UniProtKB - P41587 (VIPR2_HUMAN)
Protein
Vasoactive intestinal polypeptide receptor 2
Gene
VIPR2
Organism
Homo sapiens (Human)
Status
Functioni
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.1 Publication
GO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: ProtInc
- peptide hormone binding Source: GO_Central
- vasoactive intestinal polypeptide receptor activity Source: GO_Central
GO - Biological processi
- activation of adenylate cyclase activity Source: Ensembl
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- cell-cell signaling Source: ProtInc
- cell surface receptor signaling pathway Source: InterPro
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of smooth muscle cell proliferation Source: Ensembl
- signal transduction Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P41587 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Names & Taxonomyi
Protein namesi | Recommended name: Vasoactive intestinal polypeptide receptor 2Short name: VIP-R-2 Alternative name(s): Helodermin-preferring VIP receptor Pituitary adenylate cyclase-activating polypeptide type III receptor Short name: PACAP type III receptor Short name: PACAP-R-3 Short name: PACAP-R3 VPAC2 |
Gene namesi | Name:VIPR2 Synonyms:VIP2R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106018.13 |
HGNCi | HGNC:12695, VIPR2 |
MIMi | 601970, gene |
neXtProti | NX_P41587 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 126 | ExtracellularSequence analysisAdd BLAST | 103 | |
Transmembranei | 127 – 151 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 152 – 158 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 159 – 178 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 179 – 203 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 204 – 227 | Helical; Name=3Sequence analysisAdd BLAST | 24 | |
Topological domaini | 228 – 240 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 241 – 262 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 263 – 279 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 280 – 303 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 304 – 328 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 329 – 348 | Helical; Name=6Sequence analysisAdd BLAST | 20 | |
Topological domaini | 349 – 360 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 361 – 380 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 381 – 438 | CytoplasmicSequence analysisAdd BLAST | 58 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 7434 |
MalaCardsi | VIPR2 |
OpenTargetsi | ENSG00000106018 |
PharmGKBi | PA37314 |
Miscellaneous databases
Pharosi | P41587, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4532 |
GuidetoPHARMACOLOGYi | 372 |
Polymorphism and mutation databases
BioMutai | VIPR2 |
DMDMi | 2506490 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000012860 | 24 – 438 | Vasoactive intestinal polypeptide receptor 2Add BLAST | 415 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 61 | 1 Publication | ||
Disulfide bondi | 52 ↔ 93 | 1 Publication | ||
Glycosylationi | 58 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 75 ↔ 109 | 1 Publication | ||
Glycosylationi | 88 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 92 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 202 ↔ 271 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P41587 |
PaxDbi | P41587 |
PeptideAtlasi | P41587 |
PRIDEi | P41587 |
ProteomicsDBi | 55470 [P41587-1] 67967 |
PTM databases
GlyGeni | P41587, 3 sites |
iPTMneti | P41587 |
PhosphoSitePlusi | P41587 |
Expressioni
Tissue specificityi
Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78.1 Publication
