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Protein

Pituitary adenylate cyclase-activating polypeptide type I receptor

Gene

ADCYAP1R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-HSA-187024 NGF-independant TRKA activation
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors
SIGNORiP41586

Protein family/group databases

TCDBi9.A.14.4.8 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor
Short name:
PACAP type I receptor
Short name:
PACAP-R-1
Short name:
PACAP-R1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000078549.14
HGNCiHGNC:242 ADCYAP1R1
MIMi102981 gene
neXtProtiNX_P41586

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 155ExtracellularSequence analysisAdd BLAST135
Transmembranei156 – 178Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini179 – 186CytoplasmicSequence analysis8
Transmembranei187 – 205Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini206 – 227ExtracellularSequence analysisAdd BLAST22
Transmembranei228 – 253Helical; Name=3Sequence analysisAdd BLAST26
Topological domaini254 – 268CytoplasmicSequence analysisAdd BLAST15
Transmembranei269 – 291Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini292 – 309ExtracellularSequence analysisAdd BLAST18
Transmembranei310 – 332Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini333 – 350CytoplasmicSequence analysisAdd BLAST18
Transmembranei351 – 371Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini372 – 385ExtracellularSequence analysisAdd BLAST14
Transmembranei386 – 405Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini406 – 468CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi114V → A: Reduced affinity for ADCYAP1. 1 Publication1
Mutagenesisi125E → R: Reduced affinity for ADCYAP1. 2 Publications1
Mutagenesisi128P → A: Reduced affinity for ADCYAP1. 1 Publication1
Mutagenesisi138E → R: Reduced affinity for ADCYAP1. 1 Publication1
Mutagenesisi139Y → A: Strongly reduced affinity for ADCYAP1. 1 Publication1

Organism-specific databases

DisGeNETi117
OpenTargetsiENSG00000078549
PharmGKBiPA24565

Chemistry databases

ChEMBLiCHEMBL5399
GuidetoPHARMACOLOGYi370

Polymorphism and mutation databases

BioMutaiADCYAP1R1
DMDMi1171986

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001284121 – 468Pituitary adenylate cyclase-activating polypeptide type I receptorAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 63
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi54 ↔ 118
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi77 ↔ 134
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei434PhosphoserineBy similarity1
Modified residuei447PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP41586
PeptideAtlasiP41586
PRIDEiP41586
ProteomicsDBi55465
55466 [P41586-2]
55467 [P41586-3]
55468 [P41586-4]
55469 [P41586-5]

PTM databases

iPTMnetiP41586
PhosphoSitePlusiP41586

Expressioni

Tissue specificityi

Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

Gene expression databases

BgeeiENSG00000078549
CleanExiHS_ADCYAP1R1
ExpressionAtlasiP41586 baseline and differential
GenevisibleiP41586 HS

Organism-specific databases

HPAiHPA030739
HPA049877

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with ADCYAP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADCYAP1P185092EBI-15635217,EBI-8588930

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106630, 1 interactor
DIPiDIP-42467N
IntActiP41586, 3 interactors
MINTiP41586

Chemistry databases

BindingDBiP41586

Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 47Combined sources22
Turni48 – 50Combined sources3
Beta strandi72 – 76Combined sources5
Helixi79 – 83Combined sources5
Beta strandi113 – 119Combined sources7
Helixi130 – 134Combined sources5

3D structure databases

ProteinModelPortaliP41586
SMRiP41586
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41586

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 139Important for ligand binding and specificityAdd BLAST15

