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Entry version 137 (16 Oct 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Reduced folate transporter

Gene

Slc19a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides (PubMed:8276792, PubMed:8664315, PubMed:9111015, PubMed:9748272). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:8276792, PubMed:9111015). Also able to mediate the import of antifolate drug methotrexate (PubMed:8276792, PubMed:8664315, PubMed:9748272). Acts as an importer of cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP (By similarity). Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates (By similarity). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (By similarity).By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.8 µM for N5-methyltetrahydrofolate (at pH 6.2)1 Publication
  2. KM=2.3 µM for N5-methyltetrahydrofolate (at pH 7.4)1 Publication
  1. Vmax=0.8 pmol/min/mg enzyme with N5-methyltetrahydrofolate as substrate (at pH 6.2)1 Publication
  2. Vmax=0.2 pmol/min/mg enzyme with N5-methyltetrahydrofolate as substrate (at pH 7.4)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Transport
LigandFolate-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-196757 Metabolism of folate and pterines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reduced folate transporterCurated
Alternative name(s):
Intestinal folate carrier 11 Publication
Short name:
IFC-11 Publication
Reduced folate carrier 11 Publication
Short name:
RFC-12 Publications
Short name:
RFC11 Publication
Solute carrier family 19 member 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc19a1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:103182 Slc19a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27CytoplasmicBy similarityAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 64ExtracellularBy similarityAdd BLAST16
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 91CytoplasmicBy similarity6
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 121ExtracellularBy similarity9
Transmembranei122 – 142Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini143 – 155CytoplasmicBy similarityAdd BLAST13
Transmembranei156 – 176Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini177 – 180ExtracellularBy similarity4
Transmembranei181 – 201Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini202 – 271CytoplasmicBy similarityAdd BLAST70
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 304ExtracellularBy similarityAdd BLAST12
Transmembranei305 – 325Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini326 – 329CytoplasmicBy similarity4
Transmembranei330 – 350Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini351 – 354ExtracellularBy similarity4
Transmembranei355 – 375Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini376 – 390CytoplasmicBy similarityAdd BLAST15
Transmembranei391 – 411Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini412 – 426ExtracellularBy similarityAdd BLAST15
Transmembranei427 – 447Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini448 – 512CytoplasmicBy similarityAdd BLAST65

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi48I → F: Induces resistance to 5,10-dideazatetrahydrofolate; when associated with G-105. 1 Publication1
Mutagenesisi105W → G: Induces resistance to 5,10-dideazatetrahydrofolate; when associated with F-48. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001786611 – 512Reduced folate transporterAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei467PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P41438

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41438

PeptideAtlas

More...
PeptideAtlasi
P41438

PRoteomics IDEntifications database

More...
PRIDEi
P41438

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P41438

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P41438

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P41438

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000001436 Expressed in 313 organ(s), highest expression level in paneth cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P41438 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P41438 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101050

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni400 – 412Required for substrate-bindingBy similarityAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3810 Eukaryota
ENOG410XT34 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183022

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000001583

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P41438

KEGG Orthology (KO)

More...
KOi
K14609

Identification of Orthologs from Complete Genome Data

More...
OMAi
FNSTGYY

Database of Orthologous Groups

More...
OrthoDBi
795242at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P41438

TreeFam database of animal gene trees

More...
TreeFami
TF313684

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002666 Folate_carrier
IPR036259 MFS_trans_sf
IPR028339 SLC19A1

The PANTHER Classification System

More...
PANTHERi
PTHR10686 PTHR10686, 1 hit
PTHR10686:SF12 PTHR10686:SF12, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01770 Folate_carrier, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028739 Folate_carrier, 1 hit
PIRSF500793 Folate_transporter_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00806 rfc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41438-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPTGQVAEK QAYEEPRQDH ELKSWRCLVF YLCFFGFMAQ LRPGESFITP
60 70 80 90 100
FLLERKFTKE QVTNEIIPML PYSHLAVLVP VFLLTDYLRY KPVLVLQCLS
110 120 130 140 150
FVCVWLLLLL GTSVVHMQLM EVFYSVTMAA RIAYSSYIFS LVHPSRYQRM
160 170 180 190 200
ASYSRAAVLL GVFISSVLGQ ALVTVGHIST YTLNCVSLGF ILFSLVLSLF
210 220 230 240 250
LKRPKRSLFF NRSTLARGAL PCELDQMHPG PDRPETRKLD RMLGTCRDSF
260 270 280 290 300
LVRMLSELVE NARQPQLRLW CLWWVFNSSG YYLITYYVHV LWRSTDSSLS
310 320 330 340 350
YNGAVDAAST LLSAITSFSA GFLSIRWTLW SKLVIAGVIA IQASLVFCMF
360 370 380 390 400
QIRDIWVCYV TFVLFRGAYQ FLVPIATFQI ASSLSKELCA LVFGINTFLA
410 420 430 440 450
TALKTCITLV VSDKRGLGLQ VRDQFRIYFI YFLMLSITCF AWAGLDGLRY
460 470 480 490 500
CQRGRHQPLA QAQELRSPLE TSVQAISLQD GDLRGPQPSA PQLLSEDGME
510
DDRGDLRVEA KA
Length:512
Mass (Da):58,150
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i640CB7AD2624BF67
GO
Isoform 2 (identifier: P41438-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-313: WWVFNSSGYYLITYYVHVLWRSTDSSLSYNGAVDAASTLLS → C

Show »
Length:472
Mass (Da):53,577
Checksum:i4BBD933AD971CE1D
GO
Isoform 3 (identifier: P41438-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-379: FQ → PS
     380-512: Missing.

