAdd BLAST | 162 | |
Transmembranei | 189 – 212 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 213 – 219 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 220 – 239 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 240 – 282 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 283 – 306 | Helical; Name=3Sequence analysisAdd BLAST | 24 | |
Topological domaini | 307 – 320 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 321 – 342 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 343 – 361 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 362 – 382 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 409 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 410 – 428 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 429 – 440 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 441 – 463 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 464 – 591 | CytoplasmicSequence analysisAdd BLAST | 128 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000012846 | 27 – 591 | Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST | 565 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 48 ↔ 117 | By similarity | ||
Disulfide bondi | 108 ↔ 148 | By similarity | ||
Disulfide bondi | 131 ↔ 170 | By similarity | ||
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 161 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | P41593 |
PaxDbi | P41593 |
PRIDEi | P41593 |
PTM databases
iPTMneti | P41593 |
PhosphoSitePlusi | P41593 |
Expressioni
Tissue specificityi
Detected in kidney.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000032492 Expressed in 293 organ(s), highest expression level in proximal tubule |
ExpressionAtlasi | P41593 baseline and differential |
Genevisiblei | P41593 MM |
Interactioni
Subunit structurei
Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8197183). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer.
By similarity1 PublicationGO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
- protein self-association Source: MGI
Protein-protein interaction databases
BioGridi | 202466, 1 interactor |
IntActi | P41593, 1 interactor |
STRINGi | 10090.ENSMUSP00000006005 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 474 – 477 | Important for interaction with G proteinsBy similarity | 4 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000158574 |
HOGENOMi | HOG000008248 |
InParanoidi | P41593 |
KOi | K04585 |
OMAi | SSGHKKW |
OrthoDBi | 651627at2759 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR002170 GPCR_2_parathyroid_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF27 PTHR45620:SF27, 1 hit |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR00249 GPCRSECRETIN PR00393 PTRHORMONER |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P41593-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTARIAPSL ALLLCCPVLS SAYALVDADD VFTKEEQIFL LHRAQAQCDK
60 70 80 90 100
LLKEVLHTAA NIMESDKGWT PASTSGKPRK EKAPGKFYPE SKENKDVPTG
110 120 130 140 150
SRRRGRPCLP EWDNIVCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWEVVPGH NRTWANYSEC LKFMTNETRE REVFDRLGMI YTVGYSMSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHMFLSF MLRAASIFVK DAVLYSGFTL
260 270 280 290 300
DEAERLTEEE LHIIAQVPPP PAAAAVGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTIFGWG LPAVFVAVWV GVRATLANTG
360 370 380 390 400
CWDLSSGHKK WIIQVPILAS VVLNFILFIN IIRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLRST LVLVPLFGVH YTVFMALPYT EVSGTLWQIQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI RKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RAGLSLPLSP RLLPATTNGH SQLPGHAKPG APAIENETIP
560 570 580 590
VTMTVPKDDG FLNGSCSGLD EEASGSARPP PLLQEEWETV M
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JG89 | A0A0G2JG89_MOUSE | Parathyroid hormone/parathyroid hor... | Pth1r | 197 | Annotation score: | ||
A0A0G2JE85 | A0A0G2JE85_MOUSE | Parathyroid hormone/parathyroid hor... | Pth1r | 198 | Annotation score: | ||
A0A0G2JEZ1 | A0A0G2JEZ1_MOUSE | Parathyroid hormone/parathyroid hor... | Pth1r | 54 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 – 28 | DA → TS in AAA40011 (PubMed:8197183).Curated | 2 | |
Sequence conflicti | 464 – 465 | Missing in AAA40011 (PubMed:8197183).Curated | 2 | |
Sequence conflicti | 500 – 501 | VS → GA in CAA55536 (PubMed:7524627).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78936 mRNA Translation: CAA55536.1 L34611 L34610 Genomic DNA Translation: AAA40011.1 BC051981 mRNA Translation: AAH51981.1 |
CCDSi | CCDS52940.1 |
PIRi | I59297 S44203 |
RefSeqi | NP_001077404.1, NM_001083935.1 NP_001077405.1, NM_001083936.1 NP_035329.2, NM_011199.2 |
Genome annotation databases
Ensembli | ENSMUST00000006005; ENSMUSP00000006005; ENSMUSG00000032492 ENSMUST00000166716; ENSMUSP00000132064; ENSMUSG00000032492 ENSMUST00000198865; ENSMUSP00000143298; ENSMUSG00000032492 |
GeneIDi | 19228 |
KEGGi | mmu:19228 |
UCSCi | uc009ruo.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78936 mRNA Translation: CAA55536.1 L34611 L34610 Genomic DNA Translation: AAA40011.1 BC051981 mRNA Translation: AAH51981.1 |
CCDSi | CCDS52940.1 |
PIRi | I59297 S44203 |
RefSeqi | NP_001077404.1, NM_001083935.1 NP_001077405.1, NM_001083936.1 NP_035329.2, NM_011199.2 |
3D structure databases
SMRi | P41593 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 202466, 1 interactor |
IntActi | P41593, 1 interactor |
STRINGi | 10090.ENSMUSP00000006005 |
Chemistry databases
ChEMBLi | CHEMBL1075300 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | P41593 |
PhosphoSitePlusi | P41593 |
Proteomic databases
MaxQBi | P41593 |
PaxDbi | P41593 |
PRIDEi | P41593 |
Genome annotation databases
Ensembli | ENSMUST00000006005; ENSMUSP00000006005; ENSMUSG00000032492 ENSMUST00000166716; ENSMUSP00000132064; ENSMUSG00000032492 ENSMUST00000198865; ENSMUSP00000143298; ENSMUSG00000032492 |
GeneIDi | 19228 |
KEGGi | mmu:19228 |
UCSCi | uc009ruo.1 mouse |
Organism-specific databases
CTDi | 5745 |
MGIi | MGI:97801 Pth1r |
Phylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000158574 |
HOGENOMi | HOG000008248 |
InParanoidi | P41593 |
KOi | K04585 |
OMAi | SSGHKKW |
OrthoDBi | 651627at2759 |
TreeFami | TF315710 |
Enzyme and pathway databases
Reactomei | R-MMU-373080 Class B/2 (Secretin family receptors) R-MMU-418555 G alpha (s) signalling events |
Miscellaneous databases
ChiTaRSi | Pth1r mouse |
PROi | PR:P41593 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032492 Expressed in 293 organ(s), highest expression level in proximal tubule |
ExpressionAtlasi | P41593 baseline and differential |
Genevisiblei | P41593 MM |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR002170 GPCR_2_parathyroid_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF27 PTHR45620:SF27, 1 hit |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR00249 GPCRSECRETIN PR00393 PTRHORMONER |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTH1R_MOUSE | |
Accessioni | P41593Primary (citable) accession number: P41593 Secondary accession number(s): Q62119, Q80WU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | July 27, 2011 | |
Last modified: | November 13, 2019 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot