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Protein

Folate receptor gamma

Gene

FOLR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101FolateBy similarity1
Binding sitei105FolateBy similarity1
Binding sitei194FolateBy similarity1

GO - Molecular functioni

  • folic acid binding Source: ProtInc

GO - Biological processi

  • folic acid transport Source: ProtInc
  • neutrophil degranulation Source: Reactome

Keywordsi

Molecular functionReceptor
LigandFolate-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Folate receptor gamma
Short name:
FR-gamma
Alternative name(s):
Folate receptor 3
Gene namesi
Name:FOLR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110203.8
HGNCiHGNC:3795 FOLR3
MIMi602469 gene
neXtProtiNX_P41439

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2352
OpenTargetsiENSG00000110203
PharmGKBiPA28211

Chemistry databases

DrugBankiDB05168 EC145
DB00158 Folic Acid

Polymorphism and mutation databases

BioMutaiFOLR3
DMDMi1169723

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000881024 – 243Folate receptor gammaAdd BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 63By similarity
Disulfide bondi55 ↔ 103By similarity
Disulfide bondi64 ↔ 107By similarity
Disulfide bondi87 ↔ 173By similarity
Disulfide bondi94 ↔ 144By similarity
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 207By similarity
Disulfide bondi137 ↔ 187By similarity
Disulfide bondi150 ↔ 167By similarity
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP41439
PeptideAtlasiP41439
PRIDEiP41439
ProteomicsDBi55460
55461 [P41439-2]

PTM databases

iPTMnetiP41439
PhosphoSitePlusiP41439

Expressioni

Tissue specificityi

Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma.

Gene expression databases

BgeeiENSG00000110203
CleanExiHS_FOLR3
ExpressionAtlasiP41439 baseline and differential
GenevisibleiP41439 HS

Interactioni

Protein-protein interaction databases

BioGridi108635, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP41439
SMRiP41439
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 126Folate bindingBy similarity5
Regioni155 – 160Folate bindingBy similarity6

Sequence similaritiesi

Belongs to the folate receptor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000010470
HOGENOMiHOG000006539
HOVERGENiHBG039612
InParanoidiP41439
KOiK13649
PhylomeDBiP41439

Family and domain databases

InterProiView protein in InterPro
IPR004269 Folate_rcpt
IPR018143 Folate_rcpt-like
IPR032934 FR-gamma
PANTHERiPTHR10517 PTHR10517, 1 hit
PTHR10517:SF17 PTHR10517:SF17, 1 hit
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P41439-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWQMMQLLL LALVTAAGSA QPRSARARTD LLNVCMNAKH HKTQPSPEDE
60 70 80 90 100
LYGQCSPWKK NACCTASTSQ ELHKDTSRLY NFNWDHCGKM EPTCKRHFIQ
110 120 130 140 150
DSCLYECSPN LGPWIRQVNQ SWRKERILNV PLCKEDCERW WEDCRTSYTC
160 170 180 190 200
KSNWHKGWNW TSGINECPAG ALCSTFESYF PTPAALCEGL WSHSFKVSNY
210 220 230 240
SRGSGRCIQM WFDSAQGNPN EEVAKFYAAA MNAGAPSRGI IDS
Length:243
Mass (Da):27,638
Last modified:November 1, 1995 - v1
Checksum:iAC7636EB5355647B
GO
Isoform Short (identifier: P41439-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-243: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:104
Mass (Da):11,827
Checksum:iCA8D27D01000D88F
GO
Isoform 3 (identifier: P41439-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-105: CSPWKKNACC...RHFIQDSCLY → VGAPQGPSPG...SATLSRTAVS

Note: No experimental confirmation available.Curated
Show »
Length:285
Mass (Da):30,899
Checksum:i66EBE907349206CA
GO

Sequence cautioni

The sequence AAH30285 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43T → I in AAH30285 (PubMed:15489334).Curated1
Isoform 3 (identifier: P41439-3)
Sequence conflicti76E → V in AAH30285 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05508955 – 105CSPWK…DSCLY → VGAPQGPSPGSVPLDDLPGA EEPEYGGDGCGGERLSPVSS PPSAVPGRRMPAARPAPARS CTRTPPACTTLTGITVVRWN PPASATLSRTAVS in isoform 3. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_001506105 – 243Missing in isoform Short. CuratedAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32564 mRNA Translation: CAA83553.1
Z32633 mRNA Translation: CAA83566.1
U08471 mRNA Translation: AAA18382.1
U08470 mRNA Translation: AAA18381.1
AP000812 Genomic DNA No translation available.
BC030285 mRNA Translation: AAH30285.1 Different initiation.
PIRiA53506
RefSeqiNP_000795.2, NM_000804.3
NP_001304974.1, NM_001318045.1
UniGeneiHs.352

Genome annotation databases

EnsembliENST00000442948; ENSP00000411161; ENSG00000110203 [P41439-2]
GeneIDi2352
KEGGihsa:2352
UCSCiuc058ezu.1 human [P41439-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFOLR3_HUMAN
AccessioniPrimary (citable) accession number: P41439
Secondary accession number(s): J3KQ90, Q05C14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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