Show »
Length:379
Mass (Da):43,371
Checksum:i898147C34EB427B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YU74D3YU74_MOUSE
Reduced folate transporter
Slc19a1
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z4F3D3Z4F3_MOUSE
Reduced folate transporter
Slc19a1
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q8X6E9Q8X6_MOUSE
Reduced folate transporter
Slc19a1
476Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YWA3F6YWA3_MOUSE
Reduced folate transporter
Slc19a1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z0I6D3Z0I6_MOUSE
Reduced folate transporter
Slc19a1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZE1D3YZE1_MOUSE
Reduced folate transporter
Slc19a1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006125273 – 313WWVFN…STLLS → C in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_006126378 – 379FQ → PS in isoform 3. 1 Publication2
Alternative sequenceiVSP_006127380 – 512Missing in isoform 3. 1 PublicationAdd BLAST133

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L36539 mRNA Translation: AAB38483.1
L23755 mRNA Translation: AAA39738.1
U32469 mRNA Translation: AAC52258.1
U66103 mRNA Translation: AAC53287.1
U57784
, U57781, U57782, U57783 Genomic DNA Translation: AAC53288.1
U57785
, U57781, U57782, U57783 Genomic DNA Translation: AAC53289.1
U57785
, U57781, U57782, U57783, U57784 Genomic DNA Translation: AAC53290.1
U57785
, U57781, U57782, U57783 Genomic DNA Translation: AAC53291.1
BC015263 mRNA Translation: AAH15263.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35947.1 [P41438-1]

Protein sequence database of the Protein Information Resource

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PIRi
A53092

NCBI Reference Sequences

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RefSeqi
NP_001186200.1, NM_001199271.1 [P41438-1]
NP_112473.1, NM_031196.3 [P41438-1]
XP_006513477.1, XM_006513414.3 [P41438-1]
XP_006513478.1, XM_006513415.3 [P41438-1]
XP_006513479.1, XM_006513416.2 [P41438-1]
XP_006513480.1, XM_006513417.2 [P41438-1]
XP_006513481.1, XM_006513418.3 [P41438-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000105410; ENSMUSP00000101050; ENSMUSG00000001436 [P41438-1]
ENSMUST00000144234; ENSMUSP00000116784; ENSMUSG00000001436 [P41438-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
20509

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20509

UCSC genome browser

More...
UCSCi
uc007fvc.2 mouse [P41438-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36539 mRNA Translation: AAB38483.1
L23755 mRNA Translation: AAA39738.1
U32469 mRNA Translation: AAC52258.1
U66103 mRNA Translation: AAC53287.1
U57784
, U57781, U57782, U57783 Genomic DNA Translation: AAC53288.1
U57785
, U57781, U57782, U57783 Genomic DNA Translation: AAC53289.1
U57785
, U57781, U57782, U57783, U57784 Genomic DNA Translation: AAC53290.1
U57785
, U57781, U57782, U57783 Genomic DNA Translation: AAC53291.1
BC015263 mRNA Translation: AAH15263.1
CCDSiCCDS35947.1 [P41438-1]
PIRiA53092
RefSeqiNP_001186200.1, NM_001199271.1 [P41438-1]
NP_112473.1, NM_031196.3 [P41438-1]
XP_006513477.1, XM_006513414.3 [P41438-1]
XP_006513478.1, XM_006513415.3 [P41438-1]
XP_006513479.1, XM_006513416.2 [P41438-1]
XP_006513480.1, XM_006513417.2 [P41438-1]
XP_006513481.1, XM_006513418.3 [P41438-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101050

PTM databases

iPTMnetiP41438
PhosphoSitePlusiP41438
SwissPalmiP41438

Proteomic databases

jPOSTiP41438
PaxDbiP41438
PeptideAtlasiP41438
PRIDEiP41438

Genome annotation databases

EnsembliENSMUST00000105410; ENSMUSP00000101050; ENSMUSG00000001436 [P41438-1]
ENSMUST00000144234; ENSMUSP00000116784; ENSMUSG00000001436 [P41438-1]
GeneIDi20509
KEGGimmu:20509
UCSCiuc007fvc.2 mouse [P41438-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6573
MGIiMGI:103182 Slc19a1

Phylogenomic databases

eggNOGiKOG3810 Eukaryota
ENOG410XT34 LUCA
GeneTreeiENSGT00950000183022
HOGENOMiHOG000001583
InParanoidiP41438
KOiK14609
OMAiFNSTGYY
OrthoDBi795242at2759
PhylomeDBiP41438
TreeFamiTF313684

Enzyme and pathway databases

ReactomeiR-MMU-196757 Metabolism of folate and pterines

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Slc19a1 mouse

Protein Ontology

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PROi
PR:P41438

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000001436 Expressed in 313 organ(s), highest expression level in paneth cell
ExpressionAtlasiP41438 baseline and differential
GenevisibleiP41438 MM

Family and domain databases

InterProiView protein in InterPro
IPR002666 Folate_carrier
IPR036259 MFS_trans_sf
IPR028339 SLC19A1
PANTHERiPTHR10686 PTHR10686, 1 hit
PTHR10686:SF12 PTHR10686:SF12, 1 hit
PfamiView protein in Pfam
PF01770 Folate_carrier, 1 hit
PIRSFiPIRSF028739 Folate_carrier, 1 hit
PIRSF500793 Folate_transporter_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00806 rfc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS19A1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41438
Secondary accession number(s): Q62450, Q62451
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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