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Protein

Folate transporter 1

Gene

SLC19A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H+-pump.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandFolate-binding

Enzyme and pathway databases

ReactomeiR-HSA-196757 Metabolism of folate and pterines
SIGNORiP41440

Protein family/group databases

TCDBi2.A.48.1.1 the reduced folate carrier (rfc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Folate transporter 1
Short name:
FOLT
Alternative name(s):
Intestinal folate carrier 1
Short name:
IFC-1
Placental folate transporter
Reduced folate carrier protein
Short name:
RFC
Solute carrier family 19 member 1
Gene namesi
Name:SLC19A1
Synonyms:FLOT1, RFC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000173638.18
HGNCiHGNC:10937 SLC19A1
MIMi600424 gene
neXtProtiNX_P41440

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23Cytoplasmic1 PublicationAdd BLAST23
Transmembranei24 – 44HelicalCuratedAdd BLAST21
Topological domaini45 – 70Extracellular1 PublicationAdd BLAST26
Transmembranei71 – 89HelicalCuratedAdd BLAST19
Topological domaini90 – 95Cytoplasmic1 Publication6
Transmembranei96 – 116HelicalCuratedAdd BLAST21
Topological domaini117 – 123Extracellular1 Publication7
Transmembranei124 – 144HelicalCuratedAdd BLAST21
Topological domaini145 – 159Cytoplasmic1 PublicationAdd BLAST15
Transmembranei160 – 177HelicalCuratedAdd BLAST18
Topological domaini178 – 186Extracellular1 Publication9
Transmembranei187 – 203HelicalCuratedAdd BLAST17
Topological domaini204 – 259Cytoplasmic1 PublicationAdd BLAST56
Transmembranei260 – 287HelicalCuratedAdd BLAST28
Topological domaini288 – 309Extracellular1 PublicationAdd BLAST22
Transmembranei310 – 327HelicalCuratedAdd BLAST18
Topological domaini328 – 333Cytoplasmic1 Publication6
Transmembranei334 – 354HelicalCuratedAdd BLAST21
Topological domaini355 – 360Extracellular1 Publication6
Transmembranei361 – 378HelicalCuratedAdd BLAST18
Topological domaini379 – 394Cytoplasmic1 PublicationAdd BLAST16
Transmembranei395 – 419HelicalCuratedAdd BLAST25
Topological domaini420 – 433Extracellular1 PublicationAdd BLAST14
Transmembranei434 – 454HelicalCuratedAdd BLAST21
Topological domaini455 – 591Cytoplasmic1 PublicationAdd BLAST137

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6573
MalaCardsiSLC19A1
OpenTargetsiENSG00000173638
Orphaneti306574 Methotrexate dose selection
PharmGKBiPA327

Chemistry databases

ChEMBLiCHEMBL4833
DrugBankiDB00563 Methotrexate
DB06813 Pralatrexate
GuidetoPHARMACOLOGYi1014

Polymorphism and mutation databases

BioMutaiSLC19A1
DMDMi12643280

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001786601 – 591Folate transporter 1Add BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei225PhosphoserineCombined sources1
Modified residuei474PhosphoserineBy similarity1
Modified residuei485PhosphoserineBy similarity1
Modified residuei499PhosphoserineCombined sources1
Modified residuei503PhosphoserineCombined sources1

Post-translational modificationi

Heavily glycosylated.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP41440
MaxQBiP41440
PaxDbiP41440
PeptideAtlasiP41440
PRIDEiP41440
ProteomicsDBi55462
55463 [P41440-2]

PTM databases

iPTMnetiP41440
PhosphoSitePlusiP41440
SwissPalmiP41440

Expressioni

Tissue specificityi

Placenta, liver, and to a much smaller extent, in lung.

