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Protein

Ran GTPase-activating protein 1

Gene

rna1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the nuclear Ras-related regulatory protein spi1 (Ran), converting it to the putatively inactive GDP-bound state.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei74Critical residue for GTP hydrolysis1

GO - Molecular functioni

  • GTPase activator activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ran GTPase-activating protein 1
Short name:
Protein rna1
Gene namesi
Name:rna1
ORF Names:SPAC22E12.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC22E12.07
PomBaseiSPAC22E12.07 rna1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567411 – 386Ran GTPase-activating protein 1Add BLAST386

Proteomic databases

MaxQBiP41391
PaxDbiP41391
PRIDEiP41391

PTM databases

iPTMnetiP41391

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi278353, 16 interactors
IntActiP41391, 1 interactor
STRINGi4896.SPAC22E12.07.1

Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP41391
SMRiP41391
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41391

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 48LRR 1Add BLAST26
Repeati85 – 112LRR 2Add BLAST28
Repeati113 – 141LRR 3Add BLAST29
Repeati179 – 206LRR 4Add BLAST28
Repeati207 – 235LRR 5Add BLAST29
Repeati236 – 264LRR 6Add BLAST29
Repeati265 – 293LRR 7Add BLAST29
Repeati294 – 322LRR 8Add BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi323 – 374Asp/Glu-rich (acidic)Add BLAST52

Sequence similaritiesi

Belongs to the RNA1 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000195026
InParanoidiP41391
KOiK14319
OMAiDLETVIC
OrthoDBiEOG092C0KYA
PhylomeDBiP41391

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR027038 RanGap
PANTHERiPTHR24113 PTHR24113, 1 hit

Sequencei

Sequence statusi: Complete.

P41391-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRFSIEGKS LKLDAITTED EKSVFAVLLE DDSVKEIVLS GNTIGTEAAR
60 70 80 90 100
WLSENIASKK DLEIAEFSDI FTGRVKDEIP EALRLLLQAL LKCPKLHTVR
110 120 130 140 150
LSDNAFGPTA QEPLIDFLSK HTPLEHLYLH NNGLGPQAGA KIARALQELA
160 170 180 190 200
VNKKAKNAPP LRSIICGRNR LENGSMKEWA KTFQSHRLLH TVKMVQNGIR
210 220 230 240 250
PEGIEHLLLE GLAYCQELKV LDLQDNTFTH LGSSALAIAL KSWPNLRELG
260 270 280 290 300
LNDCLLSARG AAAVVDAFSK LENIGLQTLR LQYNEIELDA VRTLKTVIDE
310 320 330 340 350
KMPDLLFLEL NGNRFSEEDD VVDEIREVFS TRGRGELDEL DDMEELTDEE
360 370 380
EEDEEEEAES QSPEPETSEE EKEDKELADE LSKAHI
Length:386
Mass (Da):43,236
Last modified:November 1, 1995 - v1
Checksum:i8E1C9C506988A7F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69882 Genomic DNA Translation: CAA49509.1
CU329670 Genomic DNA Translation: CAA93894.1
PIRiS37691
RefSeqiNP_594833.1, NM_001020262.2

Genome annotation databases

EnsemblFungiiSPAC22E12.07.1; SPAC22E12.07.1:pep; SPAC22E12.07
GeneIDi2541863
KEGGispo:SPAC22E12.07

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69882 Genomic DNA Translation: CAA49509.1
CU329670 Genomic DNA Translation: CAA93894.1
PIRiS37691
RefSeqiNP_594833.1, NM_001020262.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5DX-ray2.70C/F/I/L1-386[»]
1K5GX-ray3.10C/F/I/L1-386[»]
1YRGX-ray2.66A/B2-386[»]
2CA6X-ray2.20A/B1-386[»]
ProteinModelPortaliP41391
SMRiP41391
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278353, 16 interactors
IntActiP41391, 1 interactor
STRINGi4896.SPAC22E12.07.1

PTM databases

iPTMnetiP41391

Proteomic databases

MaxQBiP41391
PaxDbiP41391
PRIDEiP41391

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC22E12.07.1; SPAC22E12.07.1:pep; SPAC22E12.07
GeneIDi2541863
KEGGispo:SPAC22E12.07

Organism-specific databases

EuPathDBiFungiDB:SPAC22E12.07
PomBaseiSPAC22E12.07 rna1

Phylogenomic databases

HOGENOMiHOG000195026
InParanoidiP41391
KOiK14319
OMAiDLETVIC
OrthoDBiEOG092C0KYA
PhylomeDBiP41391

Miscellaneous databases

EvolutionaryTraceiP41391
PROiPR:P41391

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR027038 RanGap
PANTHERiPTHR24113 PTHR24113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNA1_SCHPO
AccessioniPrimary (citable) accession number: P41391
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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