Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor ligand superfamily member 9

Gene

TNFSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.1 Publication

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc
  • tumor necrosis factor receptor binding Source: InterPro
  • tumor necrosis factor receptor superfamily binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 9
Alternative name(s):
4-1BB ligand
Short name:
4-1BBL
Gene namesi
Name:TNFSF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000125657.4
HGNCiHGNC:11939 TNFSF9
MIMi606182 gene
neXtProtiNX_P41273

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini50 – 254ExtracellularSequence analysisAdd BLAST205

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8744
OpenTargetsiENSG00000125657
PharmGKBiPA36629

Polymorphism and mutation databases

BioMutaiTNFSF9
DMDMi728739

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855011 – 254Tumor necrosis factor ligand superfamily member 9Add BLAST254

Proteomic databases

EPDiP41273
MaxQBiP41273
PaxDbiP41273
PeptideAtlasiP41273
PRIDEiP41273
ProteomicsDBi55457

PTM databases

iPTMnetiP41273
PhosphoSitePlusiP41273

Expressioni

Tissue specificityi

Expressed in brain, placenta, lung, skeletal muscle and kidney.

Gene expression databases

BgeeiENSG00000125657 Expressed in 122 organ(s), highest expression level in ectocervix
CleanExiHS_TNFSF9
ExpressionAtlasiP41273 baseline and differential
GenevisibleiP41273 HS

Organism-specific databases

HPAiHPA059857

Interactioni

Subunit structurei

Homotrimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114281, 45 interactors
DIPiDIP-3020N
STRINGi9606.ENSP00000245817

Structurei

Secondary structure

1254
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP41273
SMRiP41273
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41273

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 41Poly-Leu7

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4ZC Eukaryota
ENOG4111EDT LUCA
GeneTreeiENSGT00390000006244
HOGENOMiHOG000154658
HOVERGENiHBG079273
InParanoidiP41273
KOiK05472
OMAiWQLTQGA
OrthoDBiEOG091G0GL6
PhylomeDBiP41273
TreeFamiTF338523

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

P41273-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEYASDASLD PEAPWPPAPR ARACRVLPWA LVAGLLLLLL LAAACAVFLA
60 70 80 90 100
CPWAVSGARA SPGSAASPRL REGPELSPDD PAGLLDLRQG MFAQLVAQNV
110 120 130 140 150
LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR
160 170 180 190 200
RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ
210 220 230 240 250
GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS

PRSE
Length:254
Mass (Da):26,625
Last modified:February 1, 1995 - v1
Checksum:i827551F34563E508
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01192817P → A. Corresponds to variant dbSNP:rs442511Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03398 mRNA Translation: AAA53134.1
BC104805 mRNA Translation: AAI04806.1
BC104807 mRNA Translation: AAI04808.1
CCDSiCCDS12169.1
PIRiI38427
RefSeqiNP_003802.1, NM_003811.3
UniGeneiHs.1524

Genome annotation databases

EnsembliENST00000245817; ENSP00000245817; ENSG00000125657
GeneIDi8744
KEGGihsa:8744
UCSCiuc002mfh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03398 mRNA Translation: AAA53134.1
BC104805 mRNA Translation: AAI04806.1
BC104807 mRNA Translation: AAI04808.1
CCDSiCCDS12169.1
PIRiI38427
RefSeqiNP_003802.1, NM_003811.3
UniGeneiHs.1524

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X29X-ray2.30A80-246[»]
6BWVX-ray2.40A/B89-242[»]
6CPRX-ray2.70A/B/C80-244[»]
6CU0X-ray3.20A/B/C/D/E/F80-244[»]
6D3NX-ray2.70A80-244[»]
ProteinModelPortaliP41273
SMRiP41273
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114281, 45 interactors
DIPiDIP-3020N
STRINGi9606.ENSP00000245817

PTM databases

iPTMnetiP41273
PhosphoSitePlusiP41273

Polymorphism and mutation databases

BioMutaiTNFSF9
DMDMi728739

Proteomic databases

EPDiP41273
MaxQBiP41273
PaxDbiP41273
PeptideAtlasiP41273
PRIDEiP41273
ProteomicsDBi55457

Protocols and materials databases

DNASUi8744
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245817; ENSP00000245817; ENSG00000125657
GeneIDi8744
KEGGihsa:8744
UCSCiuc002mfh.2 human

Organism-specific databases

CTDi8744
DisGeNETi8744
EuPathDBiHostDB:ENSG00000125657.4
GeneCardsiTNFSF9
HGNCiHGNC:11939 TNFSF9
HPAiHPA059857
MIMi606182 gene
neXtProtiNX_P41273
OpenTargetsiENSG00000125657
PharmGKBiPA36629
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4ZC Eukaryota
ENOG4111EDT LUCA
GeneTreeiENSGT00390000006244
HOGENOMiHOG000154658
HOVERGENiHBG079273
InParanoidiP41273
KOiK05472
OMAiWQLTQGA
OrthoDBiEOG091G0GL6
PhylomeDBiP41273
TreeFamiTF338523

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors

Miscellaneous databases

ChiTaRSiTNFSF9 human
EvolutionaryTraceiP41273
GenomeRNAii8744
PROiPR:P41273
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125657 Expressed in 122 organ(s), highest expression level in ectocervix
CleanExiHS_TNFSF9
ExpressionAtlasiP41273 baseline and differential
GenevisibleiP41273 HS

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNFL9_HUMAN
AccessioniPrimary (citable) accession number: P41273
Secondary accession number(s): Q2M3S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again