Gene expression databases

BgeeiENSG00000173638 Expressed in 183 organ(s), highest expression level in blood
CleanExiHS_FLOT1
HS_RFC1
HS_SLC19A1
ExpressionAtlasiP41440 baseline and differential
GenevisibleiP41440 HS

Organism-specific databases

HPAiHPA024802

Interactioni

Protein-protein interaction databases

BioGridi112461, 6 interactors
IntActiP41440, 4 interactors
STRINGi9606.ENSP00000308895

Chemistry databases

BindingDBiP41440

Structurei

3D structure databases

ProteinModelPortaliP41440
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3810 Eukaryota
ENOG410XT34 LUCA
GeneTreeiENSGT00510000046382
HOGENOMiHOG000001583
HOVERGENiHBG054198
InParanoidiP41440
KOiK14609
OMAiHILWNVV
OrthoDBiEOG091G0BSJ
PhylomeDBiP41440
TreeFamiTF313684

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002666 Folate_carrier
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR028339 RFC
PANTHERiPTHR10686 PTHR10686, 1 hit
PTHR10686:SF12 PTHR10686:SF12, 1 hit
PfamiView protein in Pfam
PF01770 Folate_carrier, 1 hit
PIRSFiPIRSF028739 Folate_carrier, 1 hit
PIRSF500793 Folate_transporter_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00806 rfc, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41440-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP
60 70 80 90 100
YLLGPDKNFT REQVTNEITP VLSYSYLAVL VPVFLLTDYL RYTPVLLLQG
110 120 130 140 150
LSFVSVWLLL LLGHSVAHMQ LMELFYSVTM AARIAYSSYI FSLVRPARYQ
160 170 180 190 200
RVAGYSRAAV LLGVFTSSVL GQLLVTVGRV SFSTLNYISL AFLTFSVVLA
210 220 230 240 250
LFLKRPKRSL FFNRDDRGRC ETSASELERM NPGPGGKLGH ALRVACGDSV
260 270 280 290 300
LARMLRELGD SLRRPQLRLW SLWWVFNSAG YYLVVYYVHI LWNEVDPTTN
310 320 330 340 350
SARVYNGAAD AASTLLGAIT SFAAGFVKIR WARWSKLLIA GVTATQAGLV
360 370 380 390 400
FLLAHTRHPS SIWLCYAAFV LFRGSYQFLV PIATFQIASS LSKELCALVF
410 420 430 440 450
GVNTFFATIV KTIITFIVSD VRGLGLPVRK QFQLYSVYFL ILSIIYFLGA
460 470 480 490 500
MLDGLRHCQR GHHPRQPPAQ GLRSAAEEKA AQALSVQDKG LGGLQPAQSP
510 520 530 540 550
PLSPEDSLGA VGPASLEQRQ SDPYLAQAPA PQAAEFLSPV TTPSPCTLCS
560 570 580 590
AQASGPEAAD ETCPQLAVHP PGVSKLGLQC LPSDGVQNVN Q
Length:591
Mass (Da):64,868
Last modified:December 1, 2000 - v3
Checksum:i0437B1615F5517EB
GO
Isoform 2 (identifier: P41440-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: MVPSSPAVEK...GPDKNFTREQ → MRPQPAEPAPGGRGNEACSIHSE

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):60,034
Checksum:i491A0402C6E9A05F
GO
Isoform 3 (identifier: P41440-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     432-591: FQLYSVYFLI...PSDGVQNVNQ → NEELHVASLS...PVCPSEVCPS