Gene expression databases
Bgeei | ENSG00000106018, Expressed in esophagus and 150 other tissues |
ExpressionAtlasi | P41587, baseline and differential |
Genevisiblei | P41587, HS |
Organism-specific databases
HPAi | ENSG00000106018, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 113275, 103 interactors |
IntActi | P41587, 96 interactors |
MINTi | P41587 |
STRINGi | 9606.ENSP00000262178 |
Chemistry databases
BindingDBi | P41587 |
Miscellaneous databases
RNActi | P41587, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P41587 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158089 |
HOGENOMi | CLU_002753_4_4_1 |
InParanoidi | P41587 |
OMAi | KACTGVW |
OrthoDBi | 651627at2759 |
PhylomeDBi | P41587 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR001571, GPCR_2_VIP_rcpt IPR002284, GPCR_2_VIP_rcpt_2 |
PANTHERi | PTHR45620:SF22, PTHR45620:SF22, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00491, VASOACTVEIPR PR01155, VIP2RECEPTOR |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P41587-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRTLLPPALL TCWLLAPVNS IHPECRFHLE IQEEETKCAE LLRSQTEKHK
60 70 80 90 100
ACSGVWDNIT CWRPANVGET VTVPCPKVFS NFYSKAGNIS KNCTSDGWSE
110 120 130 140 150
TFPDFVDACG YSDPEDESKI TFYILVKAIY TLGYSVSLMS LATGSIILCL
160 170 180 190 200
FRKLHCTRNY IHLNLFLSFI LRAISVLVKD DVLYSSSGTL HCPDQPSSWV
210 220 230 240 250
GCKLSLVFLQ YCIMANFFWL LVEGLYLHTL LVAMLPPRRC FLAYLLIGWG
260 270 280 290 300
LPTVCIGAWT AARLYLEDTG CWDTNDHSVP WWVIRIPILI SIIVNFVLFI
310 320 330 340 350
SIIRILLQKL TSPDVGGNDQ SQYKRLAKST LLLIPLFGVH YMVFAVFPIS
360 370 380 390 400
ISSKYQILFE LCLGSFQGLV VAVLYCFLNS EVQCELKRKW RSRCPTPSAS
410 420 430
RDYRVCGSSF SRNGSEGALQ FHRGSRAQSF LQTETSVI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JCP7 | C9JCP7_HUMAN | Vasoactive intestinal polypeptide r... | VIPR2 | 579 | Annotation score: | ||
E9PCR5 | E9PCR5_HUMAN | Vasoactive intestinal polypeptide r... | VIPR2 | 77 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 424 | G → A in AAC37569 (PubMed:7811244).Curated | 1 | |
Sequence conflicti | 424 | G → A in AAC41756 (PubMed:7811244).Curated | 1 | |
Sequence conflicti | 424 | G → A in AAC50872 (PubMed:8933357).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011811 | 39 | A → T. Corresponds to variant dbSNP:rs1062609Ensembl. | 1 | |
Natural variantiVAR_011812 | 412 | R → H. Corresponds to variant dbSNP:rs1042620Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056684 | 1 – 103 | MRTLL…SETFP → MPLWEAPSDHPANPPATLQG HTSLPGCQEEPARDPQSGLP QITSESSSFSEGSLPSWSSG PAGAKLNASHEGIGSSSDGN GDSKAATERVVSAMDTVRRK HPE in isoform 2. 1 PublicationAdd BLAST | 103 | |
Alternative sequenceiVSP_056685 | 104 – 119 | Missing in isoform 2. 1 PublicationAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36566 mRNA Translation: AAC37569.1 L40764 Genomic DNA Translation: AAC41756.1 U18810 mRNA Translation: AAC50872.1 X95097 mRNA Translation: CAA64474.1 Y18423 , Y18424, Y18425, Y18426, Y18427, Y18428, Y18429, Y18430, Y18431 Genomic DNA Translation: CAB41899.1 BT007118 mRNA Translation: AAP35782.1 AK131406 mRNA Translation: BAD18553.1 AC004863 Genomic DNA No translation available. AC007269 Genomic DNA No translation available. AF027390 Genomic DNA No translation available. CH236954 Genomic DNA Translation: EAL23936.1 CH471149 Genomic DNA Translation: EAX04596.1 BC010569 mRNA Translation: AAH10569.1 |
CCDSi | CCDS5950.1 [P41587-1] CCDS78295.1 [P41587-2] |
PIRi | G02822 |
RefSeqi | NP_001291451.1, NM_001304522.1 NP_001295188.1, NM_001308259.1 [P41587-2] NP_003373.2, NM_003382.4 [P41587-1] |
