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Protein

Folate transporter 1

Gene

SLC19A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H+-pump.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • folate:anion antiporter activity Source: BHF-UCL
  • folic acid binding Source: GO_Central
  • folic acid transmembrane transporter activity Source: BHF-UCL
  • methotrexate transmembrane transporter activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandFolate-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196757 Metabolism of folate and pterines

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P41440

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.48.1.1 the reduced folate carrier (rfc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Folate transporter 1
Short name:
FOLT
Alternative name(s):
Intestinal folate carrier 1
Short name:
IFC-1
Placental folate transporter
Reduced folate carrier protein
Short name:
RFC
Solute carrier family 19 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC19A1
Synonyms:FLOT1, RFC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173638.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10937 SLC19A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600424 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41440

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 23Cytoplasmic1 PublicationAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 44HelicalCuratedAdd BLAST21
Topological domaini45 – 70Extracellular1 PublicationAdd BLAST26
Transmembranei71 – 89HelicalCuratedAdd BLAST19
Topological domaini90 – 95Cytoplasmic1 Publication6
Transmembranei96 – 116HelicalCuratedAdd BLAST21
Topological domaini117 – 123Extracellular1 Publication7
Transmembranei124 – 144HelicalCuratedAdd BLAST21
Topological domaini145 – 159Cytoplasmic1 PublicationAdd BLAST15
Transmembranei160 – 177HelicalCuratedAdd BLAST18
Topological domaini178 – 186Extracellular1 Publication9
Transmembranei187 – 203HelicalCuratedAdd BLAST17
Topological domaini204 – 259Cytoplasmic1 PublicationAdd BLAST56
Transmembranei260 – 287HelicalCuratedAdd BLAST28
Topological domaini288 – 309Extracellular1 PublicationAdd BLAST22
Transmembranei310 – 327HelicalCuratedAdd BLAST18
Topological domaini328 – 333Cytoplasmic1 Publication6
Transmembranei334 – 354HelicalCuratedAdd BLAST21
Topological domaini355 – 360Extracellular1 Publication6
Transmembranei361 – 378HelicalCuratedAdd BLAST18
Topological domaini379 – 394Cytoplasmic1 PublicationAdd BLAST16
Transmembranei395 – 419HelicalCuratedAdd BLAST25
Topological domaini420 – 433Extracellular1 PublicationAdd BLAST14
Transmembranei434 – 454HelicalCuratedAdd BLAST21
Topological domaini455 – 591Cytoplasmic1 PublicationAdd BLAST137

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6573

MalaCards human disease database

More...
MalaCardsi
SLC19A1

Open Targets

More...
OpenTargetsi
ENSG00000173638

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
413690 Methotrexate toxicity or dose selection

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA327

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4833

Drug and drug target database

More...
DrugBanki
DB00563 Methotrexate
DB06813 Pralatrexate

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1014

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC19A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643280

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001786601 – 591Folate transporter 1Add BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei5PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei225PhosphoserineCombined sources1
Modified residuei474PhosphoserineBy similarity1
Modified residuei485PhosphoserineBy similarity1
Modified residuei499PhosphoserineCombined sources1
Modified residuei503PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Heavily glycosylated.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P41440

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P41440

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41440

PeptideAtlas

More...
PeptideAtlasi
P41440

PRoteomics IDEntifications database

More...
PRIDEi
P41440

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55462
55463 [P41440-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P41440

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P41440

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P41440

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Placenta, liver, and to a much smaller extent, in lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173638 Expressed in 183 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_FLOT1
HS_RFC1
HS_SLC19A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P41440 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P41440 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024802

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112461, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P41440, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000308895

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P41440

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P41440

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3810 Eukaryota
ENOG410XT34 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153519

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000001583

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054198

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41440

KEGG Orthology (KO)

More...
KOi
K14609

Identification of Orthologs from Complete Genome Data

More...
OMAi
HILWNVV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0BSJ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P41440

TreeFam database of animal gene trees

More...
TreeFami
TF313684

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002666 Folate_carrier
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR028339 RFC