Note: No experimental confirmation available.
Show »
Length:489
Mass (Da):54,262
Checksum:i64D568ECA8030F70
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTQ3H3BTQ3_HUMAN
Folate transporter 1
SLC19A1
545Annotation score:
C9JKP4C9JKP4_HUMAN
Folate transporter 1
SLC19A1
182Annotation score:
H0Y4T2H0Y4T2_HUMAN
Folate transporter 1
SLC19A1
269Annotation score:
C9J8K6C9J8K6_HUMAN
Folate transporter 1
SLC19A1
154Annotation score:
E9PIL5E9PIL5_HUMAN
Folate transporter 1
SLC19A1
60Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62 – 63EQ → DE (PubMed:7826387).Curated2
Sequence conflicti62 – 63EQ → DE (PubMed:7641195).Curated2
Sequence conflicti268R → P in AAA98442 (PubMed:7826387).Curated1
Sequence conflicti457H → D in AAB35058 (PubMed:7641195).Curated1
Sequence conflicti483A → R in AAB35058 (PubMed:7641195).Curated1
Sequence conflicti549C → S (PubMed:7826387).Curated1
Sequence conflicti549C → S (PubMed:7641195).Curated1
Sequence conflicti549C → S (PubMed:7852378).Curated1
Sequence conflicti549C → S (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02021027H → R5 PublicationsCorresponds to variant dbSNP:rs1051266EnsemblClinVar.1
Natural variantiVAR_052404558A → V. Corresponds to variant dbSNP:rs35786590Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428911 – 63MVPSS…FTREQ → MRPQPAEPAPGGRGNEACSI HSE in isoform 2. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_044497432 – 591FQLYS…QNVNQ → NEELHVASLSLWKSHLRLAA DTLSSEGSSGSGPRSWFLSP TLRAALHGPVCPSEVCPS in isoform 3. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15939 mRNA Translation: AAA98442.1
U19720 mRNA Translation: AAC50180.1
S78996 mRNA Translation: AAB35058.1
U17566 mRNA Translation: AAA74914.1
U92873
, U92869, U92870, U92871, U92872 Genomic DNA Translation: AAC26162.1
AF004354 mRNA Translation: AAB61417.1
AK303168 mRNA Translation: BAH13909.1
AK313125 mRNA Translation: BAG35945.1
AL163302 Genomic DNA Translation: CAB90483.1 Sequence problems.
BX322561 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09331.1
BC003068 mRNA Translation: AAH03068.1
CCDSiCCDS13725.1 [P41440-1]
CCDS56217.1 [P41440-2]
CCDS56218.1 [P41440-3]
PIRiI38924
I52728
RefSeqiNP_001192135.1, NM_001205206.1 [P41440-3]
NP_001192136.1, NM_001205207.1 [P41440-2]
NP_919231.1, NM_194255.2 [P41440-1]
XP_011528002.1, XM_011529700.2 [P41440-1]
XP_011528003.1, XM_011529701.2 [P41440-1]
XP_011528004.1, XM_011529702.2 [P41440-1]
XP_011528005.1, XM_011529703.2 [P41440-1]
XP_011528006.1, XM_011529704.2
XP_016883935.1, XM_017028446.1
UniGeneiHs.736903
Hs.84190

Genome annotation databases

EnsembliENST00000311124; ENSP00000308895; ENSG00000173638 [P41440-1]
ENST00000380010; ENSP00000369347; ENSG00000173638 [P41440-3]
ENST00000485649; ENSP00000441772; ENSG00000173638 [P41440-2]
GeneIDi6573
KEGGihsa:6573
UCSCiuc002zhl.3 human [P41440-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15939 mRNA Translation: AAA98442.1
U19720 mRNA Translation: AAC50180.1
S78996 mRNA Translation: AAB35058.1
U17566 mRNA Translation: AAA74914.1
U92873
, U92869, U92870, U92871, U92872 Genomic DNA Translation: AAC26162.1
AF004354 mRNA Translation: AAB61417.1
AK303168 mRNA Translation: BAH13909.1
AK313125 mRNA Translation: BAG35945.1
AL163302 Genomic DNA Translation: CAB90483.1 Sequence problems.
BX322561 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09331.1
BC003068 mRNA Translation: AAH03068.1
CCDSiCCDS13725.1 [P41440-1]
CCDS56217.1 [P41440-2]
CCDS56218.1 [P41440-3]
PIRiI38924
I52728
RefSeqiNP_001192135.1, NM_001205206.1 [P41440-3]
NP_001192136.1, NM_001205207.1 [P41440-2]
NP_919231.1, NM_194255.2 [P41440-1]
XP_011528002.1, XM_011529700.2 [P41440-1]
XP_011528003.1, XM_011529701.2 [P41440-1]
XP_011528004.1, XM_011529702.2 [P41440-1]
XP_011528005.1, XM_011529703.2 [P41440-1]
XP_011528006.1, XM_011529704.2
XP_016883935.1, XM_017028446.1
UniGeneiHs.736903
Hs.84190

