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Protein

Acylphosphatase-1

Gene

ACYP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei26PROSITE-ProRule annotation1
Active sitei44PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

SABIO-RKiP41500

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-1 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, erythrocyte/testis isozyme
Acylphosphatase, organ-common type isozyme
Acylphosphate phosphohydrolase 1
Gene namesi
Name:ACYP1
Synonyms:ACYPE
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:25598 ACYP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001585342 – 101Acylphosphatase-1Add BLAST100
Isoform ACY1 (identifier: P41500-2)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Isoform ACY1 (identifier: P41500-2)
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP41500
PRIDEiP41500

PTM databases

iPTMnetiP41500

Expressioni

Tissue specificityi

Organ-common type isozyme is found in many different tissues.

Gene expression databases

BgeeiENSBTAG00000013992

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018595

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 19Combined sources11
Beta strandi21 – 24Combined sources4
Helixi25 – 35Combined sources11
Beta strandi39 – 44Combined sources6
Beta strandi50 – 57Combined sources8
Helixi58 – 70Combined sources13
Beta strandi77 – 88Combined sources12
Beta strandi95 – 100Combined sources6

3D structure databases

ProteinModelPortaliP41500
SMRiP41500
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41500

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 101Acylphosphatase-likePROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated

Phylogenomic databases

eggNOGiKOG3360 Eukaryota
ENOG41126ER LUCA
GeneTreeiENSGT00390000011103
HOGENOMiHOG000292688
HOVERGENiHBG050454
InParanoidiP41500
KOiK01512
OMAiQNTDQGT
OrthoDBiEOG091G0XR1
TreeFamiTF300288

Family and domain databases

InterProiView protein in InterPro
IPR020456 Acylphosphatase
IPR001792 Acylphosphatase-like_dom
IPR036046 Acylphosphatase-like_dom_sf
IPR017968 Acylphosphatase_CS
PANTHERiPTHR10029 PTHR10029, 1 hit
PfamiView protein in Pfam
PF00708 Acylphosphatase, 1 hit
PRINTSiPR00112 ACYLPHPHTASE
SUPFAMiSSF54975 SSF54975, 1 hit
PROSITEiView protein in PROSITE
PS00150 ACYLPHOSPHATASE_1, 1 hit
PS00151 ACYLPHOSPHATASE_2, 1 hit
PS51160 ACYLPHOSPHATASE_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Note: It is uncertain whether isoform ACY1 is produced by alternative initiation or another biological event.
Isoform ACY2 (identifier: P41500-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMAEGDTLI SVDYEIFGKV QGVFFRKYTQ AEGKKLGLVG WVQNTDQGTV
60 70 80 90 100
QGQLQGPASK VRHMQEWLET KGSPKSHIDR ASFHNEKVIV KLDYTDFQIV

K
Length:101
Mass (Da):11,432
Last modified:January 23, 2007 - v2
Checksum:i92DC05E7BF0D86B7
GO
Isoform ACY1 (identifier: P41500-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Show »
Length:99
Mass (Da):11,214
Checksum:i73DBBF3C27569C06
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0260231 – 2Missing in isoform ACY1. Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114901 mRNA Translation: AAI14902.1
PIRiA61449
RefSeqiNP_001039447.1, NM_001045982.2 [P41500-1]
XP_005212005.1, XM_005211948.3 [P41500-1]
UniGeneiBt.33942

Genome annotation databases

EnsembliENSBTAT00000018595; ENSBTAP00000018595; ENSBTAG00000013992 [P41500-1]
GeneIDi507844
KEGGibta:507844

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiACYP1_BOVIN
AccessioniPrimary (citable) accession number: P41500
Secondary accession number(s): Q1RMH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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