The PANTHER Classification System

More...
PANTHERi
PTHR10686 PTHR10686, 1 hit
PTHR10686:SF12 PTHR10686:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01770 Folate_carrier, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028739 Folate_carrier, 1 hit
PIRSF500793 Folate_transporter_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00806 rfc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41440-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP
60 70 80 90 100
YLLGPDKNFT REQVTNEITP VLSYSYLAVL VPVFLLTDYL RYTPVLLLQG
110 120 130 140 150
LSFVSVWLLL LLGHSVAHMQ LMELFYSVTM AARIAYSSYI FSLVRPARYQ
160 170 180 190 200
RVAGYSRAAV LLGVFTSSVL GQLLVTVGRV SFSTLNYISL AFLTFSVVLA
210 220 230 240 250
LFLKRPKRSL FFNRDDRGRC ETSASELERM NPGPGGKLGH ALRVACGDSV
260 270 280 290 300
LARMLRELGD SLRRPQLRLW SLWWVFNSAG YYLVVYYVHI LWNEVDPTTN
310 320 330 340 350
SARVYNGAAD AASTLLGAIT SFAAGFVKIR WARWSKLLIA GVTATQAGLV
360 370 380 390 400
FLLAHTRHPS SIWLCYAAFV LFRGSYQFLV PIATFQIASS LSKELCALVF
410 420 430 440 450
GVNTFFATIV KTIITFIVSD VRGLGLPVRK QFQLYSVYFL ILSIIYFLGA
460 470 480 490 500
MLDGLRHCQR GHHPRQPPAQ GLRSAAEEKA AQALSVQDKG LGGLQPAQSP
510 520 530 540 550
PLSPEDSLGA VGPASLEQRQ SDPYLAQAPA PQAAEFLSPV TTPSPCTLCS
560 570 580 590
AQASGPEAAD ETCPQLAVHP PGVSKLGLQC LPSDGVQNVN Q
Length:591
Mass (Da):64,868
Last modified:December 1, 2000 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0437B1615F5517EB
GO
Isoform 2 (identifier: P41440-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: MVPSSPAVEK...GPDKNFTREQ → MRPQPAEPAPGGRGNEACSIHSE

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):60,034
Checksum:i491A0402C6E9A05F
GO
Isoform 3 (identifier: P41440-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     432-591: FQLYSVYFLI...PSDGVQNVNQ → NEELHVASLS...PVCPSEVCPS

Note: No experimental confirmation available.
Show »
Length:489
Mass (Da):54,262
Checksum:i64D568ECA8030F70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTQ3H3BTQ3_HUMAN
Folate transporter 1
SLC19A1
545Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4T2H0Y4T2_HUMAN
Folate transporter 1
SLC19A1
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKP4C9JKP4_HUMAN
Folate transporter 1
SLC19A1
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8K6C9J8K6_HUMAN
Folate transporter 1
SLC19A1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIL5E9PIL5_HUMAN
Folate transporter 1
SLC19A1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62 – 63EQ → DE (PubMed:7826387).Curated2
Sequence conflicti62 – 63EQ → DE (PubMed:7641195).Curated2
Sequence conflicti268R → P in AAA98442 (PubMed:7826387).Curated1
Sequence conflicti457H → D in AAB35058 (PubMed:7641195).Curated1
Sequence conflicti483A → R in AAB35058 (PubMed:7641195).Curated1
Sequence conflicti549C → S (PubMed:7826387).Curated1
Sequence conflicti549C → S (PubMed:7641195).Curated1
Sequence conflicti549C → S (PubMed:7852378).Curated1
Sequence conflicti549C → S (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02021027H → R5 PublicationsCorresponds to variant dbSNP:rs1051266EnsemblClinVar.1
Natural variantiVAR_052404558A → V. Corresponds to variant dbSNP:rs35786590Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0428911 – 63MVPSS…FTREQ → MRPQPAEPAPGGRGNEACSI HSE in isoform 2. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_044497432 – 591FQLYS…QNVNQ → NEELHVASLSLWKSHLRLAA DTLSSEGSSGSGPRSWFLSP TLRAALHGPVCPSEVCPS in isoform 3. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U15939 mRNA Translation: AAA98442.1
U19720 mRNA Translation: AAC50180.1
S78996 mRNA Translation: AAB35058.1
U17566 mRNA Translation: AAA74914.1
U92873
, U92869, U92870, U92871, U92872 Genomic DNA Translation: AAC26162.1
AF004354 mRNA Translation: AAB61417.1
AK303168 mRNA Translation: BAH13909.1
AK313125 mRNA Translation: BAG35945.1
AL163302 Genomic DNA Translation: CAB90483.1 Sequence problems.
BX322561 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09331.1
BC003068 mRNA Translation: AAH03068.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13725.1 [P41440-1]
CCDS56217.1 [P41440-2]
CCDS56218.1 [P41440-3]

Protein sequence database of the Protein Information Resource

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PIRi
I38924
I52728

NCBI Reference Sequences

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RefSeqi
NP_001192135.1, NM_001205206.1 [P41440-3]
NP_001192136.1, NM_001205207.1 [P41440-2]
NP_919231.1, NM_194255.2 [P41440-1]
XP_011528002.1, XM_011529700.2 [P41440-1]
XP_011528003.1, XM_011529701.2 [P41440-1]
XP_011528004.1, XM_011529702.2 [P41440-1]
XP_011528005.1, XM_011529703.2 [P41440-1]
XP_011528006.1, XM_011529704.2
XP_016883935.1, XM_017028446.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.736903
Hs.84190