3D structure databases

ProteinModelPortaliP41440
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112461, 6 interactors
IntActiP41440, 4 interactors
STRINGi9606.ENSP00000308895

Chemistry databases

BindingDBiP41440
ChEMBLiCHEMBL4833
DrugBankiDB00563 Methotrexate
DB06813 Pralatrexate
GuidetoPHARMACOLOGYi1014

Protein family/group databases

TCDBi2.A.48.1.1 the reduced folate carrier (rfc) family

PTM databases

iPTMnetiP41440
PhosphoSitePlusiP41440
SwissPalmiP41440

Polymorphism and mutation databases

BioMutaiSLC19A1
DMDMi12643280

Proteomic databases

EPDiP41440
MaxQBiP41440
PaxDbiP41440
PeptideAtlasiP41440
PRIDEiP41440
ProteomicsDBi55462
55463 [P41440-2]

Protocols and materials databases

DNASUi6573
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311124; ENSP00000308895; ENSG00000173638 [P41440-1]
ENST00000380010; ENSP00000369347; ENSG00000173638 [P41440-3]
ENST00000485649; ENSP00000441772; ENSG00000173638 [P41440-2]
GeneIDi6573
KEGGihsa:6573
UCSCiuc002zhl.3 human [P41440-1]

Organism-specific databases

CTDi6573
DisGeNETi6573
EuPathDBiHostDB:ENSG00000173638.18
GeneCardsiSLC19A1
HGNCiHGNC:10937 SLC19A1
HPAiHPA024802
MalaCardsiSLC19A1
MIMi600424 gene
neXtProtiNX_P41440
OpenTargetsiENSG00000173638
Orphaneti306574 Methotrexate dose selection
PharmGKBiPA327
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3810 Eukaryota
ENOG410XT34 LUCA
GeneTreeiENSGT00510000046382
HOGENOMiHOG000001583
HOVERGENiHBG054198
InParanoidiP41440
KOiK14609
OMAiHILWNVV
OrthoDBiEOG091G0BSJ
PhylomeDBiP41440
TreeFamiTF313684

Enzyme and pathway databases

ReactomeiR-HSA-196757 Metabolism of folate and pterines
SIGNORiP41440

Miscellaneous databases

ChiTaRSiSLC19A1 human
GeneWikiiSLC19A1
GenomeRNAii6573
PROiPR:P41440
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173638 Expressed in 183 organ(s), highest expression level in blood
CleanExiHS_FLOT1
HS_RFC1
HS_SLC19A1
ExpressionAtlasiP41440 baseline and differential
GenevisibleiP41440 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002666 Folate_carrier
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR028339 RFC
PANTHERiPTHR10686 PTHR10686, 1 hit
PTHR10686:SF12 PTHR10686:SF12, 1 hit
PfamiView protein in Pfam
PF01770 Folate_carrier, 1 hit
PIRSFiPIRSF028739 Folate_carrier, 1 hit
PIRSF500793 Folate_transporter_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00806 rfc, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS19A1_HUMAN
AccessioniPrimary (citable) accession number: P41440
Secondary accession number(s): B2R7U8
, B7Z8C3, E9PFY4, O00553, O60227, Q13026, Q9BTX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 1, 2000
Last modified: October 10, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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