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UniProtKB - P41587 (VIPR2_HUMAN)

Entry version 181 (02 Jun 2021)
Sequence version 2 (01 Nov 1997)
Previous versions | rss
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Protein

Vasoactive intestinal polypeptide receptor 2

Gene

VIPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P41587

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418555, G alpha (s) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 2
Short name:
VIP-R-2
Alternative name(s):
Helodermin-preferring VIP receptor
Pituitary adenylate cyclase-activating polypeptide type III receptor
Short name:
PACAP type III receptor
Short name:
PACAP-R-3
Short name:
PACAP-R3
VPAC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VIPR2
Synonyms:VIP2R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12695, VIPR2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601970, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P41587

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000106018.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 126ExtracellularSequence analysisAdd BLAST103
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei127 – 151Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini152 – 158CytoplasmicSequence analysis7
Transmembranei159 – 178Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini179 – 203ExtracellularSequence analysisAdd BLAST25
Transmembranei204 – 227Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini228 – 240CytoplasmicSequence analysisAdd BLAST13
Transmembranei241 – 262Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini263 – 279ExtracellularSequence analysisAdd BLAST17
Transmembranei280 – 303Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini304 – 328CytoplasmicSequence analysisAdd BLAST25
Transmembranei329 – 348Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini349 – 360ExtracellularSequence analysisAdd BLAST12
Transmembranei361 – 380Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini381 – 438CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7434

MalaCards human disease database

More...MalaCardsi		VIPR2

Open Targets

More...OpenTargetsi		ENSG00000106018

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37314

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P41587, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4532

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		372

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VIPR2

Domain mapping of disease mutations (DMDM)

More...DMDMi		2506490

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001286024 – 438Vasoactive intestinal polypeptide receptor 2Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi38 ↔ 611 Publication
Disulfide bondi52 ↔ 931 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi75 ↔ 1091 Publication
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi202 ↔ 271By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P41587

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P41587

PeptideAtlas

More...PeptideAtlasi		P41587

PRoteomics IDEntifications database

More...PRIDEi		P41587

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55470 [P41587-1]
67967

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P41587, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P41587

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P41587

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106018, Expressed in esophagus and 151 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P41587, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P41587, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000106018, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113275, 105 interactors

Protein interaction database and analysis system

More...IntActi		P41587, 96 interactors

Molecular INTeraction database

More...MINTi		P41587

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262178

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P41587

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P41587, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1438
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P41587

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4564, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158089

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002753_4_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P41587

Identification of Orthologs from Complete Genome Data

More...OMAi		KACTGVW

Database of Orthologous Groups

More...OrthoDBi		651627at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P41587

TreeFam database of animal gene trees

More...TreeFami		TF315710

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR001571, GPCR_2_VIP_rcpt
IPR002284, GPCR_2_VIP_rcpt_2

The PANTHER Classification System

More...PANTHERi		PTHR45620:SF22, PTHR45620:SF22, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF02793, HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00249, GPCRSECRETIN
PR00491, VASOACTVEIPR
PR01155, VIP2RECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00008, HormR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111418, SSF111418, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00649, G_PROTEIN_RECEP_F2_1, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRTLLPPALL TCWLLAPVNS IHPECRFHLE IQEEETKCAE LLRSQTEKHK 
        60         70         80         90        100
ACSGVWDNIT CWRPANVGET VTVPCPKVFS NFYSKAGNIS KNCTSDGWSE 
       110        120        130        140        150
TFPDFVDACG YSDPEDESKI TFYILVKAIY TLGYSVSLMS LATGSIILCL 
       160        170        180        190        200
FRKLHCTRNY IHLNLFLSFI LRAISVLVKD DVLYSSSGTL HCPDQPSSWV 
       210        220        230        240        250
GCKLSLVFLQ YCIMANFFWL LVEGLYLHTL LVAMLPPRRC FLAYLLIGWG 
       260        270        280        290        300
LPTVCIGAWT AARLYLEDTG CWDTNDHSVP WWVIRIPILI SIIVNFVLFI 
       310        320        330        340        350
SIIRILLQKL TSPDVGGNDQ SQYKRLAKST LLLIPLFGVH YMVFAVFPIS 
       360        370        380        390        400
ISSKYQILFE LCLGSFQGLV VAVLYCFLNS EVQCELKRKW RSRCPTPSAS 
       410        420        430 
RDYRVCGSSF SRNGSEGALQ FHRGSRAQSF LQTETSVI
Length:438
Mass (Da):49,479
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i265A43A70BE09699
GO
Isoform 2 (identifier: P41587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: MRTLLPPALL...TSDGWSETFP → MPLWEAPSDH...MDTVRRKHPE
     104-119: Missing.

