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UniProtKB - P41544 (SYS1_YEAST)
Protein
Protein SYS1
Gene
SYS1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Necessary for the targeting of ARL3 to the Golgi. Involved in protein trafficking. May serve as a receptor for acetylated ARL3.
Miscellaneous
Present with 238 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- Golgi to endosome transport Source: SGD
- Golgi to plasma membrane protein transport Source: SGD
- protein localization to Golgi apparatus Source: SGD
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-6811440, Retrograde transport at the Trans-Golgi-Network |
Names & Taxonomyi
Protein namesi | Recommended name: Protein SYS1 |
Gene namesi | Name:SYS1 Ordered Locus Names:YJL004C ORF Names:J1402, YJR83.17 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003541, SYS1 |
VEuPathDBi | FungiDB:YJL004C |
Subcellular locationi
Golgi apparatus
Cytosol
- cytosol Source: GOC
Golgi apparatus
- integral component of Golgi membrane Source: SGD
- trans-Golgi network Source: SGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 30 – 52 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 53 – 78 | LumenalSequence analysisAdd BLAST | 26 | |
Transmembranei | 79 – 101 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 102 – 105 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 106 – 125 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 126 – 131 | LumenalSequence analysis | 6 | |
Transmembranei | 132 – 154 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 155 – 203 | CytoplasmicSequence analysisAdd BLAST | 49 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213942 | 1 – 203 | Protein SYS1Add BLAST | 203 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 15 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 192 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | P41544 |
PRIDEi | P41544 |
PTM databases
iPTMneti | P41544 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33753, 394 interactors |
DIPi | DIP-2613N |
IntActi | P41544, 39 interactors |
MINTi | P41544 |
STRINGi | 4932.YJL004C |
Miscellaneous databases
RNActi | P41544, protein |
Structurei
3D structure databases
AlphaFoldDBi | P41544 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the SYS1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4697, Eukaryota |
GeneTreei | ENSGT00940000154347 |
HOGENOMi | CLU_081382_1_0_1 |
InParanoidi | P41544 |
OMAi | EYEMVGM |
Family and domain databases
InterProi | View protein in InterPro IPR019185, Integral_membrane_SYS1-rel |
PANTHERi | PTHR12952, PTHR12952, 1 hit |
Pfami | View protein in Pfam PF09801, SYS1, 1 hit |
i Sequence
Sequence statusi: Complete.
P41544-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSIRRYLRV PNELKPSQIF KQDSLSPSKI GLQIVLLQIF YYTTAIVLFY
60 70 80 90 100
CWAKLAGYDL NIKEWLFSWE NIDFTNAYGL SISLLWLLDS LICVFFLTVI
110 120 130 140 150
VGRSKLAWDF AITIHAINFI VVFLYTRKFP SFSWFFLQIL SSLILIFLGT
160 170 180 190 200
WTTRWRELRD TFFEGLVDPN EGEVGLVTPS QQHSNHSELE QSPIQLKDLE
SQI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 149 – 203 | GTWTT…LESQI → ALT in AAA85159 (PubMed:7720878).CuratedAdd BLAST | 55 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U22326 Genomic DNA Translation: AAA85159.1 Z49279 Genomic DNA Translation: CAA89294.1 X87611 Genomic DNA Translation: CAA60918.1 AY558345 Genomic DNA Translation: AAS56671.1 X03449 Genomic DNA Translation: CAA27176.1 BK006943 Genomic DNA Translation: DAA08787.1 |
PIRi | S55184 |
RefSeqi | NP_012530.1, NM_001181438.1 |
Genome annotation databases
EnsemblFungii | YJL004C_mRNA; YJL004C; YJL004C |
GeneIDi | 853453 |
KEGGi | sce:YJL004C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U22326 Genomic DNA Translation: AAA85159.1 Z49279 Genomic DNA Translation: CAA89294.1 X87611 Genomic DNA Translation: CAA60918.1 AY558345 Genomic DNA Translation: AAS56671.1 X03449 Genomic DNA Translation: CAA27176.1 BK006943 Genomic DNA Translation: DAA08787.1 |
PIRi | S55184 |
RefSeqi | NP_012530.1, NM_001181438.1 |
3D structure databases
AlphaFoldDBi | P41544 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33753, 394 interactors |
DIPi | DIP-2613N |
IntActi | P41544, 39 interactors |
MINTi | P41544 |
STRINGi | 4932.YJL004C |
PTM databases
iPTMneti | P41544 |
Proteomic databases
PaxDbi | P41544 |
PRIDEi | P41544 |
Protocols and materials databases
DNASUi | 853453 |
Genome annotation databases
EnsemblFungii | YJL004C_mRNA; YJL004C; YJL004C |
GeneIDi | 853453 |
KEGGi | sce:YJL004C |
Organism-specific databases
SGDi | S000003541, SYS1 |
VEuPathDBi | FungiDB:YJL004C |
Phylogenomic databases
eggNOGi | KOG4697, Eukaryota |
GeneTreei | ENSGT00940000154347 |
HOGENOMi | CLU_081382_1_0_1 |
InParanoidi | P41544 |
OMAi | EYEMVGM |
Enzyme and pathway databases
Reactomei | R-SCE-6811440, Retrograde transport at the Trans-Golgi-Network |
Miscellaneous databases
PROi | PR:P41544 |
RNActi | P41544, protein |
Family and domain databases
InterProi | View protein in InterPro IPR019185, Integral_membrane_SYS1-rel |
PANTHERi | PTHR12952, PTHR12952, 1 hit |
Pfami | View protein in Pfam PF09801, SYS1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYS1_YEAST | |
Accessioni | P41544Primary (citable) accession number: P41544 Secondary accession number(s): D6VWH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names - SIMILARITY comments
Index of protein domains and families