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Protein

CD27 antigen

Gene

Cd27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
CD27 antigen
Alternative name(s):
CD27L receptor
T-cell activation antigen CD27
Tumor necrosis factor receptor superfamily member 7
CD_antigen: CD27
Gene namesi
Name:Cd27
Synonyms:Tnfrsf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:88326 Cd27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 182ExtracellularSequence analysisAdd BLAST159
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 250CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003457224 – 250CD27 antigenAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 39PROSITE-ProRule annotation
Disulfide bondi40 ↔ 53PROSITE-ProRule annotation
Disulfide bondi43 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 96PROSITE-ProRule annotation
Disulfide bondi87 ↔ 104PROSITE-ProRule annotation
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 117PROSITE-ProRule annotation
Disulfide bondi112 ↔ 120PROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP41272
PaxDbiP41272
PRIDEiP41272

PTM databases

iPTMnetiP41272
PhosphoSitePlusiP41272

Expressioni

Tissue specificityi

In thymus and spleen, but not in non-lymphoid tissues.

Gene expression databases

BgeeiENSMUSG00000030336 Expressed in 71 organ(s), highest expression level in thymus
CleanExiMM_CD27
ExpressionAtlasiP41272 baseline and differential
GenevisibleiP41272 MM

Interactioni

Subunit structurei

Homodimer. Interacts with SIVA1 and TRAF2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi204252, 2 interactors
IntActiP41272, 1 interactor
STRINGi10090.ENSMUSP00000032486

Structurei

3D structure databases

ProteinModelPortaliP41272
SMRiP41272
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 63TNFR-Cys 1Add BLAST38
Repeati64 – 104TNFR-Cys 2Add BLAST41
Repeati105 – 141TNFR-Cys 3Add BLAST37

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZUP Eukaryota
ENOG410ZDEA LUCA
GeneTreeiENSGT00510000049297
HOGENOMiHOG000082545
HOVERGENiHBG018200
InParanoidiP41272
KOiK05144
OMAiCTECDPP
OrthoDBiEOG091G0KN1
PhylomeDBiP41272
TreeFamiTF336960

Family and domain databases

CDDicd13408 TNFRSF7, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022328 TNFR_7
IPR034000 TNFRSF7_N
PRINTSiPR01960 TNFACTORR7
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P41272-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWPPPYWLC MLGTLVGLSA TLAPNSCPDK HYWTGGGLCC RMCEPGTFFV
60 70 80 90 100
KDCEQDRTAA QCDPCIPGTS FSPDYHTRPH CESCRHCNSG FLIRNCTVTA
110 120 130 140 150
NAECSCSKNW QCRDQECTEC DPPLNPALTR QPSETPSPQP PPTHLPHGTE
160 170 180 190 200
KPSWPLHRQL PNSTVYSQRS SHRPLCSSDC IRIFVTFSSM FLIFVLGAIL
210 220 230 240 250
FFHQRRNHGP NEDRQAVPEE PCPYSCPREE EGSAIPIQED YRKPEPAFYP
Length:250
Mass (Da):28,164
Last modified:February 1, 1995 - v1
Checksum:i48477C2E0C244697
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7W5D3Z7W5_MOUSE
CD27 antigen
Cd27
190Annotation score:
B7ZW87B7ZW87_MOUSE
CD27 antigen
Cd27
146Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24495 mRNA No translation available.
CCDSiCCDS39639.1
PIRiA49053
RefSeqiNP_001028298.1, NM_001033126.2
UniGeneiMm.367714

Genome annotation databases

EnsembliENSMUST00000032486; ENSMUSP00000032486; ENSMUSG00000030336
GeneIDi21940
KEGGimmu:21940
UCSCiuc009duc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24495 mRNA No translation available.
CCDSiCCDS39639.1
PIRiA49053
RefSeqiNP_001028298.1, NM_001033126.2
UniGeneiMm.367714

3D structure databases

ProteinModelPortaliP41272
SMRiP41272
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204252, 2 interactors
IntActiP41272, 1 interactor
STRINGi10090.ENSMUSP00000032486

PTM databases

iPTMnetiP41272
PhosphoSitePlusiP41272

Proteomic databases

EPDiP41272
PaxDbiP41272
PRIDEiP41272

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032486; ENSMUSP00000032486; ENSMUSG00000030336
GeneIDi21940
KEGGimmu:21940
UCSCiuc009duc.1 mouse

Organism-specific databases

CTDi939
MGIiMGI:88326 Cd27

Phylogenomic databases

eggNOGiENOG410IZUP Eukaryota
ENOG410ZDEA LUCA
GeneTreeiENSGT00510000049297
HOGENOMiHOG000082545
HOVERGENiHBG018200
InParanoidiP41272
KOiK05144
OMAiCTECDPP
OrthoDBiEOG091G0KN1
PhylomeDBiP41272
TreeFamiTF336960

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Miscellaneous databases

PROiPR:P41272
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030336 Expressed in 71 organ(s), highest expression level in thymus
CleanExiMM_CD27
ExpressionAtlasiP41272 baseline and differential
GenevisibleiP41272 MM

Family and domain databases

CDDicd13408 TNFRSF7, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022328 TNFR_7
IPR034000 TNFRSF7_N
PRINTSiPR01960 TNFACTORR7
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD27_MOUSE
AccessioniPrimary (citable) accession number: P41272
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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