Show »
Length:422
Mass (Da):46,756
Checksum:iA05B08247F869DEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JCP7C9JCP7_HUMAN
Vasoactive intestinal polypeptide r...
VIPR2
579Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCR5E9PCR5_HUMAN
Vasoactive intestinal polypeptide r...
VIPR2
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti424G → A in AAC37569 (PubMed:7811244).Curated1
Sequence conflicti424G → A in AAC41756 (PubMed:7811244).Curated1
Sequence conflicti424G → A in AAC50872 (PubMed:8933357).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01181139A → T. Corresponds to variant dbSNP:rs1062609Ensembl.1
Natural variantiVAR_011812412R → H. Corresponds to variant dbSNP:rs1042620Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0566841 – 103MRTLL…SETFP → MPLWEAPSDHPANPPATLQG HTSLPGCQEEPARDPQSGLP QITSESSSFSEGSLPSWSSG PAGAKLNASHEGIGSSSDGN GDSKAATERVVSAMDTVRRK HPE in isoform 2. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_056685104 – 119Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L36566 mRNA Translation: AAC37569.1
L40764 Genomic DNA Translation: AAC41756.1
U18810 mRNA Translation: AAC50872.1
X95097 mRNA Translation: CAA64474.1
Y18423 Y18431 Genomic DNA Translation: CAB41899.1
BT007118 mRNA Translation: AAP35782.1
AK131406 mRNA Translation: BAD18553.1
AC004863 Genomic DNA No translation available.
AC007269 Genomic DNA No translation available.
AF027390 Genomic DNA No translation available.
CH236954 Genomic DNA Translation: EAL23936.1
CH471149 Genomic DNA Translation: EAX04596.1
BC010569 mRNA Translation: AAH10569.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5950.1 [P41587-1]
CCDS78295.1 [P41587-2]

Protein sequence database of the Protein Information Resource

More...PIRi		G02822

NCBI Reference Sequences

More...RefSeqi		NP_001291451.1, NM_001304522.1
NP_001295188.1, NM_001308259.1 [P41587-2]
NP_003373.2, NM_003382.4 [P41587-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262178; ENSP00000262178; ENSG00000106018 [P41587-1]
ENST00000377633; ENSP00000366860; ENSG00000106018 [P41587-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7434

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7434

UCSC genome browser

More...UCSCi		uc064jts.1, human [P41587-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36566 mRNA Translation: AAC37569.1
L40764 Genomic DNA Translation: AAC41756.1
U18810 mRNA Translation: AAC50872.1
X95097 mRNA Translation: CAA64474.1
Y18423 Y18431 Genomic DNA Translation: CAB41899.1
BT007118 mRNA Translation: AAP35782.1
AK131406 mRNA Translation: BAD18553.1
AC004863 Genomic DNA No translation available.
AC007269 Genomic DNA No translation available.
AF027390 Genomic DNA No translation available.
CH236954 Genomic DNA Translation: EAL23936.1
CH471149 Genomic DNA Translation: EAX04596.1
BC010569 mRNA Translation: AAH10569.1
CCDSiCCDS5950.1 [P41587-1]
CCDS78295.1 [P41587-2]
PIRiG02822
RefSeqiNP_001291451.1, NM_001304522.1
NP_001295188.1, NM_001308259.1 [P41587-2]
NP_003373.2, NM_003382.4 [P41587-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X57X-ray2.10A/B/C26-118[»]
SMRiP41587
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113275, 105 interactors
IntActiP41587, 96 interactors
MINTiP41587
STRINGi9606.ENSP00000262178

Chemistry databases

BindingDBiP41587
ChEMBLiCHEMBL4532
GuidetoPHARMACOLOGYi372

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP41587, 3 sites
iPTMnetiP41587
PhosphoSitePlusiP41587

Genetic variation databases

BioMutaiVIPR2
DMDMi2506490

Proteomic databases

MassIVEiP41587
PaxDbiP41587
PeptideAtlasiP41587
PRIDEiP41587
ProteomicsDBi55470 [P41587-1]
67967

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18979, 321 antibodies

The DNASU plasmid repository

More...DNASUi		7434

Genome annotation databases

EnsembliENST00000262178; ENSP00000262178; ENSG00000106018 [P41587-1]
ENST00000377633; ENSP00000366860; ENSG00000106018 [P41587-2]
GeneIDi7434
KEGGihsa:7434
UCSCiuc064jts.1, human [P41587-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7434
DisGeNETi7434

GeneCards: human genes, protein and diseases

More...GeneCardsi		VIPR2
HGNCiHGNC:12695, VIPR2
HPAiENSG00000106018, Low tissue specificity
MalaCardsiVIPR2
MIMi601970, gene
neXtProtiNX_P41587
OpenTargetsiENSG00000106018
PharmGKBiPA37314
VEuPathDBiHostDB:ENSG00000106018.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4564, Eukaryota
GeneTreeiENSGT00940000158089
HOGENOMiCLU_002753_4_4_1
InParanoidiP41587
OMAiKACTGVW
OrthoDBi651627at2759
PhylomeDBiP41587
TreeFamiTF315710

Enzyme and pathway databases

PathwayCommonsiP41587
ReactomeiR-HSA-418555, G alpha (s) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7434, 5 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VIPR2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		VIPR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7434
PharosiP41587, Tchem

Protein Ontology

More...PROi		PR:P41587
RNActiP41587, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000106018, Expressed in esophagus and 151 other tissues
ExpressionAtlasiP41587, baseline and differential
GenevisibleiP41587, HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR001571, GPCR_2_VIP_rcpt
IPR002284, GPCR_2_VIP_rcpt_2
PANTHERiPTHR45620:SF22, PTHR45620:SF22, 1 hit
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF02793, HRM, 1 hit
PRINTSiPR00249, GPCRSECRETIN
PR00491, VASOACTVEIPR
PR01155, VIP2RECEPTOR
SMARTiView protein in SMART
SM00008, HormR, 1 hit
SUPFAMiSSF111418, SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649, G_PROTEIN_RECEP_F2_1, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVIPR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41587
Secondary accession number(s): Q13053
, Q15870, Q53Y09, Q6ZN22, Q9UCW0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: June 2, 2021
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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