Genome annotation databases
Ensembli | ENST00000262178; ENSP00000262178; ENSG00000106018 [P41587-1] ENST00000377633; ENSP00000366860; ENSG00000106018 [P41587-2] |
GeneIDi | 7434 |
KEGGi | hsa:7434 |
UCSCi | uc064jts.1, human [P41587-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36566 mRNA Translation: AAC37569.1 L40764 Genomic DNA Translation: AAC41756.1 U18810 mRNA Translation: AAC50872.1 X95097 mRNA Translation: CAA64474.1 Y18423 , Y18424, Y18425, Y18426, Y18427, Y18428, Y18429, Y18430, Y18431 Genomic DNA Translation: CAB41899.1 BT007118 mRNA Translation: AAP35782.1 AK131406 mRNA Translation: BAD18553.1 AC004863 Genomic DNA No translation available. AC007269 Genomic DNA No translation available. AF027390 Genomic DNA No translation available. CH236954 Genomic DNA Translation: EAL23936.1 CH471149 Genomic DNA Translation: EAX04596.1 BC010569 mRNA Translation: AAH10569.1 |
CCDSi | CCDS5950.1 [P41587-1] CCDS78295.1 [P41587-2] |
PIRi | G02822 |
RefSeqi | NP_001291451.1, NM_001304522.1 NP_001295188.1, NM_001308259.1 [P41587-2] NP_003373.2, NM_003382.4 [P41587-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2X57 | X-ray | 2.10 | A/B/C | 26-118 | [»] | |
SMRi | P41587 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113275, 103 interactors |
IntActi | P41587, 96 interactors |
MINTi | P41587 |
STRINGi | 9606.ENSP00000262178 |
Chemistry databases
BindingDBi | P41587 |
ChEMBLi | CHEMBL4532 |
GuidetoPHARMACOLOGYi | 372 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P41587, 3 sites |
iPTMneti | P41587 |
PhosphoSitePlusi | P41587 |
Polymorphism and mutation databases
BioMutai | VIPR2 |
DMDMi | 2506490 |
Proteomic databases
MassIVEi | P41587 |
PaxDbi | P41587 |
PeptideAtlasi | P41587 |
PRIDEi | P41587 |
ProteomicsDBi | 55470 [P41587-1] 67967 |
Protocols and materials databases
Antibodypediai | 18979, 318 antibodies |
DNASUi | 7434 |
Genome annotation databases
Ensembli | ENST00000262178; ENSP00000262178; ENSG00000106018 [P41587-1] ENST00000377633; ENSP00000366860; ENSG00000106018 [P41587-2] |
GeneIDi | 7434 |
KEGGi | hsa:7434 |
UCSCi | uc064jts.1, human [P41587-1] |
Organism-specific databases
CTDi | 7434 |
DisGeNETi | 7434 |
EuPathDBi | HostDB:ENSG00000106018.13 |
GeneCardsi | VIPR2 |
HGNCi | HGNC:12695, VIPR2 |
HPAi | ENSG00000106018, Low tissue specificity |
MalaCardsi | VIPR2 |
MIMi | 601970, gene |
neXtProti | NX_P41587 |
OpenTargetsi | ENSG00000106018 |
PharmGKBi | PA37314 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158089 |
HOGENOMi | CLU_002753_4_4_1 |
InParanoidi | P41587 |
OMAi | KACTGVW |
OrthoDBi | 651627at2759 |
PhylomeDBi | P41587 |
TreeFami | TF315710 |
Enzyme and pathway databases
PathwayCommonsi | P41587 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Miscellaneous databases
BioGRID-ORCSi | 7434, 3 hits in 842 CRISPR screens |
ChiTaRSi | VIPR2, human |
GeneWikii | VIPR2 |
GenomeRNAii | 7434 |
Pharosi | P41587, Tchem |
PROi | PR:P41587 |
RNActi | P41587, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106018, Expressed in esophagus and 150 other tissues |
ExpressionAtlasi | P41587, baseline and differential |
Genevisiblei | P41587, HS |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR001571, GPCR_2_VIP_rcpt IPR002284, GPCR_2_VIP_rcpt_2 |
PANTHERi | PTHR45620:SF22, PTHR45620:SF22, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00491, VASOACTVEIPR PR01155, VIP2RECEPTOR |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VIPR2_HUMAN | |
Accessioni | P41587Primary (citable) accession number: P41587 Secondary accession number(s): Q13053 Q9UCW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries