UniProtKB - P41437 (IAP3_NPVOP)
Protein
E3 ubiquitin-protein ligase IAP-3
Gene
IAP3
Organism
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
Status
Functioni
RING-finger E3 ubiquitin ligase required to prevent cellular apoptosis in infected cells. Ubiquitinates and subsquently targets host pro-apoptotic cellular proteins such as HID for degradation by the proteasome.1 Publication
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 148 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 151 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 168 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 175 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 221 – 256 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transferase activity Source: UniProtKB-KW
GO - Biological processi
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Apoptosis, Host-virus interaction, Modulation of host ubiquitin pathway by viral E3 ligase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Protein family/group databases
MEROPSi | I32.010 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase IAP-3 (EC:2.3.2.27)Alternative name(s): IAP-3 RING-type E3 ubiquitin transferase IAP-3Curated |
Gene namesi | Name:IAP3 Synonyms:IAP ORF Names:ORF35 |
Organismi | Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) |
Taxonomic identifieri | 262177 [NCBI] |
Taxonomic lineagei | Viruses › Baculoviridae › Alphabaculovirus |
Virus hosti | Orgyia pseudotsugata (Douglas-fir tussock moth) [TaxID: 33414] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000122371 | 1 – 268 | E3 ubiquitin-protein ligase IAP-3Add BLAST | 268 |
Post-translational modificationi
Auto-ubiquitinated.
Keywords - PTMi
Ubl conjugationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 18 – 84 | BIR 1Add BLAST | 67 | |
Repeati | 111 – 178 | BIR 2Add BLAST | 68 |
Sequence similaritiesi
Belongs to the IAP family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 221 – 256 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 |
Keywords - Domaini
Repeat, Zinc-fingerFamily and domain databases
CDDi | cd00022, BIR, 2 hits |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001370, BIR_rpt IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00653, BIR, 2 hits |
SMARTi | View protein in SMART SM00238, BIR, 2 hits |
PROSITEi | View protein in PROSITE PS01282, BIR_REPEAT_1, 2 hits PS50143, BIR_REPEAT_2, 2 hits PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P41437-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSRAIGAPQ EGADMKNKAA RLGTYTNWPV QFLEPSRMAA SGFYYLGRGD
60 70 80 90 100
EVRCAFCKVE ITNWVRGDDP ETDHKRWAPQ CPFVRNNAHD TPHDRAPPAR
110 120 130 140 150
SAAAHPQYAT EAARLRTFAE WPRGLKQRPE ELAEAGFFYT GQGDKTRCFC
160 170 180 190 200
CDGGLKDWEP DDAPWQQHAR WYDRCEYVLL VKGRDFVQRV MTEACVVRDA
210 220 230 240 250
DNEPHIERPA VEAEVADDRL CKICLGAEKT VCFVPCGHVV ACGKCAAGVT
260
TCPVCRGQLD KAVRMYQV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22564 Genomic DNA Translation: AAB02610.1 U75930 Genomic DNA Translation: AAC59034.1 |
PIRi | A53989 |
RefSeqi | NP_046191.1, NC_001875.2 |
Genome annotation databases
GeneIDi | 912041 |
KEGGi | vg:912041 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22564 Genomic DNA Translation: AAB02610.1 U75930 Genomic DNA Translation: AAC59034.1 |
PIRi | A53989 |
RefSeqi | NP_046191.1, NC_001875.2 |
3D structure databases
SMRi | P41437 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | I32.010 |
Genome annotation databases
GeneIDi | 912041 |
KEGGi | vg:912041 |
Family and domain databases
CDDi | cd00022, BIR, 2 hits |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001370, BIR_rpt IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00653, BIR, 2 hits |
SMARTi | View protein in SMART SM00238, BIR, 2 hits |
PROSITEi | View protein in PROSITE PS01282, BIR_REPEAT_1, 2 hits PS50143, BIR_REPEAT_2, 2 hits PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IAP3_NPVOP | |
Accessioni | P41437Primary (citable) accession number: P41437 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families