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118800
HOGENOMiHOG000008249
HOVERGENiHBG008318
InParanoidiP41586
KOiK04587
PhylomeDBiP41586
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR002285 GPCR_2_PACAP_1_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF228 PTHR12011:SF228, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01156 PACAPRECEPTR
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform N (identifier: P41586-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS
60 70 80 90 100
SPGCPGMWDN ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF
110 120 130 140 150
GDSNSLDLSD MGVVSRNCTE DGWSEPFPHY FDACGFDEYE SETGDQDYYY
160 170 180 190 200
LSVKALYTVG YSTSLVTLTT AMVILCRFRK LHCTRNFIHM NLFVSFMLRA
210 220 230 240 250
ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN YFWLFIEGLY
260 270 280 290 300
LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN
310 320 330 340 350
DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR
360 370 380 390 400
LARSTLLLIP LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY
410 420 430 440 450
CFLNGEVQAE IKRKWRSWKV NRYFAVDFKH RHPSLASSGV NGGTQLSILS
460
KSSSQIRMSG LPADNLAT
Length:468
Mass (Da):53,314
Last modified:November 1, 1995 - v1
Checksum:iBB515B84E9F28977
GO
Isoform N-HOP1 (identifier: P41586-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: Y → YFSCVQKCYCKPQRAQQHSCKMSELSTIT

Show »
Length:496
Mass (Da):56,531
Checksum:iCBA040A9924D367A
GO
Isoform S (identifier: P41586-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-109: Missing.

Show »
Length:447
Mass (Da):51,030
Checksum:i71C127C1056CA6AD
GO
Isoform S-HOP1 (identifier: P41586-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-109: Missing.
     348-348: Y → YFSCVQKCYCKPQRAQQHSCKMSELSTIT

Show »
Length:475
Mass (Da):54,248
Checksum:i11ECA8F276CE00B9
GO
Isoform VS (identifier: P41586-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-88: Missing.
     89-109: Missing.

Show »
Length:411
Mass (Da):46,957
Checksum:i614BB6FB467ABD2A
GO

Sequence cautioni

The sequence BAA04466 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform N-HOP1 (identifier: P41586-2)
Sequence conflicti350Missing in AAI43680 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04266953 – 88Missing in isoform VS. CuratedAdd BLAST36
Alternative sequenceiVSP_04267089 – 109Missing in isoform S, isoform S-HOP1 and isoform VS. CuratedAdd BLAST21
Alternative sequenceiVSP_042671348Y → YFSCVQKCYCKPQRAQQHSC KMSELSTIT in isoform N-HOP1 and isoform S-HOP1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17516 mRNA Translation: BAA04466.1 Different initiation.
AB065700 Genomic DNA Translation: BAC05923.1
AY366498 mRNA Translation: AAQ72806.1
AK290046 mRNA Translation: BAF82735.1
AC006466 Genomic DNA No translation available.
BC117116 mRNA Translation: AAI17117.1
BC136267 mRNA Translation: AAI36268.1
BC143679 mRNA Translation: AAI43680.1
CH471073 Genomic DNA Translation: EAW93978.1
U09216 Genomic DNA Translation: AAA19323.1
CCDSiCCDS5433.1 [P41586-1]
CCDS56480.1 [P41586-2]
CCDS56481.1 [P41586-3]
PIRiJN0902
RefSeqiNP_001109.2, NM_001118.4 [P41586-1]
NP_001186564.1, NM_001199635.1 [P41586-2]
NP_001186565.1, NM_001199636.1
NP_001186566.1, NM_001199637.1 [P41586-3]
XP_005249675.1, XM_005249618.4 [P41586-5]
XP_016867226.1, XM_017011737.1 [P41586-4]
UniGeneiHs.377783

Genome annotation databases

EnsembliENST00000304166; ENSP00000306620; ENSG00000078549 [P41586-1]
ENST00000396211; ENSP00000379514; ENSG00000078549 [P41586-2]
ENST00000409363; ENSP00000387335; ENSG00000078549 [P41586-3]
ENST00000614107; ENSP00000483721; ENSG00000078549 [P41586-2]
GeneIDi117
KEGGihsa:117
UCSCiuc003tca.3 human [P41586-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPACR_HUMAN
AccessioniPrimary (citable) accession number: P41586
Secondary accession number(s): A8K1Y1
, B7ZLA7, B8ZZK3, Q17S10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 18, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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