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Protein

Mannose-binding protein C

Gene

Mbl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processComplement activation lectin pathway, Complement pathway, Immunity, Innate immunity
LigandCalcium, Lectin, Mannose-binding

Enzyme and pathway databases

ReactomeiR-MMU-166662 Lectin pathway of complement activation
R-MMU-166663 Initial triggering of complement

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-binding protein C
Short name:
MBP-C
Alternative name(s):
Mannan-binding protein
RA-reactive factor P28A subunit
Short name:
RARF/P28A
Gene namesi
Name:Mbl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:96924 Mbl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001740519 – 244Mannose-binding protein CAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29InterchainPROSITE-ProRule annotation
Disulfide bondi34InterchainPROSITE-ProRule annotation
Modified residuei434-hydroxyprolineSequence analysis1
Modified residuei584-hydroxyprolineSequence analysis1
Modified residuei694-hydroxyprolineSequence analysis1
Modified residuei784-hydroxyprolineSequence analysis1
Modified residuei814-hydroxyprolineSequence analysis1
Disulfide bondi151 ↔ 240PROSITE-ProRule annotation
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi218 ↔ 232PROSITE-ProRule annotation

Post-translational modificationi

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP41317
PeptideAtlasiP41317
PRIDEiP41317

PTM databases

iPTMnetiP41317
PhosphoSitePlusiP41317

Expressioni

Gene expression databases

BgeeiENSMUSG00000024863 Expressed in 84 organ(s), highest expression level in primary oocyte
CleanExiMM_MBL2
ExpressionAtlasiP41317 baseline and differential
GenevisibleiP41317 MM

Interactioni

Subunit structurei

Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201335, 1 interactor
STRINGi10090.ENSMUSP00000025797

Structurei

3D structure databases

ProteinModelPortaliP41317
SMRiP41317
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 96Collagen-likeAdd BLAST59
Domaini129 – 241C-type lectinPROSITE-ProRule annotationAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili108 – 126By similarityAdd BLAST19

Domaini

The coiled-coil domain mediates trimerization.By similarity

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104102
HOGENOMiHOG000085660
HOVERGENiHBG108270
InParanoidiP41317
KOiK03991
OMAiYSETVTC
OrthoDBiEOG091G0R93
PhylomeDBiP41317
TreeFamiTF330481

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR008160 Collagen
IPR016187 CTDL_fold
IPR037570 Mannose-binding_protein
PANTHERiPTHR24020:SF0 PTHR24020:SF0, 1 hit
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41317-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIFTSFLLL CVVTVVYAET LTEGVQNSCP VVTCSSPGLN GFPGKDGRDG
60 70 80 90 100
AKGEKGEPGQ GLRGLQGPPG KVGPTGPPGN PGLKGAVGPK GDRGDRAEFD
110 120 130 140 150
TSEIDSEIAA LRSELRALRN WVLFSLSEKV GKKYFVSSVK KMSLDRVKAL
160 170 180 190 200
CSEFQGSVAT PRNAEENSAI QKVAKDIAYL GITDVRVEGS FEDLTGNRVR
210 220 230 240
YTNWNDGEPN NTGDGEDCVV ILGNGKWNDV PCSDSFLAIC EFSD
Length:244
Mass (Da):25,957
Last modified:February 1, 1996 - v2
Checksum:i49AE84E2290DEB0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3I → L in AAB19343 (PubMed:1712818).Curated1
Sequence conflicti15V → A in AAB19343 (PubMed:1712818).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S42294 mRNA Translation: AAB19343.1
U09016
, U09013, U09014, U09015 Genomic DNA Translation: AAA82010.1
D11440 mRNA Translation: BAA02005.1
BC010760 mRNA Translation: AAH10760.1
CCDSiCCDS29742.1
PIRiI48651 LNMSMC
RefSeqiNP_034906.1, NM_010776.1
XP_006526793.1, XM_006526730.1
UniGeneiMm.30045

Genome annotation databases

EnsembliENSMUST00000025797; ENSMUSP00000025797; ENSMUSG00000024863
GeneIDi17195
KEGGimmu:17195
UCSCiuc008hel.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Mannose-binding protein C

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S42294 mRNA Translation: AAB19343.1
U09016
, U09013, U09014, U09015 Genomic DNA Translation: AAA82010.1
D11440 mRNA Translation: BAA02005.1
BC010760 mRNA Translation: AAH10760.1
CCDSiCCDS29742.1
PIRiI48651 LNMSMC
RefSeqiNP_034906.1, NM_010776.1
XP_006526793.1, XM_006526730.1
UniGeneiMm.30045

3D structure databases

ProteinModelPortaliP41317
SMRiP41317
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201335, 1 interactor
STRINGi10090.ENSMUSP00000025797

PTM databases

iPTMnetiP41317
PhosphoSitePlusiP41317

Proteomic databases

PaxDbiP41317
PeptideAtlasiP41317
PRIDEiP41317

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025797; ENSMUSP00000025797; ENSMUSG00000024863
GeneIDi17195
KEGGimmu:17195
UCSCiuc008hel.1 mouse

Organism-specific databases

CTDi4153
MGIiMGI:96924 Mbl2

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104102
HOGENOMiHOG000085660
HOVERGENiHBG108270
InParanoidiP41317
KOiK03991
OMAiYSETVTC
OrthoDBiEOG091G0R93
PhylomeDBiP41317
TreeFamiTF330481

Enzyme and pathway databases

ReactomeiR-MMU-166662 Lectin pathway of complement activation
R-MMU-166663 Initial triggering of complement

Miscellaneous databases

PROiPR:P41317
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024863 Expressed in 84 organ(s), highest expression level in primary oocyte
CleanExiMM_MBL2
ExpressionAtlasiP41317 baseline and differential
GenevisibleiP41317 MM

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR008160 Collagen
IPR016187 CTDL_fold
IPR037570 Mannose-binding_protein
PANTHERiPTHR24020:SF0 PTHR24020:SF0, 1 hit
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMBL2_MOUSE
AccessioniPrimary (citable) accession number: P41317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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