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Protein

Nucleoprotein

Gene

N

Organism
Rinderpest virus (strain Kuwait 82/1) (RDV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases.

GO - Molecular functioni

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
NP
Short name:
Protein N
Gene namesi
Name:N
Synonyms:NP
OrganismiRinderpest virus (strain Kuwait 82/1) (RDV)
Taxonomic identifieri39006 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiBos indicus (Zebu) [TaxID: 9915]
Bos taurus (Bovine) [TaxID: 9913]
Bubalus bubalis (Domestic water buffalo) [TaxID: 89462]
Capra hircus (Goat) [TaxID: 9925]
Gazella (gazelles) [TaxID: 9933]
Giraffa camelopardalis (Giraffe) [TaxID: 9894]
Hippopotamus [TaxID: 9832]
Ovis aries (Sheep) [TaxID: 9940]
Suidae (pigs) [TaxID: 9821]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426781 – 525NucleoproteinAdd BLAST525

Proteomic databases

PRIDEiP41359

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. In nucleocapsid, binds the P protein and thereby positions the polymerase on the template (By similarity).By similarity

Structurei

3D structure databases

SMRiP41359
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 400NcoreBy similarityAdd BLAST400
Regioni401 – 525NtailBy similarityAdd BLAST125

Domaini

Ncore is globular and carries regions required for N self-assembly and RNA-binding. Ntail is an intrinsically disordered monomeric domain (By similarity).By similarity

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002021 Paramyx_ncap
PfamiView protein in Pfam
PF00973 Paramyxo_ncap, 1 hit

Sequencei

Sequence statusi: Complete.

P41359-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLLKSLAL FKKNKDKPPL AAGSGGAIRG IKHVIIVPIP GDSSITTRSR
60 70 80 90 100
LLDRLVKMVG DPDISGPKLT GALISILSLF VESPGQLIQR ITDDPDISIK
110 120 130 140 150
LVEVVQSDKT QSGLTFASRG TSMDDEADRY FTYDEPNDGE ERQSYWFENR
160 170 180 190 200
EIQDIEVQDP EGFNMILATI LAQIWILLAK AVTAPDTAAD SELRRWVKYT
210 220 230 240 250
QQRRVIGEFK LDKGWLDTVR NRIAEDLSLR RFMVALILDI KRTPGNKPRI
260 270 280 290 300
AEMICDIDTY IVEAGLASFI LTIKFGIETM YPALGLHEFA GELSTIESLM
310 320 330 340 350
NLYQQMGELA PYMVILENSI QNKFSAGAYP LLWSYAMGVG VELENSMGGL
360 370 380 390 400
NFGRSYFDPA YFRLGQEMVR RSAGKVSSNL ASELGITEEE ARLVSEIAAY
410 420 430 440 450
TGDDRNNRTS GPKQAQVSFL RTDQGGETQN NASKRDEARA PQIRKEARTS
460 470 480 490 500
SKSDKYKEDT DKEPMSPSVK TLIDVDTTPE VDTDPLGSKK SAEALIRLQA
510 520
MASILEDSTF GNDSPRAYND RDLLS
Length:525
Mass (Da):58,253
Last modified:February 1, 1995 - v1
Checksum:i9AD1BD2699AB1F00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34262 Genomic RNA Translation: CAA84017.1
PIRiS47308

Similar proteinsi

Entry informationi

Entry nameiNCAP_RINDU
AccessioniPrimary (citable) accession number: P41359
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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