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000311124; ENSP00000308895; ENSG00000173638 [P41440-1]
ENST00000380010; ENSP00000369347; ENSG00000173638 [P41440-3]
ENST00000485649; ENSP00000441772; ENSG00000173638 [P41440-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6573

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6573

UCSC genome browser

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UCSCi
uc002zhl.3 human [P41440-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15939 mRNA Translation: AAA98442.1
U19720 mRNA Translation: AAC50180.1
S78996 mRNA Translation: AAB35058.1
U17566 mRNA Translation: AAA74914.1
U92873
, U92869, U92870, U92871, U92872 Genomic DNA Translation: AAC26162.1
AF004354 mRNA Translation: AAB61417.1
AK303168 mRNA Translation: BAH13909.1
AK313125 mRNA Translation: BAG35945.1
AL163302 Genomic DNA Translation: CAB90483.1 Sequence problems.
BX322561 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09331.1
BC003068 mRNA Translation: AAH03068.1
CCDSiCCDS13725.1 [P41440-1]
CCDS56217.1 [P41440-2]
CCDS56218.1 [P41440-3]
PIRiI38924
I52728
RefSeqiNP_001192135.1, NM_001205206.1 [P41440-3]
NP_001192136.1, NM_001205207.1 [P41440-2]
NP_919231.1, NM_194255.2 [P41440-1]
XP_011528002.1, XM_011529700.2 [P41440-1]
XP_011528003.1, XM_011529701.2 [P41440-1]
XP_011528004.1, XM_011529702.2 [P41440-1]
XP_011528005.1, XM_011529703.2 [P41440-1]
XP_011528006.1, XM_011529704.2
XP_016883935.1, XM_017028446.1
UniGeneiHs.736903
Hs.84190

3D structure databases

ProteinModelPortaliP41440
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112461, 6 interactors
IntActiP41440, 4 interactors
STRINGi9606.ENSP00000308895

Chemistry databases

BindingDBiP41440
ChEMBLiCHEMBL4833
DrugBankiDB00563 Methotrexate
DB06813 Pralatrexate
GuidetoPHARMACOLOGYi1014

Protein family/group databases

TCDBi2.A.48.1.1 the reduced folate carrier (rfc) family

PTM databases

iPTMnetiP41440
PhosphoSitePlusiP41440
SwissPalmiP41440

Polymorphism and mutation databases

BioMutaiSLC19A1
DMDMi12643280

Proteomic databases

EPDiP41440
MaxQBiP41440
PaxDbiP41440
PeptideAtlasiP41440
PRIDEiP41440
ProteomicsDBi55462
55463 [P41440-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6573
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311124; ENSP00000308895; ENSG00000173638 [P41440-1]
ENST00000380010; ENSP00000369347; ENSG00000173638 [P41440-3]
ENST00000485649; ENSP00000441772; ENSG00000173638 [P41440-2]
GeneIDi6573
KEGGihsa:6573
UCSCiuc002zhl.3 human [P41440-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6573
DisGeNETi6573
EuPathDBiHostDB:ENSG00000173638.18

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC19A1
HGNCiHGNC:10937 SLC19A1
HPAiHPA024802
MalaCardsiSLC19A1
MIMi600424 gene
neXtProtiNX_P41440
OpenTargetsiENSG00000173638
Orphaneti413690 Methotrexate toxicity or dose selection
PharmGKBiPA327

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3810 Eukaryota
ENOG410XT34 LUCA
GeneTreeiENSGT00940000153519
HOGENOMiHOG000001583
HOVERGENiHBG054198
InParanoidiP41440
KOiK14609
OMAiHILWNVV
OrthoDBiEOG091G0BSJ
PhylomeDBiP41440
TreeFamiTF313684

Enzyme and pathway databases

ReactomeiR-HSA-196757 Metabolism of folate and pterines
SIGNORiP41440

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC19A1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC19A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6573

Protein Ontology

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PROi
PR:P41440

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173638 Expressed in 183 organ(s), highest expression level in blood
CleanExiHS_FLOT1
HS_RFC1
HS_SLC19A1
ExpressionAtlasiP41440 baseline and differential
GenevisibleiP41440 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002666 Folate_carrier
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR028339 RFC
PANTHERiPTHR10686 PTHR10686, 1 hit
PTHR10686:SF12 PTHR10686:SF12, 1 hit
PfamiView protein in Pfam
PF01770 Folate_carrier, 1 hit
PIRSFiPIRSF028739 Folate_carrier, 1 hit
PIRSF500793 Folate_transporter_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00806 rfc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS19A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41440
Secondary accession number(s): B2R7U8
, B7Z8C3, E9PFY4, O00553, O60227, Q13026, Q9BTX8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 1, 2000
Last modified: December 5, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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