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Protein

Putative type II secretion system protein H

Gene

gspH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7707-MONOMER
MetaCyc:G7707-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein H
Short name:
T2SS protein H
Alternative name(s):
Protein transport protein HofH
Putative general secretion pathway protein H
Gene namesi
Name:gspH
Synonyms:hofH, hopH
Ordered Locus Names:b3329, JW3291
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12887 gspH

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000242161 – 6By similarity6
ChainiPRO_00000242177 – 169Putative type II secretion system protein HAdd BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7N-methylphenylalaninePROSITE-ProRule annotation1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP41443
PRIDEiP41443

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
paaXP760862EBI-1129978,EBI-544692

Protein-protein interaction databases

BioGridi4262246, 206 interactors
IntActiP41443, 4 interactors
STRINGi316385.ECDH10B_3504

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 61Combined sources28
Beta strandi65 – 69Combined sources5
Beta strandi74 – 78Combined sources5
Beta strandi83 – 85Combined sources3
Beta strandi89 – 91Combined sources3
Turni96 – 98Combined sources3
Beta strandi99 – 101Combined sources3
Beta strandi105 – 114Combined sources10
Beta strandi123 – 126Combined sources4
Beta strandi130 – 132Combined sources3
Beta strandi135 – 141Combined sources7
Turni142 – 144Combined sources3
Beta strandi147 – 158Combined sources12
Beta strandi160 – 163Combined sources4
Turni164 – 167Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KNQNMR-A30-169[»]
ProteinModelPortaliP41443
SMRiP41443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP H family.Curated

Phylogenomic databases

eggNOGiENOG41069X0 Bacteria
COG2165 LUCA
HOGENOMiHOG000125353
InParanoidiP41443
KOiK02457
OMAiEEQDSWF

Family and domain databases

InterProiView protein in InterPro
IPR012902 N_methyl_site
IPR022346 T2SS_GspH
IPR002416 T2SS_protein-H
PfamiView protein in Pfam
PF12019 GspH, 1 hit
PF07963 N_methyl, 1 hit
PRINTSiPR00885 BCTERIALGSPH
TIGRFAMsiTIGR02532 IV_pilin_GFxxxE, 1 hit
TIGR01708 typeII_sec_gspH, 1 hit
PROSITEiView protein in PROSITE
PS00409 PROKAR_NTER_METHYL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQQRGFTLL EMMLVLALVA ITASVVLFTY GREDVASTRA RETAARFTAA
60 70 80 90 100
LELAIDRATL SGQPVGIHFS DSAWRIMVPG KTPSAWRWVP LQEDAADESQ
110 120 130 140 150
NDWDEELSIH LQPFKPDDSN QPQVVILADG QITPFSLLMA NAGTGEPLLT
160
LVCSGSWPLD QTLARDTRP
Length:169
Mass (Da):18,565
Last modified:November 1, 1995 - v1
Checksum:iD42B1127FBB81A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58126.1
U00096 Genomic DNA Translation: AAC76354.1
AP009048 Genomic DNA Translation: BAE77962.1
U20786 Genomic DNA Translation: AAA69032.1
PIRiD65126
RefSeqiNP_417788.1, NC_000913.3
WP_001076046.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76354; AAC76354; b3329
BAE77962; BAE77962; BAE77962
GeneIDi947834
KEGGiecj:JW3291
eco:b3329
PATRICifig|1411691.4.peg.3402

Similar proteinsi

Entry informationi

Entry nameiGSPH_ECOLI
AccessioniPrimary (citable) accession number: P41443
Secondary accession number(s): Q2M6Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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